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Metabolic Profiling of Aortic Stenosis and Hypertrophic Cardiomyopathy Identifies Mechanistic Contrasts in Substrate Utilisation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1001/jama.292.19.2350openalex-snapshot
Prognostic Significance of Left Ventricular Mass Change During Treatment of Hypertension
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Association of Acylcarnitines With Left Ventricular Remodeling in Patients With Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
inferredcites →https://doi.org/10.1006/jmcc.2000.1266openalex-snapshot
Abnormal Mitochondrial Respiration in Failed Human Myocardium
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Bioinformatics and Computational Biology Solutions Using R and Bioconductor
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Return to the fetal gene program protects the stressed heart: a strong hypothesis
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Long-chain acylcarnitine content determines the pattern of energy metabolism in cardiac mitochondria
inferredcites →https://doi.org/10.1016/0002-9149(88)91203-9openalex-snapshot
Altered global myocardial substrate preference at rest and during pacing in coronary artery disease with stable angina pectoris
inferredcites →https://doi.org/10.1016/0006-2952(96)00204-3openalex-snapshot
Inhibition of carnitine palmitoyltransferase-1 in rat heart and liver by perhexiline and amiodarone
inferredcites →https://doi.org/10.1016/b978-0-12-800280-3.00012-8openalex-snapshot
Methods for Performing Lipidomics in White Adipose Tissue
inferredcites →https://doi.org/10.1016/j.athoracsur.2008.02.075openalex-snapshot
Influence of Concentric Left Ventricular Remodeling on Early Mortality After Aortic Valve Replacement
inferredcites →https://doi.org/10.1016/j.cmet.2013.12.003openalex-snapshot
β-Aminoisobutyric Acid Induces Browning of White Fat and Hepatic β-Oxidation and Is Inversely Correlated with Cardiometabolic Risk Factors
inferredcites →https://doi.org/10.1016/j.jacc.2015.02.018openalex-snapshot
Metabolic Disturbances Identified in Plasma Are Associated With Outcomes in Patients With Heart Failure
inferredcites →https://doi.org/10.1016/j.jacc.2015.10.079openalex-snapshot
Prognostic Implications of Long-Chain Acylcarnitines in Heart Failure and Reversibility With Mechanical Circulatory Support
inferredcites →https://doi.org/10.1016/j.jcmg.2015.06.007openalex-snapshot
Association of a 4-Tiered Classification of LV Hypertrophy With Adverse CV Outcomes in the General Population
inferredcites →https://doi.org/10.1016/j.yjmcc.2008.01.008openalex-snapshot
Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart
inferredcites →https://doi.org/10.1016/j.yjmcc.2008.10.025openalex-snapshot
PGC-1α and ERRα target gene downregulation is a signature of the failing human heart
inferredcites →https://doi.org/10.1016/j.yjmcc.2012.12.014openalex-snapshot
Effects of perhexiline-induced fuel switch on the cardiac proteome and metabolome
inferredcites →https://doi.org/10.1016/s0140-6736(14)60107-0openalex-snapshot
Cardiovascular remodelling in coronary artery disease and heart failure
inferredcites →https://doi.org/10.1016/s0735-1097(02)01967-8openalex-snapshot
Altered myocardial fatty acid and glucose metabolism in idiopathic dilated cardiomyopathy
inferredcites →https://doi.org/10.1016/s0735-1097(02)03009-7openalex-snapshot
Hypertrophic cardiomyopathy due to sarcomeric gene mutations is characterized by impaired energy metabolism irrespective of the degree of hypertrophy
inferredcites →https://doi.org/10.1038/nrcardio.2011.138openalex-snapshot
Metabolomics as a tool for cardiac research
inferredcites →https://doi.org/10.1039/c4mb00594eopenalex-snapshot
Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy
inferredcites →https://doi.org/10.1042/cs0990027openalex-snapshot
First clinical trial with etomoxir in patients with chronic congestive heart failure
inferredcites →https://doi.org/10.1056/nejm199005313222203openalex-snapshot
Prognostic Implications of Echocardiographically Determined Left Ventricular Mass in the Framingham Heart Study
inferredcites →https://doi.org/10.1056/nejm200006153422403openalex-snapshot
Magnitude of Left Ventricular Hypertrophy and Risk of Sudden Death in Hypertrophic Cardiomyopathy
inferredcites →https://doi.org/10.1056/nejmra063052openalex-snapshot
The Failing Heart — An Engine Out of Fuel
inferredcites →https://doi.org/10.1056/nejmra1313875openalex-snapshot
Aortic-Valve Stenosis — From Patients at Risk to Severe Valve Obstruction
inferredcites →https://doi.org/10.1073/pnas.0408962102openalex-snapshot
ATP flux through creatine kinase in the normal, stressed, and failing human heart
inferredcites →https://doi.org/10.1074/jbc.m103826200openalex-snapshot
Reactivation of Peroxisome Proliferator-activated Receptor α Is Associated with Contractile Dysfunction in Hypertrophied Rat Heart
inferredcites →https://doi.org/10.1093/bioinformatics/18.suppl_1.s96openalex-snapshot
Variance stabilization applied to microarray data calibration and to the quantification of differential expression
inferredcites →https://doi.org/10.1093/cvr/cvw051openalex-snapshot
Normalization of cardiac substrate utilization and left ventricular hypertrophy precede functional recovery in heart failure regression
inferredcites →https://doi.org/10.1093/eurheartj/ehi758openalex-snapshot
Women, ‘non-specific’ chest pain, and normal or near-normal coronary angiograms are not synonymous with favourable outcomeThe opinions expressed in this article are not necessarily those of the Editors of the European Heart Journal or of the European Society of Cardiology.
inferredcites →https://doi.org/10.1093/eurheartj/ehi816openalex-snapshot
Effects of metabolic modulation by trimetazidine on left ventricular function and phosphocreatine/adenosine triphosphate ratio in patients with heart failure
inferredcites →https://doi.org/10.1093/eurheartj/ehl040openalex-snapshot
Persistent chest pain predicts cardiovascular events in women without obstructive coronary artery disease: results from the NIH-NHLBI-sponsored Women's Ischaemia Syndrome Evaluation (WISE) study
inferredcites →https://doi.org/10.1093/eurheartj/ehm605openalex-snapshot
Left ventricular mass predicts heart failure not related to previous myocardial infarction: the Cardiovascular Health Study
inferredcites →https://doi.org/10.1111/j.1445-5994.1997.tb00909.xopenalex-snapshot
Perhexiline improves symptomatic status in elderly patients with severe aortic stenosis
inferredcites →https://doi.org/10.1111/j.2517-6161.1995.tb02031.xopenalex-snapshot
Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing
inferredcites →https://doi.org/10.1136/hrt.2010.192997openalex-snapshot
Prognostic effect of inappropriately high left ventricular mass in asymptomatic severe aortic stenosis
inferredcites →https://doi.org/10.1152/ajpheart.00820.2016openalex-snapshot
Circulating acylcarnitine profile in human heart failure: a surrogate of fatty acid metabolic dysregulation in mitochondria and beyond
inferredcites →https://doi.org/10.1152/ajpheart.00887.2007openalex-snapshot
Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy
inferredcites →https://doi.org/10.1152/ajpheart.2000.278.4.h1345openalex-snapshot
Myocardial substrate metabolism influences left ventricular energetics in vivo
inferredcites →https://doi.org/10.1152/physrev.00015.2009openalex-snapshot
Myocardial Fatty Acid Metabolism in Health and Disease
inferredcites →https://doi.org/10.1161/01.cir.0000023531.22727.c1openalex-snapshot
Impaired Myocardial Fatty Acid Oxidation and Reduced Protein Expression of Retinoid X Receptor-α in Pacing-Induced Heart Failure
inferredcites →https://doi.org/10.1161/01.cir.100.20.2113openalex-snapshot
Progressive Loss of Myocardial ATP Due to a Loss of Total Purines During the Development of Heart Failure in Dogs
inferredcites →https://doi.org/10.1161/01.cir.81.4.1260openalex-snapshot
Efficacy and safety of perhexiline maleate in refractory angina. A double-blind placebo-controlled clinical trial of a novel antianginal agent.
inferredcites →https://doi.org/10.1161/01.cir.96.7.2190openalex-snapshot
Myocardial Phosphocreatine-to-ATP Ratio Is a Predictor of Mortality in Patients With Dilated Cardiomyopathy
inferredcites →https://doi.org/10.1161/circheartfailure.112.000228openalex-snapshot
Cardiac Insulin-Resistance and Decreased Mitochondrial Energy Production Precede the Development of Systolic Heart Failure After Pressure-Overload Hypertrophy
inferredcites →https://doi.org/10.1161/circheartfailure.114.001151openalex-snapshot
Metabolomic Analysis of Pressure-Overloaded and Infarcted Mouse Hearts
inferredcites →https://doi.org/10.1161/circheartfailure.114.001167openalex-snapshot
The Gut Hormone Ghrelin Partially Reverses Energy Substrate Metabolic Alterations in the Failing Heart
inferredcites →https://doi.org/10.1161/circheartfailure.114.001469openalex-snapshot
Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart
inferredcites →https://doi.org/10.1161/circheartfailure.115.002216openalex-snapshot
Peroxisome Proliferator Activated Receptor-α Association With Silent Information Regulator 1 Suppresses Cardiac Fatty Acid Metabolism in the Failing Heart
inferredcites →https://doi.org/10.1161/circimaging.112.973834openalex-snapshot
Global Strain in Severe Aortic Valve Stenosis
inferredcites →https://doi.org/10.1161/circimaging.113.000559openalex-snapshot
Myocardial Steatosis and Left Ventricular Contractile Dysfunction in Patients With Severe Aortic Stenosis
inferredcites →https://doi.org/10.1161/circresaha.111.242974openalex-snapshot
Disease Pathways and Novel Therapeutic Targets in Hypertrophic Cardiomyopathy
inferredcites →https://doi.org/10.1161/circresaha.112.268128openalex-snapshot
Cardiac-Specific Deletion of Acetyl CoA Carboxylase 2 Prevents Metabolic Remodeling During Pressure-Overload Hypertrophy
inferredcites →https://doi.org/10.1161/circresaha.113.300376openalex-snapshot
Cardiac Metabolism in Heart Failure
inferredcites →https://doi.org/10.1161/circulationaha.105.551457openalex-snapshot
Metabolic Modulation With Perhexiline in Chronic Heart Failure
inferredcites →https://doi.org/10.1161/circulationaha.108.816116openalex-snapshot
Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Ischemia/Reperfusion
inferredcites →https://doi.org/10.1161/circulationaha.109.849919openalex-snapshot
Metabolomic Profiling of Cardiac Substrate Utilization
inferredcites →https://doi.org/10.1161/circulationaha.109.934059openalex-snapshot
Metabolic Modulator Perhexiline Corrects Energy Deficiency and Improves Exercise Capacity in Symptomatic Hypertrophic Cardiomyopathy
inferredcites →https://doi.org/10.1161/circulationaha.115.017355openalex-snapshot
The Failing Heart Relies on Ketone Bodies as a Fuel
inferredcites →https://doi.org/10.1161/circulationaha.115.017545openalex-snapshot
Evidence for Intramyocardial Disruption of Lipid Metabolism and Increased Myocardial Ketone Utilization in Advanced Human Heart Failure
inferredcites →https://doi.org/10.1161/hypertensionaha.108.114702openalex-snapshot
AMP Activated Protein Kinase-α2 Deficiency Exacerbates Pressure-Overload–Induced Left Ventricular Hypertrophy and Dysfunction in Mice
inferredcites →https://doi.org/10.1161/hypertensionaha.111.174128openalex-snapshot
AMP Activated Protein Kinase-α2 Regulates Expression of Estrogen-Related Receptor-α, a Metabolic Transcription Factor Related to Heart Failure Development
inferredcites →https://doi.org/10.1161/res.0000000000000097openalex-snapshot
Assessing Cardiac Metabolism
inferredcites →https://doi.org/10.1172/jci.insight.84897openalex-snapshot
Mitochondrial protein hyperacetylation in the failing heart
inferredcites →https://doi.org/10.1172/jci108079openalex-snapshot
Wall stress and patterns of hypertrophy in the human left ventricle.
inferredcites →https://doi.org/10.1172/jci116676openalex-snapshot
Bioenergetic abnormalities associated with severe left ventricular hypertrophy.
inferredcites →https://doi.org/10.1172/jci35111openalex-snapshot
Metabolite profiling of blood from individuals undergoing planned myocardial infarction reveals early markers of myocardial injury
inferredcites →https://doi.org/10.1172/jci9056openalex-snapshot
Deactivation of peroxisome proliferator–activated receptor-α during cardiac hypertrophic growth
inferredcites →https://doi.org/10.1177/108155899704500810openalex-snapshot
Cardiac High-Energy Phosphate Metabolism in Patients with Aortic Valve Disease Assessed by 31 P-Magnetic Resonance Spectroscopy
inferredcites →https://doi.org/10.1186/1471-2105-7-3openalex-snapshot
Gene selection and classification of microarray data using random forest
inferredcites →https://doi.org/10.1186/1472-6882-14-232openalex-snapshot
Plasma metabonomics study on Chinese medicine syndrome evolution of heart failure rats caused by LAD ligation
inferredcites →https://doi.org/10.1186/gb-2004-5-10-r80openalex-snapshot
Bioconductor: open software development for computational biology and bioinformatics
inferredcites →https://doi.org/10.3390/molecules200711915openalex-snapshot
Urinary Metabolomic Profiling Reveals the Effect of Shenfu Decoction on Chronic Heart Failure in Rats
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1038/s12276-022-00803-2openalex-snapshot
Metabolic flux between organs measured by arteriovenous metabolite gradients
inferred← citeshttps://doi.org/10.1161/circulationaha.121.053575openalex-snapshot
Altered Cardiac Energetics and Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy
inferred← citeshttps://doi.org/10.1186/s12944-024-02232-8openalex-snapshot
Independent risk factors of left ventricular hypertrophy in non-diabetic individuals in Sierra Leone - a cross-sectional study
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