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TLR4 inhibitor resatorvid provides neuroprotection in experimental traumatic brain injury: Implication in the treatment of human brain injury

https://doi.org/10.1016/j.neuint.2014.05.003

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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High mobility group box protein‐1 promotes cerebral edema after traumatic brain injury via activation of toll‐like receptor 4

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Clinical trials in traumatic brain injury: current problems and future solutions

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Elevated Cerebral Cortical CD24 Levels in Patients and Mice with Traumatic Brain Injury: A Potential Negative Role in Nuclear Factor Kappa B/Inflammatory Factor Pathway

inferredcites →https://doi.org/10.1007/s13311-011-0095-4openalex-snapshot

CR8, a Selective and Potent CDK Inhibitor, Provides Neuroprotection in Experimental Traumatic Brain Injury

inferredcites →https://doi.org/10.1016/j.biopha.2005.08.007openalex-snapshot

TAK1 downregulation reduces IL-1β induced expression of MMP13, MMP1 and TNF-alpha

inferredcites →https://doi.org/10.1016/j.ejphar.2007.06.027openalex-snapshot

Therapeutic effects of TAK-242, a novel selective Toll-like receptor 4 signal transduction inhibitor, in mouse endotoxin shock model

inferredcites →https://doi.org/10.1016/j.ejphar.2008.01.026openalex-snapshot

TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain

inferredcites →https://doi.org/10.1016/j.ejphar.2009.11.066openalex-snapshot

d-Cycloserine improves functional outcome after traumatic brain injury with wide therapeutic window

inferredcites →https://doi.org/10.1016/j.expneurol.2008.12.019openalex-snapshot

Simvastatin reduces secondary brain injury caused by cortical contusion in rats: Possible involvement of TLR4/NF-κB pathway

inferredcites →https://doi.org/10.1016/j.neuroscience.2013.02.022openalex-snapshot

Inhibition of transforming growth factor beta-activated kinase 1 confers neuroprotection after traumatic brain injury in rats

inferredcites →https://doi.org/10.1016/j.tips.2012.06.007openalex-snapshot

Targeting of TAK1 in inflammatory disorders and cancer

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A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

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Ubiquitin-mediated activation of TAK1 and IKK

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Pharmacological inhibition of TLR4-NOX4 signal protects against neuronal death in transient focal ischemia

inferredcites →https://doi.org/10.1046/j.1471-4159.2000.740740.xopenalex-snapshot

Caspase‐3 Mediated Neuronal Death After Traumatic Brain Injury in Rats

inferredcites →https://doi.org/10.1073/pnas.0305741101openalex-snapshot

Dynamic changes in N -methyl- d -aspartate receptors after closed head injury in mice: Implications for treatment of neurological and cognitive deficits

inferredcites →https://doi.org/10.1089/neu.2011.2244openalex-snapshot

Exogenous Administration of PACAP Alleviates Traumatic Brain Injury in Rats through a Mechanism Involving the TLR4/MyD88/NF-κB Pathway

inferredcites →https://doi.org/10.1089/neu.2012.2511openalex-snapshot

Comparing the Predictive Value of Multiple Cognitive, Affective, and Motor Tasks after Rodent Traumatic Brain Injury

inferredcites →https://doi.org/10.1089/neu.2013.3019openalex-snapshot

Pharmacotherapy of Traumatic Brain Injury: State of the Science and the Road Forward: Report of the Department of Defense Neurotrauma Pharmacology Workgroup

inferredcites →https://doi.org/10.1097/ccm.0b013e3181e7c5c9openalex-snapshot

A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*

inferredcites →https://doi.org/10.1101/gad.1360605openalex-snapshot

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

inferredcites →https://doi.org/10.1111/j.1476-5381.2010.01163.xopenalex-snapshot

Animal modelling of traumatic brain injury in preclinical drug development: where do we go from here?

inferredcites →https://doi.org/10.1124/mol.105.019695openalex-snapshot

A Novel Cyclohexene Derivative, Ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), Selectively Inhibits Toll-Like Receptor 4-Mediated Cytokine Production through Suppression of Intracellular Signaling

inferredcites →https://doi.org/10.1124/mol.110.068064openalex-snapshot

TAK-242 (Resatorvid), a Small-Molecule Inhibitor of Toll-Like Receptor (TLR) 4 Signaling, Binds Selectively to TLR4 and Interferes with Interactions between TLR4 and Its Adaptor Molecules

inferredcites →https://doi.org/10.1161/strokeaha.113.001038openalex-snapshot

Toll-Like Receptor 4 Antagonist Attenuates Intracerebral Hemorrhage–Induced Brain Injury

inferredcites →https://doi.org/10.1371/journal.pone.0030294openalex-snapshot

Wogonin Improves Histological and Functional Outcomes, and Reduces Activation of TLR4/NF-κB Signaling after Experimental Traumatic Brain Injury

inferredcites →https://doi.org/10.1371/journal.pone.0057208openalex-snapshot

Absence of TLR4 Reduces Neurovascular Unit and Secondary Inflammatory Process after Traumatic Brain Injury in Mice

inferredcites →https://doi.org/10.1517/14728210902769601openalex-snapshot

Emerging treatments for traumatic brain injury

inferredcites →https://doi.org/10.1602/neurorx.1.1.71openalex-snapshot

Critical appraisal of neuroprotection trials in head injury: What have we learned?

inferredcites →https://doi.org/10.2165/11634020-000000000-00000openalex-snapshot

A Review of Neuroprotection Pharmacology and Therapies in Patients with Acute Traumatic Brain Injury

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4603789openalex-extracted

inferred← citeshttps://doi.org/10.1002/jnr.24132openalex-snapshot

Non‐invasive diagnosis and treatment strategies for traumatic brain injury: an update

inferred← citeshttps://doi.org/10.1007/s10571-016-0356-1openalex-snapshot

Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway

inferred← citeshttps://doi.org/10.1007/s10571-016-0397-5openalex-snapshot

Up-Regulation of TAB3 Is Involved in Neuronal Apoptosis After Intracerebral Hemorrhage

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Adenosine kinase facilitated astrogliosis-induced cortical neuronal death in traumatic brain injury

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Neuropathic pain in traumatic brain injury: consequences, mechanisms, and therapeutic avenues

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Traumatic Brain Injury: Mechanistic Insight on Pathophysiology and Potential Therapeutic Targets

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Inhibition of the Receptor for Advanced Glycation End-Products (RAGE) Attenuates Neuroinflammation While Sensitizing Cortical Neurons Towards Death in Experimental Subarachnoid Hemorrhage

inferred← citeshttps://doi.org/10.1016/j.bbi.2017.10.021openalex-snapshot

Selective activation of cannabinoid receptor-2 reduces neuroinflammation after traumatic brain injury via alternative macrophage polarization

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Effects of Toll-like receptor 4 inhibition on spatial memory and cell proliferation in male and female adult and aged mice

inferred← citeshttps://doi.org/10.1016/j.bbr.2026.116358openalex-snapshot

TAK-242 has sex-dependent effects on the acquisition of two-way active avoidance conditioning

inferred← citeshttps://doi.org/10.1016/j.brainres.2016.05.003openalex-snapshot

Inhibition of myeloid differentiation factor 88(MyD88) by ST2825 provides neuroprotection after experimental traumatic brain injury in mice

inferred← citeshttps://doi.org/10.1016/j.expneurol.2015.05.024openalex-snapshot

Treatment of traumatic brain injury with anti-inflammatory drugs

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Neuroimmune responses in the developing brain following traumatic brain injury

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Activating toll-like receptor 4 after traumatic brain injury inhibits neuroinflammation and the accelerated development of seizures in rats

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e29484openalex-snapshot

Neuroprotective effects of takinib on an experimental traumatic brain injury rat model via inhibition of transforming growth factor beta-activated kinase 1

inferred← citeshttps://doi.org/10.1016/j.jss.2016.07.014openalex-snapshot

Tetrahydrocurcumin provides neuroprotection in rats after traumatic brain injury: autophagy and the PI3K/AKT pathways as a potential mechanism

inferred← citeshttps://doi.org/10.1016/j.neubiorev.2016.02.013openalex-snapshot

Innate immune receptor Toll-like receptor 4 signalling in neuropsychiatric diseases

inferred← citeshttps://doi.org/10.1016/j.neuropharm.2018.07.022openalex-snapshot

Role of Toll-like receptor mediated signaling in traumatic brain injury

inferred← citeshttps://doi.org/10.1016/j.phrs.2020.105172openalex-snapshot

Role of Innate Immune Receptor TLR4 and its endogenous ligands in epileptogenesis

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Gallic Acid-Modified Polyethylenimine–Polypropylene Carbonate–Polyethylenimine Nanoparticles: Synthesis, Characterization, and Anti-Periodontitis Evaluation

inferred← citeshttps://doi.org/10.1038/s41419-023-05898-7openalex-snapshot

Neutrophil extracellular traps aggravate neuronal endoplasmic reticulum stress and apoptosis via TLR9 after traumatic brain injury

inferred← citeshttps://doi.org/10.1038/s41420-025-02350-xopenalex-snapshot

NINJ1-mediated plasma membrane rupture of pyroptotic endothelial cells exacerbates blood-brain barrier destruction caused by neutrophil extracellular traps in traumatic brain injury

inferred← citeshttps://doi.org/10.1038/s41598-024-80331-3openalex-snapshot

Administration of monophosphoryl lipid A shortly after traumatic brain injury blocks the following spatial and avoidance memory loss and neuroinflammation

inferred← citeshttps://doi.org/10.1038/srep41689openalex-snapshot

Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration

inferred← citeshttps://doi.org/10.1055/s-0035-1544237openalex-snapshot

Emerging Therapies in Traumatic Brain Injury

inferred← citeshttps://doi.org/10.1089/neu.2019.6955openalex-snapshot

Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects

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The neutrophil extracellular traps in neurological diseases: an update

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Innate immune signaling mediates differential acute and long-term outcomes of repeated vs single TBI in Drosophila

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Targeting toll-like receptor-4 (TLR4)—an emerging therapeutic target for persistent pain states

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Infiltrating anti-inflammatory monocytes modulate microglial activation through toll-like receptor 4/interferon–dependent pathways following traumatic brain injury

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Inhibition of the TLR4 signalling pathway with TAK-242 reduces RSV infection and cytokine release in primary airway epithelial cells

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Inflammation in central nervous system diseases

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Mechanisms and Potential Therapeutic Applications of Microglial Activation after Brain Injury

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Blocking receptor for advanced glycation end products (RAGE) or toll‐like receptor 4 (TLR4) prevents posttraumatic epileptogenesis in mice

inferred← citeshttps://doi.org/10.1126/sciadv.aax8847openalex-snapshot

Neutrophil extracellular traps exacerbate neurological deficits after traumatic brain injury

inferred← citeshttps://doi.org/10.1155/2016/4706915openalex-snapshot

Inhibition of TLR4 Signalling-Induced Inflammation Attenuates Secondary Injury after Diffuse Axonal Injury in Rats

inferred← citeshttps://doi.org/10.1155/2021/9931742openalex-snapshot

The Role of Neutrophil Extracellular Traps in Central Nervous System Diseases and Prospects for Clinical Application

inferred← citeshttps://doi.org/10.1159/000524536openalex-snapshot

Silencing of TRIM44 Inhibits Inflammation and Alleviates Traumatic Brain Injury in Rats by Downregulating TLR4-NF-κB Signaling

inferred← citeshttps://doi.org/10.1177/0271678x261468877openalex-snapshot

Toll like receptor 4 (TLR4) in neuroinflammation: From acute hemorrhagic stroke to chronic neurodegeneration

inferred← citeshttps://doi.org/10.1186/s12974-024-03122-7openalex-snapshot

The contribution of the meningeal immune interface to neuroinflammation in traumatic brain injury

inferred← citeshttps://doi.org/10.12659/msm.894148openalex-snapshot

Hyperbaric Oxygen Alleviates Secondary Brain Injury After Trauma Through Inhibition of TLR4/NF-κB Signaling Pathway

inferred← citeshttps://doi.org/10.1615/critrevbiomedeng.2018027166openalex-snapshot

Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes

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Inhibition of toll-like receptor 4 protects against inflammation-induced mechanobiological alterations to intervertebral disc cells

inferred← citeshttps://doi.org/10.3389/fnagi.2022.901117openalex-snapshot

Microglial polarization in TBI: Signaling pathways and influencing pharmaceuticals

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TLR4 mediates post-traumatic depression via kynurenine pathway activation in a murine traumatic brain injury model

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Serum Amyloid A1/Toll-Like Receptor-4 Axis, an Important Link between Inflammation and Outcome of TBI Patients

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Toll-like Receptors and Thrombopoiesis

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Hyperbaric Oxygen Therapy Alleviates Paclitaxel-Induced Peripheral Neuropathy Involving Suppressing TLR4-MyD88-NF-κB Signaling Pathway

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Design, Physicochemical Characterization, and In Vitro Permeation of Innovative Resatorvid Topical Formulations for Targeted Skin Drug Delivery

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