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Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Imatinib mesylate in idiopathic and postpolycythemic myelofibrosis
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The sequence of histological changes in mouse lungs after single doses of X-rays
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Transgenic Overexpression of Platelet-Derived Growth Factor-C in the Mouse Heart Induces Cardiac Fibrosis, Hypertrophy, and Dilated Cardiomyopathy
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Specific Inhibitors of Platelet-Derived Growth Factor or Epidermal Growth Factor Receptor Tyrosine Kinase Reduce Pulmonary Fibrosis in Rats
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Emphysematous Lesions, Inflammation, and Fibrosis in the Lungs of Transgenic Mice Overexpressing Platelet-Derived Growth Factor
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The preferential homing of a platelet derived growth factor receptor-recognizing macromolecule to fibroblast-like cells in fibrotic tissue
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Involvement of platelet-derived growth factor in disease: development of specific antagonists
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Endostatin's Antiangiogenic Signaling Network
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Exaggerated Spontaneous Release of Platelet-Derived Growth Factor by Alveolar Macrophages from Patients with Idiopathic Pulmonary Fibrosis
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Transforming Growth Factor β in Tissue Fibrosis
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The Protein Kinase Complement of the Human Genome
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inferredcites →https://doi.org/10.1378/chest.111.4.1061openalex-snapshot
Pulmonary Radiation Injury
inferredcites →https://doi.org/10.1378/chest.124.4.1187openalex-snapshot
Idiopathic Pulmonary Fibrosis
inferredcites →https://doi.org/10.1667/0033-7587(2003)159[0805:ibacco]2.0.co;2openalex-snapshot
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TNF- alpha stimulation of fibroblast proliferation. Dependence on platelet-derived growth factor (PDGF) secretion and alteration of PDGF receptor expression.
inferredcites →https://doi.org/10.4161/cc.3.11.1209openalex-snapshot
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What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Pathogenetic mechanisms in radiation fibrosis
inferred← citeshttps://doi.org/10.1016/j.radonc.2011.05.064openalex-snapshot
New insights into the molecular pathology of radiation-induced pneumopathy
inferred← citeshttps://doi.org/10.1016/j.radonc.2020.11.020openalex-snapshot
Idiopathic pulmonary fibrosis: Current knowledge, future perspectives and its importance in radiation oncology
inferred← citeshttps://doi.org/10.1016/j.radonc.2025.110837openalex-snapshot
Diagnosis and treatment of radiation induced pneumonitis in patients with lung cancer: An ESTRO clinical practice guideline
inferred← citeshttps://doi.org/10.1016/j.rdc.2007.12.003openalex-snapshot
Novel Treatment Approaches to Fibrosis in Scleroderma
inferred← citeshttps://doi.org/10.1016/j.resp.2012.01.002openalex-snapshot
Protective effects of bone marrow mononuclear cell therapy on lung and heart in an elastase-induced emphysema model
inferred← citeshttps://doi.org/10.1016/j.resp.2015.10.004openalex-snapshot
Nicotine reduces the levels of surfactant proteins A and D via Wnt/β-catenin and PKC signaling in human airway epithelial cells
inferred← citeshttps://doi.org/10.1016/j.semarthrit.2010.10.002openalex-snapshot
Coagulation and Autoimmunity in Scleroderma Interstitial Lung Disease
inferred← citeshttps://doi.org/10.1016/j.semarthrit.2012.06.001openalex-snapshot
Therapeutic Inhibition of Tyrosine Kinases in Systemic Sclerosis: A Review of Published Experience on the First 108 Patients Treated with Imatinib
inferred← citeshttps://doi.org/10.1016/j.semarthrit.2017.05.004openalex-snapshot
The role of platelets in autoimmunity, vasculopathy, and fibrosis: Implications for systemic sclerosis
inferred← citeshttps://doi.org/10.1016/j.taap.2020.115272openalex-snapshot
Pulmonary toxicants and fibrosis: innate and adaptive immune mechanisms
inferred← citeshttps://doi.org/10.1016/j.tranon.2018.09.009openalex-snapshot
Advances in Molecular Mechanisms and Treatment of Radiation-Induced Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.1016/j.trim.2021.101514openalex-snapshot
Expression of transforming growth factor β pathway components in chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation
inferred← citeshttps://doi.org/10.1016/j.trim.2025.102328openalex-snapshot
Immune mediators as therapeutic targets in GvHD; cytokines, growth factors, chemokines, and co-stimulation /co-inhibition
inferred← citeshttps://doi.org/10.1016/j.vetimm.2007.10.010openalex-snapshot
Transportation stress alters the circulating steroid environment and neutrophil gene expression in beef bulls
inferred← citeshttps://doi.org/10.1016/s0300-2896(05)70763-8openalex-snapshot
Fibrosis pulmonar idiopática: en busca de un tratamiento eficaz
inferred← citeshttps://doi.org/10.1016/s1054-3589(08)57011-6openalex-snapshot
New Developments in the Therapy of Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.1016/s1579-2129(07)60115-3openalex-snapshot
Experimental Models for the Study of Pulmonary Fibrosis: Current Usefulness and Future Promise
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.6b00935openalex-snapshot
Idiopathic Pulmonary Fibrosis: Current Status, Recent Progress, and Emerging Targets
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.7b00164openalex-snapshot
Discovery of Indolinone-Based Multikinase Inhibitors as Potential Therapeutics for Idiopathic Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.1038/bjc.2017.13openalex-snapshot
A combination of low-dose bevacizumab and imatinib enhances vascular normalisation without inducing extracellular matrix deposition
inferred← citeshttps://doi.org/10.1038/gt.2008.93openalex-snapshot
Targeted inhibition of platelet-derived growth factor receptor-β subunit in hepatic stellate cells ameliorates hepatic fibrosis in rats
inferred← citeshttps://doi.org/10.1038/npre.2011.5908.1openalex-snapshot
SARS-CoV Regulates Immune Function-Related Gene Expressions in Human Monocytic Cells
inferred← citeshttps://doi.org/10.1038/nrc.2016.73openalex-snapshot
The biology and function of fibroblasts in cancer
inferred← citeshttps://doi.org/10.1038/nrc2106openalex-snapshot
Molecular mechanisms of cardiotoxicity of tyrosine kinase inhibition
inferred← citeshttps://doi.org/10.1038/nrd3297openalex-snapshot
Targeting non-malignant disorders with tyrosine kinase inhibitors
inferred← citeshttps://doi.org/10.1038/s12276-019-0228-0openalex-snapshot
Notch1 promotes the pericyte-myofibroblast transition in idiopathic pulmonary fibrosis through the PDGFR/ROCK1 signal pathway
inferred← citeshttps://doi.org/10.1038/s41392-025-02541-zopenalex-snapshot
Wnt-associated DKK3 in keratinocytes mediates radiation-induced hyperplasia, dermatitis and skin fibrosis
inferred← citeshttps://doi.org/10.1038/s41467-020-20323-9openalex-snapshot
The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2
inferred← citeshttps://doi.org/10.1038/s41572-019-0064-5openalex-snapshot
Radiotherapy toxicity
inferred← citeshttps://doi.org/10.1038/s41586-024-08542-2openalex-snapshot
RUNX2 promotes fibrosis via an alveolar-to-pathological fibroblast transition
inferred← citeshttps://doi.org/10.1038/s41592-025-02808-xopenalex-snapshot
Deep generative modeling of sample-level heterogeneity in single-cell genomics
inferred← citeshttps://doi.org/10.1038/s41598-018-19343-9openalex-snapshot
Pharmacological targeting of BET proteins attenuates radiation-induced lung fibrosis
inferred← citeshttps://doi.org/10.1038/s41598-021-90674-wopenalex-snapshot
Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis
inferred← citeshttps://doi.org/10.1055/a-2649-9359openalex-snapshot
Emerging Concepts in Fibroblast Biology and Progressive Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.1056/nejmoa1103690openalex-snapshot
Efficacy of a Tyrosine Kinase Inhibitor in Idiopathic Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.1073/pnas.0705505104openalex-snapshot
Transcriptional network governing the angiogenic switch in human pancreatic cancer
inferred← citeshttps://doi.org/10.1080/01902140701634827openalex-snapshot
IMATINIB MESYLATE INHIBITS FIBROGENESIS IN ASBESTOS-INDUCED INTERSTITIAL PNEUMONIA
inferred← citeshttps://doi.org/10.1080/0284186x.2018.1479072openalex-snapshot
Imatinib may reduce chemotherapy-induced pneumonitis. A report on four cases from the SWENOTECA
inferred← citeshttps://doi.org/10.1080/03008207.2020.1828379openalex-snapshot
Force dependent effects of chronic overuse on fibrosis-related genes and proteins in skeletal muscles
inferred← citeshttps://doi.org/10.1080/08923973.2018.1533025openalex-snapshot
Radiation-induced lung injury: impact on macrophage dysregulation and lipid alteration – a review
inferred← citeshttps://doi.org/10.1080/09553000600930103openalex-snapshot
Candidate protein biodosimeters of human exposure to ionizing radiation
inferred← citeshttps://doi.org/10.1080/09553002.2018.1532619openalex-snapshot
Modeling radiation-induced lung injury: lessons learned from whole thorax irradiation
inferred← citeshttps://doi.org/10.1080/14397595.2019.1696505openalex-snapshot
Nintedanib: New indication for systemic sclerosis-associated interstitial lung disease
inferred← citeshttps://doi.org/10.1080/14728222.2019.1653281openalex-snapshot
Targeting platelet-derived growth factor receptor β inhibits the proliferation and motility of human pterygial fibroblasts
inferred← citeshttps://doi.org/10.1080/15376516.2021.1934765openalex-snapshot
Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats
inferred← citeshttps://doi.org/10.1080/2162402x.2015.1123366openalex-snapshot
Combined inhibition of TGFβ and PDGF signaling attenuates radiation-induced pulmonary fibrosis
inferred← citeshttps://doi.org/10.1089/ars.2007.1914openalex-snapshot
Transforming Growth Factor- β Activation in the Lung: Focus on Fibrosis and Reactive Oxygen Species
inferred← citeshttps://doi.org/10.1089/ars.2007.1942openalex-snapshot
Oxidant–Antioxidant Imbalance as a Potential Contributor to the Progression of Human Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.1089/vim.2011.0099openalex-snapshot
SARS-CoV Regulates Immune Function-Related Gene Expression in Human Monocytic Cells
inferred← citeshttps://doi.org/10.1093/bioinformatics/bty133openalex-snapshot
A novel computational approach for drug repurposing using systems biology
inferred← citeshttps://doi.org/10.1093/cvr/cvn063openalex-snapshot
Imatinib mesylate attenuates fibrosis in coxsackievirus b3-induced chronic myocarditis
inferred← citeshttps://doi.org/10.1093/gbe/evad053openalex-snapshot
Single-Cell RNA Sequencing Reveals Microevolution of the Stickleback Immune System
inferred← citeshttps://doi.org/10.1093/jnci/djw339openalex-snapshot
Effects of CTGF Blockade on Attenuation and Reversal of Radiation-Induced Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.1093/jrr/rru008openalex-snapshot
The expression of aquaporins 1 and 5 in rat lung after thoracic irradiation
inferred← citeshttps://doi.org/10.1093/ndt/gfl691openalex-snapshot
PDGF-D inhibition by CR002 ameliorates tubulointerstitial fibrosis following experimental glomerulonephritis
inferred← citeshttps://doi.org/10.1093/rheumatology/ken369openalex-snapshot
A novel therapeutic approach to the treatment of scleroderma-associated pulmonary complications: safety and efficacy of combination therapy with imatinib and cyclophosphamide
inferred← citeshttps://doi.org/10.1093/rheumatology/ken431openalex-snapshot
Imatinib as a novel therapeutic approach for fibrotic disorders
inferred← citeshttps://doi.org/10.1096/fj.06-7510comopenalex-snapshot
A new microrheometric approach reveals individual and cooperative roles for TGF‐β1 and IL‐1β in fibroblast‐mediated stiffening of collagen gels
inferred← citeshttps://doi.org/10.1096/fj.07-105627openalex-snapshot
Dual inhibition of c‐abl and PDGF receptor signaling by dasatinib and nilotinib for the treatment of dermal fibrosis
inferred← citeshttps://doi.org/10.1096/fj.09-129833openalex-snapshot
Imatinib attenuates skeletal muscle dystrophy in mdx mice
inferred← citeshttps://doi.org/10.1097/coc.0000000000000023openalex-snapshot
Off-Target Effects of BCR-ABL and JAK2 Inhibitors
inferred← citeshttps://doi.org/10.1097/cpm.0b013e3181efac67openalex-snapshot
Radiation Pneumonitis
inferred← citeshttps://doi.org/10.1097/nen.0b013e3181e9a34bopenalex-snapshot
Targeting Fibrosis in Duchenne Muscular Dystrophy
inferred← citeshttps://doi.org/10.1097/rhu.0b013e3181637404openalex-snapshot
Basic Science for the Clinician 48: Tyrosine Kinases in Disease
inferred← citeshttps://doi.org/10.1101/2022.01.04.474955openalex-snapshot
Saracatinib, a Selective Src Kinase Inhibitor, Blocks Fibrotic Responses in In Vitro, In Vivo and Ex Vivo Models of Pulmonary Fibrosis
inferred← citeshttps://doi.org/10.1101/2024.05.26.595932openalex-snapshot
WITHDRAWN: Physiological modeling and biomechanical insights of cytokine modulation in COVID-19 and pulmonary fibrosis through a multi-dimensional graph-based approach
inferred← citeshttps://doi.org/10.1101/2025.06.16.659944openalex-snapshot
Single cell transcriptomics in a treatment-segregated cohort exposes a STAT3-regulated therapeutic gap in idiopathic pulmonary fibrosis
inferred← citeshttps://doi.org/10.1101/gad.1653708openalex-snapshot
Role of platelet-derived growth factors in physiology and medicine
inferred← citeshttps://doi.org/10.1101/gad.260554.115openalex-snapshot
PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity
inferred← citeshttps://doi.org/10.1111/1756-185x.12075openalex-snapshot
Effects of imatinib mesylate on pulmonary allergic vasculitis in a murine model
inferred← citeshttps://doi.org/10.1111/acer.70012openalex-snapshot
Chronic binge alcohol dysregulates omental adipose tissue extracellular matrix in simian immunodeficiency virus‐infected macaques
inferred← citeshttps://doi.org/10.1111/cas.14578openalex-snapshot
Functional diversity of cancer‐associated fibroblasts in modulating drug resistance
inferred← citeshttps://doi.org/10.1111/epi.16019openalex-snapshot
A pericyte‐glia scarring develops at the leaky capillaries in the hippocampus during seizure activity
inferred← citeshttps://doi.org/10.1111/exd.12673openalex-snapshot
Current frontiers in systemic sclerosis pathogenesis
inferred← citeshttps://doi.org/10.1111/imr.12977openalex-snapshot
COVID‐19 and pulmonary fibrosis: A potential role for lung epithelial cells and fibroblasts
inferred← citeshttps://doi.org/10.1111/j.1365-2710.2008.01006.xopenalex-snapshot
Effects of angiotensin on the expression of fibrosis-associated cytokines, growth factors, and matrix proteins in human lung fibroblasts
inferred← citeshttps://doi.org/10.1111/j.1524-475x.2007.00219.xopenalex-snapshot
Cellular and molecular pathology of HTS: basis for treatment
inferred← citeshttps://doi.org/10.1111/j.1524-475x.2010.00662.xopenalex-snapshot
Cellular/extracellular matrix cross‐talk in scar evolution and control
inferred← citeshttps://doi.org/10.1111/j.1600-0609.2008.01061.xopenalex-snapshot
Platelet‐derived growth factor may be associated with fibrosis in a Down syndrome patient with transient myeloproliferative disorder
inferred← citeshttps://doi.org/10.1111/jcmm.12276openalex-snapshot
Grape seed pro‐anthocyanidins ameliorates radiation‐induced lung injury
inferred← citeshttps://doi.org/10.1111/joim.12690openalex-snapshot
Involvement of platelet‐derived growth factor ligands and receptors in tumorigenesis
inferred← citeshttps://doi.org/10.1111/wrr.12691openalex-snapshot
Plasma‐based biomaterials for the treatment of cutaneous radiation injury
inferred← citeshttps://doi.org/10.1111/wrr.12937openalex-snapshot
Myofibroblast progeny in wound biology and wound healing studies
inferred← citeshttps://doi.org/10.11138/sob/2015.4.1.003openalex-snapshot
Pulmonary fibrosis and lung cancer: not the same disease, but not so different
inferred← citeshttps://doi.org/10.1124/jpet.113.208223openalex-snapshot
Antifibrotic and Anti-inflammatory Activity of the Tyrosine Kinase Inhibitor Nintedanib in Experimental Models of Lung Fibrosis
inferred← citeshttps://doi.org/10.1124/jpet.123.001695openalex-snapshot
Paclitaxel Aggravating Radiation-Induced Pulmonary Fibrosis Is Associated with the Down-Regulation of the Negative Regulatory Function of Spry2
inferred← citeshttps://doi.org/10.1126/scitranslmed.3008973openalex-snapshot
Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice
inferred← citeshttps://doi.org/10.1136/ard.2009.120196openalex-snapshot
Tyrosine kinase inhibitors for the treatment of fibrotic diseases such as systemic sclerosis: towards molecular targeted therapies
inferred← citeshttps://doi.org/10.1136/thx.2009.134353openalex-snapshot
Increased expression of 5-hydroxytryptamine2A/B receptors in idiopathic pulmonary fibrosis: a rationale for therapeutic intervention
inferred← citeshttps://doi.org/10.1139/bcb-2014-0095openalex-snapshot
The role of miR-29 in pulmonary fibrosis
inferred← citeshttps://doi.org/10.1152/ajpcell.00060.2014openalex-snapshot
Cellular Mechanisms of Tissue Fibrosis. 8. Current and future drug targets in fibrosis: focus on Rho GTPase-regulated gene transcription
inferred← citeshttps://doi.org/10.1152/ajpcell.00114.2014openalex-snapshot
ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling
inferred← citeshttps://doi.org/10.1152/ajpheart.00656.2015openalex-snapshot
Tyrosine kinase inhibitor BIBF1000 does not hamper right ventricular pressure adaptation in rats
inferred← citeshttps://doi.org/10.1152/ajplung.00346.2015openalex-snapshot
Elevated expression of NEU1 sialidase in idiopathic pulmonary fibrosis provokes pulmonary collagen deposition, lymphocytosis, and fibrosis
inferred← citeshttps://doi.org/10.1152/japplphysiol.00241.2025openalex-snapshot
Integrative physiological study of radiation-induced lung injury: effects on cardiac function and kidney integrity
inferred← citeshttps://doi.org/10.1155/2013/759760openalex-snapshot
The Multifaceted Aspects of Interstitial Lung Disease in Rheumatoid Arthritis
inferred← citeshttps://doi.org/10.1155/2021/3963659openalex-snapshot
Idiopathic Pulmonary Comorbidities and Mechanisms
inferred← citeshttps://doi.org/10.1157/13109471openalex-snapshot
Modelos experimentales para el estudio de la fibrosis pulmonar: utilidad práctica actual y futura
inferred← citeshttps://doi.org/10.1158/0008-5472.can-04-1668openalex-snapshot
Trimodal Cancer Treatment: Beneficial Effects of Combined Antiangiogenesis, Radiation, and Chemotherapy
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-04-1223openalex-snapshot
Inhibition of αvβ3 Integrin Survival Signaling Enhances Antiangiogenic and Antitumor Effects of Radiotherapy
inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-07-1893openalex-snapshot
Combination of Vascular Endothelial Growth Factor Receptor/Platelet-Derived Growth Factor Receptor Inhibition Markedly Improves Radiation Tumor Therapy
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