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Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration

https://doi.org/10.1038/srep41689
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Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1001/jamaneurol.2014.3558openalex-snapshot
Inflammation and Neuroprotection in Traumatic Brain Injury
inferredcites →https://doi.org/10.1002/(sici)1097-0177(199804)211:4<306::aid-aja2>3.0.co;2-lopenalex-snapshot
Embryonic implantation in galectin 1/galectin 3 double mutant mice
inferredcites →https://doi.org/10.1002/glia.22581openalex-snapshot
High mobility group box protein‐1 promotes cerebral edema after traumatic brain injury via activation of toll‐like receptor 4
inferredcites →https://doi.org/10.1002/glia.22898openalex-snapshot
Astrocyte reactivity after brain injury—: The role of galectins 1 and 3
inferredcites →https://doi.org/10.1002/jnr.23300openalex-snapshot
Blood–brain barrier and traumatic brain injury
inferredcites →https://doi.org/10.1007/s10571-015-0182-xopenalex-snapshot
Local Injection of Lenti–BDNF at the Lesion Site Promotes M2 Macrophage Polarization and Inhibits Inflammatory Response After Spinal Cord Injury in Mice
inferredcites →https://doi.org/10.1016/j.acthis.2012.11.010openalex-snapshot
The pleiotropic effects of galectin-3 in neuroinflammation: A review
inferredcites →https://doi.org/10.1016/j.bbi.2012.06.008openalex-snapshot
Neuroinflammation after traumatic brain injury: Opportunities for therapeutic intervention
inferredcites →https://doi.org/10.1016/j.bcp.2015.11.003openalex-snapshot
Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders
inferredcites →https://doi.org/10.1016/j.brainres.2012.07.058openalex-snapshot
Characterization of inflammatory gene expression and galectin-3 function after spinal cord injury in mice
inferredcites →https://doi.org/10.1016/j.brainres.2015.12.024openalex-snapshot
Therapies negating neuroinflammation after brain trauma
inferredcites →https://doi.org/10.1016/j.brainres.2016.01.051openalex-snapshot
Focal release of neurotrophic factors by biodegradable microspheres enhance motor and sensory axonal regeneration in vitro and in vivo
inferredcites →https://doi.org/10.1016/j.brainresrev.2009.11.008openalex-snapshot
Gliotransmission: Exocytotic release from astrocytes
inferredcites →https://doi.org/10.1016/j.canlet.2011.09.003openalex-snapshot
Galectin-3 – A jack-of-all-trades in cancer
inferredcites →https://doi.org/10.1016/j.cca.2016.02.029openalex-snapshot
The change of plasma galectin-3 concentrations after traumatic brain injury
inferredcites →https://doi.org/10.1016/j.celrep.2015.02.012openalex-snapshot
Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation
inferredcites →https://doi.org/10.1016/j.expneurol.2015.05.024openalex-snapshot
Treatment of traumatic brain injury with anti-inflammatory drugs
inferredcites →https://doi.org/10.1016/j.expneurol.2015.07.006openalex-snapshot
Lack of galectin-3 improves the functional outcome and tissue sparing by modulating inflammatory response after a compressive spinal cord injury
inferredcites →https://doi.org/10.1016/j.it.2012.03.001openalex-snapshot
Toll-like receptor (TLR) and inflammasome actions in the central nervous system
inferredcites →https://doi.org/10.1016/j.nbd.2009.12.024openalex-snapshot
Galectin-3 contributes to neonatal hypoxic–ischemic brain injury
inferredcites →https://doi.org/10.1016/j.neuint.2014.05.003openalex-snapshot
TLR4 inhibitor resatorvid provides neuroprotection in experimental traumatic brain injury: Implication in the treatment of human brain injury
inferredcites →https://doi.org/10.1016/j.neulet.2007.11.057openalex-snapshot
Toll-like receptor 2 contributes to glial cell activation and heme oxygenase-1 expression in traumatic brain injury
inferredcites →https://doi.org/10.1016/j.neurobiolaging.2014.12.024openalex-snapshot
Head trauma in sport and neurodegenerative disease: an issue whose time has come?
inferredcites →https://doi.org/10.1016/s0169-328x(97)00158-7openalex-snapshot
Alterations in BDNF and NT-3 mRNAs in rat hippocampus after experimental brain trauma
inferredcites →https://doi.org/10.1016/s0304-3940(00)01499-3openalex-snapshot
Nerve growth factor-mediated expression of galectin-3 in mouse dorsal root ganglion neurons
inferredcites →https://doi.org/10.1023/b:glyc.0000014072.34840.04openalex-snapshot
Introduction to galectins
inferredcites →https://doi.org/10.1038/nri2873openalex-snapshot
Sterile inflammation: sensing and reacting to damage
inferredcites →https://doi.org/10.1038/nrn3710openalex-snapshot
Microglial phagocytosis of live neurons
inferredcites →https://doi.org/10.1038/srep21607openalex-snapshot
High-throughput proteomics reveal alarmins as amplifiers of tissue pathology and inflammation after spinal cord injury
inferredcites →https://doi.org/10.1055/b-0035-108581openalex-snapshot
4 Histology and Histopathology
inferredcites →https://doi.org/10.1073/pnas.1308679110openalex-snapshot
Phagocytosis executes delayed neuronal death after focal brain ischemia
inferredcites →https://doi.org/10.1073/pnas.1525528113openalex-snapshot
New tools for studying microglia in the mouse and human CNS
inferredcites →https://doi.org/10.1089/089771503770195777openalex-snapshot
Gene Expression Profile Changes Are Commonly Modulated across Models and Species after Traumatic Brain Injury
inferredcites →https://doi.org/10.1089/neu.1999.16.501openalex-snapshot
Alterations in BDNF and trkB mRNA Levels in the Cerebral Cortex Following Experimental Brain Trauma in Rats
inferredcites →https://doi.org/10.1089/neu.2014.3811openalex-snapshot
A New Panel of Blood Biomarkers for the Diagnosis of Mild Traumatic Brain Injury/Concussion in Adults
inferredcites →https://doi.org/10.1089/neu.2015.4268openalex-snapshot
Microglial/Macrophage Polarization Dynamics following Traumatic Brain Injury
inferredcites →https://doi.org/10.1093/glycob/cwu086openalex-snapshot
Galectin-3 in angiogenesis and metastasis
inferredcites →https://doi.org/10.1097/nen.0000000000000199openalex-snapshot
The Small-Molecule TrkB Agonist 7, 8-Dihydroxyflavone Decreases Hippocampal Newborn Neuron Death After Traumatic Brain Injury
inferredcites →https://doi.org/10.1155/2013/429815openalex-snapshot
Microglia Control Neuronal Network Excitability via BDNF Signalling
inferredcites →https://doi.org/10.1172/jci41356openalex-snapshot
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
inferredcites →https://doi.org/10.1186/1742-2094-10-27openalex-snapshot
Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury
inferredcites →https://doi.org/10.1186/1742-2094-7-32openalex-snapshot
Chronic upregulation of activated microglia immunoreactive for galectin-3/Mac-2 and nerve growth factor following diffuse axonal injury
inferredcites →https://doi.org/10.1186/1742-2094-8-130openalex-snapshot
Delayed inflammatory mRNA and protein expression after spinal cord injury
inferredcites →https://doi.org/10.1186/1742-2094-9-196openalex-snapshot
Primary phagocytosis of viable neurons by microglia activated with LPS or Aβ is dependent on calreticulin/LRP phagocytic signalling
inferredcites →https://doi.org/10.1186/1742-2094-9-236openalex-snapshot
New perspectives on central and peripheral immune responses to acute traumatic brain injury
inferredcites →https://doi.org/10.1186/1742-2094-9-247openalex-snapshot
Rod microglia: elongation, alignment, and coupling to form trains across the somatosensory cortex after experimental diffuse brain injury
inferredcites →https://doi.org/10.1186/s12974-016-0581-zopenalex-snapshot
Brain trauma elicits non-canonical macrophage activation states
inferredcites →https://doi.org/10.1186/s13049-015-0133-zopenalex-snapshot
Factors that may improve outcomes of early traumatic brain injury care: prospective multicenter study in Austria
inferredcites →https://doi.org/10.1186/s13287-015-0268-xopenalex-snapshot
PSA-NCAM positive neural progenitors stably expressing BDNF promote functional recovery in a mouse model of spinal cord injury
inferredcites →https://doi.org/10.1186/s40478-014-0156-0openalex-snapshot
The role of Galectin-3 in α-synuclein-induced microglial activation
inferredcites →https://doi.org/10.1242/jeb.124.1.225openalex-snapshot
Cell Surface Glycoconjugates and Carbohydrate-Binding Proteins: Possible Recognition Signals in Sensory Neurone Development
inferredcites →https://doi.org/10.1371/journal.pone.0057208openalex-snapshot
Absence of TLR4 Reduces Neurovascular Unit and Secondary Inflammatory Process after Traumatic Brain Injury in Mice
inferredcites →https://doi.org/10.1371/journal.pone.0097096openalex-snapshot
Rod Microglia: A Morphological Definition
inferredcites →https://doi.org/10.1371/journal.pone.0113397openalex-snapshot
Post-Injury Treatment with 7,8-Dihydroxyflavone, a TrkB Receptor Agonist, Protects against Experimental Traumatic Brain Injury via PI3K/Akt Signaling
inferredcites →https://doi.org/10.1371/journal.pone.0148001openalex-snapshot
Call Off the Dog(ma): M1/M2 Polarization Is Concurrent following Traumatic Brain Injury
inferredcites →https://doi.org/10.14670/hh-26.247openalex-snapshot
Regulated expression of galectin-3, a multifunctional glycan-binding protein, in haematopoietic and non-haematopoietic tissues.
inferredcites →https://doi.org/10.1523/jneurosci.0605-15.2015openalex-snapshot
A Single Bolus of Docosahexaenoic Acid Promotes Neuroplastic Changes in the Innervation of Spinal Cord Interneurons and Motor Neurons and Improves Functional Recovery after Spinal Cord Injury
inferredcites →https://doi.org/10.4049/jimmunol.1000154openalex-snapshot
Galectin-3 Exerts Cytokine-Like Regulatory Actions through the JAK–STAT Pathway
inferredcites →https://doi.org/10.4049/jimmunol.180.4.2650openalex-snapshot
Regulation of Alternative Macrophage Activation by Galectin-3
inferredcites →https://doi.org/10.4049/jimmunol.181.4.2781openalex-snapshot
Galectin-3 Is a Negative Regulator of Lipopolysaccharide-Mediated Inflammation
inferredcites →https://doi.org/10.5607/en.2014.23.2.138openalex-snapshot
A Decade of Research on TLR2 Discovering Its Pivotal Role in Glial Activation and Neuroinflammation in Neurodegenerative Diseases

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.5144196openalex-extracted
Ai-Driven Discovery of Brain-Penetrant Galectin-3 Inhibitors for Alzheimer's Disease Therapy
inferred← citeshttps://doi.org/10.1002/adfm.202100643openalex-snapshot
Pectic Galactan Polysaccharide‐Based Gene Delivery System for Targeting Neuroinflammation
inferred← citeshttps://doi.org/10.1002/biot.202300089openalex-snapshot
A simple, flexible, and high‐efficiency western blot analysis for age‐related human induced neurons
inferred← citeshttps://doi.org/10.1002/eji.201847890openalex-snapshot
Deletion of Galectin‐3 attenuates acute pancreatitis in mice by affecting activation of innate inflammatory cells
inferred← citeshttps://doi.org/10.1002/glia.23815openalex-snapshot
Benefits of physical exercise on cognition and glial white matter pathology in a mouse model of vascular cognitive impairment and dementia
inferred← citeshttps://doi.org/10.1002/glia.23945openalex-snapshot
Sialylation acts as a checkpoint for innate immune responses in the central nervous system
inferred← citeshttps://doi.org/10.1002/glia.24217openalex-snapshot
Long‐term priming of hypothalamic microglia is associated with energy balance disturbances under diet‐induced obesity
inferred← citeshttps://doi.org/10.1007/978-3-030-04615-6_11openalex-snapshot
The Role of Galectin-3 in Subarachnoid Hemorrhage: A Preliminary Study
inferred← citeshttps://doi.org/10.1007/s00401-019-02013-zopenalex-snapshot
Galectin-3, a novel endogenous TREM2 ligand, detrimentally regulates inflammatory response in Alzheimer’s disease
inferred← citeshttps://doi.org/10.1007/s10753-025-02301-9openalex-snapshot
Effects of Troxerutin on Oxidative Stress, Inflammation and Galectin- 3 Expression in Intracerebroventricular Kainic Acid-Induced Neurotoxicity
inferred← citeshttps://doi.org/10.1007/s11126-020-09731-8openalex-snapshot
Galectin-1 and Galectin-3 Levels in Patients with Schizophrenia and their Unaffected Siblings
inferred← citeshttps://doi.org/10.1007/s12035-019-1527-0openalex-snapshot
Delayed Galectin-3-Mediated Reprogramming of Microglia After Stroke is Protective
inferred← citeshttps://doi.org/10.1016/j.abb.2020.108602openalex-snapshot
Galectin-3 knock down inhibits cardiac ischemia-reperfusion injury through interacting with bcl-2 and modulating cell apoptosis
inferred← citeshttps://doi.org/10.1016/j.bbi.2024.01.002openalex-snapshot
Injured sensory neurons-derived galectin-3 contributes to neuropathic pain via programming microglia in the spinal dorsal horn
inferred← citeshttps://doi.org/10.1016/j.bbrc.2026.154606openalex-snapshot
Galectin-3 accelerates the progression of cerebral infarction by regulating the ERK/ROS/BRD4-mediated P2X7R/MerTK balance in microglia
inferred← citeshttps://doi.org/10.1016/j.biocel.2020.105881openalex-snapshot
The therapeutic potential of galectin-3 inhibition in fibrotic disease
inferred← citeshttps://doi.org/10.1016/j.brainres.2021.147642openalex-snapshot
Blast-induced injury responsive relative gene expression of traumatic brain injury biomarkers in human brain microvascular endothelial cells
inferred← citeshttps://doi.org/10.1016/j.brainres.2025.149560openalex-snapshot
Galectin-3 activates microglia and promotes neurological impairment via NLRP3/pyroptosis pathway following traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2022.01.008openalex-snapshot
Anti-inflammatory effect of P2Y1 receptor blocker MRS2179 in a rat model of traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.cca.2025.120189openalex-snapshot
Association of serum galectin3 levels with six-month functional outcome of severe traumatic brain injury and the mediation effect of acute lung injury: A two-center prospective cohort study
inferred← citeshttps://doi.org/10.1016/j.cccb.2023.100158openalex-snapshot
Fornix degeneration in risk factors of Alzheimer's disease, possible trigger of cognitive decline
inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109727openalex-snapshot
CCR2 deficiency alters activation of microglia subsets in traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.dci.2021.104333openalex-snapshot
Molecular characterization and antibacterial ability of galectin-3 and galectin-9 in Onychostoma macrolepis
inferred← citeshttps://doi.org/10.1016/j.drudis.2017.11.004openalex-snapshot
Galectin-3: mediator of microglia responses in injured brain
inferred← citeshttps://doi.org/10.1016/j.ejphar.2022.175360openalex-snapshot
Hippocampal Galectin-3 knockdown alleviates lipopolysaccharide-induced neurotoxicity and cognitive deficits by inhibiting TLR4/NF-кB signaling in aged mice
inferred← citeshttps://doi.org/10.1016/j.expneurol.2024.114777openalex-snapshot
Galectin-3 modulates microglial activation and neuroinflammation in early brain injury after subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.1016/j.expneurol.2024.114785openalex-snapshot
Galectin-3 absence alters lymphocytes populations dynamics behavior and promotes functional recovery after spinal cord injury in mice
inferred← citeshttps://doi.org/10.1016/j.fsi.2020.04.012openalex-snapshot
Characterization and functional study of Galectin3 from Japanese flounder (Paralichthys olivaceus)
inferred← citeshttps://doi.org/10.1016/j.isci.2018.10.013openalex-snapshot
Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity
inferred← citeshttps://doi.org/10.1016/j.jad.2020.12.050openalex-snapshot
Relationship between novel inflammatory biomarker galectin-3 and depression symptom severity in a large community-based sample
inferred← citeshttps://doi.org/10.1016/j.jbc.2023.105400openalex-snapshot
The universe of galectin-binding partners and their functions in health and disease
inferred← citeshttps://doi.org/10.1016/j.jep.2025.120695openalex-snapshot
Effects and mechanism of berberine in ameliorating microglia-mediated hypothalamic inflammation by downregulating the MAPK and NF-κB pathway
inferred← citeshttps://doi.org/10.1016/j.jff.2024.106220openalex-snapshot
Neuroprotective effect of rice bran enzymatic extract-supplemented diets in a murine model of Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.jneumeth.2019.04.005openalex-snapshot
Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system
inferred← citeshttps://doi.org/10.1016/j.jneuroim.2020.577386openalex-snapshot
Relationship between inflammatory biomarker galectin-3 and hippocampal volume in a community study
inferred← citeshttps://doi.org/10.1016/j.jocn.2019.08.032openalex-snapshot
A preliminary data: Evaluation of serum Galectin-3 levels in patients with Idiopathic Parkinson's Disease
inferred← citeshttps://doi.org/10.1016/j.jphs.2021.03.011openalex-snapshot
Pentoxifylline treatment alleviates kidney ischemia/reperfusion injury: Novel involvement of galectin-3 and ASK-1/JNK & ERK1/2/NF-κB/HMGB-1 trajectories
inferred← citeshttps://doi.org/10.1016/j.neuint.2017.12.003openalex-snapshot
A potential impact of Helicobacter pylori -related galectin-3 in neurodegeneration
inferred← citeshttps://doi.org/10.1016/j.npep.2019.02.001openalex-snapshot
Neuroinflammation induced by the peptide amyloid-β (25–35) increase the presence of galectin-3 in astrocytes and microglia and impairs spatial memory
inferred← citeshttps://doi.org/10.1016/j.numecd.2023.10.014openalex-snapshot
Association between galectin-3 and the prognosis of patients with stroke: A meta-analysis of observational studies
inferred← citeshttps://doi.org/10.1016/j.peptides.2025.171415openalex-snapshot
Impact of galanin receptors 2 and 3 double-knockout on neuroinflammation and functional recovery following traumatic brain injury
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2017.10.006openalex-snapshot
Toll-like receptors and their role in persistent pain
inferred← citeshttps://doi.org/10.1016/j.phrs.2025.107834openalex-snapshot
AI-driven discovery of brain-penetrant Galectin-3 inhibitors for Alzheimer's disease therapy
inferred← citeshttps://doi.org/10.1016/j.prp.2023.154331openalex-snapshot
Conditioned medium from bone marrow mesenchymal stem cells relieves spinal cord injury through suppression of Gal-3/NLRP3 and M1 microglia/macrophage polarization
inferred← citeshttps://doi.org/10.1016/j.sajb.2026.05.032openalex-snapshot
Neuroprotective effect of Centaurium erythraea, Cichorium intybus, and Potentilla erecta polyherbal mixture on diabetes-induced histological alterations in the visual system
inferred← citeshttps://doi.org/10.1016/j.tips.2023.06.001openalex-snapshot
Targeting galectin-3 in inflammatory and fibrotic diseases
inferred← citeshttps://doi.org/10.1021/acsabm.9b00958openalex-snapshot
A Method for in Vivo Quantification Of Cytokine IL-1β In The Rat Intrathecal Space
inferred← citeshttps://doi.org/10.1021/acschemneuro.3c00344openalex-snapshot
Increased Gal-3 Mediates Microglia Activation and Neuroinflammation via the TREM2 Signaling Pathway in Prion Infection
inferred← citeshttps://doi.org/10.1038/s41388-022-02324-8openalex-snapshot
OLFM4 deficiency delays the progression of colitis to colorectal cancer by abrogating PMN-MDSCs recruitment
inferred← citeshttps://doi.org/10.1038/s41419-022-05058-3openalex-snapshot
Galectin-3, a rising star in modulating microglia activation under conditions of neurodegeneration
inferred← citeshttps://doi.org/10.1038/s41419-024-07014-9openalex-snapshot
Dopaminergic neurons lacking Caspase-3 avoid apoptosis but undergo necrosis after MPTP treatment inducing a Galectin-3-dependent selective microglial phagocytic response
inferred← citeshttps://doi.org/10.1038/s41467-024-51581-6openalex-snapshot
Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning
inferred← citeshttps://doi.org/10.1038/s41598-025-98858-4openalex-snapshot
A correlational study of plasma galectin-3 as a potential predictive marker of postoperative delirium in patients with acute aortic dissection
inferred← citeshttps://doi.org/10.1074/mcp.ra119.001604openalex-snapshot
Mapping Spatiotemporal Microproteomics Landscape in Experimental Model of Traumatic Brain Injury Unveils a link to Parkinson's Disease*
inferred← citeshttps://doi.org/10.1080/1354750x.2024.2415073openalex-snapshot
The prognostic utility of galectin-3 in patients undergoing cardiac surgery: a scoping review
inferred← citeshttps://doi.org/10.1080/14789450.2020.1745069openalex-snapshot
Proteomic examination of the neuroglial secretome: lessons for the clinic
inferred← citeshttps://doi.org/10.1089/neu.2018.6170openalex-snapshot
S100 Calcium-Binding Protein A9 Knockout Contributes to Neuroprotection and Functional Improvement after Traumatic Brain Injury
inferred← citeshttps://doi.org/10.1089/neu.2019.6955openalex-snapshot
Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects
inferred← citeshttps://doi.org/10.1089/neu.2020.7229openalex-snapshot
Proteoglycan 4 Reduces Neuroinflammation and Protects the Blood–Brain Barrier after Traumatic Brain Injury
inferred← citeshttps://doi.org/10.1093/molehr/gaz030openalex-snapshot
The role of galectin-3 in spermatozoa-zona pellucida binding and its association with fertilization in vitro
inferred← citeshttps://doi.org/10.1096/fj.201902818ropenalex-snapshot
DPP‐4 inhibitor reduces striatal microglial deramification after sensorimotor cortex injury induced by external force impact
inferred← citeshttps://doi.org/10.1097/md.0000000000038620openalex-snapshot
Elevated cerebrospinal fluid galectin-3 and associated cytokines after severe traumatic brain injury in patients
inferred← citeshttps://doi.org/10.1101/2021.12.27.474223openalex-snapshot
Single-cell analysis of microglial transcriptomic diversity in subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.1101/477927openalex-snapshot
Galectin-3, A Novel Endogenous Trem2 Ligand, Regulates Inflammatory Response and Aβ Fibrilation in Alzheimer’s Disease
inferred← citeshttps://doi.org/10.1111/cea.13672openalex-snapshot
Protective role of Galectin‐7 for skin barrier impairment in atopic dermatitis
inferred← citeshttps://doi.org/10.1111/cns.13899openalex-snapshot
Phagocytic microglia and macrophages in brain injury and repair
inferred← citeshttps://doi.org/10.1111/febs.14323openalex-snapshot
Neurophagy, the phagocytosis of live neurons and synapses by glia, contributes to brain development and disease
inferred← citeshttps://doi.org/10.1111/imm.12980openalex-snapshot
Interleukin‐6 signalling mediates Galectin‐8 co‐stimulatory activity of antigen‐specific CD 4 T‐cell response
inferred← citeshttps://doi.org/10.1111/jnc.15327openalex-snapshot
Microglial phagocytosis of neurons in neurodegeneration, and its regulation
inferred← citeshttps://doi.org/10.1111/jnc.70384openalex-snapshot
Microglia at the Forefront: New Insights From the Glial Club South Cone Meeting 2025
inferred← citeshttps://doi.org/10.1126/sciadv.add9984openalex-snapshot
Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis
inferred← citeshttps://doi.org/10.1152/physrev.00011.2017openalex-snapshot
Neuronal Cell Death
inferred← citeshttps://doi.org/10.1155/2021/5827812openalex-snapshot
Serum Galectin‐3 as a Potential Predictive Biomarker Is Associated with Poststroke Cognitive Impairment
inferred← citeshttps://doi.org/10.1155/2022/2924773openalex-snapshot
Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis
inferred← citeshttps://doi.org/10.1186/s12868-018-0428-xopenalex-snapshot
Mice lacking galectin-3 (Lgals3) function have decreased home cage movement
inferred← citeshttps://doi.org/10.1186/s12974-022-02589-6openalex-snapshot
Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration
inferred← citeshttps://doi.org/10.1186/s12974-022-02637-1openalex-snapshot
Microglia dynamics in aging-related neurobehavioral and neuroinflammatory diseases
inferred← citeshttps://doi.org/10.1186/s13148-021-01128-zopenalex-snapshot
DNA methylation under the major depression pathway predicts pediatric quality of life four-month post-pediatric mild traumatic brain injury
inferred← citeshttps://doi.org/10.1186/s13578-021-00592-7openalex-snapshot
Galectin-3: a key player in microglia-mediated neuroinflammation and Alzheimer's disease
inferred← citeshttps://doi.org/10.1248/cpb.c23-00464openalex-snapshot
Neuroimmune Dysfunction in Alzheimer’s Disease and Other Forms of Dementia
inferred← citeshttps://doi.org/10.12677/acm.2025.152458openalex-snapshot
To Investigate the Effect of Galactin-3 on Brain Injury after Cerebral Hemorrhage in Rats Based on TLR-4/NF-κB Signaling Pathway
inferred← citeshttps://doi.org/10.12688/f1000research.25979.1openalex-snapshot
Immunopathology of galectin-3: an increasingly promising target in COVID-19
inferred← citeshttps://doi.org/10.1371/journal.pone.0268962openalex-snapshot
Deep learning for behaviour classification in a preclinical brain injury model
inferred← citeshttps://doi.org/10.1530/ec-18-0108openalex-snapshot
Depression in type 1 diabetes was associated with high levels of circulating galectin-3
inferred← citeshttps://doi.org/10.1530/ec-18-0336openalex-snapshot
Soluble CD163 was linked to galectin-3, diabetic retinopathy and antidepressants in type 1 diabetes
inferred← citeshttps://doi.org/10.18632/aging.202610openalex-snapshot
The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke
inferred← citeshttps://doi.org/10.18632/aging.205014openalex-snapshot
Galectin-3 promotes brain injury by modulating the phenotype of microglia via binding TLR-4 after intracerebral hemorrhage
inferred← citeshttps://doi.org/10.18632/oncotarget.23106openalex-snapshot
Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system
inferred← citeshttps://doi.org/10.21203/rs.3.rs-141155/v1openalex-snapshot
Galectin-3 in the Gut-liver axis Regulates Autistic-like Behaviors by Mechanism Associated with Cerebral Shank-3+ cell Niches in BALB/c Mice
inferred← citeshttps://doi.org/10.2147/jir.s273858openalex-snapshot
Pharmacological Inhibition of Galectin-3 Ameliorates Diabetes-Associated Cognitive Impairment, Oxidative Stress and Neuroinflammation in vivo and in vitro
inferred← citeshttps://doi.org/10.26226/morressier.6076f2e66e987178c2dbdf3copenalex-snapshot
CCR2 deficiency alters activation of microglia subsets in traumatic brain injury
inferred← citeshttps://doi.org/10.3389/fcell.2021.649854openalex-snapshot
Notch1 and Galectin-3 Modulate Cortical Reactive Astrocyte Response After Brain Injury
inferred← citeshttps://doi.org/10.3389/fendo.2020.00030openalex-snapshot
Overexpression of Galectin 3 in Pancreatic β Cells Amplifies β-Cell Apoptosis and Islet Inflammation in Type-2 Diabetes in Mice
inferred← citeshttps://doi.org/10.3389/fimmu.2019.02647openalex-snapshot
Calreticulin and Galectin-3 Opsonise Bacteria for Phagocytosis by Microglia
inferred← citeshttps://doi.org/10.3389/fimmu.2020.599104openalex-snapshot
Galectin-Levels Are Elevated in Infants Born Preterm Due to Amniotic Infection and Rapidly Decline in the Neonatal Period
inferred← citeshttps://doi.org/10.3389/fimmu.2020.607587openalex-snapshot
The Role of Tenascin-C in Tissue Injury and Repair After Stroke
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1738589openalex-snapshot
Cytokines and related signaling pathways in traumatic brain injury
inferred← citeshttps://doi.org/10.3389/fimmu.2026.1778798openalex-snapshot
HMC3 revealed: how much do these “Microglia” really tell us?
inferred← citeshttps://doi.org/10.3389/fnana.2021.767330openalex-snapshot
Galectins and Their Ligand Glycoconjugates in the Central Nervous System Under Physiological and Pathological Conditions
inferred← citeshttps://doi.org/10.3389/fncel.2018.00242openalex-snapshot
An Overview of in vitro Methods to Study Microglia
inferred← citeshttps://doi.org/10.3389/fncel.2018.00398openalex-snapshot
Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson’s Disease
inferred← citeshttps://doi.org/10.3389/fncel.2019.00157openalex-snapshot
Differential Cellular Expression of Galectin-1 and Galectin-3 After Intracerebral Hemorrhage
inferred← citeshttps://doi.org/10.3389/fncel.2020.00162openalex-snapshot
Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration
inferred← citeshttps://doi.org/10.3389/fncel.2020.567404openalex-snapshot
Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models
inferred← citeshttps://doi.org/10.3389/fncel.2020.594304openalex-snapshot
Applying hiPSCs and Biomaterials Towards an Understanding and Treatment of Traumatic Brain Injury
inferred← citeshttps://doi.org/10.3389/fncel.2022.923811openalex-snapshot
Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations
inferred← citeshttps://doi.org/10.3389/fncel.2024.1335849openalex-snapshot
Reactive gliosis in traumatic brain injury: a comprehensive review
inferred← citeshttps://doi.org/10.3389/fneur.2026.1851363openalex-snapshot
Predictive value of Galectin-3 in cognitive impairment: a systematic review and meta-analysis
inferred← citeshttps://doi.org/10.3389/fnins.2018.00430openalex-snapshot
Investigation of Gal-3 Expression Pattern in Serum and Cerebrospinal Fluid of Patients Suffering From Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.3389/fnmol.2018.00158openalex-snapshot
Microglial Lectins in Health and Neurological Diseases
inferred← citeshttps://doi.org/10.3389/fopht.2022.905352openalex-snapshot
Differential Retinal Ganglion Cell Vulnerability, A Critical Clue for the Identification of Neuroprotective Genes in Glaucoma
inferred← citeshttps://doi.org/10.3389/fphar.2021.588587openalex-snapshot
Galectin-3 Mediated Inflammatory Response Contributes to Neurological Recovery by QiShenYiQi in Subacute Stroke Model
inferred← citeshttps://doi.org/10.3389/fphar.2021.706439openalex-snapshot
Galectin-3 Deletion Reduces LPS and Acute Colitis-Induced Pro-Inflammatory Microglial Activation in the Ventral Mesencephalon
inferred← citeshttps://doi.org/10.3389/fphar.2022.713100openalex-snapshot
A Precision Medicine Agenda in Traumatic Brain Injury
inferred← citeshttps://doi.org/10.3389/fpsyt.2018.00271openalex-snapshot
IL-33/ST2 Pathway and Galectin-3 as a New Analytes in Pathogenesis and Cardiometabolic Risk Evaluation in Psychosis
inferred← citeshttps://doi.org/10.3390/biom10050798openalex-snapshot
Galectin-3: Roles in Neurodevelopment, Neuroinflammation, and Behavior
inferred← citeshttps://doi.org/10.3390/biom12050603openalex-snapshot
Advances in Visualizing Microglial Cells in Human Central Nervous System Tissue
inferred← citeshttps://doi.org/10.3390/biomedicines10030518openalex-snapshot
Characterisation of Severe Traumatic Brain Injury Severity from Fresh Cerebral Biopsy of Living Patients: An Immunohistochemical Study
inferred← citeshttps://doi.org/10.3390/biomedicines9060639openalex-snapshot
Beneficial Effects of Mineralocorticoid Receptor Pathway Blockade against Endothelial Inflammation Induced by SARS-CoV-2 Spike Protein
inferred← citeshttps://doi.org/10.3390/brainsci8020030openalex-snapshot
Possible Role of Inflammation and Galectin-3 in Brain Injury after Subarachnoid Hemorrhage
inferred← citeshttps://doi.org/10.3390/cells10040800openalex-snapshot
Placental Glycoredox Dysregulation Associated with Disease Progression in an Animal Model of Superimposed Preeclampsia
inferred← citeshttps://doi.org/10.3390/cells9071717openalex-snapshot
Microglia: Agents of the CNS Pro-Inflammatory Response
inferred← citeshttps://doi.org/10.3390/ijms23031170openalex-snapshot
Gal3 Plays a Deleterious Role in a Mouse Model of Endotoxemia
inferred← citeshttps://doi.org/10.3390/ijms242115516openalex-snapshot
The Role of Galectin-3 in Retinal Degeneration and Other Ocular Diseases: A Potential Novel Biomarker and Therapeutic Target
inferred← citeshttps://doi.org/10.3390/ijms26104699openalex-snapshot
Sweet Aging: Glycocalyx and Galectins in CNS Aging and Neurodegenerative Disorders
inferred← citeshttps://doi.org/10.3390/ijms26178149openalex-snapshot
A Semi-Automated and Unbiased Microglia Morphology Analysis Following Mild Traumatic Brain Injury in Rats
inferred← citeshttps://doi.org/10.3390/jcdd8110139openalex-snapshot
Biomarkers Utility: At the Borderline between Cardiology and Neurology
inferred← citeshttps://doi.org/10.3390/jcm8101719openalex-snapshot
Reformulating Pro-Oxidant Microglia in Neurodegeneration
inferred← citeshttps://doi.org/10.4049/jimmunol.1502532openalex-snapshot
Activated Microglia Desialylate and Phagocytose Cells via Neuraminidase, Galectin-3, and Mer Tyrosine Kinase
inferred← citeshttps://doi.org/10.4049/jimmunol.1701172openalex-snapshot
Galectin-1: A Jack-of-All-Trades in the Resolution of Acute and Chronic Inflammation
inferred← citeshttps://doi.org/10.4103/1673-5374.266910openalex-snapshot
Neuroinflammation and oxidative stress act in concert to promote neurodegeneration in the diabetic retina and optic nerve: galectin-3 participation
inferred← citeshttps://doi.org/10.4103/1673-5374.293134openalex-snapshot
Regulation of neuroimmune processes by damage- and resolution-associated molecular patterns
inferred← citeshttps://doi.org/10.4103/1673-5374.330589openalex-snapshot
Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage
inferred← citeshttps://doi.org/10.6084/m9.figshare.21152882openalex-snapshot
Additional file 1 of Genetic targeting or pharmacological inhibition of galectin-3 dampens microglia reactivity and delays retinal degeneration
inferred← citeshttps://doi.org/10.65457/jnmmi-2026-0004openalex-snapshot
In vivo PET imaging of galectins
inferred← citeshttps://doi.org/10.70675/29123d99z419ez476dza406z3333a44da69dopenalex-snapshot
In depth systemic biology analysis of central nervous system injuries
inferred← citeshttps://doi.org/10.7861/clinmed.23-6-s81openalex-snapshot
Temporal profile of cerebrospinal fluid galactin-3 and associated cytokine responses after severe traumatic brain injury in patients: a retrospective study
inferred← citeshttps://doi.org/10.7861/fhj.10-3-s18openalex-snapshot
Temporal profile of cerebrospinal fluid galactin-3 and associated cytokine responses after severe traumatic brain injury in patients: a retrospective study
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