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Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Efficacy and Safety of Exercise Training in Patients With Chronic Heart Failure
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Disorders of carnitine transport and the carnitine cycle
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Myocardial energetics in heart failure
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Polymorphic variants in tenascin-C (TNC) are associated with atherosclerosis and coronary artery disease
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The effects of exercise on cardiovascular biomarkers in patients with chronic heart failure
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Targeting mitochondrial oxidative metabolism as an approach to treat heart failure
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Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance
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Maximal Oxidative Capacity during Exercise Is Associated with Skeletal Muscle Fuel Selection and Dynamic Changes in Mitochondrial Protein Acetylation
inferredcites →https://doi.org/10.1016/j.jacc.2009.08.012openalex-snapshot
Micronutrient Deficiencies
inferredcites →https://doi.org/10.1016/j.jacc.2010.12.044openalex-snapshot
Mitochondrial Targeted Antioxidant Peptide Ameliorates Hypertensive Cardiomyopathy
inferredcites →https://doi.org/10.1016/j.jacc.2012.08.1021openalex-snapshot
Mitochondria as a Therapeutic Target in Heart Failure
inferredcites →https://doi.org/10.1016/j.jacc.2015.02.018openalex-snapshot
Metabolic Disturbances Identified in Plasma Are Associated With Outcomes in Patients With Heart Failure
inferredcites →https://doi.org/10.1016/j.jchf.2014.06.013openalex-snapshot
Effects of Left Ventricular Assist Device Support on Biomarkers of Cardiovascular Stress, Fibrosis, Fluid Homeostasis, Inflammation, and Renal Injury
inferredcites →https://doi.org/10.1016/s0022-2828(95)91551-6openalex-snapshot
Effects of long-term therapy with ACE inhibitors, captopril, enalapril and trandolapril, on myocardial energy metabolism in rats with heart failure following myocardial infarction
inferredcites →https://doi.org/10.1016/s0092-8674(01)00241-0openalex-snapshot
Molecular Mechanisms of Human Hypertension
inferredcites →https://doi.org/10.1016/s0140-6736(14)61889-4openalex-snapshot
The war against heart failure: the Lancet lecture
inferredcites →https://doi.org/10.1038/496152aopenalex-snapshot
Genetics: A gene of rare effect
inferredcites →https://doi.org/10.1038/clpt.2014.174openalex-snapshot
Serendipity and the Discovery of Novel Compounds That Restore Mitochondrial Plasticity
inferredcites →https://doi.org/10.1056/nejmra063052openalex-snapshot
The Failing Heart — An Engine Out of Fuel
inferredcites →https://doi.org/10.1093/hmg/ddn020openalex-snapshot
Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (PLA2G7) gene and cardiovascular disease in case–control and family datasets
inferredcites →https://doi.org/10.1097/fjc.0000000000000155openalex-snapshot
Bendavia, a Mitochondria-targeting Peptide, Improves Postinfarction Cardiac Function, Prevents Adverse Left Ventricular Remodeling, and Restores Mitochondria-related Gene Expression in Rats
inferredcites →https://doi.org/10.1152/physrev.00006.2004openalex-snapshot
Myocardial Substrate Metabolism in the Normal and Failing Heart
inferredcites →https://doi.org/10.1161/01.cir.100.22.2248openalex-snapshot
Arrhythmias and Conduction Defects as Presenting Symptoms of Fatty Acid Oxidation Disorders in Children
inferredcites →https://doi.org/10.1161/circgenetics.109.852814openalex-snapshot
Association of a Peripheral Blood Metabolic Profile With Coronary Artery Disease and Risk of Subsequent Cardiovascular Events
inferredcites →https://doi.org/10.1161/circgenetics.114.000223openalex-snapshot
Integrated Metabolomics and Genomics
inferredcites →https://doi.org/10.1161/circheartfailure.113.000406openalex-snapshot
Global Proteomics and Pathway Analysis of Pressure-Overload–Induced Heart Failure and Its Attenuation by Mitochondrial-Targeted Peptides
inferredcites →https://doi.org/10.1161/circheartfailure.114.001469openalex-snapshot
Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart
inferredcites →https://doi.org/10.1161/circulationaha.107.702795openalex-snapshot
Metabolic Mechanisms in Heart Failure
inferredcites →https://doi.org/10.1161/circulationaha.111.060368openalex-snapshot
Metabolomic Profiling for the Identification of Novel Biomarkers and Mechanisms Related to Common Cardiovascular Diseases
inferredcites →https://doi.org/10.1161/circulationaha.114.011647openalex-snapshot
The Heart Is Just a Muscle
inferredcites →https://doi.org/10.1161/jaha.113.000542openalex-snapshot
A Plasma Long‐Chain Acylcarnitine Predicts Cardiovascular Mortality in Incident Dialysis Patients
inferredcites →https://doi.org/10.2337/db12-0466openalex-snapshot
Acylcarnitines

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Association of Acylcarnitines With Left Ventricular Remodeling in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
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Neurohormonal Blockade and Clinical Outcomes in Patients With Heart Failure Supported by Left Ventricular Assist Devices
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Acute and long‐term administration of palmitoylcarnitine induces muscle‐specific insulin resistance in mice
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Homeostasis of Carnitine
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What Are Carnitine Deficiency and Carnitine Insufficiency?
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Simplified plasma essential amino acid-based profiling provides metabolic information and prognostic value additive to traditional risk factors in heart failure
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Plasma acylcarnitines are associated with pulmonary hypertension
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Hyperammonemia, Lactic Acidosis, and Arrhythmia in a Newborn
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Plasma Metabolomic Signatures of Mitochondrial Energetic Disruption in Severe Primary Graft Dysfunction After Heart Transplantation
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Circulating metabolic signatures of heart failure in precision cardiology
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Metabolic profiling of aortic stenosis and hypertrophic cardiomyopathy identifies mechanistic contrasts in substrate utilization
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Metabolic Profiling of Aortic Stenosis and Hypertrophic Cardiomyopathy Identifies Mechanistic Contrasts in Substrate Utilisation
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Hydroxymethylglutaryl‐CoA reductase activity is essential for mitochondrial β‐oxidation of fatty acids to prevent lethal accumulation of long‐chain acylcarnitines in the mouse liver
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Cardiomyopathy in obesity, insulin resistance and diabetes
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Intrauterine growth restriction elevates circulating acylcarnitines and suppresses fatty acid metabolism genes in the fetal sheep heart
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Acylcarnitines: Nomenclature, Biomarkers, Therapeutic Potential, Drug Targets, and Clinical Trials
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Comprehensive quantification of fuel use by the failing and nonfailing human heart
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Omics Study of Ovarian Malignancies: From Urine Metabolomic Profile to Minimally Invasive MicroRNA Markers
inferred← citeshttps://doi.org/10.1136/openhrt-2024-003078openalex-snapshot
SGLT2 inhibition, acylcarnitines and heart failure: a Mendelian randomization study
inferred← citeshttps://doi.org/10.1152/ajpheart.00184.2021openalex-snapshot
Long-chain acylcarnitine 18:1 acutely increases human atrial myocardial contractility and arrhythmia susceptibility
inferred← citeshttps://doi.org/10.1152/ajpheart.00820.2016openalex-snapshot
Circulating acylcarnitine profile in human heart failure: a surrogate of fatty acid metabolic dysregulation in mitochondria and beyond
inferred← citeshttps://doi.org/10.1152/ajpheart.00841.2024openalex-snapshot
Sex-specific modulation of cardiac fibrosis and lipid metabolism by B-vitamins in heart failure with reduced ejection fraction in mice
inferred← citeshttps://doi.org/10.1155/2017/6970631openalex-snapshot
Metabolomics and Cardiology: Toward the Path of Perinatal Programming and Personalized Medicine
inferred← citeshttps://doi.org/10.1159/000524722openalex-snapshot
Metabolic and Metabolomics Insights into Dilated Cardiomyopathy
inferred← citeshttps://doi.org/10.11606/d.5.2016.tde-08082016-125225openalex-snapshot
Herdabilidade de fenótipos metabólicos em uma população brasileira: diabetes mellitus tipo 2 como modelo de aplicação
inferred← citeshttps://doi.org/10.1161/circheartfailure.118.004953openalex-snapshot
Increased Cardiac Uptake of Ketone Bodies and Free Fatty Acids in Human Heart Failure and Hypertrophic Left Ventricular Remodeling
inferred← citeshttps://doi.org/10.1161/circheartfailure.123.010813openalex-snapshot
Metabolic Profiling Identifies 1-MetHis and 3-IPA as Potential Diagnostic Biomarkers for Patients With Acute and Chronic Heart Failure With Reduced Ejection Fraction
inferred← citeshttps://doi.org/10.1161/circheartfailure.124.011980openalex-snapshot
Metabolic Effects of the SGLT2 Inhibitor Dapagliflozin in Heart Failure Across the Spectrum of Ejection Fraction
inferred← citeshttps://doi.org/10.1161/circheartfailure.124.012373openalex-snapshot
SGLT2 Inhibitors and Their Effect on Metabolism in Patients With Heart Failure
inferred← citeshttps://doi.org/10.1161/circimaging.121.012943openalex-snapshot
Progress and Research Priorities in Imaging Genomics for Heart and Lung Disease: Summary of an NHLBI Workshop
inferred← citeshttps://doi.org/10.1161/circresaha.117.311002openalex-snapshot
Cardiovascular Metabolomics
inferred← citeshttps://doi.org/10.1161/circresaha.121.318160openalex-snapshot
Reverse Remodeling With Left Ventricular Assist Devices
inferred← citeshttps://doi.org/10.1161/circresaha.122.321923openalex-snapshot
Metabolomic Signatures Associated With Pulmonary Arterial Hypertension Outcomes
inferred← citeshttps://doi.org/10.1161/circresaha.123.321759openalex-snapshot
Cardiac Metabolism in Heart Failure and Implications for Uremic Cardiomyopathy
inferred← citeshttps://doi.org/10.1161/circresaha.126.328542openalex-snapshot
Metabolomic Profiles and Changes During the 20 Years Preceding Heart Failure
inferred← citeshttps://doi.org/10.1161/circulationaha.122.060402openalex-snapshot
Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure With Reduced Ejection Fraction: DEFINE-HF
inferred← citeshttps://doi.org/10.1161/hcg.0000000000000058openalex-snapshot
Heart Failure in the Era of Precision Medicine: A Scientific Statement From the American Heart Association
inferred← citeshttps://doi.org/10.1161/hypertensionaha.122.20139openalex-snapshot
Metabolome-Wide Association Study of Cord Blood Metabolites With Blood Pressure in Childhood and Adolescence
inferred← citeshttps://doi.org/10.1161/hypertensionaha.125.25261openalex-snapshot
Plasma Metabolomic and Proteomic Signatures of Blood Pressure Management After Bariatric Surgery Among Adolescents
inferred← citeshttps://doi.org/10.1161/jaha.115.003190openalex-snapshot
Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure
inferred← citeshttps://doi.org/10.1161/jaha.123.031825openalex-snapshot
Longitudinal Lipidomic Signature of Coronary Heart Disease in American Indian People
inferred← citeshttps://doi.org/10.1161/jaha.124.039248openalex-snapshot
Metabolite Profiles of Heart Failure, Central Hemodynamic Derangement, and Response to Heart Transplantation
inferred← citeshttps://doi.org/10.1172/jci.insight.168563openalex-snapshot
Mitochondrial metabolites predict adverse cardiovascular events in individuals with diabetes
inferred← citeshttps://doi.org/10.1177/1479164117733627openalex-snapshot
Metabolomic profile of arterial stiffness in aged adults
inferred← citeshttps://doi.org/10.1186/s12872-017-0518-1openalex-snapshot
Metabolomic profiling in patients undergoing Off-Pump or On-Pump coronary artery bypass surgery
inferred← citeshttps://doi.org/10.1186/s12916-023-02967-8openalex-snapshot
Metabolic systems approaches update molecular insights of clinical phenotypes and cardiovascular risk in patients with homozygous familial hypercholesterolemia
inferred← citeshttps://doi.org/10.1186/s12931-019-1167-yopenalex-snapshot
Plasma metabolomics and clinical predictors of survival differences in COPD patients
inferred← citeshttps://doi.org/10.1186/s12931-023-02515-1openalex-snapshot
Accumulation of oxysterols in the erythrocytes of COVID-19 patients as a biomarker for case severity
inferred← citeshttps://doi.org/10.1186/s12933-021-01353-zopenalex-snapshot
Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy
inferred← citeshttps://doi.org/10.1186/s13073-024-01395-4openalex-snapshot
Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation
inferred← citeshttps://doi.org/10.1210/jc.2018-01408openalex-snapshot
Letter to the Editor: “Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris”
inferred← citeshttps://doi.org/10.1253/circj.cj-17-1184openalex-snapshot
Metabolomic Analysis in Heart Failure
inferred← citeshttps://doi.org/10.1253/circj.cj-23-0577openalex-snapshot
Association Between Serum 3-Hydroxyisobutyric Acid and Prognosis in Patients With Chronic Heart Failure ― An Analysis of the KUNIUMI Registry Chronic Cohort ―
inferred← citeshttps://doi.org/10.12677/jcpm.2024.34362openalex-snapshot
Metabolomics: A New Chapter in Unlocking the Mysteries of Life and Disease Treatment
inferred← citeshttps://doi.org/10.1371/journal.pone.0218153openalex-snapshot
Metabolic modulation predicts heart failure tests performance
inferred← citeshttps://doi.org/10.1371/journal.pone.0354734openalex-snapshot
Monitoring radiation exposure through skin swab multi-omic profiling
inferred← citeshttps://doi.org/10.1536/ihj.20-053openalex-snapshot
Decreases in Circulating Concentrations of Short-Chain Acylcarnitines are Associated with Systolic Function Improvement After Decompensated Heart Failure
inferred← citeshttps://doi.org/10.21037/acs-2020-cfmcs-117openalex-snapshot
Metabolomic profile of patients with left ventricular assist devices: a pilot study
inferred← citeshttps://doi.org/10.21037/jtd-21-22openalex-snapshot
Narrative review of metabolomics in cardiovascular disease
inferred← citeshttps://doi.org/10.21203/rs.3.rs-9400683/v1openalex-snapshot
Serum Metabolomic Profiling Reveals Mitochondrial Dysfunction and Novel Diagnostic Biomarkers in Autoimmune Gastritis
inferred← citeshttps://doi.org/10.2174/1566524019666191113120828openalex-snapshot
Mass Spectrometric Analysis of L-carnitine and its Esters: Potential Biomarkers of Disturbances in Carnitine Homeostasis
inferred← citeshttps://doi.org/10.2174/1573403x17666210525103512openalex-snapshot
The Utility of Circulating and Imaging Biomarkers Alone and in Combination in Heart Failure
inferred← citeshttps://doi.org/10.2217/bmm-2019-0176openalex-snapshot
Serum Metabolic Characteristics and Biomarkers of Early-Stage Heart Failure
inferred← citeshttps://doi.org/10.26481/dis.20210108jvopenalex-snapshot
Causes and consequences of dilated cardiomyopathy
inferred← citeshttps://doi.org/10.31083/j.rcm2305165openalex-snapshot
Cardiac Hypertrophy: From Pathophysiological Mechanisms to Heart Failure Development
inferred← citeshttps://doi.org/10.3177/jnsv.71.140openalex-snapshot
The J-Curve Relationship between Free Carnitine Levels and Cardiovascular Events in Patients with Heart Failure
inferred← citeshttps://doi.org/10.3389/fcvm.2020.622236openalex-snapshot
Characteristics of Blood Metabolic Profile in Coronary Heart Disease, Dilated Cardiomyopathy and Valvular Heart Disease Induced Heart Failure
inferred← citeshttps://doi.org/10.3389/fcvm.2021.753470openalex-snapshot
Unraveling the Metabolic Derangements Occurring in Non-infarcted Areas of Pig Hearts With Chronic Heart Failure
inferred← citeshttps://doi.org/10.3389/fcvm.2021.792350openalex-snapshot
Metabolic Impairment in Coronary Artery Disease: Elevated Serum Acylcarnitines Under the Spotlights
inferred← citeshttps://doi.org/10.3389/fcvm.2022.965899openalex-snapshot
Aberrant branched-chain amino acid catabolism in cardiovascular diseases
inferred← citeshttps://doi.org/10.3389/fcvm.2024.1409340openalex-snapshot
Genetic drivers of human plasma metabolites that determine mortality in heart failure patients with reduced ejection fraction
inferred← citeshttps://doi.org/10.3389/fcvm.2026.1805737openalex-snapshot
Metabolic-epigenetic axis in cardiovascular inflammatory injury: regulatory mechanisms and intervention strategies
inferred← citeshttps://doi.org/10.3389/fmolb.2026.1755542openalex-snapshot
Untargeted metabolomics reveals immune-metabolic signatures in established cases of rheumatoid arthritis
inferred← citeshttps://doi.org/10.3389/fphys.2020.577856openalex-snapshot
Long-Chain Acylcarnitines and Cardiac Excitation-Contraction Coupling: Links to Arrhythmias
inferred← citeshttps://doi.org/10.3389/fphys.2022.831829openalex-snapshot
New Insights Into Energy Substrate Utilization and Metabolic Remodeling in Cardiac Physiological Adaption
inferred← citeshttps://doi.org/10.3390/biom12070969openalex-snapshot
Understanding How Heart Metabolic Derangement Shows Differential Stage Specificity for Heart Failure with Preserved and Reduced Ejection Fraction
inferred← citeshttps://doi.org/10.3390/biom13010095openalex-snapshot
Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis
inferred← citeshttps://doi.org/10.3390/biom14030309openalex-snapshot
Beyond Natriuretic Peptides: Unveiling the Power of Emerging Biomarkers in Heart Failure
inferred← citeshttps://doi.org/10.3390/biom15010027openalex-snapshot
Plasma Levels of Propionylcarnitine Improved Prediction of Heart Failure and All-Cause Mortality in Patients with Stable Coronary Artery Disease
inferred← citeshttps://doi.org/10.3390/biom16010057openalex-snapshot
Dodecanedioic Acid: Alternative Carbon Substrate or Toxic Metabolite?
inferred← citeshttps://doi.org/10.3390/books978-3-03921-346-7openalex-snapshot
Cancer Metabolomics 2018
inferred← citeshttps://doi.org/10.3390/ijerph18147598openalex-snapshot
Heart Metabolism in Sepsis-Induced Cardiomyopathy—Unusual Metabolic Dysfunction of the Heart
inferred← citeshttps://doi.org/10.3390/ijms19020500openalex-snapshot
Interventional Left Atrial Appendage Closure Affects the Metabolism of Acylcarnitines
inferred← citeshttps://doi.org/10.3390/ijms20133360openalex-snapshot
Metabolomic Studies of Tissue Injury in Nonhuman Primates Exposed to Gamma-Radiation
inferred← citeshttps://doi.org/10.3390/ijms22073569openalex-snapshot
Metabolomics in Severe Aortic Stenosis Reveals Intermediates of Nitric Oxide Synthesis as Most Distinctive Markers
inferred← citeshttps://doi.org/10.3390/ijms22168468openalex-snapshot
Long-Chain Acyl-Carnitines Interfere with Mitochondrial ATP Production Leading to Cardiac Dysfunction in Zebrafish
inferred← citeshttps://doi.org/10.3390/ijms23062960openalex-snapshot
Heart Failure and Drug Therapies: A Metabolic Review
inferred← citeshttps://doi.org/10.3390/ijms23126809openalex-snapshot
Derangements and Reversibility of Energy Metabolism in Failing Hearts Resulting from Volume Overload: Transcriptomics and Metabolomics Analyses
inferred← citeshttps://doi.org/10.3390/ijms231810456openalex-snapshot
Metabolomic Profiling of End-Stage Heart Failure Secondary to Chronic Chagas Cardiomyopathy
inferred← citeshttps://doi.org/10.3390/ijms26031318openalex-snapshot
The Lower Concentration of Plasma Acetyl-Carnitine in Epicardial Artery Disease—A Preliminary Report
inferred← citeshttps://doi.org/10.3390/ijms26062703openalex-snapshot
Drug Discovery and Development for Heart Failure Using Multi-Omics Approaches
inferred← citeshttps://doi.org/10.3390/ijms27146451openalex-snapshot
Targeted Serum Organic-Acid Profiling Identifies Candidate Metabolic Signatures in Peripartum Cardiomyopathy: A Case-Control Study
inferred← citeshttps://doi.org/10.3390/life12060869openalex-snapshot
Serum Metabolomic Signatures for Knee Cartilage Volume Loss over 10 Years in Community-Dwelling Older Adults
inferred← citeshttps://doi.org/10.3390/life13041027openalex-snapshot
Targeting Mitochondrial Metabolism to Save the Failing Heart
inferred← citeshttps://doi.org/10.3390/life16030514openalex-snapshot
The Use of Metabolomes in Risk Stratification of Patients with Heart Failure: A Scoping Review
inferred← citeshttps://doi.org/10.3390/metabo11010051openalex-snapshot
L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine
inferred← citeshttps://doi.org/10.3390/metabo11040196openalex-snapshot
Long-Chain Acylcarnitines and Monounsaturated Fatty Acids Discriminate Heart Failure Patients According to Pulmonary Hypertension Status
inferred← citeshttps://doi.org/10.3390/metabo11060339openalex-snapshot
Identification of Circulating Diagnostic Biomarkers for Coronary Microvascular Disease in Postmenopausal Women Using Machine-Learning Techniques
inferred← citeshttps://doi.org/10.3390/metabo11090615openalex-snapshot
Analysis of Metabolic Markers in Patients with Chronic Heart Failure before and after LVAD Implantation
inferred← citeshttps://doi.org/10.3390/metabo11090621openalex-snapshot
Lipid Metabolite Biomarkers in Cardiovascular Disease: Discovery and Biomechanism Translation from Human Studies
inferred← citeshttps://doi.org/10.3390/metabo12030216openalex-snapshot
Whole Blood Metabolite Profiles Reflect Changes in Energy Metabolism in Heart Failure
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