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Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.molbiopara.2006.06.003openalex-snapshot
Molecular genetic transfection of the coccidian parasite Sarcocystis neurona
inferredcites →https://doi.org/10.1016/j.molbiopara.2010.12.009openalex-snapshot
Structure determination of glycogen synthase kinase-3 from Leishmania major and comparative inhibitor structure–activity relationships with Trypanosoma brucei GSK-3
inferredcites →https://doi.org/10.1016/j.pep.2005.01.016openalex-snapshot
Protein production by auto-induction in high-density shaking cultures
inferredcites →https://doi.org/10.1016/j.vetpar.2015.01.026openalex-snapshot
An update on Sarcocystis neurona infections in animals and equine protozoal myeloencephalitis (EPM)
inferredcites →https://doi.org/10.1016/s0304-4017(00)00376-9openalex-snapshot
Diclazuril preventive therapy of gamma interferon knockout mice fed Sarcocystis neurona sporocysts
inferredcites →https://doi.org/10.1016/s0304-4017(00)00384-8openalex-snapshot
A review of Sarcocystis neurona and equine protozoal myeloencephalitis (EPM)
inferredcites →https://doi.org/10.1016/s0737-0806(06)82197-0openalex-snapshot
Treatment of equine protozoal myeloencephalitis with nitazoxanide
inferredcites →https://doi.org/10.1016/s0960-9822(98)70198-8openalex-snapshot
Design of allele-specific inhibitors to probe protein kinase signaling
inferredcites →https://doi.org/10.1021/acs.jmedchem.6b00760openalex-snapshot
Development of an Orally Available and Central Nervous System (CNS) Penetrant Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitor with Minimal Human Ether-a-go-go-Related Gene (hERG) Activity for the Treatment of Toxoplasmosis
inferredcites →https://doi.org/10.1021/acsmedchemlett.5b00319openalex-snapshot
SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1
inferredcites →https://doi.org/10.1021/jm201713hopenalex-snapshot
Development of Toxoplasma gondii Calcium-Dependent Protein Kinase 1 (TgCDPK1) Inhibitors with Potent Anti-Toxoplasma Activity
inferredcites →https://doi.org/10.1021/ml100096topenalex-snapshot
Discovery of Potent and Selective Inhibitors of CDPK1 from C. parvum and T. gondii
inferredcites →https://doi.org/10.1021/ml400315sopenalex-snapshot
Potent and Selective Inhibitors of CDPK1 from T. gondii and C. parvum Based on a 5-Aminopyrazole-4-carboxamide Scaffold
inferredcites →https://doi.org/10.1038/emboj.2012.299openalex-snapshot
Distinct signalling pathways control Toxoplasma egress and host‐cell invasion
inferredcites →https://doi.org/10.1038/nature09022openalex-snapshot
Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma
inferredcites →https://doi.org/10.1038/nsmb.1795openalex-snapshot
Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium
inferredcites →https://doi.org/10.1038/nsmb.1818openalex-snapshot
Toxoplasma gondii calcium-dependent protein kinase 1 is a target for selective kinase inhibitors
inferredcites →https://doi.org/10.1053/j.ctep.2006.01.003openalex-snapshot
Equine Protozoal Myeloencephalitis: Treatment, Prognosis, and Prevention
inferredcites →https://doi.org/10.1093/infdis/jit327openalex-snapshot
A Novel Calcium-Dependent Protein Kinase Inhibitor as a Lead Compound for Treating Cryptosporidiosis
inferredcites →https://doi.org/10.1093/infdis/jit522openalex-snapshot
A Specific Inhibitor of PfCDPK4 Blocks Malaria Transmission: Chemical-genetic Validation
inferredcites →https://doi.org/10.1111/j.1476-5381.2009.00207.xopenalex-snapshot
An introduction to QT interval prolongation and non‐clinical approaches to assessing and reducing risk
inferredcites →https://doi.org/10.1111/j.1550-7408.1999.tb06067.xopenalex-snapshot
Characterization of aSarcocystis neurona.Isolate (SN6) from a Naturally Infected Horse from Oregon
inferredcites →https://doi.org/10.1111/j.1939-1676.1995.tb01094.xopenalex-snapshot
An Echocardiographic Study of Atrial Fibrillation in Horses: Before and After Conversion to Sinus Rhythm
inferredcites →https://doi.org/10.1126/science.1233606openalex-snapshot
Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay
inferredcites →https://doi.org/10.1128/aac.01823-13openalex-snapshot
Bumped Kinase Inhibitor 1294 Treats Established Toxoplasma gondii Infection
inferredcites →https://doi.org/10.1172/jci61822openalex-snapshot
Transmission of malaria to mosquitoes blocked by bumped kinase inhibitors
inferredcites →https://doi.org/10.1177/1040638715584995openalex-snapshot
A new trivalent SnSAG surface antigen chimera for efficient detection of antibodies against Sarcocystis neurona and diagnosis of equine protozoal myeloencephalitis
inferredcites →https://doi.org/10.1177/1087057109335749openalex-snapshot
Buffer Optimization of Thermal Melt Assays of Plasmodium Proteins for Detection of Small-Molecule Ligands
inferredcites →https://doi.org/10.1186/s13071-014-0611-6openalex-snapshot
Theileria equi isolates vary in susceptibility to imidocarb dipropionate but demonstrate uniform in vitro susceptibility to a bumped kinase inhibitor
inferredcites →https://doi.org/10.1371/journal.pone.0092929openalex-snapshot
Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy
inferredcites →https://doi.org/10.1645/0022-3395(2000)086[1150:icosni]2.0.co;2openalex-snapshot
Immunohistochemical Confirmation ofSarcocystis neuronaInfections in Raccoons, Mink, Cat, Skunk, and Pony
inferredcites →https://doi.org/10.2460/ajvr.69.3.396openalex-snapshot
Effect of intermittent oral administration of ponazuril on experimental Sarcocystis neurona infection of horses
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4577525openalex-extracted
Single and Combination Treatment of Toxoplasma Gondii Infections with a Bumped Kinase Inhibitor and Artemisone in Vitro and with Artemiside in Experimentally Infected Mice
inferred← citeshttps://doi.org/10.1002/9781119477204.ch32openalex-snapshot
Infectious, inflammatory, and immune diseases
inferred← citeshttps://doi.org/10.1016/j.cveq.2022.05.003openalex-snapshot
Equine Protozoal Myeloencephalitis
inferred← citeshttps://doi.org/10.1016/j.exppara.2017.01.001openalex-snapshot
Extended-spectrum antiprotozoal bumped kinase inhibitors: A review
inferred← citeshttps://doi.org/10.1016/j.exppara.2023.108655openalex-snapshot
Single and combination treatment of Toxoplasma gondii infections with a bumped kinase inhibitor and artemisone in vitro and with artemiside in experimentally infected mice
inferred← citeshttps://doi.org/10.1016/j.ijpara.2017.06.002openalex-snapshot
In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum
inferred← citeshttps://doi.org/10.1016/j.ijpara.2017.08.005openalex-snapshot
In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites
inferred← citeshttps://doi.org/10.1016/j.ijpara.2022.10.002openalex-snapshot
In vitro cultivation methods for coccidian parasite research
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2018.02.002openalex-snapshot
High-throughput screen of drug repurposing library identifies inhibitors of Sarcocystis neurona growth
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2019.03.004openalex-snapshot
Bumped kinase inhibitor 1369 is effective against Cystoisospora suis in vivo and in vitro
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2020.08.005openalex-snapshot
Reduced treatment frequencies with bumped kinase inhibitor 1369 are effective against porcine cystoisosporosis
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2021.05.001openalex-snapshot
In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2021.08.007openalex-snapshot
Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo
inferred← citeshttps://doi.org/10.1016/j.ijpddr.2024.100553openalex-snapshot
Efficacy of the bumped kinase inhibitor BKI-1708 against the cyst-forming apicomplexan parasites Toxoplasma gondii and Neospora caninum in vitro and in experimentally infected mice
inferred← citeshttps://doi.org/10.1016/j.vetpar.2020.109336openalex-snapshot
One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases
inferred← citeshttps://doi.org/10.1017/s0031182021002055openalex-snapshot
Sarcocystis neurona,Neosporaspp. andToxoplasma gondiiinfections in horses and equine protozoal myeloencephalitis (EPM): five decades of personal experience, perspectives and update
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b01663openalex-snapshot
Novel Molecules To Treat Chronic Central Nervous System Toxoplasmosis
inferred← citeshttps://doi.org/10.1039/c6md00675bopenalex-snapshot
Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues
inferred← citeshttps://doi.org/10.1080/17460441.2023.2276349openalex-snapshot
In vitro screening technologies for the discovery and development of novel drugs against Toxoplasma gondii
inferred← citeshttps://doi.org/10.1101/2025.10.22.684074openalex-snapshot
Bumped kinase inhibitor BKI-1708 interferes in cytokinesis and drives baryzoite stage conversion in the cyst-forming apicomplexan parasites Toxoplasma gondii, Neospora caninum and Besnoitia besnoiti
inferred← citeshttps://doi.org/10.1128/aac.00051-18openalex-snapshot
Toxoplasma Calcium-Dependent Protein Kinase 1 Inhibitors: Probing Activity and Resistance Using Cellular Thermal Shift Assays
inferred← citeshttps://doi.org/10.1128/msphere.00111-24openalex-snapshot
Temporal gene expression during asexual development of the apicomplexan Sarcocystis neurona
inferred← citeshttps://doi.org/10.1371/journal.pone.0259109openalex-snapshot
Transcriptional dynamics in the protozoan parasite Sarcocystis neurona and mammalian host cells after treatment with a specific inhibitor of apicomplexan mRNA polyadenylation
inferred← citeshttps://doi.org/10.3389/fcimb.2025.1633384openalex-snapshot
Proteome changes during in vitro culture adaptation of Toxoplasma gondii archetypal II and III field isolates
inferred← citeshttps://doi.org/10.3390/ani15030444openalex-snapshot
Recent Issues in the Development and Application of Targeted Therapies with Respect to Individual Animal Variability
inferred← citeshttps://doi.org/10.3390/pathogens6010012openalex-snapshot
Genome-Wide Identification and Evolutionary Analysis of Sarcocystis neurona Protein Kinases
inferred← citeshttps://doi.org/10.3390/pathogens9050382openalex-snapshot
Neospora caninum: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294
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