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Idiopathic pulmonary fibrosis (IPF) signaling pathways and protective roles of melatonin

https://doi.org/10.1016/j.lfs.2018.03.032

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Exogenously administered and endogenously produced melatonin reduce hyperbaric oxygen-induced oxidative stress in rat lung

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TGF-β1 targets the GSK-3β/β-catenin pathway via ERK activation in the transition of human lung fibroblasts into myofibroblasts

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New cellular and molecular mechanisms of lung injury and fibrosis in idiopathic pulmonary fibrosis

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Melatonin Impairs the Inflammatory Response and Inhibits the Sphingosine Kinase Signaling Pathway in an Animal Model of Liver Fibrosis

inferredcites →https://doi.org/10.1016/s0891-5849(98)00276-7openalex-snapshot

Melatonin and taurine reduce early glomerulopathy in diabetic rats

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TGF-β signaling by Smad proteins

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Smad7: a new key player in TGF-β-associated disease

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Endothelin-1 production is associated with eosinophilic rather than neutrophilic airway inflammation

inferredcites →https://doi.org/10.1034/j.1600-079x.2002.10796.xopenalex-snapshot

The effect of melatonin on bleomycin‐induced pulmonary fibrosis in rats

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Cloning and expression of a cDNA encoding an endothelin receptor

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TGF-β signalling from cell membrane to nucleus through SMAD proteins

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Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells

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Non-Smad pathways in TGF-β signaling

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Melatonin prevents retinal oxidative stress and vascular changes in diabetic rats

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Smad-dependent and Smad-independent pathways in TGF-β family signalling

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PKB/Akt modulates TGF-β signalling through a direct interaction with Smad3

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Akt interacts directly with Smad3 to regulate the sensitivity to TGF-β-induced apoptosis

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Activin/TGF-β induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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WNT and β-catenin signalling: diseases and therapies

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Fibrotic disease and the TH1/TH2 paradigm

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Chronic Activation of the Renin-Angiotensin System Induces Lung Fibrosis

inferredcites →https://doi.org/10.1042/bst0311171openalex-snapshot

VEGF signalling: integration and multi-tasking in endothelial cell biology

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Role of JAK-STAT pathway in pulmonary fibrosis

inferredcites →https://doi.org/10.1055/s-2007-971056openalex-snapshot

Protective Effects of Chronic Melatonin Treatment Against Renal Ischemia/Reperfusion Injury in Streptozotocin-Induced Diabetic Rats

inferredcites →https://doi.org/10.1056/nejmoa1113354openalex-snapshot

Prednisone, Azathioprine, and N -Acetylcysteine for Pulmonary Fibrosis

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A FoxO–Smad synexpression group in human keratinocytes

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Inhibition of Wnt/β-catenin/CREB binding protein (CBP) signaling reverses pulmonary fibrosis

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Compromised peroxisomes in idiopathic pulmonary fibrosis, a vicious cycle inducing a higher fibrotic response via TGF-β signaling

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Caveolin-1 Expression Inhibits Wnt/β-Catenin/Lef-1 Signaling by Recruiting β-Catenin to Caveolae Membrane Domains

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Phosphatidylinositol 3-Kinase Function Is Required for Transforming Growth Factor β-mediated Epithelial to Mesenchymal Transition and Cell Migration

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Amphiregulin, an Epidermal Growth Factor Receptor Ligand, Plays an Essential Role in the Pathogenesis of Transforming Growth Factor-β-induced Pulmonary Fibrosis

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A Central Role for the JNK Pathway in Mediating the Antagonistic Activity of Pro-inflammatory Cytokines against Transforming Growth Factor-β-driven SMAD3/4-specific Gene Expression

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Interferon-γ Interferes with Transforming Growth Factor-β Signaling through Direct Interaction of YB-1 with Smad3

inferredcites →https://doi.org/10.1074/jbc.m311430200openalex-snapshot

Endothelin-1 Induces Expression of Matrix-associated Genes in Lung Fibroblasts through MEK/ERK

inferredcites →https://doi.org/10.1074/jbc.m413223200openalex-snapshot

Type I Transforming Growth Factor β Receptor Binds to and Activates Phosphatidylinositol 3-Kinase

inferredcites →https://doi.org/10.1074/jbc.m601288200openalex-snapshot

Endoglin Structure and Function

inferredcites →https://doi.org/10.1074/jbc.m908162199openalex-snapshot

Up-regulation of Caveolin Attenuates Epidermal Growth Factor Signaling in Senescent Cells

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The histopathological evaluation of the effectiveness of melatonin as a protectant against acute lung injury induced by radiation therapy in a rat model

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Cell size and invasion in TGF-β–induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway

inferredcites →https://doi.org/10.1084/jem.20041393openalex-snapshot

Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis

inferredcites →https://doi.org/10.1084/jem.20061536openalex-snapshot

Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis

inferredcites →https://doi.org/10.1084/jem.20092121openalex-snapshot

Bleomycin and IL-1β–mediated pulmonary fibrosis is IL-17A dependent

inferredcites →https://doi.org/10.1084/jem.20110551openalex-snapshot

Integrating mechanisms of pulmonary fibrosis

inferredcites →https://doi.org/10.1091/mbc.01-11-0529openalex-snapshot

Expression of Caveolin-1 Induces Premature Cellular Senescence in Primary Cultures of Murine Fibroblasts

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Melatonin attenuates lung ischaemia–reperfusion injury via inhibition of oxidative stress and inflammation

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Role of PDGF in fibrotic diseases and systemic sclerosis

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Accelerated wound healing in tumor necrosis factor receptor p55‐deficient mice with reduced leukocyte infiltration

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Imatinib mesylate blocks a non‐Smad TGF‐β pathway and reduces renal fibrogenesis in vivo

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Electrical inhibition of lens epithelial cell proliferation: an additional factor in secondary cataract?

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Continuous light and L-NAME-induced left ventricular remodelling: different protection with melatonin and captopril

inferredcites →https://doi.org/10.1097/bor.0b013e32834b3309openalex-snapshot

β-catenin signaling

inferredcites →https://doi.org/10.1101/gad.1350705openalex-snapshot

Smad transcription factors

inferredcites →https://doi.org/10.1111/bph.13898openalex-snapshot

Melatonin in regulation of inflammatory pathways in rheumatoid arthritis and osteoarthritis: involvement of circadian clock genes

inferredcites →https://doi.org/10.1111/fcp.12303openalex-snapshot

Pretreatment with melatonin protects against cyclophosphamide‐induced oxidative stress and renal damage in mice

inferredcites →https://doi.org/10.1111/fcp.12355openalex-snapshot

Melatonin attenuates homocysteine‐induced injury in human umbilical vein endothelial cells

inferredcites →https://doi.org/10.1111/fcp.12361openalex-snapshot

Protective effect of melatonin in the diabetic rat retina

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Effects of melatonin on the oxidant/antioxidant status and lung histopathology in rabbits exposed to cigarette smoke

inferredcites →https://doi.org/10.1111/j.1471-4159.2005.03589.xopenalex-snapshot

Nitric oxide down‐regulates caveolin‐1 expression in rat brains during focal cerebral ischemia and reperfusion injury

inferredcites →https://doi.org/10.1111/j.1471-4159.2009.06061.xopenalex-snapshot

Fibroblast growth factor 9 prevents MPP+‐induced death of dopaminergic neurons and is involved in melatonin neuroprotection in vivo and in vitro

inferredcites →https://doi.org/10.1111/j.1582-4934.2008.00295.xopenalex-snapshot

Caveolae structure and function

inferredcites →https://doi.org/10.1111/j.1600-079x.2004.00162.xopenalex-snapshot

Prophylactic use of melatonin protects against focal cerebral ischemia in mice: role of endothelin converting enzyme‐1

inferredcites →https://doi.org/10.1111/j.1600-079x.2005.00229.xopenalex-snapshot

Melatonin limits lung injury in bleomycin treated mice

inferredcites →https://doi.org/10.1111/j.1600-079x.2005.00251.xopenalex-snapshot

Correlation among cytokines, bronchopulmonary dysplasia and modality of ventilation in preterm newborns: improvement with melatonin treatment

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Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro‐/anti‐inflammatory cytokine network, protection against oxidative damage and anti‐apoptotic effects

inferredcites →https://doi.org/10.1111/j.1600-079x.2005.00272.xopenalex-snapshot

Preventive effect of melatonin on bleomycin‐induced lung fibrosis in rats

inferredcites →https://doi.org/10.1111/j.1600-079x.2006.00364.xopenalex-snapshot

Melatonin prevents H2O2‐induced activation of rat hepatic stellate cells

inferredcites →https://doi.org/10.1111/j.1600-079x.2007.00498.xopenalex-snapshot

Melatonin modulates the expression of VEGF and HIF‐1α induced by CoCl2 in cultured cancer cells

inferredcites →https://doi.org/10.1111/j.1600-079x.2009.00678.xopenalex-snapshot

Melatonin down‐regulates HIF‐1α expression through inhibition of protein translation in prostate cancer cells

inferredcites →https://doi.org/10.1111/j.1600-079x.2009.00699.xopenalex-snapshot

Melatonin reduces cardiac inflammatory injury induced by acute exercise

inferredcites →https://doi.org/10.1111/j.1600-079x.2009.00729.xopenalex-snapshot

Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer

inferredcites →https://doi.org/10.1111/j.1600-079x.2009.00733.xopenalex-snapshot

Inhibitory effect of melatonin on lung oxidative stress induced by respiratory syncytial virus infection in mice

inferredcites →https://doi.org/10.1111/j.1600-079x.2009.00742.xopenalex-snapshot

Melatonin suppresses tumor angiogenesis by inhibiting HIF-1α stabilization under hypoxia

inferredcites →https://doi.org/10.1111/j.1600-079x.2010.00808.xopenalex-snapshot

Oral melatonin attenuates lung inflammation and airway hyperreactivity induced by inhalation of aerosolized pancreatic fluid in rats

inferredcites →https://doi.org/10.1111/j.1600-079x.2011.00865.xopenalex-snapshot

Sphingosine kinase 1 pathway is involved in melatonin-induced HIF-1α inactivation in hypoxic PC-3 prostate cancer cells

inferredcites →https://doi.org/10.1111/j.1600-079x.2011.00899.xopenalex-snapshot

Melatonin supplementation ameliorates oxidative stress and inflammatory signaling induced by strenuous exercise in adult human males

inferredcites →https://doi.org/10.1111/j.1600-079x.2011.00933.xopenalex-snapshot

Melatonin prevents human pancreatic carcinoma cell PANC‐1‐induced human umbilical vein endothelial cell proliferation and migration by inhibiting vascular endothelial growth factor expression

inferredcites →https://doi.org/10.1111/j.1600-079x.2011.00950.xopenalex-snapshot

Melatonin suppresses acrolein‐induced IL‐8 production in human pulmonary fibroblasts

inferredcites →https://doi.org/10.1111/j.1600-079x.2012.00972.xopenalex-snapshot

Melatonin inhibits type 1 interferon signaling of toll‐like receptor 4 via heme oxygenase‐1 induction in hepatic ischemia/reperfusion

inferredcites →https://doi.org/10.1111/j.1749-6632.2000.tb05402.xopenalex-snapshot

Melatonin and Its Relation to the Immune System and Inflammation

inferredcites →https://doi.org/10.1111/jpi.12007openalex-snapshot

Regulation of vascular endothelial growth factor by melatonin in human breast cancer cells

inferredcites →https://doi.org/10.1111/jpi.12020openalex-snapshot

Melatonin treatment improves adipose‐derived mesenchymal stem cell therapy for acute lung ischemia–reperfusion injury

inferredcites →https://doi.org/10.1111/jpi.12071openalex-snapshot

Melatonin ameliorates A ngiotensin II ‐induced vascular endothelial damage via its antioxidative properties

inferredcites →https://doi.org/10.1111/jpi.12084openalex-snapshot

Insulin and IGF 1 enhance IL ‐17‐induced chemokine expression through a GSK 3B‐dependent mechanism: a new target for melatonin's anti‐inflammatory action

inferredcites →https://doi.org/10.1111/jpi.12131openalex-snapshot

Melatonin reduces endothelin‐1 expression and secretion in colon cancer cells through the inactivation of FoxO‐1 and NF ‐κβ

inferredcites →https://doi.org/10.1111/jpi.12184openalex-snapshot

Melatonin attenuates hypoxic pulmonary hypertension by inhibiting the inflammation and the proliferation of pulmonary arterial smooth muscle cells

inferredcites →https://doi.org/10.1111/jpi.12192openalex-snapshot

Melatonin attenuates neutrophil inflammation and mucus secretion in cigarette smoke‐induced chronic obstructive pulmonary diseases via the suppression of Erk‐Sp1 signaling

inferredcites →https://doi.org/10.1111/jpi.12199openalex-snapshot

Systemic combined melatonin–mitochondria treatment improves acute respiratory distress syndrome in the rat

inferredcites →https://doi.org/10.1111/jpi.12218openalex-snapshot

Melatonin‐mediated inhibition of P urkinje neuron P ‐type C a 2+ channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3‐kinase‐dependent protein kinase C delta pathway

inferredcites →https://doi.org/10.1111/jpi.12238openalex-snapshot

Melatonin ameliorates amyloid beta‐induced memory deficits, tau hyperphosphorylation and neurodegeneration via PI 3/Akt/ GS k3β pathway in the mouse hippocampus

inferredcites →https://doi.org/10.1111/jpi.12302openalex-snapshot

Melatonin: the dawning of a treatment for fibrosis?

inferredcites →https://doi.org/10.1111/jpi.12360openalex-snapshot

Melatonin as an antioxidant: under promises but over delivers

inferredcites →https://doi.org/10.1111/jpi.12362openalex-snapshot

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

inferredcites →https://doi.org/10.1111/jpi.12435openalex-snapshot

Melatonin inhibits nucleus pulposus ( NP ) cell proliferation and extracellular matrix ( ECM ) remodeling via the melatonin membrane receptors mediated PI 3K‐Akt pathway

inferredcites →https://doi.org/10.1124/jpet.105.091249openalex-snapshot

Transforming Growth Factor-β-Dependent Growth Inhibition in Primary Vascular Smooth Muscle Cells Is p38-Dependent

inferredcites →https://doi.org/10.1124/pr.54.3.431openalex-snapshot

Caveolae: From Cell Biology to Animal Physiology

inferredcites →https://doi.org/10.1128/iai.74.3.1471-1479.2006openalex-snapshot

Interleukin-5 (IL-5) Augments the Progression of Liver Fibrosis by Regulating IL-13 Activity

inferredcites →https://doi.org/10.1136/annrheumdis-2014-205740openalex-snapshot

Sirt1 regulates canonical TGF-β signalling to control fibroblast activation and tissue fibrosis

inferredcites →https://doi.org/10.1136/thx.48.9.931openalex-snapshot

Cytokines and pulmonary fibrosis.

inferredcites →https://doi.org/10.1139/cjpp-2015-0277openalex-snapshot

Melatonin synergistically enhances protective effect of atorvastatin against gentamicin-induced nephrotoxicity in rat kidney

inferredcites →https://doi.org/10.1139/cjpp-2016-0409openalex-snapshot

Protective mechanisms of melatonin against hydrogen-peroxide-induced toxicity in human bone-marrow-derived mesenchymal stem cells

inferredcites →https://doi.org/10.1146/annurev.cellbio.20.010403.113126openalex-snapshot

THE WNT SIGNALING PATHWAY IN DEVELOPMENT AND DISEASE

inferredcites →https://doi.org/10.1146/annurev.pharmtox.48.121506.124841openalex-snapshot

Caveolae as Organizers of Pharmacologically Relevant Signal Transduction Molecules

inferredcites →https://doi.org/10.1152/ajpendo.00629.2010openalex-snapshot

Angiotensin II plays a critical role in diabetic pulmonary fibrosis most likely via activation of NADPH oxidase-mediated nitrosative damage

inferredcites →https://doi.org/10.1152/ajpgi.00051.2005openalex-snapshot

TGF-β1 gene transfer to the mouse colon leads to intestinal fibrosis

inferredcites →https://doi.org/10.1152/ajpgi.00186.2004openalex-snapshot

The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-β type II receptor gene transfer

inferredcites →https://doi.org/10.1152/ajplung.00185.2015openalex-snapshot

FGF9 and FGF18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts in vitro

inferredcites →https://doi.org/10.1152/ajplung.00258.2012openalex-snapshot

TGF-β-Smad3 signaling in emphysema and pulmonary fibrosis: an epigenetic aberration of normal development?

inferredcites →https://doi.org/10.1152/ajplung.00432.2005openalex-snapshot

Extravascular sources of lung angiotensin peptide synthesis in idiopathic pulmonary fibrosis

inferredcites →https://doi.org/10.1152/ajplung.00484.2016openalex-snapshot

Inflammation-induced caveolin-1 and BMPRII depletion promotes endothelial dysfunction and TGF-β-driven pulmonary vascular remodeling

inferredcites →https://doi.org/10.1152/ajplung.90207.2008openalex-snapshot

The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties

inferredcites →https://doi.org/10.1152/ajprenal.00264.2002openalex-snapshot

Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats

inferredcites →https://doi.org/10.1152/physiol.00011.2014openalex-snapshot

Melatonin: Exceeding Expectations

inferredcites →https://doi.org/10.1155/2012/289243openalex-snapshot

The Roles of Mitogen-Activated Protein Kinase Pathways in TGF-β-Induced Epithelial-Mesenchymal Transition

inferredcites →https://doi.org/10.1155/2012/875910openalex-snapshot

Angiotensinogen Gene Transcription in Pulmonary Fibrosis

inferredcites →https://doi.org/10.1155/2014/639531openalex-snapshot

The Beneficial Effect of Melatonin in Brain Endothelial Cells against Oxygen-Glucose Deprivation Followed by Reperfusion-Induced Injury

inferredcites →https://doi.org/10.1155/2016/3528274openalex-snapshot

Protective Effects of Melatonin on Retinal Inflammation and Oxidative Stress in Experimental Diabetic Retinopathy

inferredcites →https://doi.org/10.1158/0008-5472.can-05-1522openalex-snapshot

Transforming Growth Factor-β Activation of Phosphatidylinositol 3-Kinase Is Independent of Smad2 and Smad3 and Regulates Fibroblast Responses via p21-Activated Kinase-2

inferredcites →https://doi.org/10.1159/000430268openalex-snapshot

Platelet-Derived Growth Factor and Transforming Growth Factor β1 Regulate ARDS-Associated Lung Fibrosis Through Distinct Signaling Pathways

inferredcites →https://doi.org/10.1164/ajrccm.150.4.7921471openalex-snapshot

The Epidemiology of Interstitial Lung Diseases

inferredcites →https://doi.org/10.1164/ajrccm.152.6.8520779openalex-snapshot

Localization of Platelet-Derived Growth Factor and Insulin-Like Growth Factor I in the Fibrotic Lung

inferredcites →https://doi.org/10.1164/rccm.200308-1111ocopenalex-snapshot

Heterogeneous Increase in CD34-positive Alveolar Capillaries in Idiopathic Pulmonary Fibrosis

inferredcites →https://doi.org/10.1164/rccm.200602-205ocopenalex-snapshot

Fibroblast Foci Are Not Discrete Sites of Lung Injury or Repair

inferredcites →https://doi.org/10.1164/rccm.200811-1794ocopenalex-snapshot

Overexpression of Fibroblast Growth Factor-10 during Both Inflammatory and Fibrotic Phases Attenuates Bleomycin-induced Pulmonary Fibrosis in Mice

inferredcites →https://doi.org/10.1164/rccm.2009-040glopenalex-snapshot

An Official ATS/ERS/JRS/ALAT Statement: Idiopathic Pulmonary Fibrosis: Evidence-based Guidelines for Diagnosis and Management

inferredcites →https://doi.org/10.1165/rcmb.2004-0205ocopenalex-snapshot

Keratinocyte Growth Factor Expression by Fibroblasts in Pulmonary Fibrosis

inferredcites →https://doi.org/10.1165/rcmb.2008-0485tropenalex-snapshot

WNT Signaling in Lung Disease

inferredcites →https://doi.org/10.1165/rcmb.2009-0388tropenalex-snapshot

Endothelin in Pulmonary Fibrosis

inferredcites →https://doi.org/10.1165/rcmb.2012-0524ocopenalex-snapshot

WNT/β-Catenin Signaling Induces IL-1β Expression by Alveolar Epithelial Cells in Pulmonary Fibrosis

inferredcites →https://doi.org/10.1165/rcmb.2014-0184ocopenalex-snapshot

Fibroblast Growth Factor 2 Is Required for Epithelial Recovery, but Not for Pulmonary Fibrosis, in Response to Bleomycin

inferredcites →https://doi.org/10.1167/iovs.06-0804openalex-snapshot

Effect of VEGF-A on Expression of Profibrotic Growth Factor and Extracellular Matrix Genes in the Retina

inferredcites →https://doi.org/10.1172/jci12568openalex-snapshot

Transient expression of IL-1β induces acute lung injury and chronic repair leading to pulmonary fibrosis

inferredcites →https://doi.org/10.1172/jci19133openalex-snapshot

Inhibition of airway remodeling in IL-5–deficient mice

inferredcites →https://doi.org/10.1172/jci19603openalex-snapshot

Imatinib mesylate inhibits the profibrogenic activity of TGF-β and prevents bleomycin-mediated lung fibrosis

inferredcites →https://doi.org/10.1172/jci200420729openalex-snapshot

Disorders of lung matrix remodeling

inferredcites →https://doi.org/10.1172/jci5909openalex-snapshot

Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production

inferredcites →https://doi.org/10.1177/074873001129002051openalex-snapshot

Biology of Mammalian Photoperiodism and the Critical Role of the Pineal Gland and Melatonin

inferredcites →https://doi.org/10.1177/1534735409353332openalex-snapshot

Molecular Mechanisms of Melatonin Anticancer Effects

inferredcites →https://doi.org/10.1177/2156587215621672openalex-snapshot

Comparison of the Protective Effects of Melatonin and Silymarin Against Gentamicin-Induced Nephrotoxicity in Rats

inferredcites →https://doi.org/10.1183/09031936.00024711openalex-snapshot

Metalloproteinases in idiopathic pulmonary fibrosis

inferredcites →https://doi.org/10.1183/09031936.00130310openalex-snapshot

Renin is an angiotensin-independent profibrotic mediator: role in pulmonary fibrosis

inferredcites →https://doi.org/10.1183/09031936.00152106openalex-snapshot

Inhibition of PDGF, VEGF and FGF signalling attenuates fibrosis

showing the first 200 of 251 · page through all 251

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Alleviative effects of combined topical melatonin and rutin on imiquimod-induced psoriasis mouse model

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A Comprehensive Review on Pulmonary Fibrosis (PF): Histological Spectrum, Diagnosis, Risk Factors, Pathogenesis, Molecular Pathophysiology, and Current Treatment Options

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The interplay between ASMase signaling pathway and NLRP3 in the epithelial to mesenchymal transition of HBE cells induced by silica

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Integrative analyses of genes associated with idiopathic pulmonary fibrosis

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Melatonin alleviates LPS‐induced endoplasmic reticulum stress and inflammation in spermatogonial stem cells

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Antifibrosis treatment by inhibition of VEGF, FGF, and PDGF receptors improves bladder wall remodeling and detrusor overactivity in association with modulation of C‐fiber afferent activity in mice with spinal cord injury

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Melatonin: Roles in influenza, Covid‐19, and other viral infections

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Protection of melatonin against long‐term radon exposure‐caused lung injury

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Advances in Characterizing Recently-Identified Molecular Actions of Melatonin: Clinical Implications

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Integrative omics analysis identifies biomarkers of idiopathic pulmonary fibrosis

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Possible benefits of exogenous melatonin for individuals on dialysis: a narrative review on potential mechanisms and clinical implications

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Ameliorative effects of topical ramelteon on imiquimod-induced psoriasiform inflammation in mice

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Clinical Application of Melatonin in the Treatment of Cardiovascular Diseases: Current Evidence and New Insights into the Cardioprotective and Cardiotherapeutic Properties

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Potential mechanisms and therapeutic strategies for LPS-associated female fertility decline

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Celastrol-Ligustrazine compound proven to be a novel drug candidate for idiopathic pulmonary fibrosis by intervening in the TGF-β1 mediated pathways-an experimental in vitro and vivo study

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Latest progress on the molecular mechanisms of idiopathic pulmonary fibrosis

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Melatonin ameliorates chronic copper-induced lung injury

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Crocin: a protective natural antioxidant against pulmonary fibrosis induced by bleomycin

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Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis

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Melatonin and oral diseases: possible therapeutic roles based on cellular mechanisms

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Signaling pathways in skin cancers and the protective functions of melatonin

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Appraisal of mechanisms of radioprotection and therapeutic approaches of radiation countermeasures

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Inhibition of EP300 and DDR1 synergistically alleviates pulmonary fibrosis in vitro and in vivo

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Evaluating the protective effects of melatonin on di(2-ethylhexyl) phthalate-induced testicular injury in adult mice

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SARS-CoV-2 and ACE2: The biology and clinical data settling the ARB and ACEI controversy

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Melatonin and gastrointestinal cancers: Current evidence based on underlying signaling pathways

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Structural impact, ligand–protein interactions, and molecular phenotypic effects of TGF-β1 gene variants: In silico analysis with implications for idiopathic pulmonary fibrosis

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Customizable resveratrol spray-dried micro-composites for inhalation as a promising contender for treatment of idiopathic pulmonary fibrosis

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Emodin attenuates silica-induced lung injury by inhibition of inflammation, apoptosis and epithelial-mesenchymal transition

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Melatonin attenuates LPS-induced pyroptosis in acute lung injury by inhibiting NLRP3-GSDMD pathway via activating Nrf2/HO-1 signaling axis

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β-carboline alkaloids attenuate bleomycin induced pulmonary fibrosis in mice through inhibiting NF-kb/p65 phosphorylation and epithelial-mesenchymal transition

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Inhibitory effects of alkaline extract from the pericarp of Citrus reticulata Blanco on collagen behavior in bleomycin-induced pulmonary fibrosis

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Lungs as target of COVID-19 infection: Protective common molecular mechanisms of vitamin D and melatonin as a new potential synergistic treatment

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Endogenous tryptophan metabolite 5-Methoxytryptophan inhibits pulmonary fibrosis by downregulating the TGF-β/SMAD3 and PI3K/AKT signaling pathway

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Melatonin effect on platelets and coagulation: Implications for a prophylactic indication in COVID-19

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Phytomelatonin: a potential phytotherapeutic intervention on COVID-19-exposed individuals

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Prenatal light exposure affects diurnal rhythms and visual development of the layer embryonic retina

inferred← citeshttps://doi.org/10.1016/j.taap.2019.05.015openalex-snapshot

M10 peptide attenuates silica-induced pulmonary fibrosis by inhibiting Smad2 phosphorylation

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Melatonin prevents pulmonary fibrosis caused by PM2.5 exposure by targeting epithelial-mesenchymal transition

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Melatonin potentials against viral infections including COVID-19: Current evidence and new findings

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Intramolecular cyclization of N -aryl amides for the synthesis of 3-amino oxindoles

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MicroRNA-27a targets Sfrp1 to induce renal fibrosis in diabetic nephropathy by activating Wnt/β-Catenin signalling

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Gallium-68 Labelled Radiopharmaceuticals for Imaging Inflammatory Disorders

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Mitochondrial dysfunction in age-related macular degeneration: melatonin as a potential treatment

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Fendrr synergizes with Wnt signalling to regulate fibrosis related genes during lung development via its RNA:dsDNA triplex element

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Melatonin regulates proliferation, apoptosis and invasion of trophoblasts in preeclampsia by inhibiting endoplasmic reticulum stress

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Melatonin ameliorates endocrine dysfunction and defective sperm integrity associated with high‐fat diet‐induced obesity in male Wistar rats

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Anticonvulsant effect of melatonin through ATP‐sensitive channels in mice

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Melatonin and morphine: potential beneficial effects of co‐use

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A nutraceutical strategy for downregulating TGFβ signalling: prospects for prevention of fibrotic disorders, including post-COVID-19 pulmonary fibrosis

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Effect of Total Flavonoids of Oxytropis falcata Bunge on the Expression of p‐JAK1‐and p‐STAT1‐Related Proteins in Idiopathic Pulmonary Fibrosis

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Transcriptome Classification Reveals Molecular Subgroups in Idiopathic Pulmonary Fibrosis

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Gallic acid ameliorates di-(2-ethylhexyl) phthalate-induced testicular injury in adult mice

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An updated review of mechanistic potentials of melatonin against cancer: pivotal roles in angiogenesis, apoptosis, autophagy, endoplasmic reticulum stress and oxidative stress

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Melatonin-pretreated mesenchymal stem cell-derived exosomes alleviate cavernous fibrosis in a rat model of nerve injury-induced erectile dysfunction via miR-145-5p/TGF-β/Smad axis

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Protective role of melatonin against adipose-hepatic metabolic comorbidities in experimentally induced obese rat model

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The mechanism of lung tissue YKL-40 promoting the interstitial transformation of alveolar epithelial cells and its effect on TGF-β1 level in mice with idiopathic pulmonary fibrosis

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Integration of Transcriptomic and Proteomic Profiles Identifies Potential Biomarkers in Idiopathic Pulmonary Fibrosis

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Diabetic Pneumopathy- A Novel Diabetes-associated Complication: Pathophysiology, the Underlying Mechanism and Combination Medication

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Beneficial Effects of Melatonin and Atorvastatin on Retinopathy in Streptozocin-induced Diabetic Rats

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Interleukin-17A: A Potential Therapeutic Target in Chronic Lung Diseases

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Melatonin and Regulation of miRNAs: Novel Targeted Therapy for Cancerous and Noncancerous Disease

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Targeting Oxidative Stress as a Therapeutic Approach for Idiopathic Pulmonary Fibrosis

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Protective effects and mechanism of curcumin in animal models of pulmonary fibrosis: a preclinical systematic review and meta-analysis

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The potential therapeutic role of curcumin in osteoporosis treatment: based on multiple signaling pathways

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Effects of Radon-222 Exposure on Lung Oxidative Stress and Superoxide Dismutase in Male Albino Rats: Roles of Melatonin as an Antioxidant.

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The Coronavirus Disease 2019 (COVID-19): Key Emphasis on Melatonin Safety and Therapeutic Efficacy

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Melatonin as a Potential Adjuvant Treatment for COVID-19 beyond Sleep Disorders

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Effects of the Hypomethylating Agent Guadecitabine on Peripheral Blood Mononuclear Cell Methylomes and Immune Cell Populations in Small-Cell Lung Cancer Patients

inferred← citeshttps://doi.org/10.3390/v13040659openalex-snapshot

Melatonin Inhibits Dengue Virus Infection via the Sirtuin 1-Mediated Interferon Pathway

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Role of melatonin in respiratory diseases (Review)

inferred← citeshttps://doi.org/10.3892/ijmm.2021.4880openalex-snapshot

Pineal hormone melatonin as an adjuvant treatment for COVID‑19 (Review)

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Role of Macrophage in Pathogenesis of Pulmonary Fibrosis: A Review

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Bronchioalveolar organoids as a tool to study transforming growth factor-β and cigarette smoke–induced lung pathology

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[Expression of ubiquitin-specific protease 7 in lung tissue of preterm rats after hyperoxia exposure].

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