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Role and mechanism of the action of angiopoietin-like protein ANGPTL4 in plasma lipid metabolism

https://doi.org/10.1016/j.jlr.2021.100150
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamacardio.2018.2866openalex-snapshot
Association of Genetically Enhanced Lipoprotein Lipase–Mediated Lipolysis and Low-Density Lipoprotein Cholesterol–Lowering Alleles With Risk of Coronary Disease and Type 2 Diabetes
inferredcites →https://doi.org/10.1016/j.bbalip.2014.03.013openalex-snapshot
Physiological regulation of lipoprotein lipase
inferredcites →https://doi.org/10.1016/j.bbrc.2006.07.032openalex-snapshot
Insulin downregulates angiopoietin-like protein 4 mRNA in 3T3-L1 adipocytes
inferredcites →https://doi.org/10.1016/j.bbrc.2012.07.038openalex-snapshot
Lipasin, a novel nutritionally-regulated liver-enriched factor that regulates serum triglyceride levels
inferredcites →https://doi.org/10.1016/j.bbrc.2012.07.048openalex-snapshot
Inactivation of lipoprotein lipase occurs on the surface of THP-1 macrophages where oligomers of angiopoietin-like protein 4 are formed
inferredcites →https://doi.org/10.1016/j.bbrc.2012.12.025openalex-snapshot
Lipasin, thermoregulated in brown fat, is a novel but atypical member of the angiopoietin-like protein family
inferredcites →https://doi.org/10.1016/j.cmet.2007.02.002openalex-snapshot
Glycosylphosphatidylinositol-Anchored High-Density Lipoprotein-Binding Protein 1 Plays a Critical Role in the Lipolytic Processing of Chylomicrons
inferredcites →https://doi.org/10.1016/j.cmet.2010.04.016openalex-snapshot
GPIHBP1 Is Responsible for the Entry of Lipoprotein Lipase into Capillaries
inferredcites →https://doi.org/10.1016/j.cmet.2010.11.002openalex-snapshot
Angptl4 Protects against Severe Proinflammatory Effects of Saturated Fat by Inhibiting Fatty Acid Uptake into Mesenteric Lymph Node Macrophages
inferredcites →https://doi.org/10.1016/j.cmet.2019.05.023openalex-snapshot
GPIHBP1 and Lipoprotein Lipase, Partners in Plasma Triglyceride Metabolism
inferredcites →https://doi.org/10.1016/j.heliyon.2021.e07898openalex-snapshot
Angiopoietin-like protein 4 (ANGPTL4) is an inhibitor of endothelial lipase (EL) while the ANGPTL4/8 complex has reduced EL-inhibitory activity
inferredcites →https://doi.org/10.1016/j.jacl.2018.02.006openalex-snapshot
Regulation of angiopoietin-like 4 and lipoprotein lipase in human adipose tissue
inferredcites →https://doi.org/10.1016/j.jlr.2021.100071openalex-snapshot
ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding
inferredcites →https://doi.org/10.1016/j.molmet.2014.11.003openalex-snapshot
Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity
inferredcites →https://doi.org/10.1016/j.molmet.2017.06.007openalex-snapshot
Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting
inferredcites →https://doi.org/10.1016/j.molmet.2017.06.014openalex-snapshot
ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase
inferredcites →https://doi.org/10.1016/j.molmet.2020.101033openalex-snapshot
Fasting induces ANGPTL4 and reduces LPL activity in human adipose tissue
inferredcites →https://doi.org/10.1016/s0021-9258(19)39601-2openalex-snapshot
The response of lipoprotein lipase to feeding and fasting. Evidence for posttranslational regulation.
inferredcites →https://doi.org/10.1016/s0021-9258(19)68930-1openalex-snapshot
Secretion of lipoprotein lipase by macrophages in culture.
inferredcites →https://doi.org/10.1038/ncomms12313openalex-snapshot
ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression
inferredcites →https://doi.org/10.1038/ng.3561openalex-snapshot
Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease
inferredcites →https://doi.org/10.1038/ng1984openalex-snapshot
Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL
inferredcites →https://doi.org/10.1038/nm.2297openalex-snapshot
Brown adipose tissue activity controls triglyceride clearance
inferredcites →https://doi.org/10.1038/s41588-018-0222-9openalex-snapshot
Genetics of blood lipids among ~300,000 multi-ethnic participants of the Million Veteran Program
inferredcites →https://doi.org/10.1038/s41598-021-87020-5openalex-snapshot
Regulation of plasma triglyceride partitioning by adipose-derived ANGPTL4 in mice
inferredcites →https://doi.org/10.1042/0264-6021:3460603openalex-snapshot
Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis
inferredcites →https://doi.org/10.1042/bj3130893openalex-snapshot
Forms of lipoprotein lipase in rat tissues: in adipose tissue the proportion of inactive lipase increases on fasting
inferredcites →https://doi.org/10.1055/s-0032-1321864openalex-snapshot
Angiopoietin-Like Protein 4 is Differentially Regulated by Glucocorticoids and Insulin in vitro and in vivo in Healthy Humans
inferredcites →https://doi.org/10.1056/nejmoa1507652openalex-snapshot
Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease
inferredcites →https://doi.org/10.1056/nejmoa1510926openalex-snapshot
Inactivating Variants in ANGPTL4 and Risk of Coronary Artery Disease
inferredcites →https://doi.org/10.1056/nejmoa1612790openalex-snapshot
Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease
inferredcites →https://doi.org/10.1073/pnas.0604026103openalex-snapshot
Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue
inferredcites →https://doi.org/10.1073/pnas.0705041104openalex-snapshot
Lipid-lowering effects of anti-angiopoietin-like 4 antibody recapitulate the lipid phenotype found in angiopoietin-like 4 knockout mice
inferredcites →https://doi.org/10.1073/pnas.1217552109openalex-snapshot
Atypical angiopoietin-like protein that regulates ANGPTL3
inferredcites →https://doi.org/10.1073/pnas.1400889111openalex-snapshot
Fatty acid-inducible ANGPTL4 governs lipid metabolic response to exercise
inferredcites →https://doi.org/10.1073/pnas.1900983116openalex-snapshot
Lipoprotein lipase is active as a monomer
inferredcites →https://doi.org/10.1073/pnas.1920202117openalex-snapshot
Unfolding of monomeric lipoprotein lipase by ANGPTL4: Insight into the regulation of plasma triglyceride metabolism
inferredcites →https://doi.org/10.1073/pnas.2026650118openalex-snapshot
The intrinsic instability of the hydrolase domain of lipoprotein lipase facilitates its inactivation by ANGPTL4-catalyzed unfolding
inferredcites →https://doi.org/10.1074/jbc.m004029200openalex-snapshot
Characterization of the Fasting-induced Adipose Factor FIAF, a Novel Peroxisome Proliferator-activated Receptor Target Gene
inferredcites →https://doi.org/10.1074/jbc.m109.025452openalex-snapshot
Angiopoietin-like 4 (ANGPTL4, Fasting-induced Adipose Factor) Is a Direct Glucocorticoid Receptor Target and Participates in Glucocorticoid-regulated Triglyceride Metabolism
inferredcites →https://doi.org/10.1074/jbc.m111.294124openalex-snapshot
Angiopoietin-like 4 (Angptl4) Protein Is a Physiological Mediator of Intracellular Lipolysis in Murine Adipocytes
inferredcites →https://doi.org/10.1074/jbc.m113.497602openalex-snapshot
Angiopoietin-like Protein 4 Inhibition of Lipoprotein Lipase
inferredcites →https://doi.org/10.1074/jbc.m117.803973openalex-snapshot
The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure
inferredcites →https://doi.org/10.1074/jbc.m200325200openalex-snapshot
Down-regulation of Adipose Tissue Lipoprotein Lipase during Fasting Requires That a Gene, Separate from the Lipase Gene, Is Switched On
inferredcites →https://doi.org/10.1074/jbc.m203215200openalex-snapshot
ANGPTL3 Decreases Very Low Density Lipoprotein Triglyceride Clearance by Inhibition of Lipoprotein Lipase
inferredcites →https://doi.org/10.1074/jbc.m403058200openalex-snapshot
The Direct Peroxisome Proliferator-activated Receptor Target Fasting-induced Adipose Factor (FIAF/PGAR/ANGPTL4) Is Present in Blood Plasma as a Truncated Protein That Is Increased by Fenofibrate Treatment
inferredcites →https://doi.org/10.1074/jbc.m506519200openalex-snapshot
The Fasting-induced Adipose Factor/Angiopoietin-like Protein 4 Is Physically Associated with Lipoproteins and Governs Plasma Lipid Levels and Adiposity
inferredcites →https://doi.org/10.1074/jbc.m807899200openalex-snapshot
Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)
inferredcites →https://doi.org/10.1074/jbc.m809802200openalex-snapshot
A Highly Conserved Motif within the NH2-terminal Coiled-coil Domain of Angiopoietin-like Protein 4 Confers Its Inhibitory Effects on Lipoprotein Lipase by Disrupting the Enzyme Dimerization
inferredcites →https://doi.org/10.1074/jbc.m900553200openalex-snapshot
Genetic Variation in ANGPTL4 Provides Insights into Protein Processing and Function
inferredcites →https://doi.org/10.1074/jbc.ra118.002426openalex-snapshot
Angiopoietin-like 4 promotes the intracellular cleavage of lipoprotein lipase by PCSK3/furin in adipocytes
inferredcites →https://doi.org/10.1074/jbc.ra118.005932openalex-snapshot
Mapping the sites of the lipoprotein lipase (LPL)–angiopoietin-like protein 4 (ANGPTL4) interaction provides mechanistic insight into LPL inhibition
inferredcites →https://doi.org/10.1097/mol.0000000000000676openalex-snapshot
Regulation of lipoprotein lipase-mediated lipolysis of triglycerides
inferredcites →https://doi.org/10.1101/gad.209296.112openalex-snapshot
Biochemistry and pathophysiology of intravascular and intracellular lipolysis
inferredcites →https://doi.org/10.1111/j.1365-2362.2005.01470.xopenalex-snapshot
Tissue‐specific regulation of lipoprotein lipase in humans: effects of fasting
inferredcites →https://doi.org/10.1128/mcb.00370-09openalex-snapshot
Peroxisome Proliferator-Activated Receptor β/δ (PPARβ/δ) but Not PPARα Serves as a Plasma Free Fatty Acid Sensor in Liver
inferredcites →https://doi.org/10.1128/mcb.20.14.5343-5349.2000openalex-snapshot
Peroxisome Proliferator-Activated Receptor γ Target Gene Encoding a Novel Angiopoietin-Related Protein Associated with Adipose Differentiation
inferredcites →https://doi.org/10.1152/ajpendo.00084.2012openalex-snapshot
Identification of RIFL, a novel adipocyte-enriched insulin target gene with a role in lipid metabolism
inferredcites →https://doi.org/10.1152/ajpendo.00144.2021openalex-snapshot
Chronic high-fat feeding and prolonged fasting in liver-specific ANGPTL4 knockout mice
inferredcites →https://doi.org/10.1152/ajpendo.00299.2011openalex-snapshot
Plasma mannose-binding lectin is stimulated by PPARα in humans
inferredcites →https://doi.org/10.1152/ajplegacy.1959.197.3.667openalex-snapshot
Effect of nutrition on activity and release of lipase from rat adipose tissue
inferredcites →https://doi.org/10.1152/physiolgenomics.00117.2020openalex-snapshot
Probing metabolic memory in the hepatic response to fasting
inferredcites →https://doi.org/10.1161/atvbaha.107.151894openalex-snapshot
Angptl4 Upregulates Cholesterol Synthesis in Liver via Inhibition of LPL- and HL-Dependent Hepatic Cholesterol Uptake
inferredcites →https://doi.org/10.1161/atvbaha.108.182147openalex-snapshot
Caloric Restriction and Exercise Increase Plasma ANGPTL4 Levels in Humans via Elevated Free Fatty Acids
inferredcites →https://doi.org/10.1161/atvbaha.113.301698openalex-snapshot
Overexpression of Angiopoietin-Like Protein 4 Protects Against Atherosclerosis Development
inferredcites →https://doi.org/10.1161/circresaha.110.217380openalex-snapshot
Induction of Cardiac Angptl4 by Dietary Fatty Acids Is Mediated by Peroxisome Proliferator-Activated Receptor β/δ and Protects Against Fatty Acid–Induced Oxidative Stress
inferredcites →https://doi.org/10.1172/jci.insight.138777openalex-snapshot
ANGPTL8 has both endocrine and autocrine effects on substrate utilization
inferredcites →https://doi.org/10.1172/jci.insight.97918openalex-snapshot
Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis
inferredcites →https://doi.org/10.1172/jci140989openalex-snapshot
Hepatocyte-specific suppression of ANGPTL4 improves obesity-associated diabetes and mitigates atherosclerosis in mice
inferredcites →https://doi.org/10.1172/jci37118openalex-snapshot
Rare loss-of-function mutations in ANGPTL family members contribute to plasma triglyceride levels in humans
inferredcites →https://doi.org/10.1186/1471-2350-12-89openalex-snapshot
ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial
inferredcites →https://doi.org/10.1186/1472-6793-12-13openalex-snapshot
Linking nutritional regulation of Angptl4, Gpihbp1, and Lmf1 to lipoprotein lipase activity in rodent adipose tissue
inferredcites →https://doi.org/10.1186/s12864-018-4834-3openalex-snapshot
The whole transcriptome effects of the PPARα agonist fenofibrate on livers of hepatocyte humanized mice
inferredcites →https://doi.org/10.1186/s12944-016-0231-6openalex-snapshot
ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels and predicts cardiovascular disease risk in Type 2 diabetic Tunisian population
inferredcites →https://doi.org/10.1194/jlr.c200010-jlr200openalex-snapshot
Angiopoietin-like protein 4 is a potent hyperlipidemia-inducing factor in mice and inhibitor of lipoprotein lipase
inferredcites →https://doi.org/10.1194/jlr.ilr120000780openalex-snapshot
ANGPTL4 inactivates lipoprotein lipase by catalyzing the irreversible unfolding of LPL's hydrolase domain
inferredcites →https://doi.org/10.1194/jlr.m065011openalex-snapshot
Regulation of plasma lipid homeostasis by hepatic lipoprotein lipase in adult mice
inferredcites →https://doi.org/10.1194/jlr.m067363openalex-snapshot
Angiopoietin-like 4 promotes intracellular degradation of lipoprotein lipase in adipocytes
inferredcites →https://doi.org/10.1194/jlr.m074278openalex-snapshot
Feeding Angptl4−/− mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites
inferredcites →https://doi.org/10.1194/jlr.m075689openalex-snapshot
ANGPTL8 requires ANGPTL3 to inhibit lipoprotein lipase and plasma triglyceride clearance
inferredcites →https://doi.org/10.1194/jlr.m088807openalex-snapshot
On the mechanism of angiopoietin-like protein 8 for control of lipoprotein lipase activity
inferredcites →https://doi.org/10.1194/jlr.m094128openalex-snapshot
Characterization of ANGPTL4 function in macrophages and adipocytes using Angptl4-knockout and Angptl4-hypomorphic mice
inferredcites →https://doi.org/10.1194/jlr.m400138-jlr200openalex-snapshot
Oligomerization state-dependent hyperlipidemic effect of angiopoietin-like protein 4
inferredcites →https://doi.org/10.1194/jlr.ra120000781openalex-snapshot
Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids
inferredcites →https://doi.org/10.1210/en.2005-0476openalex-snapshot
Transgenic Angiopoietin-Like (Angptl)4 Overexpression and Targeted Disruption of Angptl4 and Angptl3: Regulation of Triglyceride Metabolism
inferredcites →https://doi.org/10.1371/journal.pgen.1009501openalex-snapshot
ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease
inferredcites →https://doi.org/10.1371/journal.pone.0046212openalex-snapshot
Angiopoietin-Like 4 Mediates PPAR Delta Effect on Lipoprotein Lipase-Dependent Fatty Acid Uptake but Not on Beta-Oxidation in Myotubes
inferredcites →https://doi.org/10.2217/17460875.1.2.227openalex-snapshot
Fasting-induced adipose factor/angiopoietin–like protein 4: a potential target for dyslipidemia?
inferredcites →https://doi.org/10.2337/db07-1438openalex-snapshot
Muscle-Derived Angiopoietin-Like Protein 4 Is Induced by Fatty Acids via Peroxisome Proliferator–Activated Receptor (PPAR)-δ and Is of Metabolic Relevance in Humans
inferredcites →https://doi.org/10.3945/ajcn.112.043687openalex-snapshot
Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes
inferredcites →https://doi.org/10.7554/elife.08428openalex-snapshot
ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure
inferredcites →https://doi.org/10.7554/elife.20958openalex-snapshot
The angiopoietin-like protein ANGPTL4 catalyzes unfolding of the hydrolase domain in lipoprotein lipase and the endothelial membrane protein GPIHBP1 counteracts this unfolding

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4604176openalex-extracted
Trophic Transfer and Subcellular Effects of Ovatoxins in the Gilthead Seabream Sparus Aurata: A Focus on Lipid Metabolism Alterations
inferred← citeshttps://doi.org/10.2139/ssrn.4606226openalex-extracted
Angptl4 May Serve as a Marker of Cognitive Impairment in Patients with Cerebral Small Vessel Disease
inferred← citeshttps://doi.org/10.2139/ssrn.4795161openalex-extracted
Adipose Angptl8 Controls Glucose and Energy Metabolism and its Suppression in Mice Improves Diet Induced Obesity and Inflammation
inferred← citeshttps://doi.org/10.1002/adbi.202200093openalex-snapshot
The Regulation of Triacylglycerol Metabolism and Lipoprotein Lipase Activity
inferred← citeshttps://doi.org/10.1002/advs.202413525openalex-snapshot
FGF19‐Activated Hepatic Stellate Cells Release ANGPTL4 that Promotes Colorectal Cancer Liver Metastasis
inferred← citeshttps://doi.org/10.1002/advs.202522295openalex-snapshot
CGRP Enhances the Regeneration of Bone Defects by Regulating Bone Marrow Mesenchymal Stem Cells Through Promoting ANGPTL4 Secretion by Bone Blood Vessels
inferred← citeshttps://doi.org/10.1002/bies.202400203openalex-snapshot
Mechanisms of Lipid‐Associated Macrophage Accrual in Metabolically Stressed Adipose Tissue
inferred← citeshttps://doi.org/10.1002/clc.24246openalex-snapshot
Correlation between the serum FABP4, ANGPTL3, and ANGPTL4 levels and coronary artery disease
inferred← citeshttps://doi.org/10.1002/cph4.70220openalex-snapshot
Microbiome‐Derived Metabolite Networks in Metabolic Dysfunction‐Associated Fatty Liver Disease: Mechanistic Integration of Gut‐Liver Axis Signaling and Therapeutic Targeting
inferred← citeshttps://doi.org/10.1002/jgm.3740openalex-snapshot
ANGPTL4—A protein involved in glucose metabolism, lipid metabolism, and tumor development
inferred← citeshttps://doi.org/10.1002/mco2.70934openalex-snapshot
Metabolic Syndrome: From Mechanisms to Therapeutic Interventions
inferred← citeshttps://doi.org/10.1007/978-981-95-7000-3_17openalex-snapshot
The Role of Exercise in Fat Oxidation and Its Impact on Adolescent Metabolism
inferred← citeshttps://doi.org/10.1007/s10555-022-10058-yopenalex-snapshot
Obesity and cancer—extracellular matrix, angiogenesis, and adrenergic signaling as unusual suspects linking the two diseases
inferred← citeshttps://doi.org/10.1007/s10792-024-03348-7openalex-snapshot
ANGPTL4 promotes choroidal neovascularization and subretinal fibrosis through the endothelial‒mesenchymal transition
inferred← citeshttps://doi.org/10.1007/s11626-024-00861-yopenalex-snapshot
Knockdown of ANGPTL4 inhibits adipogenesis of preadipocyte via autophagy
inferred← citeshttps://doi.org/10.1007/s11626-025-01092-5openalex-snapshot
Co-cultured adipocytes alter the expression of genes involved in extracellular matrix remodeling and metabolic adaptation in muscle cells
inferred← citeshttps://doi.org/10.1007/s11883-024-01254-yopenalex-snapshot
Inhibition of the ANGPTL3/8 Complex for the Prevention and Treatment of Atherosclerotic Cardiovascular Disease
inferred← citeshttps://doi.org/10.1007/s11883-026-01441-zopenalex-snapshot
The Angiopoietin-like Protein (ANGPTL) Axis in Dyslipidemia: Mechanisms, Cardiovascular Risk, and Emerging Therapies
inferred← citeshttps://doi.org/10.1007/s12013-023-01185-6openalex-snapshot
Fatty Acids and their Proteins in Adipose Tissue Inflammation
inferred← citeshttps://doi.org/10.1007/s43440-026-00874-2openalex-snapshot
Hypocholesterolemic agents and the gut microbiota: a review of interactions and modulatory activity
inferred← citeshttps://doi.org/10.1016/j.ajpath.2025.11.003openalex-snapshot
Loss of Angptl4 Protects Mice from Intestinal Colitis and Tumorigenesis with Alternative Activation of Macrophages
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2024.117558openalex-snapshot
Impact of loss-of-function in angiopoietin-like 4 on the human phenome
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2025.120414openalex-snapshot
Multiomics in atherosclerotic cardiovascular disease
inferred← citeshttps://doi.org/10.1016/j.atherosclerosis.2025.120485openalex-snapshot
Associations of ANGPTL proteins and complexes with progression of coronary artery calcification and coronary events
inferred← citeshttps://doi.org/10.1016/j.bbalip.2022.159154openalex-snapshot
Postprandial consequences of lipid absorption in the onset of obesity: Role of intestinal CD36
inferred← citeshttps://doi.org/10.1016/j.bbalip.2024.159461openalex-snapshot
Silencing ANGPTL8 reduces mouse preadipocyte differentiation and insulin signaling
inferred← citeshttps://doi.org/10.1016/j.biopha.2023.114509openalex-snapshot
The effects of GPR40 agonists on hair growth are mediated by ANGPTL4
inferred← citeshttps://doi.org/10.1016/j.cbpc.2025.110336openalex-snapshot
Transcriptomic profiling reveals tetrabromobisphenol A-induced dysregulation of hepatic lipid homeostasis in common carp (Cyprinus carpio)
inferred← citeshttps://doi.org/10.1016/j.cca.2024.117775openalex-snapshot
The association between plasma angiopoietin-like protein 4, glucose and lipid metabolism during pregnancy, placental function, and risk of delivering large-for-gestational-age neonates
inferred← citeshttps://doi.org/10.1016/j.cellsig.2023.110697openalex-snapshot
Angiopoietin-like 4 induces head and neck squamous cell carcinoma cell migration through the NRP1/ABL1/PXN pathway
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.141413openalex-snapshot
Subcellular effects and lipid metabolism alterations in the gilthead seabream Sparus aurata fed on ovatoxins-contaminated mussels.
inferred← citeshttps://doi.org/10.1016/j.chemphyslip.2023.105325openalex-snapshot
Recent advances in regulating lipid metabolism to prevent coronary heart disease
inferred← citeshttps://doi.org/10.1016/j.cmet.2025.03.001openalex-snapshot
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin
inferred← citeshttps://doi.org/10.1016/j.ebiom.2025.105748openalex-snapshot
An ANGPTL4 inhibitory antibody safely improves lipid profiles in non-human primates
inferred← citeshttps://doi.org/10.1016/j.ejim.2022.06.016openalex-snapshot
Serum and urine angiopoietin-like protein 4 levels correlate with different degrees of dislipidemea and proteinuria in patients with primary nephrotic syndrome
inferred← citeshttps://doi.org/10.1016/j.envint.2025.109763openalex-snapshot
Assessing the impact of perfluoroalkyl substances on liver health: a comprehensive study using multi-donor human liver spheroids
inferred← citeshttps://doi.org/10.1016/j.foodres.2025.118175openalex-snapshot
Pine nut oil as a functional alternative to corn oil: Process selection, provenance profiling, and multi-omics evidence of lipid-lowering efficacy in Western-diet mice
inferred← citeshttps://doi.org/10.1016/j.ijcard.2023.131164openalex-snapshot
Culprit lesion plaque characteristics and angiopoietin like 4 in acute coronary syndrome: A virtual histology-intravascular ultrasound analysis
inferred← citeshttps://doi.org/10.1016/j.isci.2024.111292openalex-snapshot
Adipocyte Angptl8 deletion improves glucose and energy metabolism and obesity associated inflammation in mice
inferred← citeshttps://doi.org/10.1016/j.isci.2026.115844openalex-snapshot
Cholesterol metabolism dysregulated by key HBV mutations revealed through multi-omics profiling
inferred← citeshttps://doi.org/10.1016/j.jcmgh.2024.101409openalex-snapshot
Molecular Regulation and Therapeutic Targeting of VLDL Production in Cardiometabolic Disease
inferred← citeshttps://doi.org/10.1016/j.jlr.2023.100438openalex-snapshot
ANGPTL4/8 promotes plasmin-mediated cleavage of LPL inhibitors
inferred← citeshttps://doi.org/10.1016/j.jlr.2023.100441openalex-snapshot
Decoding the role of angiopoietin-like protein 4/8 complex–mediated plasmin generation in the regulation of LPL activity
inferred← citeshttps://doi.org/10.1016/j.jlr.2023.100481openalex-snapshot
Human HDL subclasses modulate energy metabolism in skeletal muscle cells
inferred← citeshttps://doi.org/10.1016/j.jlr.2024.100526openalex-snapshot
Characterization of sexual dimorphism in ANGPTL4 levels and function
inferred← citeshttps://doi.org/10.1016/j.jlr.2024.100577openalex-snapshot
Triglyceride-rich lipoprotein, remnant cholesterol, and apolipoproteins CII, CIII, and E in patients with schizophrenia
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2023.109324openalex-snapshot
Linoleic acid-induced ANGPTL4 inhibits C2C12 skeletal muscle differentiation by suppressing Wnt/β-catenin
inferred← citeshttps://doi.org/10.1016/j.jpba.2024.116652openalex-snapshot
An exploratory multi-omics study reveals distinct molecular signatures of ulcerative colitis and Crohn's disease and their correlation with disease activity
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2023.108544openalex-snapshot
Severe hypertriglyceridemia: Existing and emerging therapies
inferred← citeshttps://doi.org/10.1016/j.phymed.2022.154276openalex-snapshot
Diosgenin protects against podocyte injury in early phase of diabetic nephropathy through regulating SIRT6
inferred← citeshttps://doi.org/10.1016/j.phymed.2025.156920openalex-snapshot
Mult-omics analysis reveals the lipid-lowering effects of sea buckthorn and milk thistle solid beverage in hyperlipidemic rats
inferred← citeshttps://doi.org/10.1016/j.plipres.2024.101303openalex-snapshot
Lipid sensing by PPARα: Role in controlling hepatocyte gene regulatory networks and the metabolic response to fasting
inferred← citeshttps://doi.org/10.1016/j.psj.2025.105003openalex-snapshot
LncRNA A2ml2 inhibits fatty liver hemorrhage syndrome progression and function as ceRNA to target LPL by sponging miR-143-5p
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.168949openalex-snapshot
PPARβ/δ-ANGPTL4 axis mediates the promotion of mono-2-ethylhexyl phthalic acid on MYCN-amplified neuroblastoma development
inferred← citeshttps://doi.org/10.1016/j.tem.2024.02.016openalex-snapshot
A unified model for regulating lipoprotein lipase activity
inferred← citeshttps://doi.org/10.1016/j.tem.2024.11.004openalex-snapshot
Intracellular endothelial cell metabolism in vascular function and dysfunction
inferred← citeshttps://doi.org/10.1038/s41366-023-01271-yopenalex-snapshot
Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention
inferred← citeshttps://doi.org/10.1038/s41467-023-43900-0openalex-snapshot
Suppression of angiopoietin-like 4 reprograms endothelial cell metabolism and inhibits angiogenesis
inferred← citeshttps://doi.org/10.1038/s41598-026-46925-9openalex-snapshot
Liver transcriptome dynamics in Holstein cows during the periparturient transition
inferred← citeshttps://doi.org/10.1039/d3fo01257copenalex-snapshot
Microbiota dysbiosis caused by dietetic patterns as a promoter of Alzheimer's disease through metabolic syndrome mechanisms
inferred← citeshttps://doi.org/10.1039/d4fo00502copenalex-snapshot
Punicic acid ameliorates obesity-related hyperlipidemia and fatty liver in mice via regulation of intestinal flora and lipopolysaccharide-related signaling pathways
inferred← citeshttps://doi.org/10.1063/5.0291646openalex-snapshot
Fat promotes growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer
inferred← citeshttps://doi.org/10.1073/pnas.2214081120openalex-snapshot
Angiopoietin-like protein 4/8 complex-mediated plasmin generation leads to cleavage of the complex and restoration of LPL activity
inferred← citeshttps://doi.org/10.1073/pnas.2322332121openalex-snapshot
Carboxyl-terminal sequences in APOA5 are important for suppressing ANGPTL3/8 activity
inferred← citeshttps://doi.org/10.1073/pnas.2510265123openalex-snapshot
Targeting the ANGPTL4/NRP1/ABL1/RAD51 axis reverses cisplatin resistance by impairing DNA damage repair in head and neck cancer
inferred← citeshttps://doi.org/10.1093/jnci/djaf137openalex-snapshot
Proteogenomic and observational evidence implicate ANGPTL4 as a potential therapeutic target for colorectal cancer prevention
inferred← citeshttps://doi.org/10.1097/mca.0000000000001239openalex-snapshot
Application of systemic inflammation indices and lipid metabolism-related factors in coronary artery disease
inferred← citeshttps://doi.org/10.1097/mol.0000000000000910openalex-snapshot
Angiopoietin-like protein 8: a multifaceted protein instrumental in regulating triglyceride metabolism
inferred← citeshttps://doi.org/10.1097/mol.0000000000000917openalex-snapshot
Novel functions of Tribbles-homolog 1 in liver, adipocytes and atherosclerosis
inferred← citeshttps://doi.org/10.1101/2022.06.12.22276286openalex-snapshot
Lipoprotein profile and metabolic fine-mapping of genetic lipid risk loci
inferred← citeshttps://doi.org/10.1101/2025.05.08.652142openalex-snapshot
Metabolic reprogramming by endothelial ANGPTL4 depletion protects against diabetic kidney disease
inferred← citeshttps://doi.org/10.1101/2025.07.10.664224openalex-snapshot
High-fat circulating nutrients promote growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer
inferred← citeshttps://doi.org/10.1101/2025.07.31.665751openalex-snapshot
Secretion and Transfer of Adipose Lipoprotein Lipase Utilizes Neutral Sphingomyelinase 2 Generated Exosomes
inferred← citeshttps://doi.org/10.1101/2025.09.16.25335948openalex-snapshot
Exploring sex-specific causal links between thousands of proteins and lipid metabolism using the UK Biobank Pharma proteomics data
inferred← citeshttps://doi.org/10.1111/jdi.14304openalex-snapshot
Angiopoietin‐like 4 is a potential biomarker for diabetic kidney disease in type 2 diabetes patients
inferred← citeshttps://doi.org/10.1126/sciadv.adn6068openalex-snapshot
Renal Angptl4 is a key fibrogenic molecule in progressive diabetic kidney disease
inferred← citeshttps://doi.org/10.1128/msystems.01424-25openalex-snapshot
Early-life proteomic and microbiome features signal obesity risk across 26 years of follow-up
inferred← citeshttps://doi.org/10.1146/annurev-nutr-120524-013857openalex-snapshot
Regulation of Adipose Tissue Metabolism During Fasting
inferred← citeshttps://doi.org/10.1152/ajpendo.00162.2025openalex-snapshot
Obesity versus endurance exercise training: plasma triacylglycerol and muscle lipoprotein lipase activity at the crossroads of lipid accumulation in muscle
inferred← citeshttps://doi.org/10.1155/jdr/6683126openalex-snapshot
Umbilical Cord Mesenchymal Stem Cells Attenuate Podocyte Injury in Diabetic Nephropathy Rats by Inhibiting Angpltl4/Integrin β 3 in the Glomerulus
inferred← citeshttps://doi.org/10.1158/2767-9764.crc-24-0016openalex-snapshot
ANGPTL4 Suppresses Clear Cell Renal Cell Carcinoma via Inhibition of Lysosomal Acid Lipase
inferred← citeshttps://doi.org/10.1161/atvbaha.122.317840openalex-snapshot
Epicardial Adipose Tissue Ceramides Are Related to Lipoprotein Lipase Activity in Coronary Artery Disease: Unfolding a Missing Link
inferred← citeshttps://doi.org/10.1161/atvbaha.125.323273openalex-snapshot
Cytosolic Versus Lysosomal Lipolysis in Adipose Tissue: Opposing Roles in Cardiometabolic Disease
inferred← citeshttps://doi.org/10.1161/circgen.124.004933openalex-snapshot
Evaluating the Cardiometabolic Efficacy and Safety of Lipoprotein Lipase Pathway Targets in Combination With Approved Lipid-Lowering Targets: A Drug Target Mendelian Randomization Study
inferred← citeshttps://doi.org/10.1161/circresaha.123.323284openalex-snapshot
VLDL Biogenesis and Secretion: It Takes a Village
inferred← citeshttps://doi.org/10.1161/circresaha.126.327471openalex-snapshot
Cardiac Lipid Metabolism: Cells, Metabolites, and Rhythms
inferred← citeshttps://doi.org/10.1161/circulationaha.124.069272openalex-snapshot
Associations of Circulating ANGPTL3, C-Terminal Domain–Containing ANGPTL4, and ANGPTL3/8 and ANGPTL4/8 Complexes with LPL Activity, Diabetes, Inflammation, and Cardiovascular Mortality
inferred← citeshttps://doi.org/10.1172/jci.insight.157896openalex-snapshot
ANGPTL4 influences the therapeutic response of patients with neovascular age-related macular degeneration by promoting choroidal neovascularization
inferred← citeshttps://doi.org/10.1172/jci181754openalex-snapshot
Absence of the intracellular lipolytic inhibitor G0S2 enhances intravascular triglyceride clearance and abolishes diet-induced hypertriglyceridemia
inferred← citeshttps://doi.org/10.1177/14791641231205428openalex-snapshot
Molecular mechanisms of diabetic heart disease: Insights from transcriptomic technologies
inferred← citeshttps://doi.org/10.1186/s12891-024-08015-7openalex-snapshot
Screening and validation of key genes associated with osteoarthritis
inferred← citeshttps://doi.org/10.1186/s12916-024-03700-9openalex-snapshot
Common pitfalls in drug target Mendelian randomization and how to avoid them
inferred← citeshttps://doi.org/10.1186/s12929-025-01163-5openalex-snapshot
Obesity induces phenotypic switching of gastric smooth muscle cells through the activation of the PPARD/PDK4/ANGPTL4 pathway
inferred← citeshttps://doi.org/10.1186/s12933-026-03209-wopenalex-snapshot
Drug targets for lipid modification and risk of type 2 diabetes: a cis-Mendelian randomization study
inferred← citeshttps://doi.org/10.1186/s12944-026-02973-8openalex-snapshot
Associations of ANGPTL3/4/8 proteins and complexes with heart failure and heart failure mortality
inferred← citeshttps://doi.org/10.1186/s12967-023-04819-8openalex-snapshot
ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1
inferred← citeshttps://doi.org/10.1186/s13020-026-01441-wopenalex-snapshot
Calculus Bovis ameliorates primary sclerosing cholangitis via a dual-pronged mechanism restoring bile acid and lipid homeostasis in the gut-liver axis
inferred← citeshttps://doi.org/10.1186/s13024-024-00772-2openalex-snapshot
Proteomic analysis of APOEε4 carriers implicates lipid metabolism, complement and lymphocyte signaling in cognitive resilience
inferred← citeshttps://doi.org/10.1186/s13073-025-01492-yopenalex-snapshot
Longitudinal analysis of genetic and environmental interplay in human metabolic profiles and the implication for metabolic health
inferred← citeshttps://doi.org/10.1186/s13098-025-01837-yopenalex-snapshot
Unraveling the complexities of diet induced obesity and glucolipid dysfunction in metabolic syndrome
inferred← citeshttps://doi.org/10.1186/s13293-026-00934-5openalex-snapshot
Exploring sex-specific causal links between thousands of proteins and lipid metabolism using the UK Biobank Pharma Proteomics Project data
inferred← citeshttps://doi.org/10.1186/s13578-022-00898-0openalex-snapshot
The lymphatic vascular system: much more than just a sewer
inferred← citeshttps://doi.org/10.1289/ehp12785openalex-snapshot
Molecular and Metabolic Analysis of Arsenic-Exposed Humanized AS3MT Mice
inferred← citeshttps://doi.org/10.1371/journal.pone.0328551openalex-snapshot
Transcriptome combined single-cell sequencing explores molecular mechanisms of ANGPTL4 in sepsis-induced acute lung injury
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2926036/v1openalex-snapshot
ANGPTL4 accelerates carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1
inferred← citeshttps://doi.org/10.2147/jir.s426439openalex-snapshot
ANGPTL4 May Regulate the Crosstalk Between Intervertebral Disc Degeneration and Type 2 Diabetes Mellitus: A Combined Analysis of Bioinformatics and Rat Models
inferred← citeshttps://doi.org/10.24976/discov.med.202436180.16openalex-snapshot
Effect of Deletion of ANGPTL4 Gene on Viability, Migration and Invasion Ability and Apoptosis of Hepatocellular Carcinoma Cells
inferred← citeshttps://doi.org/10.31435/ijitss.1(49).2026.4754openalex-snapshot
ALTERNATIVES TO STATINS IN THE TREATMENT OF HYPERCHOLESTEROLEMIA
inferred← citeshttps://doi.org/10.31435/rsglobal_ws/30092022/7872openalex-snapshot
MECHANISMS OF THE INFLUENCE OF SODIUM-GLUCOSE COTRANSPORTER-2 INHIBITORS ON LDL RECEPTOR FUNCTION AND CARDIOVASCULAR RISK IN TYPE 2 DM (literature review)
inferred← citeshttps://doi.org/10.32708/uutfd.1666630openalex-snapshot
Increase in ANGPTL4 Levels and Its Relationship with Metabolic Parameters in Prediabetes Model
inferred← citeshttps://doi.org/10.3389/fendo.2023.1322869openalex-snapshot
The chylomicron saga: time to focus on postprandial metabolism
inferred← citeshttps://doi.org/10.3389/fgene.2022.983283openalex-snapshot
A homozygous variant in the GPIHBP1 gene in a child with severe hypertriglyceridemia and a systematic literature review
inferred← citeshttps://doi.org/10.3389/fmolb.2022.909151openalex-snapshot
Triglyceride and Triglyceride-Rich Lipoproteins in Atherosclerosis
inferred← citeshttps://doi.org/10.3389/fphar.2024.1475198openalex-snapshot
Angiopoietin-like protein 4 dysregulation in kidney diseases: a promising biomarker and therapeutic target
inferred← citeshttps://doi.org/10.3389/fphar.2026.1803412openalex-snapshot
Kidney angiopoietin-like protein 4 regulates fibrotic responses in diabetic kidney disease
inferred← citeshttps://doi.org/10.3389/fphys.2022.1057721openalex-snapshot
Comprehensive molecular and morphological resolution of blubber stratification in a deep-diving, fasting-adapted seal
inferred← citeshttps://doi.org/10.3390/antiox12020449openalex-snapshot
Effects of Microalgae on Metabolic Syndrome
inferred← citeshttps://doi.org/10.3390/biom13071091openalex-snapshot
Pro-Calcifying Role of Enzymatically Modified LDL (eLDL) in Aortic Valve Sclerosis via Induction of IL-6 and IL-33
inferred← citeshttps://doi.org/10.3390/biomedicines14071574openalex-snapshot
Hypertriglyceridaemia-Associated Acute Pancreatitis: Pathophysiological Insights and Advances in Clinical Management
inferred← citeshttps://doi.org/10.3390/cancers17142364openalex-snapshot
ANGPTL4: A Comprehensive Review of 25 Years of Research
inferred← citeshttps://doi.org/10.3390/cancers18071176openalex-snapshot
ANGPTL3, Apo CIII, Leptin and Triglycerides Are Elevated in Metastatic Prostate Cancer
inferred← citeshttps://doi.org/10.3390/cells14241954openalex-snapshot
The Molecular Mechanisms of Muscle–Adipose Crosstalk: Myokines, Adipokines, Lipokines and the Mediating Role of Exosomes
inferred← citeshttps://doi.org/10.3390/genes13050746openalex-snapshot
Spatiotemporal Regulation of Circular RNA Expression during Liver Development of Chinese Indigenous Ningxiang Pigs
inferred← citeshttps://doi.org/10.3390/genes13122215openalex-snapshot
Comprehensive Analysis of Potential Prognostic Values of ANGPTLs in Colorectal Cancer
inferred← citeshttps://doi.org/10.3390/ijms241713288openalex-snapshot
Advances in Treatment of Dyslipidemia
inferred← citeshttps://doi.org/10.3390/ijms242015422openalex-snapshot
Endothelial Cell Dysfunction and Hypoxia as Potential Mediators of Pain in Fabry Disease: A Human-Murine Translational Approach
inferred← citeshttps://doi.org/10.3390/ijms27041952openalex-snapshot
Lavender Essential Oil-Induced Enhancement of Exercise-Responsive Myokine Expression and Alteration of Muscle-Related Gene Networks in an in Vitro Muscle Contraction Model
inferred← citeshttps://doi.org/10.3390/ijms27177917openalex-snapshot
Key Hepatokines Linking MASLD and Type 2 Diabetes: From Pathophysiological Mechanisms to Therapeutic Modulation
inferred← citeshttps://doi.org/10.3390/jcm12134399openalex-snapshot
Triglyceride-Rich Lipoprotein Metabolism: Key Regulators of Their Flux
inferred← citeshttps://doi.org/10.3390/jcm14197026openalex-snapshot
Time-Restricted Eating, ANGPTL4, and Reduction in Residual Cardiovascular Risk
inferred← citeshttps://doi.org/10.3390/jcm14217599openalex-snapshot
Increased Serum Angiopoietin-like Peptide 4 in Impaired Glucose Tolerance and Diabetes Subjects with or Without Hepatic Steatosis
inferred← citeshttps://doi.org/10.3390/jcm15103631openalex-snapshot
Angiopoietin-like Proteins 4 and 8 in Diabetic Complications: Associations with Neuropathy and Metabolic Parameters in Type 2 Diabetes
inferred← citeshttps://doi.org/10.3390/livers5040065openalex-snapshot
Implication of the Androgen Receptor in Muscle–Liver Crosstalk: An Overlooked Mechanistic Link in Lean-MASLD
inferred← citeshttps://doi.org/10.3390/md21090462openalex-snapshot
Therapeutic Potentials of Microalgae and Their Bioactive Compounds on Diabetes Mellitus
inferred← citeshttps://doi.org/10.3390/medicina61010083openalex-snapshot
Identification of Interactive Genetic Loci Linked to Insulin Resistance in Metabolic Syndrome—An Update
inferred← citeshttps://doi.org/10.3390/metabo13020149openalex-snapshot
Pregnancy Toxemia in Ewes: A Review of Molecular Metabolic Mechanisms and Management Strategies
inferred← citeshttps://doi.org/10.3724/abbs.2023055openalex-snapshot
Angiopoietin-like 4 promotes epidermal stem cell proliferation and migration and contributes to cutaneous wound re-epithelialization
inferred← citeshttps://doi.org/10.3724/abbs.2025145openalex-snapshot
Angptl4 is upregulated by microenvironmental factors during the wound healing process and promotes epidermal stem cell proliferation via PRL8a6
inferred← citeshttps://doi.org/10.3892/ijo.2024.5715openalex-snapshot
Emerging roles of angiopoietin‑like 4 in human tumors (Review)
inferred← citeshttps://doi.org/10.5114/aoms/189504openalex-snapshot
Plasma Angiopoietin-like Protein 4 as a Novel Biomarker Predicting 10-year Mortality in a Community-based Population: A Longitudinal Cohort Study
inferred← citeshttps://doi.org/10.54393/pbmj.v8i2.1207openalex-snapshot
Analysis of Genetic Variants of ANGPTL4 Gene Responsible for Atherosclerosis Severity in Cardiac Patients
inferred← citeshttps://doi.org/10.6002/ect.mesot2025.p191openalex-snapshot
Angiopoietins and Angiopoietin-Like Proteins as New Biomarkers in Posttransplant Diabetes Mellitus: A Single-Center Study From Kuwait.
inferred← citeshttps://doi.org/10.6084/m9.figshare.24987722openalex-snapshot
Additional file 1 of ANGPTL4 accelerates ovarian serous cystadenocarcinoma carcinogenesis and angiogenesis in the tumor microenvironment by activating the JAK2/STAT3 pathway and interacting with ESM1
inferred← citeshttps://doi.org/10.64898/2025.12.03.692043openalex-snapshot
Mitophagy promotes metabolic reprogramming to enhance keratinocyte migration via ANGPTL4 during wound healing
inferred← citeshttps://doi.org/10.64898/2026.01.28.702158openalex-snapshot
Synergistic interactions between Bacteroides intestinalis and Arabinoxylan Mitigates Inflammatory and Metabolic Dysfunction
inferred← citeshttps://doi.org/10.70675/3043b5b4z2339z4ad9z8616zd229a6ccbb8fopenalex-snapshot
Étude du rôle de l'Amphiréguline et de l'Angiopoïetine-like 4 sur la fuite vasculaire en post arrêt cardiaque
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