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Single and Combination Treatment of Toxoplasma Gondii Infections with a Bumped Kinase Inhibitor and Artemisone in Vitro and with Artemiside in Experimentally Infected Mice

https://doi.org/10.2139/ssrn.4577525
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Calcium-Dependent Signaling and Kinases in Apicomplexan Parasites
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Neosporosis, Toxoplasmosis, and Sarcocystosis in Ruminants
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Drug combination therapy increases successful drug repositioning
inferredcites →https://doi.org/10.1016/j.exppara.2017.01.001openalex-extracted
Extended-spectrum antiprotozoal bumped kinase inhibitors: A review
inferredcites →https://doi.org/10.1016/j.ijantimicag.2020.106099openalex-extracted
Comparative assessment of the effects of bumped kinase inhibitors on early zebrafish embryo development and pregnancy in mice
inferredcites →https://doi.org/10.1016/j.ijpara.2012.08.004openalex-extracted
In vitro culture systems for the study of apicomplexan parasites in farm animals
inferredcites →https://doi.org/10.1016/j.ijpara.2016.08.003openalex-extracted
Selective inhibition of Sarcocystis neurona calcium-dependent protein kinase 1 for equine protozoal myeloencephalitis therapy
inferredcites →https://doi.org/10.1016/j.ijpara.2017.08.005openalex-extracted
In vitro efficacy of bumped kinase inhibitors against Besnoitia besnoiti tachyzoites
inferredcites →https://doi.org/10.1016/j.ijpara.2020.01.006openalex-extracted
Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned
inferredcites →https://doi.org/10.1016/j.ijpddr.2014.02.002openalex-extracted
Drug repurposing and human parasitic protozoan diseases
inferredcites →https://doi.org/10.1016/j.ijpddr.2021.05.001openalex-extracted
In vitro activity, safety and in vivo efficacy of the novel bumped kinase inhibitor BKI-1748 in non-pregnant and pregnant mice experimentally infected with Neospora caninum tachyzoites and Toxoplasma gondii oocysts
inferredcites →https://doi.org/10.1016/j.ijpddr.2021.08.007openalex-extracted
Endochin-like quinolones (ELQs) and bumped kinase inhibitors (BKIs): Synergistic and additive effects of combined treatments against Neospora caninum infection in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.ijpddr.2022.11.005openalex-extracted
Proteomic characterization of Toxoplasma gondii ME49 derived strains resistant to the artemisinin derivatives artemiside and artemisone implies potential mode of action independent of ROS formation
inferredcites →https://doi.org/10.1016/j.phrs.2016.11.012openalex-extracted
Artemisinin and its derivatives in treating protozoan infections beyond malaria
inferredcites →https://doi.org/10.1016/j.pt.2019.01.005openalex-extracted
Advances in the Development of Anti-Toxoplasma gondii Vaccines: Challenges, Opportunities, and Perspectives
inferredcites →https://doi.org/10.1016/j.vetpar.2020.109336openalex-extracted
One health therapeutics: Target-Based drug development for cryptosporidiosis and other apicomplexa diseases
inferredcites →https://doi.org/10.1021/acs.jmedchem.6b01586openalex-extracted
Structure–Activity Relationship of the Antimalarial Ozonide Artefenomel (OZ439)
inferredcites →https://doi.org/10.1021/acs.jmedchem.9b00069openalex-extracted
Development of 5-Aminopyrazole-4-carboxamide-based Bumped-Kinase Inhibitors for Cryptosporidiosis Therapy
inferredcites →https://doi.org/10.1111/hiv.12402openalex-extracted
A systematic review and meta‐analysis of the relative efficacy and safety of treatment regimens for HIV ‐associated cerebral toxoplasmosis: is trimethoprim‐sulfamethoxazole a real option?
inferredcites →https://doi.org/10.1111/pim.12398openalex-extracted
Development of vaccines for parasitic diseases of animals: Challenges and opportunities
inferredcites →https://doi.org/10.1128/aac.00502-09openalex-extracted
Artemisone and Artemiside Control Acute and Reactivated Toxoplasmosis in a Murine Model
inferredcites →https://doi.org/10.1128/aac.00990-21openalex-extracted
Toward New Transmission-Blocking Combination Therapies: Pharmacokinetics of 10-Amino-Artemisinins and 11-Aza-Artemisinin and Comparison with Dihydroartemisinin and Artemether
inferredcites →https://doi.org/10.1128/aac.02065-21openalex-extracted
Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance
inferredcites →https://doi.org/10.1128/aac.02214-17openalex-extracted
Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages
inferredcites →https://doi.org/10.1128/aac.02324-16openalex-extracted
Two Novel Calcium-Dependent Protein Kinase 1 Inhibitors Interfere with Vertical Transmission in Mice Infected with Neospora caninum Tachyzoites
inferredcites →https://doi.org/10.1128/cmr.00057-17openalex-extracted
Treatment of Toxoplasmosis: Historical Perspective, Animal Models, and Current Clinical Practice
inferredcites →https://doi.org/10.1128/cmr.05013-11openalex-extracted
Epidemiology of and Diagnostic Strategies for Toxoplasmosis
inferredcites →https://doi.org/10.1128/jcm.38.8.2929-2932.2000openalex-extracted
Real-Time PCR for Diagnosis and Follow-Up of Toxoplasma Reactivation after Allogeneic Stem Cell Transplantation Using Fluorescence Resonance Energy Transfer Hybridization Probes
inferredcites →https://doi.org/10.1186/s13071-020-04445-zopenalex-extracted
The life-cycle of Toxoplasma gondii reviewed using animations
inferredcites →https://doi.org/10.1242/jeb.00589openalex-extracted
Antimalarial drug discovery: old and new approaches
inferredcites →https://doi.org/10.1371/journal.pone.0009582openalex-extracted
Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation
inferredcites →https://doi.org/10.1371/journal.pone.0092929openalex-extracted
Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy
inferredcites →https://doi.org/10.1371/journal.pone.0178691openalex-extracted
The use of Gompertz models in growth analyses, and new Gompertz-model approach: An addition to the Unified-Richards family
inferredcites →https://doi.org/10.2147/dddt.s60973openalex-extracted
Drugs in development for toxoplasmosis: advances, challenges, and current status
inferredcites →https://doi.org/10.2307/3283832openalex-extracted
Ultrastructural Effects of Diclazuril against Toxoplasma gondii and Investigation of a Diclazuril-Resistant Mutant
inferredcites →https://doi.org/10.3389/fcimb.2018.00436openalex-extracted
Virulence in Mice of a Toxoplasma gondii Type II Isolate Does Not Correlate With the Outcome of Experimental Infection in Pregnant Sheep
inferredcites →https://doi.org/10.3389/fvets.2018.00285openalex-extracted
Endochin-Like Quinolones Exhibit Promising Efficacy Against Neospora Caninum in vitro and in Experimentally Infected Pregnant Mice
inferredcites →https://doi.org/10.3390/microorganisms8060801openalex-extracted
Neospora caninum: Differential Proteome of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294
inferredcites →https://doi.org/10.3390/pathogens10111351openalex-extracted
Comprehensive Overview of Toxoplasma gondii-Induced and Associated Diseases
inferredcites →https://doi.org/10.3390/pathogens7020033openalex-extracted
Acidocalcisome-Mitochondrion Membrane Contact Sites in Trypanosoma brucei
inferredcites →https://doi.org/10.3390/pathogens9050382openalex-extracted
Neospora caninum: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294
inferredcites →https://doi.org/10.3390/pharmaceutics13122066openalex-extracted
The Artemiside-Artemisox-Artemisone-M1 Tetrad: Efficacies against Blood Stage P. falciparum Parasites, DMPK Properties, and the Case for Artemiside
inferredcites →https://doi.org/10.4065/mcp.2011.0203openalex-extracted
Antiparasitic Therapy
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