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Chloroquine inhibits human CD4+ T-cell activation by AP-1 signaling modulation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/acr.20097openalex-snapshot
Possible protective effect of hydroxychloroquine on delaying the occurrence of integument damage in lupus: LXXI, data from a multiethnic cohort
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2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis
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2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis
inferredcites →https://doi.org/10.1007/s10787-015-0239-yopenalex-snapshot
Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases
inferredcites →https://doi.org/10.1016/0035-9203(86)90021-0openalex-snapshot
Effect of chloroquine on human lymphocyte proliferation
inferredcites →https://doi.org/10.1016/0092-8674(93)90237-kopenalex-snapshot
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
inferredcites →https://doi.org/10.1016/j.bbapap.2009.11.002openalex-snapshot
c-Jun N-terminal kinase (JNK) signaling: Recent advances and challenges
inferredcites →https://doi.org/10.1016/j.immuni.2011.09.021openalex-snapshot
The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation
inferredcites →https://doi.org/10.1016/j.intimp.2014.05.005openalex-snapshot
Therapeutic potential of chloroquine in a murine model of inflammatory bowel disease
inferredcites →https://doi.org/10.1016/j.jim.2010.09.020openalex-snapshot
T cell stimulator cells, an efficient and versatile cellular system to assess the role of costimulatory ligands in the activation of human T cells
inferredcites →https://doi.org/10.1016/j.jim.2016.01.007openalex-snapshot
Assessment of costimulation and coinhibition in a triple parameter T cell reporter line: Simultaneous measurement of NF-κB, NFAT and AP-1
inferredcites →https://doi.org/10.1038/358414a0openalex-snapshot
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter
inferredcites →https://doi.org/10.1038/cmi.2012.22openalex-snapshot
Inhibitory effects of chloroquine on the activation of plasmacytoid dendritic cells in SIVmac239-infected Chinese rhesus macaques
inferredcites →https://doi.org/10.1038/cmi.2014.94openalex-snapshot
Nitric oxide plays a key role in the suppressive activity of tolerogenic dendritic cells
inferredcites →https://doi.org/10.1038/icb.2014.81openalex-snapshot
Autophagy in T‐cell development, activation and differentiation
inferredcites →https://doi.org/10.1038/ncprheum0292openalex-snapshot
Mode of action of hydroxychloroquine in RA—evidence of an inhibitory effect on toll-like receptor signaling
inferredcites →https://doi.org/10.1038/ni.2386openalex-snapshot
Metabolic checkpoints in activated T cells
inferredcites →https://doi.org/10.1038/ni.2538openalex-snapshot
Distinct TCR signaling pathways drive proliferation and cytokine production in T cells
inferredcites →https://doi.org/10.1038/nm.2760openalex-snapshot
T cell homing to epithelial barriers in allergic disease
inferredcites →https://doi.org/10.1038/sj.embor.7401138openalex-snapshot
Molecular regulation of T‐cell anergy
inferredcites →https://doi.org/10.1038/sj.gt.3302158openalex-snapshot
Dominant-negative mutant of c-Jun gene transfer: a novel therapeutic strategy for colorectal cancer
inferredcites →https://doi.org/10.1038/sj.onc.1210643openalex-snapshot
The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors
inferredcites →https://doi.org/10.1038/srep07438openalex-snapshot
Azithromycin suppresses CD4+ T-cell activation by direct modulation of mTOR activity
inferredcites →https://doi.org/10.1056/nejmoa1303006openalex-snapshot
Therapies for Active Rheumatoid Arthritis after Methotrexate Failure
inferredcites →https://doi.org/10.1073/pnas.79.1.175openalex-snapshot
Decrease in macrophage antigen catabolism caused by ammonia and chloroquine is associated with inhibition of antigen presentation to T cells.
inferredcites →https://doi.org/10.1080/15548627.2015.1017181openalex-snapshot
A rapid and high content assay that measures cyto-ID-stained autophagic compartments and estimates autophagy flux with potential clinical applications
inferredcites →https://doi.org/10.1084/jem.181.6.2059openalex-snapshot
CD28 signals through acidic sphingomyelinase.
inferredcites →https://doi.org/10.1093/intimm/dxh370openalex-snapshot
A role for Ets1, synergizing with AP-1 and GATA-3 in the regulation of IL-5 transcription in mouse Th2 lymphocytes
inferredcites →https://doi.org/10.1097/bor.0000000000000153openalex-snapshot
Combination conventional DMARDs compared to biologicals
inferredcites →https://doi.org/10.1098/rspb.2005.3432openalex-snapshot
Quantifying lymphocyte kinetics in vivo using carboxyfluorescein diacetate succinimidyl ester
inferredcites →https://doi.org/10.1101/gad.7.11.2135openalex-snapshot
Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.
inferredcites →https://doi.org/10.1111/j.1365-2249.1995.tb06648.xopenalex-snapshot
Chloroquine inhibits T cell proliferation by interfering with IL-2 production and responsiveness
inferredcites →https://doi.org/10.1111/j.1365-3083.2010.02432.xopenalex-snapshot
Effector and Regulatory T-cell Subsets in Autoimmunity and Tissue Inflammation
inferredcites →https://doi.org/10.1128/mcb.25.3.1025-1040.2005openalex-snapshot
Inhibition of Macroautophagy Triggers Apoptosis
inferredcites →https://doi.org/10.1136/annrheumdis-2013-204573openalex-snapshot
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
inferredcites →https://doi.org/10.1136/annrheumdis-2014-eular.3004openalex-snapshot
FRI0298 The Impact of DMARD Co-Therapy on Abatacept Effectiveness in Rheumatoid Arthritis Patients. A Pan-European Analysis of RA Registries
inferredcites →https://doi.org/10.1136/ard-2022-223356openalex-snapshot
EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2016 update
inferredcites →https://doi.org/10.1136/ard.2008.101766openalex-snapshot
Clinical efficacy and side effects of antimalarials in systemic lupus erythematosus: a systematic review
inferredcites →https://doi.org/10.1136/ard.46.1.42openalex-snapshot
Uptake of chloroquine and hydroxychloroquine by human blood leucocytes in vitro: relation to cellular concentrations during antirheumatic therapy.
inferredcites →https://doi.org/10.1146/annurev.bi.63.070194.005145openalex-snapshot
SIGNAL TRANSMISSION BETWEEN THE PLASMA MEMBRANE AND NUCLEUS OF T LYMPHOCYTES
inferredcites →https://doi.org/10.1159/000373980openalex-snapshot
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
inferredcites →https://doi.org/10.1159/000374058openalex-snapshot
Chloroquine Inhibits Ca2+ Signaling in Murine CD4+ Thymocytes
inferredcites →https://doi.org/10.1163/156856005774423935openalex-snapshot
AP-1 and colorectal cancer
inferredcites →https://doi.org/10.1172/jci23025openalex-snapshot
Human lupus autoantibody–DNA complexes activate DCs through cooperation of CD32 and TLR9
inferredcites →https://doi.org/10.1182/blood.v95.11.3460openalex-snapshot
Hydroxychloroquine inhibits calcium signals in T cells: a new mechanism to explain its immunomodulatory properties
inferredcites →https://doi.org/10.1189/jlb.3a0315-135ropenalex-snapshot
The tryptophan metabolite picolinic acid suppresses proliferation and metabolic activity of CD4+ T cells and inhibits c-Myc activation
inferredcites →https://doi.org/10.1248/bpb.23.815openalex-snapshot
Transcriptional Induction of Nur77 by Indomethacin That Results in Apoptosis of Colon Cancer Cells.
inferredcites →https://doi.org/10.1371/journal.pone.0087293openalex-snapshot
Evaluating Strategies to Normalise Biological Replicates of Western Blot Data
inferredcites →https://doi.org/10.2165/00003088-199631040-00003openalex-snapshot
Clinical Pharmacokinetics and Metabolism of Chloroquine
inferredcites →https://doi.org/10.3892/or.1.2.353openalex-snapshot
C-JUN ONCOGENE EXPRESSION IN NONSMALL CELL LUNG-CANCER
inferredcites →https://doi.org/10.4049/jimmunol.162.5.2775openalex-snapshot
Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4668568openalex-extracted
Evaluation of the Anti-Plasmodial and CD4 T-Cell Modulatory Effects of Leaf Methanol Extract of Phyllanthus Muellerianus (Phyllanthaceae) (Kuntze) Exell and its Ethyl Acetate Fraction in Plasmodium Berghei-Infected Mice
inferred← citeshttps://doi.org/10.1002/med.21531openalex-snapshot
The multifaceted role of autophagy in cancer and the microenvironment
inferred← citeshttps://doi.org/10.1007/s00432-023-05576-3openalex-snapshot
The multiple roles of autophagy in uveal melanoma and the microenvironment
inferred← citeshttps://doi.org/10.1007/s12026-023-09367-3openalex-snapshot
Immunosuppression by hydroxychloroquine: mechanistic proof in in vitro experiments but limited systemic activity in a randomized placebo-controlled clinical pharmacology study
inferred← citeshttps://doi.org/10.1007/s12038-025-00501-xopenalex-snapshot
Innate immune and endoplasmic reticulum unfolded protein response pathways protect Caenorhabditis elegans against chloroquine toxicity
inferred← citeshttps://doi.org/10.1007/s13346-021-00983-wopenalex-snapshot
Segmented intravaginal ring for the combination delivery of hydroxychloroquine and anti-CCR5 siRNA nanoparticles as a potential strategy for preventing HIV infection
inferred← citeshttps://doi.org/10.1007/s41061-020-00318-2openalex-snapshot
Reviews on Biological Activity, Clinical Trial and Synthesis Progress of Small Molecules for the Treatment of COVID-19
inferred← citeshttps://doi.org/10.1016/j.coi.2020.07.005openalex-snapshot
The host targeting effect of chloroquine in malaria
inferred← citeshttps://doi.org/10.1016/j.isci.2020.101990openalex-snapshot
Hydroxychloroquine can impair tumor response to anti-PD1 in subcutaneous mouse models
inferred← citeshttps://doi.org/10.1016/j.isci.2021.103509openalex-snapshot
Hydroxychloroquine inhibits the mitochondrial antioxidant system in activated T cells
inferred← citeshttps://doi.org/10.1016/j.jbc.2021.100487openalex-snapshot
Packed red blood cells inhibit T-cell activation via ROS-dependent signaling pathways
inferred← citeshttps://doi.org/10.1016/j.jep.2024.117936openalex-snapshot
Evaluation of the antimalarial and CD4+ T-cell modulatory effects of leaf methanol extract of Phyllanthus muellerianus (Kuntze) Exell (Phyllanthaceae) in Plasmodium berghei-infected mice
inferred← citeshttps://doi.org/10.1016/j.lfs.2020.117775openalex-snapshot
A systematic review on use of aminoquinolines for the therapeutic management of COVID-19: Efficacy, safety and clinical trials
inferred← citeshttps://doi.org/10.1038/s41418-019-0287-8openalex-snapshot
Autophagy in endothelial cells and tumor angiogenesis
inferred← citeshttps://doi.org/10.1038/s41598-019-52085-wopenalex-snapshot
Chloroquine modulates inflammatory autoimmune responses through Nurr1 in autoimmune diseases
inferred← citeshttps://doi.org/10.1038/s41598-020-69001-2openalex-snapshot
Chloroquine as a promising adjuvant therapy for type 1 Diabetes Mellitus
inferred← citeshttps://doi.org/10.1080/13543784.2021.1847270openalex-snapshot
An overview on the use of antivirals for the treatment of patients with COVID19 disease
inferred← citeshttps://doi.org/10.1080/20477724.2021.1936818openalex-snapshot
Hydroxychloroquine and mortality in COVID-19 patients: a systematic review and a meta-analysis of observational studies and randomized controlled trials
inferred← citeshttps://doi.org/10.1111/jre.12924openalex-snapshot
Impact of chronic gingivitis management on the cytokine and anti‐PPAD expressions in juvenile systemic lupus erythematosus: A six‐month follow‐up
inferred← citeshttps://doi.org/10.1155/2021/6659410openalex-snapshot
Hydroxychloroquine Effects on TLR Signalling: Underexposed but Unneglectable in COVID-19
inferred← citeshttps://doi.org/10.1186/s12931-023-02526-yopenalex-snapshot
Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation
inferred← citeshttps://doi.org/10.1186/s13046-019-1148-5openalex-snapshot
Autophagy inhibition enhances PD-L1 expression in gastric cancer
inferred← citeshttps://doi.org/10.1371/journal.pone.0287738openalex-snapshot
Hydroxychloroquine reduces T cells activation recall antigen responses
inferred← citeshttps://doi.org/10.15252/emmm.202012476openalex-snapshot
Hydroxychloroquine in rheumatic autoimmune disorders and beyond
inferred← citeshttps://doi.org/10.15406/ppij.2018.06.00155openalex-snapshot
Antibodies, prophylaxis, transmission
inferred← citeshttps://doi.org/10.21203/rs.3.rs-107101/v1openalex-snapshot
Low Dose Hydroxychloroquine is Associated with Lower Mortality in COVID-19: A Meta-Analysis of 27 Studies and 44,684 Patients
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1239049/v1openalex-snapshot
Benchmarking causal reasoning algorithms for gene expression-based compound mechanism of action analysis
inferred← citeshttps://doi.org/10.2174/1389557520999200824103803openalex-snapshot
Drug Discovery by Drug Repurposing: Combating COVID-19 in the 21st Century
inferred← citeshttps://doi.org/10.2174/1874944502114010600openalex-snapshot
A Randomized Controlled Trial of Hydroxychloroquine as Prophylaxis for COVID-19 among Health Care Providers
inferred← citeshttps://doi.org/10.3389/fimmu.2020.02159openalex-snapshot
Immune Modulation as a Therapeutic Option During the SARS-CoV-2 Outbreak: The Case for Antimalarial Aminoquinolines
inferred← citeshttps://doi.org/10.3389/fimmu.2020.588776openalex-snapshot
T Cells in Autoimmunity-Associated Cardiovascular Diseases
inferred← citeshttps://doi.org/10.3389/fimmu.2021.608625openalex-snapshot
The PI3K∂-Selective Inhibitor Idelalisib Induces T- and NK-Cell Dysfunction Independently of B-Cell Malignancy-Associated Immunosuppression
inferred← citeshttps://doi.org/10.3389/fimmu.2021.628117openalex-snapshot
Superoxide Dismutase 3 Controls the Activation and Differentiation of CD4+T Cells
inferred← citeshttps://doi.org/10.3389/fphar.2020.01169openalex-snapshot
Cellular and Molecular Pathways of COVID-19 and Potential Points of Therapeutic Intervention
inferred← citeshttps://doi.org/10.3389/fphar.2024.1298928openalex-snapshot
Deciphering the immunological interactions: targeting preeclampsia with Hydroxychloroquine’s biological mechanisms
inferred← citeshttps://doi.org/10.3390/ijms21144972openalex-snapshot
Immunomodulatory Effects of Hydroxychloroquine and Chloroquine in Viral Infections and Their Potential Application in Retinal Gene Therapy
inferred← citeshttps://doi.org/10.3899/jrheum.170737openalex-snapshot
Hydroxychloroquine Inhibits the Differentiation of Th17 Cells in Systemic Lupus Erythematosus
inferred← citeshttps://doi.org/10.4049/jimmunol.2000413openalex-snapshot
COVID-19 as an Acute Inflammatory Disease
inferred← citeshttps://doi.org/10.4168/aair.2020.12.6.994openalex-snapshot
Chloroquine Treatment Suppresses Mucosal Inflammation in a Mouse Model of Eosinophilic Chronic Rhinosinusitis
inferred← citeshttps://doi.org/10.6084/m9.figshare.24098170openalex-snapshot
Additional file 1 of Macrophage migration inhibitory factor exacerbates asthmatic airway remodeling via dynamin-related protein 1-mediated autophagy activation
inferred← citeshttps://doi.org/10.70675/3eee578bzb29fz4a95z8a1az99fa6d5edb80openalex-snapshot
Control of antitumor immunity by the SQSTM1 dependent signaling
inferred← citeshttps://doi.org/10.70675/4647f4d2zd802z40abza572z8ff228db523fopenalex-snapshot
Premières étapes dans l'interaction hôte-pathogène : rôle de l'immunité locale et innée
inferred← citeshttps://doi.org/10.70675/d0ae13c6zedf6z402cz9fbfz469e58c326a0openalex-snapshot
Circadian rhythm involvement in the host immune response
inferred← citeshttps://doi.org/10.70675/d5f58b7cz43a0z4857za270zcb40959daf0dopenalex-snapshot
Pathophysiological study of Tropheryma whipplei infections
inferred← citeshttps://doi.org/10.7759/cureus.26388openalex-snapshot
Study on Hydroxychloroquinine Sulfate Being Given to the Admitted COVID -19 Positive Patients at Institute of JLNMCH, Bhagalpur, Bihar, India
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