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Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue

https://doi.org/10.1016/j.molmet.2020.101033
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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LiSa-2, a novel human liposarcoma cell line with a high capacity for terminal adipose differentiation
inferredcites →https://doi.org/10.1007/bf00253869openalex-snapshot
Lipoprotein lipase activity and serum lipoproteins in untreated Type 2 (insulin-independent) diabetes associated with obesity
inferredcites →https://doi.org/10.1016/0003-2697(78)90586-9openalex-snapshot
A modification of the Lowry procedure to simplify protein determination in membrane and lipoprotein samples
inferredcites →https://doi.org/10.1016/0026-0495(87)90144-2openalex-snapshot
Basal and postprandial lipoprotein lipase activity in adipose tissue during caloric restriction and refeeding
inferredcites →https://doi.org/10.1016/0026-0495(91)90178-yopenalex-snapshot
Tissue-specific regulation of lipoprotein lipase activity by insulin/glucose in normal-weight humans
inferredcites →https://doi.org/10.1016/j.atherosclerosis.2015.01.039openalex-snapshot
New insights into the pathophysiology of dyslipidemia in type 2 diabetes
inferredcites →https://doi.org/10.1016/j.bbalip.2014.03.013openalex-snapshot
Physiological regulation of lipoprotein lipase
inferredcites →https://doi.org/10.1016/j.bbalip.2017.02.005openalex-snapshot
TNF-α decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4
inferredcites →https://doi.org/10.1016/j.bbrc.2006.07.032openalex-snapshot
Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes
inferredcites →https://doi.org/10.1016/j.bbrc.2012.07.038openalex-snapshot
Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels
inferredcites →https://doi.org/10.1016/j.cmet.2010.04.016openalex-snapshot
GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries
inferredcites →https://doi.org/10.1016/j.cmet.2014.01.017openalex-snapshot
The GPIHBP1–LPL Complex Is Responsible for the Margination of Triglyceride-Rich Lipoproteins in Capillaries
inferredcites →https://doi.org/10.1016/j.ijcard.2005.06.056openalex-snapshot
Plasma triglycerides, an independent predictor of cardiovascular disease in men: A prospective study based on a population with prevalent metabolic syndrome
inferredcites →https://doi.org/10.1016/j.jacl.2018.02.006openalex-snapshot
Regulation of angiopoietin-like 4 and lipoprotein lipase in human adipose tissue
inferredcites →https://doi.org/10.1016/j.metabol.2020.154192openalex-snapshot
Circulating and tissue specific transcription of angiopoietin-like protein 4 in human Type 2 diabetes
inferredcites →https://doi.org/10.1016/j.molmet.2017.06.007openalex-snapshot
Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting
inferredcites →https://doi.org/10.1016/j.molmet.2017.06.014openalex-snapshot
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase
inferredcites →https://doi.org/10.1016/s0021-9150(02)00366-0openalex-snapshot
Postprandial regulation of blood lipids and adipose tissue lipoprotein lipase in type 2 diabetes patients and healthy control subjects
inferredcites →https://doi.org/10.1016/s0021-9258(18)81898-1openalex-snapshot
Insulin Regulation of Lipoprotein Lipase Activity in 3T3-L1 Adipocytes is Mediated at Posttranscriptional and Posttranslational Levels
inferredcites →https://doi.org/10.1016/s0021-9258(19)39601-2openalex-snapshot
The response of lipoprotein lipase to feeding and fasting. Evidence for posttranslational regulation.
inferredcites →https://doi.org/10.1016/s0022-2275(20)39099-4openalex-snapshot
The liberation of lipoprotein lipase by heparin from adipose tissue incubated in vitro
inferredcites →https://doi.org/10.1016/s1357-2725(03)00256-5openalex-snapshot
Nutritional regulation of lipoprotein lipase in mice
inferredcites →https://doi.org/10.1038/ijo.2016.221openalex-snapshot
Weight loss-induced cellular stress in subcutaneous adipose tissue and the risk for weight regain in overweight and obese adults
inferredcites →https://doi.org/10.1042/bj3130893openalex-snapshot
Forms of lipoprotein lipase in rat tissues: in adipose tissue the proportion of inactive lipase increases on fasting
inferredcites →https://doi.org/10.1046/j.1365-2362.2002.00945.xopenalex-snapshot
Insulin resistance affects the regulation of lipoprotein lipase in the postprandial period and in an adipose tissue‐specific manner
inferredcites →https://doi.org/10.1056/nejmoa1510926openalex-snapshot
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
inferredcites →https://doi.org/10.1056/nejmoa1611930openalex-snapshot
Autoantibodies against GPIHBP1 as a Cause of Hypertriglyceridemia
inferredcites →https://doi.org/10.1073/pnas.0604026103openalex-snapshot
Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
inferredcites →https://doi.org/10.1073/pnas.1315292110openalex-snapshot
Mice lacking ANGPTL8 (Betatrophin) manifest disrupted triglyceride metabolism without impaired glucose homeostasis
inferredcites →https://doi.org/10.1073/pnas.1515374112openalex-snapshot
Hepatic ANGPTL3 regulates adipose tissue energy homeostasis
inferredcites →https://doi.org/10.1074/jbc.m004029200openalex-snapshot
Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene
inferredcites →https://doi.org/10.1074/jbc.m109.025452openalex-snapshot
Angiopoietin-like 4 (ANGPTL4, Fasting-induced Adipose Factor) Is a Direct Glucocorticoid Receptor Target and Participates in Glucocorticoid-regulated Triglyceride Metabolism
inferredcites →https://doi.org/10.1074/jbc.m200325200openalex-snapshot
Down-regulation of Adipose Tissue Lipoprotein Lipase during Fasting Requires That a Gene, Separate from the Lipase Gene, Is Switched On
inferredcites →https://doi.org/10.1074/jbc.m403058200openalex-snapshot
The Direct Peroxisome Proliferator-activated Receptor Target Fasting-induced Adipose Factor (FIAF/PGAR/ANGPTL4) Is Present in Blood Plasma as a Truncated Protein That Is Increased by Fenofibrate Treatment
inferredcites →https://doi.org/10.1074/jbc.m506519200openalex-snapshot
The Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Is Physically Associated with Lipoproteins and Governs Plasma Lipid Levels and Adiposity
inferredcites →https://doi.org/10.1074/jbc.ra118.002426openalex-snapshot
Angiopoietin-like 4 promotes the intracellular cleavage of lipoprotein lipase by PCSK3/furin in adipocytes
inferredcites →https://doi.org/10.1093/ajcn/68.2.296openalex-snapshot
Effect of dietary macronutrient composition on tissue-specific lipoprotein lipase activity and insulin action in normal-weight subjects
inferredcites →https://doi.org/10.1097/mol.0000000000000290openalex-snapshot
Regulation of lipid metabolism by angiopoietin-like proteins
inferredcites →https://doi.org/10.1098/rsob.150272openalex-snapshot
The ANGPTL3-4-8 model, a molecular mechanism for triglyceride trafficking
inferredcites →https://doi.org/10.1111/j.1365-2362.1990.tb02263.xopenalex-snapshot
Uptake of triglyceride fatty acids in adipose tissue in vivo in man
inferredcites →https://doi.org/10.1111/j.1365-2362.2005.01470.xopenalex-snapshot
Tissue‐specific regulation of lipoprotein lipase in humans: effects of fasting
inferredcites →https://doi.org/10.1111/j.1365-2362.2006.01584.xopenalex-snapshot
Lipoprotein lipase activity/mass ratio is higher in omental than in subcutaneous adipose tissue
inferredcites →https://doi.org/10.1111/j.1432-1033.1980.tb04603.xopenalex-snapshot
Lipoprotein Lipase
inferredcites →https://doi.org/10.1128/mcb.00858-12openalex-snapshot
Short-Chain Fatty Acids Stimulate Angiopoietin-Like 4 Synthesis in Human Colon Adenocarcinoma Cells by Activating Peroxisome Proliferator-Activated Receptor γ
inferredcites →https://doi.org/10.1152/ajplegacy.1959.197.3.667openalex-snapshot
Effect of nutrition on activity and release of lipase from rat adipose tissue
inferredcites →https://doi.org/10.1161/atvbaha.107.151894openalex-snapshot
Angptl4 Upregulates Cholesterol Synthesis in Liver via Inhibition of LPL- and HL-Dependent Hepatic Cholesterol Uptake
inferredcites →https://doi.org/10.1161/atvbaha.108.182147openalex-snapshot
Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids
inferredcites →https://doi.org/10.1161/circresaha.115.306398openalex-snapshot
Surprises From Genetic Analyses of Lipid Risk Factors for Atherosclerosis
inferredcites →https://doi.org/10.1177/174182679600300214openalex-snapshot
Plasma Triglyceride Level is a Risk Factor for Cardiovascular Disease Independent of High-Density Lipoprotein Cholesterol Level: A Metaanalysis of Population-Based Prospective Studies
inferredcites →https://doi.org/10.1186/1472-6793-12-13openalex-snapshot
Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue
inferredcites →https://doi.org/10.1186/1755-8794-5-9openalex-snapshot
Adipose tissue gene expression analysis reveals changes in inflammatory, mitochondrial respiratory and lipid metabolic pathways in obese insulin-resistant subjects
inferredcites →https://doi.org/10.1186/s12944-016-0231-6openalex-snapshot
ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels and predicts cardiovascular disease risk in Type 2 diabetic Tunisian population
inferredcites →https://doi.org/10.1194/jlr.c200010-jlr200openalex-snapshot
Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
inferredcites →https://doi.org/10.1194/jlr.m067363openalex-snapshot
Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes
inferredcites →https://doi.org/10.1194/jlr.m075689openalex-snapshot
ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance
inferredcites →https://doi.org/10.1194/jlr.m088807openalex-snapshot
On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity
inferredcites →https://doi.org/10.1194/jlr.r800085-jlr200openalex-snapshot
Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
inferredcites →https://doi.org/10.1210/en.2005-0476openalex-snapshot
Transgenic Angiopoietin-Like (Angptl)4 Overexpression and Targeted Disruption of Angptl4 and Angptl3: Regulation of Triglyceride Metabolism
inferredcites →https://doi.org/10.1210/en.2015-1567openalex-snapshot
Using a 3D Culture System to Differentiate Visceral Adipocytes In Vitro
inferredcites →https://doi.org/10.1210/er.2018-00184openalex-snapshot
The Forgotten Lipids: Triglycerides, Remnant Cholesterol, and Atherosclerotic Cardiovascular Disease Risk
inferredcites →https://doi.org/10.2337/db07-1438openalex-snapshot
Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
inferredcites →https://doi.org/10.3945/ajcn.112.043687openalex-snapshot
Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes
inferredcites →https://doi.org/10.7554/elife.18156openalex-snapshot
Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node
inferredcites →https://doi.org/10.7554/elife.20958openalex-snapshot
The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1007/s12013-023-01185-6openalex-snapshot
Fatty Acids and their Proteins in Adipose Tissue Inflammation
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inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2025.120485openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbalip.2022.159262openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.bbalip.2026.159774openalex-snapshot
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Leptin Increases Hepatic Triglyceride Export via a Vagal Mechanism in Humans
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inferred← citeshttps://doi.org/10.1016/j.jacl.2023.01.005openalex-snapshot
Role of lipoprotein lipase activity measurement in the diagnosis of familial chylomicronemia syndrome
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Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism
inferred← citeshttps://doi.org/10.1016/j.jlr.2023.100441openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.jlr.2024.100526openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.jlr.2026.101124openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.plipres.2021.101140openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.tem.2020.11.005openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.tem.2023.10.002openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41467-023-43900-0openalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41467-024-45724-yopenalex-snapshot
Adipocyte p53 coordinates the response to intermittent fasting by regulating adipose tissue immune cell landscape
inferred← citeshttps://doi.org/10.1038/s41569-022-00676-yopenalex-snapshot
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inferred← citeshttps://doi.org/10.1038/s41598-024-63018-7openalex-snapshot
Comprehensive expression analysis of hormone-like substances in the subcutaneous adipose tissue of the common bottlenose dolphin Tursiops truncatus
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inferred← citeshttps://doi.org/10.1073/pnas.2214081120openalex-snapshot
Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity
inferred← citeshttps://doi.org/10.1073/pnas.2310685120openalex-snapshot
ANGPTL4 binds to the leptin receptor to regulate ectopic bone formation
inferred← citeshttps://doi.org/10.1073/pnas.2420721122openalex-snapshot
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The Importance of Lipoprotein Lipase Regulation in Atherosclerosis
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