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T cell stimulator cells, an efficient and versatile cellular system to assess the role of costimulatory ligands in the activation of human T cells
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/eji.200526347openalex-snapshot
PD‐L2:PD‐1 involvement in T cell proliferation, cytokine production, and integrin‐mediated adhesion
inferredcites →https://doi.org/10.1002/eji.200535344openalex-snapshot
No evidence for dualism in function and receptors: PD‐L2/B7‐DC is an inhibitory regulator of human T cell activation
inferredcites →https://doi.org/10.1002/eji.200838250openalex-snapshot
The capacity of the TNF family members 4‐1BBL, OX40L, CD70, GITRL, CD30L and LIGHT to costimulate human T cells
inferredcites →https://doi.org/10.1002/eji.200839028openalex-snapshot
B7‐H3 is a potent inhibitor of human T‐cell activation: No evidence for B7‐H3 and TREML2 interaction
inferredcites →https://doi.org/10.1006/clim.2002.5277openalex-snapshot
A Cell-Based Artificial Antigen-Presenting Cell Coated with Anti-CD3 and CD28 Antibodies Enables Rapid Expansion and Long-Term Growth of CD4 T Lymphocytes
inferredcites →https://doi.org/10.1007/s00262-006-0272-1openalex-snapshot
Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion
inferredcites →https://doi.org/10.1016/0092-8674(84)90039-4openalex-snapshot
An alternative pathway of T-cell activation: A functional role for the 50 kd T11 sheep erythrocyte receptor protein
inferredcites →https://doi.org/10.1016/j.coi.2009.02.010openalex-snapshot
Adoptive transfer of virus-specific and tumor-specific T cell immunity
inferredcites →https://doi.org/10.1016/j.febslet.2010.04.030openalex-snapshot
Functional signaling of membrane‐bound TL1A induces IFN‐γ expression
inferredcites →https://doi.org/10.1016/j.imlet.2009.11.009openalex-snapshot
Receptors and ligands implicated in human T cell costimulatory processes
inferredcites →https://doi.org/10.1016/j.jaci.2009.04.008openalex-snapshot
Modulation of allergen-specific T-lymphocyte function by virus-like particles decorated with HLA class II molecules
inferredcites →https://doi.org/10.1016/s1074-7613(02)00283-2openalex-snapshot
TL1A Is a TNF-like Ligand for DR3 and TR6/DcR3 and Functions as a T Cell Costimulator
inferredcites →https://doi.org/10.1021/bi900031wopenalex-snapshot
Biochemical and Structural Characterization of the Human TL1A Ectodomain ,
inferredcites →https://doi.org/10.1038/376260a0openalex-snapshot
A novel receptor involved in T-cell activation
inferredcites →https://doi.org/10.1038/cmi.2008.6openalex-snapshot
Establishment and Characterization of a Cell Based Artificial Antigen-Presenting Cell for Expansion and Activation of CD8+ T Cells Ex Vivo
inferredcites →https://doi.org/10.1038/mt.sj.6300134openalex-snapshot
Engineering Artificial Antigen-presenting Cells to Express a Diverse Array of Co-stimulatory Molecules
inferredcites →https://doi.org/10.1038/nbt0202-143openalex-snapshot
Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB
inferredcites →https://doi.org/10.1038/nm1676openalex-snapshot
T cell–encoded CD80 and 4-1BBL induce auto- and transcostimulation, resulting in potent tumor rejection
inferredcites →https://doi.org/10.1038/nrrheum.2009.181openalex-snapshot
Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis
inferredcites →https://doi.org/10.1073/pnas.0602283103openalex-snapshot
Direct stimulation of T lymphocytes by immunosomes: Virus-like particles decorated with T cell receptor/CD3 ligands plus costimulatory molecules
inferredcites →https://doi.org/10.1084/jem.194.6.797openalex-snapshot
Isolation and Characterization of Dermal Lymphatic and Blood Endothelial Cells Reveal Stable and Functionally Specialized Cell Lineages
inferredcites →https://doi.org/10.1084/jem.20071364openalex-snapshot
TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease
inferredcites →https://doi.org/10.1096/fj.09-137281openalex-snapshot
Fluorosomes: a convenient new reagent to detect and block multivalent and complex receptor‐ligand interactions
inferredcites →https://doi.org/10.1111/j.1600-065x.2009.00769.xopenalex-snapshot
Yin–Yang of costimulation: crucial controls of immune tolerance and function
inferredcites →https://doi.org/10.1111/j.1600-065x.2009.00776.xopenalex-snapshot
Translating costimulation blockade to the clinic: lessons learned from three pathways
inferredcites →https://doi.org/10.1111/j.1600-065x.2009.00778.xopenalex-snapshot
Sequence, structure, function, immunity: structural genomics of costimulation
inferredcites →https://doi.org/10.1111/j.1600-065x.2009.00781.xopenalex-snapshot
Costimulatory pathways in transplantation: challenges and new developments
inferredcites →https://doi.org/10.1128/jvi.00682-07openalex-snapshot
General Strategy for Decoration of Enveloped Viruses with Functionally Active Lipid-Modified Cytokines
inferredcites →https://doi.org/10.1139/o06-191openalex-snapshot
The role of SLAM family receptors in immune cell signalingThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB — Membrane Proteins in Health and Disease.
inferredcites →https://doi.org/10.1146/annurev.immunol.23.021704.115611openalex-snapshot
THE B7 FAMILY REVISITED
inferredcites →https://doi.org/10.1146/annurev.immunol.23.021704.115839openalex-snapshot
TNF/TNFR FAMILY MEMBERS IN COSTIMULATION OF T CELL RESPONSES
inferredcites →https://doi.org/10.1146/annurev.immunol.26.021607.090331openalex-snapshot
PD-1 and Its Ligands in Tolerance and Immunity
inferredcites →https://doi.org/10.1172/jci0217214openalex-snapshot
Adoptive therapy with CD8+ T cells: it may get by with a little help from its friends
inferredcites →https://doi.org/10.1172/jci17214openalex-snapshot
Adoptive therapy with CD8+ T cells: it may get by with a little help from its friends
inferredcites →https://doi.org/10.1172/jci32446openalex-snapshot
Adoptive T cell therapy for cancer in the clinic
inferredcites →https://doi.org/10.1182/blood-2008-10-183814openalex-snapshot
Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients
inferredcites →https://doi.org/10.1182/blood.v99.3.957openalex-snapshot
Molecular dissection of the signaling and costimulatory functions of CD150 (SLAM): CD150/SAP binding and CD150-mediated costimulation
inferredcites →https://doi.org/10.1189/jlb.0407231openalex-snapshot
Identification of the scavenger receptors SREC-I, Cla-1 (SR-BI), and SR-AI as cellular receptors for Tamm-Horsfall protein
inferredcites →https://doi.org/10.1517/14740338.7.4.411openalex-snapshot
Efficacy and safety of TNF-blocker therapy in systemic lupus erythematosus
inferredcites →https://doi.org/10.2147/btt.2009.2855openalex-snapshot
Biologic targeting in the treatment of inflammatory bowel diseases
inferredcites →https://doi.org/10.4049/jimmunol.158.9.4036openalex-snapshot
Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, cyclosporin A-sensitive T cell proliferation and IFN-gamma production
inferredcites →https://doi.org/10.4049/jimmunol.172.4.2352openalex-snapshot
Molecular Characterization of Human 4Ig-B7-H3, a Member of the B7 Family with Four Ig-Like Domains
inferredcites →https://doi.org/10.4049/jimmunol.173.10.6000openalex-snapshot
CD63 as an Activation-Linked T Cell Costimulatory Element
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/adtp.202200019openalex-snapshot
Dictating Phenotype, Function, and Fate of Human T Cells with Co‐Stimulatory Antibodies Presented by Filamentous Immune Cell Mimics
inferred← citeshttps://doi.org/10.1002/eji.201646405openalex-snapshot
The soluble cytoplasmic tail of CD45 (ct‐CD45) in human plasma contributes to keep T cells in a quiescent state
inferred← citeshttps://doi.org/10.1002/eji.201948400openalex-snapshot
TIM‐3 and CEACAM1 do not interact in cis and in trans
inferred← citeshttps://doi.org/10.1002/eji.202048603openalex-snapshot
Differentiation and activation of human CD4 T cells is associated with a gradual loss of myelin and lymphocyte protein
inferred← citeshttps://doi.org/10.1002/eji.202048762openalex-snapshot
4‐1BB costimulation promotes bystander activation of human CD8 T cells
inferred← citeshttps://doi.org/10.1007/978-1-0716-4734-9_5openalex-snapshot
Evaluation of Immune Checkpoint Inhibitors in a Jurkat-Based Transcriptional Reporter System: A Cell-Based Reporter Platform for Evaluation of Immune Checkpoint Inhibitors
inferred← citeshttps://doi.org/10.1007/s00262-021-02924-5openalex-snapshot
Diacylglycerol kinase α inhibition cooperates with PD-1-targeted therapies to restore the T cell activation program
inferred← citeshttps://doi.org/10.1007/s00262-023-03474-8openalex-snapshot
Engineered soluble, trimerized 4-1BBL variants as potent immunomodulatory agents
inferred← citeshttps://doi.org/10.1007/s00508-013-0442-zopenalex-snapshot
Researcher of the Month Oktober 2013
inferred← citeshttps://doi.org/10.1016/bs.apcsb.2017.08.003openalex-snapshot
Homo- and Heterodimerization of Proteins in Cell Signaling: Inhibition and Drug Design
inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.105748openalex-snapshot
Targeting the HVEM protein using a fragment of glycoprotein D to inhibit formation of the BTLA/HVEM complex
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.115161openalex-snapshot
BTLA-derived peptides as inhibitors of BTLA/HVEM complex formation – design, synthesis and biological evaluation
inferred← citeshttps://doi.org/10.1016/j.bios.2020.112389openalex-snapshot
Force-dependent trans-endocytosis by breast cancer cells depletes costimulatory receptor CD80 and attenuates T cell activation
inferred← citeshttps://doi.org/10.1016/j.ccell.2020.06.002openalex-snapshot
Immunogenomic Landscape of Hematological Malignancies
inferred← citeshttps://doi.org/10.1016/j.cellimm.2024.104890openalex-snapshot
Immunomodulation by galectin-9: Distinct role in T cell populations, current therapeutic avenues and future potential
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114401openalex-snapshot
IRF4 impedes human CD8 T cell function and promotes cell proliferation and PD-1 expression
inferred← citeshttps://doi.org/10.1016/j.celrep.2024.114834openalex-snapshot
Context-restricted PD-(L)1 checkpoint agonism by CTLA4-Ig therapies inhibits T cell activity
inferred← citeshttps://doi.org/10.1016/j.clim.2011.02.007openalex-snapshot
Costimulatory signals potently modulate the T cell inhibitory capacity of the therapeutic CD11a antibody Efalizumab
inferred← citeshttps://doi.org/10.1016/j.crmeth.2024.100843openalex-snapshot
Generation of dual-attribute iTNK cells from hPSCs for cancer immunotherapy
inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.118652openalex-snapshot
N-terphenylpicolinamide derivatives designed to target PD-L1 increase activation and proliferation of T cells, and their cytotoxic properties toward cancer cells
inferred← citeshttps://doi.org/10.1016/j.imlet.2011.06.010openalex-snapshot
The effects of Cyclosporine A and azathioprine on human T cells activated by different costimulatory signals
inferred← citeshttps://doi.org/10.1016/j.immuni.2024.01.007openalex-snapshot
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
inferred← citeshttps://doi.org/10.1016/j.isci.2024.109267openalex-snapshot
Transcriptional reprogramming via signaling domains of CD2, CD28, and 4-1BB
inferred← citeshttps://doi.org/10.1016/j.isci.2024.110253openalex-snapshot
BTLA and PD-1 signals attenuate TCR-mediated transcriptomic changes
inferred← citeshttps://doi.org/10.1016/j.jim.2016.01.007openalex-snapshot
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1
inferred← citeshttps://doi.org/10.1016/j.slasd.2022.03.008openalex-snapshot
A phenotypic screen for compounds that reverse cAMP-mediated suppression of T cell functions
inferred← citeshttps://doi.org/10.1016/j.tranon.2024.101892openalex-snapshot
Peptide-based inhibitors targeting the PD-1/PD-L1 axis: potential immunotherapeutics for cancer
inferred← citeshttps://doi.org/10.1016/j.vetimm.2012.01.012openalex-snapshot
Porcine SWC1 is CD52—Final determination by the use of a retroviral cDNA expression library
inferred← citeshttps://doi.org/10.1016/j.vetimm.2024.110792openalex-snapshot
Development of an in vitro assay for screening programmed death receptor-1/programmed cell death ligand 1 monoclonal antibody therapy in dogs
inferred← citeshttps://doi.org/10.1016/j.yexcr.2012.09.006openalex-snapshot
Induced expression of B7-H3 on the lung cancer cells and macrophages suppresses T-cell mediating anti-tumor immune response
inferred← citeshttps://doi.org/10.1016/j.ymthe.2018.11.015openalex-snapshot
Chimeric Antigen Receptor Library Screening Using a Novel NF-κB/NFAT Reporter Cell Platform
inferred← citeshttps://doi.org/10.1016/j.ymthe.2024.02.022openalex-snapshot
Inhibitory CARs fail to protect from immediate T cell cytotoxicity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c02037openalex-snapshot
CD160-Derived Peptide as a Bidirectional Inhibitor Toward Immune Checkpoints BTLA/HVEM and HVEM/LIGHT
inferred← citeshttps://doi.org/10.1038/s41467-022-29286-5openalex-snapshot
The engineered CD80 variant fusion therapeutic davoceticept combines checkpoint antagonism with conditional CD28 costimulation for anti-tumor immunity
inferred← citeshttps://doi.org/10.1038/s41467-024-52565-2openalex-snapshot
Mechanical force regulates ligand binding and function of PD-1
inferred← citeshttps://doi.org/10.1038/s41598-019-43529-4openalex-snapshot
Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor
inferred← citeshttps://doi.org/10.1038/s41598-019-47910-1openalex-snapshot
Therapeutic PD-L1 antibodies are more effective than PD-1 antibodies in blocking PD-1/PD-L1 signaling
inferred← citeshttps://doi.org/10.1038/srep07438openalex-snapshot
Azithromycin suppresses CD4+ T-cell activation by direct modulation of mTOR activity
inferred← citeshttps://doi.org/10.1038/srep31580openalex-snapshot
Creation of an engineered APC system to explore and optimize the presentation of immunodominant peptides of major allergens
inferred← citeshttps://doi.org/10.1038/srep42191openalex-snapshot
Chloroquine inhibits human CD4+ T-cell activation by AP-1 signaling modulation
inferred← citeshttps://doi.org/10.1073/pnas.2427254122openalex-snapshot
T lymphocyte–specific deletion of SHP1 and SHP2 promotes activation-induced cell death of CD4 + T cells and impairs antitumor response
inferred← citeshttps://doi.org/10.1080/2162402x.2017.1371895openalex-snapshot
A library-based screening method identifies neoantigen-reactive T cells in peripheral blood prior to relapse of ovarian cancer
inferred← citeshttps://doi.org/10.1080/2162402x.2019.1599635openalex-snapshot
A cell-engineered system to assess tumor cell sensitivity to CD8 + T cell-mediated cytotoxicity
inferred← citeshttps://doi.org/10.1084/jem.20150785openalex-snapshot
Identification of CD112R as a novel checkpoint for human T cells
inferred← citeshttps://doi.org/10.1093/jleuko/qiae086openalex-snapshot
Sorting nexin 27–dependent regulation of Lck and CD4 tunes the initial stages of T-cell activation
inferred← citeshttps://doi.org/10.1096/fj.14-257584openalex-snapshot
STAT3 governs hyporesponsiveness and granzyme B‐dependent suppressive capacity in human CD4 + T cells
inferred← citeshttps://doi.org/10.1096/fj.15-275594openalex-snapshot
Ig‐like transcript 4 as a cellular receptor for soluble complement fragment C4d
inferred← citeshttps://doi.org/10.1096/fj.202401639ropenalex-snapshot
LAG ‐3—An incompletely understood target in cancer therapy
inferred← citeshttps://doi.org/10.1097/tp.0b013e31823bb664openalex-snapshot
Assessment of Batch to Batch Variation in Polyclonal Antithymocyte Globulin Preparations
inferred← citeshttps://doi.org/10.1101/2024.07.17.603780openalex-snapshot
Cell state and transcription factor modulation during extended ex vivo CD8 + T-cell expansion
inferred← citeshttps://doi.org/10.1111/ajt.12514openalex-snapshot
A Comprehensive and Quantitative Analysis of the Major Specificities in Rabbit Antithymocyte Globulin Preparations
inferred← citeshttps://doi.org/10.1111/imm.13515openalex-snapshot
NKG2A ‐checkpoint inhibition and its blockade critically depends on peptides presented by its ligand HLA‐E
inferred← citeshttps://doi.org/10.1126/scisignal.adg2610openalex-snapshot
The ligand-dependent suppression of TCR signaling by the immune checkpoint receptor LAG3 depends on the cytoplasmic RRFSALE motif
inferred← citeshttps://doi.org/10.1134/s0006297919070034openalex-snapshot
T-Cell Engagers Based Bioassay for Evaluation of PD-1/PD-L1 Inhibitors Activity
inferred← citeshttps://doi.org/10.1136/jitc-2020-001521openalex-snapshot
Diacylglycerol kinase ζ limits IL-2-dependent control of PD-1 expression in tumor-infiltrating T lymphocytes
inferred← citeshttps://doi.org/10.1136/jitc-2022-004859openalex-snapshot
BND-22, a first-in-class humanized ILT2-blocking antibody, promotes antitumor immunity and tumor regression
inferred← citeshttps://doi.org/10.1158/2326-6066.cir-18-0442openalex-snapshot
PVRIG and PVRL2 Are Induced in Cancer and Inhibit CD8+ T-cell Function
inferred← citeshttps://doi.org/10.1158/2326-6066.cir-19-0877openalex-snapshot
CD226hiCD8+ T Cells Are a Prerequisite for Anti-TIGIT Immunotherapy
inferred← citeshttps://doi.org/10.1182/blood.2019002121openalex-snapshot
Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity
inferred← citeshttps://doi.org/10.1189/jlb.3a0315-135ropenalex-snapshot
The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation
inferred← citeshttps://doi.org/10.1371/journal.ppat.1003253openalex-snapshot
TIM-3 Does Not Act as a Receptor for Galectin-9
inferred← citeshttps://doi.org/10.18632/oncotarget.17615openalex-snapshot
A cellular platform for the evaluation of immune checkpoint molecules
inferred← citeshttps://doi.org/10.18632/oncotarget.24807openalex-snapshot
A Jurkat 76 based triple parameter reporter system to evaluate TCR functions and adoptive T cell strategies
inferred← citeshttps://doi.org/10.26508/lsa.202302359openalex-snapshot
A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells
inferred← citeshttps://doi.org/10.3389/fimmu.2019.02209openalex-snapshot
Neuropilin-1 Acts as a Receptor for Complement Split Products
inferred← citeshttps://doi.org/10.3389/fimmu.2020.00895openalex-snapshot
A New Strategy Toward B Cell-Based Cancer Vaccines by Active Immunization With Mimotopes of Immune Checkpoint Inhibitors
inferred← citeshttps://doi.org/10.3389/fimmu.2021.814570openalex-snapshot
Sorting Nexin 27 Enables MTOC and Secretory Machinery Translocation to the Immune Synapse
inferred← citeshttps://doi.org/10.3389/fimmu.2022.1007334openalex-snapshot
Discovery of the first PD-1 ligand encoded by a pathogen
inferred← citeshttps://doi.org/10.3389/fimmu.2022.956694openalex-snapshot
BTLA inhibition has a dominant role in the cis-complex of BTLA and HVEM
inferred← citeshttps://doi.org/10.3389/fimmu.2023.1208631openalex-snapshot
FcγR requirements and costimulatory capacity of Urelumab, Utomilumab, and Varlilumab
inferred← citeshttps://doi.org/10.3390/ijms151120209openalex-snapshot
Microenvironment of Tumor-Draining Lymph Nodes: Opportunities for Liposome-Based Targeted Therapy
inferred← citeshttps://doi.org/10.3390/ijms21228876openalex-snapshot
Fragments of gD Protein as Inhibitors of BTLA/HVEM Complex Formation - Design, Synthesis, and Cellular Studies
inferred← citeshttps://doi.org/10.3390/pathogens9121000openalex-snapshot
Immunomodulatory Effects of Recombinant Mycobacterium smegmatis Expressing Antigen-85B Epitopes in Infected J774A.1 Murine Macrophages
inferred← citeshttps://doi.org/10.3892/ijmm.2013.1572openalex-snapshot
Immunological characteristics of human umbilical cord mesenchymal stem cells and the therapeutic effects of their transplantion on hyperglycemia in diabetic rats
inferred← citeshttps://doi.org/10.4049/jimmunol.1401917openalex-snapshot
CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28−CD8+ T Cells
inferred← citeshttps://doi.org/10.4049/jimmunol.1700325openalex-snapshot
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses
inferred← citeshttps://doi.org/10.53846/goediss-3865openalex-snapshot
Neue Biomarker zur Überwachung der zellulären Immunität chronisch-entzündlicher Darmerkrankungen
inferred← citeshttps://doi.org/10.64898/2025.12.05.692493openalex-snapshot
Mapping the dynamic RNA binding proteome in human effector T cells identifies differentiation and cytotoxicity regulators
inferred← citeshttps://doi.org/10.64898/2026.01.29.702520openalex-snapshot
An early mTOR-dependent window during human T cell activation programs T cell state
inferred← citeshttps://doi.org/10.7150/ijbs.84592openalex-snapshot
Ribonuclease 1 Enhances Antitumor Immunity against Breast Cancer by Boosting T cell Activation
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