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Nrf2 as a potential target for Parkinson’s disease therapy

https://doi.org/10.1007/s00109-021-02071-5

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1 of the 123 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-28): 10.1016/j.intimp.2017.06.011 (notice 2020-05-25).

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Potential neuroprotective effect of t‐butylhydroquinone against neurotoxicity—Induced by 1‐methyl‐4‐(2′‐methylphenyl)‐1,2,3,6‐tetrahydropyridine (2′‐methyl‐MPTP) in mice

inferredcites →https://doi.org/10.1002/jbt.22044openalex-snapshot

Suppression of microRNA‐144‐3p attenuates oxygen–glucose deprivation/reoxygenation‐induced neuronal injury by promoting Brg1/Nrf2/ARE signaling

inferredcites →https://doi.org/10.1007/s00277-019-03737-4openalex-snapshot

miR-144 regulates oxidative stress tolerance of thalassemic erythroid cell via targeting NRF2

inferredcites →https://doi.org/10.1007/s10059-013-2298-5openalex-snapshot

Berberine Protects 6-Hydroxydopamine-Induced Human Dopaminergic Neuronal Cell Death through the Induction of Heme Oxygenase-1

inferredcites →https://doi.org/10.1007/s10072-018-3273-xopenalex-snapshot

The epidemiology of Parkinson’s disease in the Italian region Friuli Venezia Giulia: a population-based study with administrative data

inferredcites →https://doi.org/10.1007/s11064-011-0471-9openalex-snapshot

Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains

inferredcites →https://doi.org/10.1007/s12035-016-0028-7openalex-snapshot

Tetramethylpyrazine Ameliorates Rotenone-Induced Parkinson’s Disease in Rats: Involvement of Its Anti-Inflammatory and Anti-Apoptotic Actions

inferredcites →https://doi.org/10.1007/s12035-020-01934-1openalex-snapshot

Ferulic Acid Ameliorates MPP+/MPTP-Induced Oxidative Stress via ERK1/2-Dependent Nrf2 Activation: Translational Implications for Parkinson Disease Treatment

inferredcites →https://doi.org/10.1007/s12640-012-9362-3openalex-snapshot

Akt/Nrf2 Activated Upregulation of Heme Oxygenase-1 Involves in the Role of Rg1 Against Ferrous Iron-Induced Neurotoxicity in SK-N-SH Cells

inferredcites →https://doi.org/10.1007/s12640-020-00213-0openalex-snapshot

Perillyl Alcohol Mitigates Behavioural Changes and Limits Cell Death and Mitochondrial Changes in Unilateral 6-OHDA Lesion Model of Parkinson’s Disease Through Alleviation of Oxidative Stress

inferredcites →https://doi.org/10.1016/j.abb.2008.04.003openalex-snapshot

(−)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells

inferredcites →https://doi.org/10.1016/j.abb.2017.08.003openalex-snapshot

Nuclear factor (erythroid-derived 2)-like 2 (NRF2) drug discovery: Biochemical toolbox to develop NRF2 activators by reversible binding of Kelch-like ECH-associated protein 1 (KEAP1)

inferredcites →https://doi.org/10.1016/j.arr.2018.06.003openalex-snapshot

Nrf2: Molecular and epigenetic regulation during aging

inferredcites →https://doi.org/10.1016/j.bbrc.2005.11.095openalex-snapshot

Novel cytoprotective mechanism of anti-parkinsonian drug deprenyl: PI3K and Nrf2-derived induction of antioxidative proteins

inferredcites →https://doi.org/10.1016/j.bcp.2017.12.001openalex-snapshot

Dopamine promotes cellular iron accumulation and oxidative stress responses in macrophages

inferredcites →https://doi.org/10.1016/j.bmc.2010.08.019openalex-snapshot

Identification of organoselenium compounds that possess chemopreventive properties in human prostate cancer LNCaP cells

inferredcites →https://doi.org/10.1016/j.brainres.2017.02.021openalex-snapshot

Ellagic acid exerts protective effect in intrastriatal 6-hydroxydopamine rat model of Parkinson’s disease: Possible involvement of ERβ/Nrf2/HO-1 signaling

inferredcites →https://doi.org/10.1016/j.cbi.2016.03.023openalex-snapshot

Modulatory effects of resveratrol on endoplasmic reticulum stress-associated apoptosis and oxido-inflammatory markers in a rat model of rotenone-induced Parkinson's disease

inferredcites →https://doi.org/10.1016/j.cytogfr.2014.09.002openalex-snapshot

An overview of the molecular mechanisms and novel roles of Nrf2 in neurodegenerative disorders

inferredcites →https://doi.org/10.1016/j.ecoenv.2019.06.007openalex-snapshot

Trehalose suppresses cadmium-activated Nrf2 signaling pathway to protect against spleen injury

inferredcites →https://doi.org/10.1016/j.ejphar.2016.10.037openalex-snapshot

Antidepressant effects of TBE-31 and MCE-1, the novel Nrf2 activators, in an inflammation model of depression

inferredcites →https://doi.org/10.1016/j.envint.2017.07.001openalex-snapshot

Environmental exposure to pesticides and the risk of Parkinson's disease in the Netherlands

inferredcites →https://doi.org/10.1016/j.fct.2020.111644openalex-snapshot

Puerarin suppresses MPP+/MPTP-induced oxidative stress through an Nrf2-dependent mechanism

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2017.04.365openalex-snapshot

Epigallocatechin gallate upregulates NRF2 to prevent diabetic nephropathy via disabling KEAP1

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2017.12.010openalex-snapshot

Mkp-1 protects mice against toxin-induced liver damage by promoting the Nrf2 cytoprotective response

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2018.03.028openalex-snapshot

Rosmarinic acid attenuates β-amyloid-induced oxidative stress via Akt/GSK-3β/Fyn-mediated Nrf2 activation in PC12 cells

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2019.01.003openalex-snapshot

5-(3,4-Difluorophenyl)-3-(6-methylpyridin-3-yl)-1,2,4-oxadiazole (DDO-7263), a novel Nrf2 activator targeting brain tissue, protects against MPTP-induced subacute Parkinson's disease in mice by inhibiting the NLRP3 inflammasome and protects PC12 cells against oxidative stress

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2019.01.016openalex-snapshot

Redox regulation by NRF2 in aging and disease

inferredcites →https://doi.org/10.1016/j.freeradbiomed.2019.07.022openalex-snapshot

S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2

inferredcites →https://doi.org/10.1016/j.intimp.2017.06.011openalex-snapshot

RETRACTED: Diallyl trisulfide, a garlic polysulfide protects against As-induced renal oxidative nephrotoxicity, apoptosis and inflammation in rats by activating the Nrf2/ARE signaling pathway

inferredcites →https://doi.org/10.1016/j.intimp.2019.05.036openalex-snapshot

Astragaloside IV ameliorates motor deficits and dopaminergic neuron degeneration via inhibiting neuroinflammation and oxidative stress in a Parkinson's disease mouse model

inferredcites →https://doi.org/10.1016/j.jnutbio.2017.09.025openalex-snapshot

Grape seed procyanidin extract ameliorates lead-induced liver injury via miRNA153 and AKT/GSK-3β/Fyn-mediated Nrf2 activation

inferredcites →https://doi.org/10.1016/j.lfs.2014.08.004openalex-snapshot

Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson's disease: Involvement of ERK1/2–Nrf2 signaling pathway

inferredcites →https://doi.org/10.1016/j.molcel.2018.06.002openalex-snapshot

UBE2M Is a Stress-Inducible Dual E2 for Neddylation and Ubiquitylation that Promotes Targeted Degradation of UBE2F

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2018.11.013openalex-snapshot

Iron-related nigral degeneration influences functional topology mediated by striatal dysfunction in Parkinson's disease

inferredcites →https://doi.org/10.1016/j.pestbp.2019.03.017openalex-snapshot

Possible involvement of transcriptional activation of nuclear factor erythroid 2-related factor 2 (Nrf2) in the protective effect of caffeic acid on paraquat-induced oxidative damage in Drosophila melanogaster

inferredcites →https://doi.org/10.1016/j.phrs.2018.11.043openalex-snapshot

Naringenin targets on astroglial Nrf2 to support dopaminergic neurons

inferredcites →https://doi.org/10.1016/j.redox.2014.02.008openalex-snapshot

Concerted action of Nrf2-ARE pathway, MRN complex, HMGB1 and inflammatory cytokines - Implication in modification of radiation damage

inferredcites →https://doi.org/10.1016/j.redox.2015.01.002openalex-snapshot

Oxidative stress: a concept in redox biology and medicine

inferredcites →https://doi.org/10.1016/j.scitotenv.2019.06.405openalex-snapshot

Cadmium exposure triggers mitochondrial dysfunction and oxidative stress in chicken (Gallus gallus) kidney via mitochondrial UPR inhibition and Nrf2-mediated antioxidant defense activation

inferredcites →https://doi.org/10.1016/j.taap.2017.08.012openalex-snapshot

Central administration of tert -butylhydroquinone attenuates hypertension via regulating Nrf2 signaling in the hypothalamic paraventricular nucleus of hypertensive rats

inferredcites →https://doi.org/10.1016/j.tibs.2014.02.002openalex-snapshot

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

inferredcites →https://doi.org/10.1016/j.tox.2014.01.008openalex-snapshot

Bardoxolone methyl (BARD) ameliorates aristolochic acid (AA)-induced acute kidney injury through Nrf2 pathway

inferredcites →https://doi.org/10.1016/j.toxlet.2018.04.002openalex-snapshot

Paraquat and MPTP induce alteration in the expression profile of long noncoding RNAs in the substantia nigra of mice: Role of the transcription factor Nrf2

inferredcites →https://doi.org/10.1016/j.toxlet.2019.03.007openalex-snapshot

PERK regulates Nrf2/ARE antioxidant pathway against dibutyl phthalate-induced mitochondrial damage and apoptosis dependent of reactive oxygen species in mouse spermatocyte-derived cells

inferredcites →https://doi.org/10.1021/acs.jafc.7b04641openalex-snapshot

Comparison of Adaptive Neuroprotective Mechanisms of Sulforaphane and its Interconversion Product Erucin in in Vitro and in Vivo Models of Parkinson’s Disease

inferredcites →https://doi.org/10.1021/acs.jafc.8b04341openalex-snapshot

Lycopene Triggers Nrf2–AMPK Cross Talk to Alleviate Atrazine-Induced Nephrotoxicity in Mice

inferredcites →https://doi.org/10.1021/bi047434hopenalex-snapshot

Keap1, the Sensor for Electrophiles and Oxidants that Regulates the Phase 2 Response, Is a Zinc Metalloprotein

inferredcites →https://doi.org/10.1021/jf301511mopenalex-snapshot

Baicalein Protects against 6-OHDA-Induced Neurotoxicity through Activation of Keap1/Nrf2/HO-1 and Involving PKCα and PI3K/AKT Signaling Pathways

inferredcites →https://doi.org/10.1021/tx300171uopenalex-snapshot

Carnosic Acid Prevents 6-Hydroxydopamine-Induced Cell Death in SH-SY5Y Cells via Mediation of Glutathione Synthesis

inferredcites →https://doi.org/10.1021/tx700302sopenalex-snapshot

Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3

inferredcites →https://doi.org/10.1038/ncomms11624openalex-snapshot

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription

inferredcites →https://doi.org/10.1038/onc.2012.59openalex-snapshot

The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains

inferredcites →https://doi.org/10.1042/bj20061611openalex-snapshot

Nrf2 Neh5 domain is differentially utilized in the transactivation of cytoprotective genes

inferredcites →https://doi.org/10.1046/j.1471-4159.2001.00374.xopenalex-snapshot

Astrocytes protect neurons from nitric oxide toxicity by a glutathione‐dependent mechanism

inferredcites →https://doi.org/10.1073/pnas.0607260103openalex-snapshot

DJ-1, a cancer- and Parkinson's disease-associated protein, stabilizes the antioxidant transcriptional master regulator Nrf2

inferredcites →https://doi.org/10.1073/pnas.0813361106openalex-snapshot

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

inferredcites →https://doi.org/10.1073/pnas.0914036107openalex-snapshot

Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains

inferredcites →https://doi.org/10.1073/pnas.1305687110openalex-snapshot

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

inferredcites →https://doi.org/10.1073/pnas.1522872114openalex-snapshot

Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis

inferredcites →https://doi.org/10.1073/pnas.172398899openalex-snapshot

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

inferredcites →https://doi.org/10.1073/pnas.91.21.9926openalex-snapshot

Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region.

inferredcites →https://doi.org/10.1080/00207454.2018.1441149openalex-snapshot

Targeting crosstalk between Nuclear factor (erythroid-derived 2)-like 2 and Nuclear factor kappa beta pathway by Nrf2 activator dimethyl fumarate in epileptogenesis

inferredcites →https://doi.org/10.1080/1028415x.2016.1253171openalex-snapshot

Neuroprotective effect of fermented papaya preparation by activation of Nrf2 pathway in astrocytes

inferredcites →https://doi.org/10.1080/10715762.2019.1635251openalex-snapshot

p62/SQSTM1 protects against cisplatin-induced oxidative stress in kidneys by mediating the cross talk between autophagy and the Keap1-Nrf2 signalling pathway

inferredcites →https://doi.org/10.1080/15548627.2016.1208889openalex-snapshot

Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes

inferredcites →https://doi.org/10.1080/15548627.2017.1339845openalex-snapshot

Regulation of SQSTM1/p62 via UBA domain ubiquitination and its role in disease

inferredcites →https://doi.org/10.1080/15548627.2018.1474992openalex-snapshot

Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A

inferredcites →https://doi.org/10.1089/ars.2006.8.43openalex-snapshot

Hyperoxia Stimulates an Nrf2-ARE Transcriptional Response via ROS-EGFR-PI3K-Akt/ERK MAP Kinase Signaling in Pulmonary Epithelial Cells

inferredcites →https://doi.org/10.1089/ars.2011.4491openalex-snapshot

Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

inferredcites →https://doi.org/10.1089/ars.2012.4900openalex-snapshot

Regulation of Lifespan by the Mitochondrial Electron Transport Chain: Reactive Oxygen Species-Dependent and Reactive Oxygen Species-Independent Mechanisms

inferredcites →https://doi.org/10.1089/ars.2015.6549openalex-snapshot

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

inferredcites →https://doi.org/10.1089/ars.2016.6800openalex-snapshot

The Neuroprotective Effect of Dimethyl Fumarate in an MPTP-Mouse Model of Parkinson's Disease: Involvement of Reactive Oxygen Species/Nuclear Factor-κB/Nuclear Transcription Factor Related to NF-E2

inferredcites →https://doi.org/10.1089/jmf.2017.4078openalex-snapshot

Beneficial Effects of Flavonoids Against Parkinson's Disease

inferredcites →https://doi.org/10.1093/toxsci/59.1.169openalex-snapshot

High Sensitivity of Nrf2 Knockout Mice to Acetaminophen Hepatotoxicity Associated with Decreased Expression of ARE-Regulated Drug Metabolizing Enzymes and Antioxidant Genes

inferredcites →https://doi.org/10.1093/toxsci/kfv111openalex-snapshot

Phytoestrogen β-Ecdysterone Protects PC12 Cells Against MPP+-Induced NeurotoxicityIn Vitro: Involvement of PI3K-Nrf2-Regulated Pathway

inferredcites →https://doi.org/10.1096/fj.201900133ropenalex-snapshot

p62/SQSTM1 and Nrf2 are essential for exercise‐mediated enhancement of antioxidant protein expression in oxidative muscle

inferredcites →https://doi.org/10.1097/nen.0b013e31802d6da9openalex-snapshot

Expression of Nrf2 in Neurodegenerative Diseases

inferredcites →https://doi.org/10.1111/1750-3841.14643openalex-snapshot

Grape Peel Extract and Resveratrol Inhibit Wrinkle Formation in Mice Model Through Activation of Nrf2/HO‐1 Signaling Pathway

inferredcites →https://doi.org/10.1111/bjh.15982openalex-snapshot

Arsenic trioxide suppresses acute graft‐versus‐host disease by activating the Nrf2/HO‐1 pathway in mice

inferredcites →https://doi.org/10.1124/mol.117.110262openalex-snapshot

Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo

inferredcites →https://doi.org/10.1124/pr.117.014753openalex-snapshot

Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach

inferredcites →https://doi.org/10.1128/mcb.00180-12openalex-snapshot

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis

inferredcites →https://doi.org/10.1128/mcb.01204-10openalex-snapshot

SCF/β-TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

inferredcites →https://doi.org/10.1128/mcb.01591-09openalex-snapshot

Genetic Analysis of Cytoprotective Functions Supported by Graded Expression of Keap1

inferredcites →https://doi.org/10.1128/mcb.23.22.8137-8151.2003openalex-snapshot

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

inferredcites →https://doi.org/10.1128/mcb.25.24.10895-10906.2005openalex-snapshot

The Carboxy-Terminal Neh3 Domain of Nrf2 Is Required for Transcriptional Activation

inferredcites →https://doi.org/10.1146/annurev-pharmtox-011112-140320openalex-snapshot

Role of Nrf2 in Oxidative Stress and Toxicity

inferredcites →https://doi.org/10.1155/2017/4020198openalex-snapshot

Genetic Variations and mRNA Expression of NRF2 in Parkinson’s Disease

inferredcites →https://doi.org/10.1155/2019/6218239openalex-snapshot

Neuroprotective Role of the Nrf2 Pathway in Subarachnoid Haemorrhage and Its Therapeutic Potential

inferredcites →https://doi.org/10.1155/2019/9426867openalex-snapshot

Benefits of Vitamins in the Treatment of Parkinson’s Disease

inferredcites →https://doi.org/10.1158/0008-5472.can-12-3386openalex-snapshot

RXRα Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2

inferredcites →https://doi.org/10.1158/1541-7786.mcr-13-0246-topenalex-snapshot

The Impact of miRNA-Based Molecular Diagnostics and Treatment of NRF2-Stabilized Tumors

inferredcites →https://doi.org/10.1158/1541-7786.mcr-17-0232openalex-snapshot

miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1

inferredcites →https://doi.org/10.1158/1940-6207.capr-12-0401-topenalex-snapshot

Roles of Keap1–Nrf2 System in Upper Aerodigestive Tract Carcinogenesis

inferredcites →https://doi.org/10.1159/000475890openalex-snapshot

Targeting the KEAP1-NRF2 System to Prevent Kidney Disease Progression

inferredcites →https://doi.org/10.1172/jci130351openalex-snapshot

Oxidative stress and α-synuclein conspire in vulnerable neurons to promote Parkinson’s disease progression

inferredcites →https://doi.org/10.1176/jnp.14.2.223openalex-snapshot

An Essay on the Shaking Palsy

inferredcites →https://doi.org/10.1186/1471-2350-11-36openalex-snapshot

Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson's disease

inferredcites →https://doi.org/10.1186/1756-6606-5-35openalex-snapshot

Mitochondrial dysfunction associated with increased oxidative stress and α-synuclein accumulation in PARK2 iPSC-derived neurons and postmortem brain tissue

inferredcites →https://doi.org/10.1186/s12881-014-0131-4openalex-snapshot

Genetic associations of Nrf2-encoding NFE2L2 variants with Parkinson’s disease – a multicenter study

inferredcites →https://doi.org/10.1242/dmm.007575openalex-snapshot

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in aDrosophilamodel of Parkinson’s disease

inferredcites →https://doi.org/10.1248/bpb.b17-00091openalex-snapshot

Therapeutic Potential of the Activators of the Nuclear Factor Erythroid 2-Related Factor 2–Antioxidant Response Element Pathway in Brain Disorders

inferredcites →https://doi.org/10.1371/journal.pone.0005757openalex-snapshot

Neuroprotective Effects of the Triterpenoid, CDDO Methyl Amide, a Potent Inducer of Nrf2-Mediated Transcription

inferredcites →https://doi.org/10.1371/journal.pone.0006588openalex-snapshot

Phosphorylation of Nrf2 at Multiple Sites by MAP Kinases Has a Limited Contribution in Modulating the Nrf2-Dependent Antioxidant Response

inferredcites →https://doi.org/10.1371/journal.pone.0142438openalex-snapshot

NRF2 Regulates PINK1 Expression under Oxidative Stress Conditions

inferredcites →https://doi.org/10.14336/ad.2017.0831openalex-snapshot

Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease

inferredcites →https://doi.org/10.14336/ad.2018.0513openalex-snapshot

The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases

inferredcites →https://doi.org/10.1515/bc.2006.164openalex-snapshot

Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism

inferredcites →https://doi.org/10.1523/jneurosci.0426-16.2016openalex-snapshot

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

inferredcites →https://doi.org/10.1523/jneurosci.2246-12.2012openalex-snapshot

NADPH Oxidase 1 Mediates α-Synucleinopathy in Parkinson's Disease

inferredcites →https://doi.org/10.1523/jneurosci.3049-12.2012openalex-snapshot

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

inferredcites →https://doi.org/10.1590/s1677-5538.ibju.2018.0232openalex-snapshot

Beneficial effects of Oltipraz, nuclear factor - erythroid – 2 - related factor 2 (Nrf2), on renal damage in unilateral ureteral obstruction rat model

inferredcites →https://doi.org/10.18632/aging.102394openalex-snapshot

Neuroprotective effects of protocatechuic aldehyde through PLK2/p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson's disease

inferredcites →https://doi.org/10.2174/1381612823666170710163731openalex-snapshot

Therapeutic Strategy of Targeting Astrocytes for Neuroprotection in Parkinson's Disease

inferredcites →https://doi.org/10.2174/1381612823999171012102230openalex-snapshot

Editorial: Astrocyte-Targeted Therapeutic Strategies for Neurological Disorders

inferredcites →https://doi.org/10.3109/10715760903456084openalex-snapshot

Determination of reactive oxygen species associated with the degeneration of dopaminergic neurons during dopamine metabolism

inferredcites →https://doi.org/10.3233/jpd-140479openalex-snapshot

Fatty Acid Composition of the Anterior Cingulate Cortex Indicates a High Susceptibility to Lipid Peroxidation in Parkinson's Disease

inferredcites →https://doi.org/10.3233/jpd-191633openalex-snapshot

Long Term Response to Levodopa in Parkinson’s Disease

inferredcites →https://doi.org/10.3390/cells8080911openalex-snapshot

The Therapeutic Implications of Tea Polyphenols against Dopamine (DA) Neuron Degeneration in Parkinson’s Disease (PD)

inferredcites →https://doi.org/10.36721/pjps/29/4(sup)/04.07.2016/448/1365-1369openalex-snapshot

Nrf2 knockout: The effect on neurological dysfunction and the activation of glial cells of mice after brain injury

inferredcites →https://doi.org/10.3892/mmr.2015.4657openalex-snapshot

Curcumin ameliorates dopaminergic neuronal oxidative damage via activation of the Akt/Nrf2 pathway

inferredcites →https://doi.org/10.3892/mmr.2019.10148openalex-snapshot

Sulforaphane prevents PC12 cells from oxidative damage via the Nrf2 pathway

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Inhibiting Nrf2 Expression Exacerbates Nlrp3 Inflammasome Activation and Dopamine Neuron Degeneration in Parkinson's Disease Models

inferred← citeshttps://doi.org/10.1002/med.21939openalex-snapshot

Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis

inferred← citeshttps://doi.org/10.1002/ptr.8342openalex-snapshot

Role of Glutathione in Parkinson's Disease Pathophysiology and Therapeutic Potential of Polyphenols

inferred← citeshttps://doi.org/10.1007/s10522-026-10455-8openalex-snapshot

Dimethyl fumarate ameliorates quinolinic acid-induced ageing and neurodegeneration in Caenorhabditis elegans

inferred← citeshttps://doi.org/10.1007/s11011-024-01367-yopenalex-snapshot

Inhibitor of apoptosis stimulating protein of p53 protects against MPP+-induced neurotoxicity of dopaminergic neurons

inferred← citeshttps://doi.org/10.1007/s11011-024-01452-2openalex-snapshot

Emerging role of Nrf2 in Parkinson’s disease therapy: a critical reassessment

inferred← citeshttps://doi.org/10.1007/s11064-025-04557-xopenalex-snapshot

Sinomenine Modifies Parkinson’s Disease Through Nrf2 Activation

inferred← citeshttps://doi.org/10.1007/s11064-026-04854-zopenalex-snapshot

PARK7/HSPB1-Mediated Neuroprotective Effects of SHED in an In vitro Parkinson’s Disease Model

inferred← citeshttps://doi.org/10.1007/s12035-025-04762-3openalex-snapshot

Emodin, a Potent Anthraquinone Mitigates MPTP-Induced Parkinsons’ Disease Pathology by Regulating Nrf2 and Its Downstream Targets: In Silico and In Vivo Approach

inferred← citeshttps://doi.org/10.1007/s12035-025-05517-wopenalex-snapshot

Nrf2/Keap1 Signaling Axis in the Brain: Master Regulator of Oxidative Stress in Neurodegenerative and Psychiatric Disorders

inferred← citeshttps://doi.org/10.1016/bs.irn.2026.01.006openalex-snapshot

Activation of Nrf2 neuroprotective pathways for treatment of Parkinson’s disease: A state of art review

inferred← citeshttps://doi.org/10.1016/j.arr.2023.102077openalex-snapshot

Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential

inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.154459openalex-snapshot

Crosstalk between α-synuclein accumulation, NLRP3 inflammasome activation, oxidative stress, and apoptosis in a rotenone-induced Parkinson rat model

inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117611openalex-snapshot

Mechanism of Gastrodin against neurotoxicity based on network pharmacology, molecular docking and experimental verification

inferred← citeshttps://doi.org/10.1016/j.brainres.2025.149953openalex-snapshot

Utility of Drosophila for studying hypoxia-inducible factor (HIF) in neurodegenerative diseases: Advantages versus limitations

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2025.12.007openalex-snapshot

Identification and mechanistic exploration of a mono-carbonyl analog A1 of dietary curcumin as a potent Nrf2-dependent neuroprotective agent within a cellular model of Parkinson's disease

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.109698openalex-snapshot

α-Cyperone protects dopaminergic neurons and inhibits neuroinflammation in LPS-induced Parkinson’s disease rat model via activating Nrf2/HO-1 and suppressing NF-κB signaling pathway

inferred← citeshttps://doi.org/10.1016/j.jare.2023.11.021openalex-snapshot

Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson’s disease models

inferred← citeshttps://doi.org/10.1016/j.jchemneu.2023.102315openalex-snapshot

Caffeine alleviates anxiety-like behavior and brainstem lesions in a rotenone-induced rat model of Parkinson's disease

inferred← citeshttps://doi.org/10.1016/j.lfs.2021.120111openalex-snapshot

Nrf2/Keap1/ARE signaling: Towards specific regulation

inferred← citeshttps://doi.org/10.1016/j.nantod.2023.101770openalex-snapshot

Modulating SQSTM1/p62-dependent selective autophagy of neurons by activating Nrf2 with multifunctional nanoparticles to eliminate α-synuclein aggregates and boost therapy of Parkinson’s disease

inferred← citeshttps://doi.org/10.1016/j.neuint.2022.105325openalex-snapshot

The principal molecular mechanisms behind the activation of Keap1/Nrf2/ARE pathway leading to neuroprotective action in Parkinson's disease

inferred← citeshttps://doi.org/10.1016/j.neulet.2021.136222openalex-snapshot

Flavin-containing monooxygenase 1 deficiency promotes neuroinflammation in dopaminergic neurons in mice

inferred← citeshttps://doi.org/10.1016/j.neuro.2023.08.001openalex-snapshot

Acetyl-11-keto-beta boswellic acid(AKBA) modulates CSTC-pathway by activating SIRT-1/Nrf2-HO-1 signalling in experimental rat model of obsessive-compulsive disorder: Evidenced by CSF, blood plasma and histopathological alterations

inferred← citeshttps://doi.org/10.1016/j.neuroscience.2026.04.009openalex-snapshot

The protective effect of biochanin A on LPS/TNF-α-induced PD models is exerted by regulating ferroptosis through the Sirt1/Nrf2/GPX4 signaling pathway

inferred← citeshttps://doi.org/10.1016/j.neurot.2023.10.002openalex-snapshot

Mitochondrial dysfunction in neurodegenerative disorders

inferred← citeshttps://doi.org/10.1016/j.nut.2024.112610openalex-snapshot

Plant-derived compounds as potential neuroprotective agents in Parkinson's disease

inferred← citeshttps://doi.org/10.1016/j.taap.2024.117113openalex-snapshot

CBR-470-1 protects against cardiomyocyte death in ischaemia/reperfusion injury by activating the Nrf2–GPX4 cascade

inferred← citeshttps://doi.org/10.1021/acs.jafc.3c05285openalex-snapshot

Optimized Separation of Carthamin from Safflower by Macroporous Adsorption Resins and Its Protective Effects on PC12 Cells Injured by OGD/R via Nrf2 Signaling Pathway

inferred← citeshttps://doi.org/10.1080/09637486.2023.2243055openalex-snapshot

Vitexin and isovitexin delayed ageing and enhanced stress-resistance through the activation of the SKN-1/Nrf2 signaling pathway

inferred← citeshttps://doi.org/10.1097/md.0000000000040524openalex-snapshot

The association between age-related macular degeneration and risk of Parkinson disease: A systematic review and meta-analysis

inferred← citeshttps://doi.org/10.1111/jfbc.14451openalex-snapshot

Neuroprotective potential of Moringa oleifera mediated by NF‐kB/Nrf2/HO‐1 signaling pathway: A review

inferred← citeshttps://doi.org/10.1155/2022/1837278openalex-snapshot

Inhibition of the TLR/NF‐κB Signaling Pathway and Improvement of Autophagy Mediates Neuroprotective Effects of Plumbagin in Parkinson’s Disease

inferred← citeshttps://doi.org/10.1155/2022/7925686openalex-snapshot

MANF Inhibits α‐Synuclein Accumulation through Activation of Autophagic Pathways

inferred← citeshttps://doi.org/10.1186/s13064-026-00271-8openalex-snapshot

Mechanistic and therapeutic perspectives on the role of the Wnt/β-catenin axis in aging and neurodegeneration

inferred← citeshttps://doi.org/10.18699/vjgb-25-03openalex-snapshot

Generation and characterisation of seven induced pluripotent stem cell lines from two patients with Parkinson’s disease carrying the pathological variant c.1087G>T of the LGR4 gene

inferred← citeshttps://doi.org/10.21203/rs.3.rs-1100361/v1openalex-snapshot

Monosialoganglioside GM1 Deficiency Inhibits the Neurotrophic Effects of GDNF by Disrupting Lipid Raft Assembly

inferred← citeshttps://doi.org/10.2147/jir.s478683openalex-snapshot

Nrf2 Deficiency Exacerbates Parkinson’s Disease by Aggravating NLRP3 Inflammasome Activation in MPTP-Induced Mouse Models and LPS-Induced BV2 Cells

inferred← citeshttps://doi.org/10.2174/0113892002271342231013095255openalex-snapshot

Nrf2 Regulates the Expression of CYP2D6 by Inhibiting the Activity of Krüppel-Like Factor 9 (KLF9)

inferred← citeshttps://doi.org/10.2174/1567202619666220406082221openalex-snapshot

Downregulation of CHCHD2 may Contribute to Parkinson’s Disease by Reducing Expression of NFE2L2 and RQCD1

inferred← citeshttps://doi.org/10.26599/fshw.2024.9250068openalex-snapshot

L -Ergothioneine ameliorates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease in C57BL/6J mice by activating DJ-1

inferred← citeshttps://doi.org/10.30574/wjbphs.2023.13.3.0111openalex-snapshot

Protective effects of Auranofin on the 6-hydroxydopamine model of Parkinson's disease in rats

inferred← citeshttps://doi.org/10.31083/j.fbl2803042openalex-snapshot

Protective Effects of Querectin against MPP+-Induced Dopaminergic Neurons Injury via the Nrf2 Signaling Pathway

inferred← citeshttps://doi.org/10.3389/fphar.2022.919233openalex-snapshot

Role of Nrf2 in Parkinson’s Disease: Toward New Perspectives

inferred← citeshttps://doi.org/10.3390/antiox10111649openalex-snapshot

NRF2 Activation and Downstream Effects: Focus on Parkinson’s Disease and Brain Angiotensin

inferred← citeshttps://doi.org/10.3390/antiox14060696openalex-snapshot

Oxidative Stress: Pathological Driver in Chronic Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.3390/antiox15080926openalex-snapshot

NRF2 Deletion Results in Mobility Impairment in A53TSyn Model of Synucleinopathy

inferred← citeshttps://doi.org/10.3390/biom15010113openalex-snapshot

Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2

inferred← citeshttps://doi.org/10.3390/biomedicines12071592openalex-snapshot

Rasagiline Exerts Neuroprotection towards Oxygen–Glucose-Deprivation/Reoxygenation-Induced GAPDH-Mediated Cell Death by Activating Akt/Nrf2 Signaling

inferred← citeshttps://doi.org/10.3390/brainsci15020144openalex-snapshot

Epigallocatechin-3-Gallate, Quercetin, and Kaempferol for Treatment of Parkinson’s Disease Through Prevention of Gut Dysbiosis and Attenuation of Multiple Molecular Mechanisms of Pathogenesis

inferred← citeshttps://doi.org/10.3390/ijms23042378openalex-snapshot

Ferritinophagy and α-Synuclein: Pharmacological Targeting of Autophagy to Restore Iron Regulation in Parkinson’s Disease

inferred← citeshttps://doi.org/10.3390/ijms23073625openalex-snapshot

Nutraceuticals as Modulators of Autophagy: Relevance in Parkinson’s Disease

inferred← citeshttps://doi.org/10.3390/life13041035openalex-snapshot

Antioxidant Therapy as an Effective Strategy against Noise-Induced Hearing Loss: From Experimental Models to Clinic

inferred← citeshttps://doi.org/10.3390/nu15173751openalex-snapshot

Overview on the Polyphenol Avenanthramide in Oats (Avena sativa Linn.) as Regulators of PI3K Signaling in the Management of Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.4239/wjd.v16.i6.104851openalex-snapshot

Dose-dependent L-arginine cardiotoxicity in diabetic cardiomyopathy: Mechanisms and clinical implications

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