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Lipoic acid as a novel treatment for Alzheimer's disease and related dementias

https://doi.org/10.1016/j.pharmthera.2006.07.001

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/biof.5520170120openalex-snapshot

Lipoic acid: A multifunctional antioxidant

inferredcites →https://doi.org/10.1006/bbrc.1994.1837openalex-snapshot

β2-Microglobulin Modified with Advanced Glycation End Products Induces Interleukin-6 from Human Macrophages: Role in the Pathogenesis of Hemodialysis-Associated Amyloidosis

inferredcites →https://doi.org/10.1006/bbrc.1996.1165openalex-snapshot

Efficient Reduction of Lipoamide and Lipoic Acid by Mammalian Thioredoxin Reductase

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Glutamate receptors as a target for Alzheimer’s disease — are clinical results supporting the hope?

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Ultrastructural morphology of amyloid fibrils from neuritic and amyloid plaques

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Acrolein inhibits NADH-linked mitochondrial enzyme activity: Implications for Alzheimer's disease

inferredcites →https://doi.org/10.1007/s00018-002-8491-xopenalex-snapshot

RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease

inferredcites →https://doi.org/10.1007/s00249-005-0041-7openalex-snapshot

Metal binding in amyloid β-peptides shows intra- and inter-peptide coordination modes

inferredcites →https://doi.org/10.1007/s00360-004-0447-zopenalex-snapshot

Lipoic acid attenuates hypertension and improves insulin sensitivity, kallikrein activity and nitrite levels in high fructose-fed rats

inferredcites →https://doi.org/10.1016/0003-9861(92)90433-wopenalex-snapshot

Peroxynitrite formation from macrophage-derived nitric oxide

inferredcites →https://doi.org/10.1016/0006-2952(95)02124-8openalex-snapshot

Reduction of lipoic acid by lipoamide dehydrogenase

inferredcites →https://doi.org/10.1016/0304-3940(83)90264-1openalex-snapshot

Choline acetyltransferase immunohistochemistry in brains of alzheimer's disease patients and controls

inferredcites →https://doi.org/10.1016/0891-5849(95)00017-ropenalex-snapshot

Alpha-lipoic acid as a biological antioxidant

inferredcites →https://doi.org/10.1016/j.abb.2003.12.020openalex-snapshot

(R)-α-Lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis

inferredcites →https://doi.org/10.1016/j.bbapap.2004.09.012openalex-snapshot

Redox modulation of cellular signaling and metabolism through reversible oxidation of methionine sensors in calcium regulatory proteins

inferredcites →https://doi.org/10.1016/j.bbrc.2005.05.035openalex-snapshot

α-Lipoic acid increases insulin sensitivity by activating AMPK in skeletal muscle

inferredcites →https://doi.org/10.1016/j.brainres.2006.03.063openalex-snapshot

Age-related changes in glutathione and glutathione-related enzymes in rat brain

inferredcites →https://doi.org/10.1016/j.jneumeth.2005.12.016openalex-snapshot

Kinetic analysis of β-amyloid peptide aggregation induced by metal ions based on surface plasmon resonance biosensing

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2005.12.014openalex-snapshot

Chronic dietary α-lipoic acid reduces deficits in hippocampal memory of aged Tg2576 mice

inferredcites →https://doi.org/10.1016/s0006-2952(97)00672-2openalex-snapshot

Redox Signaling and the Emerging Therapeutic Potential of Thiol Antioxidants

inferredcites →https://doi.org/10.1016/s0006-8993(00)03176-0openalex-snapshot

β-Amyloid-induced glial expression of both pro- and anti-inflammatory cytokines in cerebral cortex of aged transgenic Tg2576 mice with Alzheimer plaque pathology

inferredcites →https://doi.org/10.1016/s0006-8993(01)02872-4openalex-snapshot

Advanced glycation endproducts co-localize with inducible nitric oxide synthase in Alzheimer’s disease

inferredcites →https://doi.org/10.1016/s0009-2797(01)00268-xopenalex-snapshot

Effect of DL-α-lipoic acid on mitochondrial enzymes in aged rats

inferredcites →https://doi.org/10.1016/s0022-1759(00)00207-6openalex-snapshot

Analysis of lipopolysaccharide (LPS)-binding characteristics of serum components using gel filtration of FITC-labeled LPS

inferredcites →https://doi.org/10.1016/s0022-3956(02)00020-1openalex-snapshot

Modeling the prevalence and incidence of Alzheimer’s disease and mild cognitive impairment

inferredcites →https://doi.org/10.1016/s0022-510x(99)00297-xopenalex-snapshot

Changes in uptake of vitamin B12 and trace metals in brains of mice treated with clioquinol

inferredcites →https://doi.org/10.1016/s0070-2137(01)80001-7openalex-snapshot

Cellular thiols and redox-regulated signal transduction

inferredcites →https://doi.org/10.1016/s0090-6980(02)00111-9openalex-snapshot

Pro-inflammatory effect of freshly solubilized β-amyloid peptides in the brain

inferredcites →https://doi.org/10.1016/s0165-0173(96)00016-1openalex-snapshot

Advanced glycation endproducts in ageing and Alzheimer's disease

inferredcites →https://doi.org/10.1016/s0166-2236(00)01749-5openalex-snapshot

Targeting small Aβ oligomers: the solution to an Alzheimer's disease conundrum?

inferredcites →https://doi.org/10.1016/s0167-4943(01)00104-2openalex-snapshot

Alpha-lipoic acid as a new treatment option for Azheimer type dementia

inferredcites →https://doi.org/10.1016/s0197-4580(02)00098-2openalex-snapshot

Progressive age-related impairment of cognitive behavior in APP23 transgenic mice

inferredcites →https://doi.org/10.1016/s0197-4580(02)00120-3openalex-snapshot

Metal complexing agents as therapies for Alzheimer’s disease

inferredcites →https://doi.org/10.1016/s0304-3940(01)02205-4openalex-snapshot

α-lipoic acid protects rat cortical neurons against cell death induced by amyloid and hydrogen peroxide through the Akt signalling pathway

inferredcites →https://doi.org/10.1016/s0306-4530(02)00087-2openalex-snapshot

Insulin dose–response effects on memory and plasma amyloid precursor protein in Alzheimer’s disease: interactions with apolipoprotein E genotype

inferredcites →https://doi.org/10.1016/s0891-5849(01)00551-2openalex-snapshot

Beneficial effects of α-lipoic acid and ascorbic acid on endothelium-dependent, nitric oxide-mediated vasodilation in diabetic patients: relation to parameters of oxidative stress

inferredcites →https://doi.org/10.1016/s0891-5849(96)00400-5openalex-snapshot

Cytosolic and Mitochondrial Systems for NADH- and NADPH-dependent Reduction of α-Lipoic Acid

inferredcites →https://doi.org/10.1016/s1474-4422(03)00502-7openalex-snapshot

Treatment of Alzheimer's disease; current status and new perspectives

inferredcites →https://doi.org/10.1021/bi990438fopenalex-snapshot

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

inferredcites →https://doi.org/10.1023/a:1007156732662openalex-snapshot

Regulation of the activity of choline acetyl transferase by lipoic acid

inferredcites →https://doi.org/10.1023/a:1017924628110openalex-snapshot

Activation of choline acetyl transferase by dihydrolipoic acid

inferredcites →https://doi.org/10.1038/374647a0openalex-snapshot

Activation of microglial cells by β-amyloid protein and interferon-γ

inferredcites →https://doi.org/10.1038/jcbfm.1995.77openalex-snapshot

Prolonged Pretreatment with α-Lipoic Acid Protects Cultured Neurons against Hypoxic, Glutamate-, or Iron-Induced Injury

inferredcites →https://doi.org/10.1038/sj.mp.4000212openalex-snapshot

Inflammatory mechanisms in Alzheimer disease: the role of beta-amyloid/glial interactions

inferredcites →https://doi.org/10.1046/j.0953-816x.2001.01820.xopenalex-snapshot

Anti‐inflammatory antioxidants attenuate the expression of inducible nitric oxide synthase mediated by advanced glycation endproducts in murine microglia

inferredcites →https://doi.org/10.1046/j.1440-1681.2000.03200.xopenalex-snapshot

Alzheimer’s Disease And Inflammation: A Review Of Cellular And Therapeutic Mechanisms

inferredcites →https://doi.org/10.1046/j.1471-4159.1997.68052092.xopenalex-snapshot

4‐Hydroxynonenal‐Derived Advanced Lipid Peroxidation End Products Are Increased in Alzheimer's Disease

inferredcites →https://doi.org/10.1046/j.1471-4159.1999.0720751.xopenalex-snapshot

Protein‐Bound Acrolein

inferredcites →https://doi.org/10.1046/j.1471-4159.1999.0722523.xopenalex-snapshot

The Glutathione System of Peroxide Detoxification Is Less Efficient in Neurons than in Astroglial Cells

inferredcites →https://doi.org/10.1046/j.1471-4159.2001.t01-1-00240.xopenalex-snapshot

Amyloid-beta peptide fragments p3 and p4 induce pro-inflammatory cytokine and chemokine production in vitro and in vivo

inferredcites →https://doi.org/10.1046/j.1471-4159.2003.01580.xopenalex-snapshot

The antioxidants α‐lipoic acid and N ‐acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice

inferredcites →https://doi.org/10.1046/j.1471-4159.2003.01988.xopenalex-snapshot

Signal transduction pathways in mouse microglia N‐11 cells activated by advanced glycation endproducts (AGEs)

inferredcites →https://doi.org/10.1055/s-2003-40452openalex-snapshot

Memory Function and Brain Glucose Metabolism

inferredcites →https://doi.org/10.1055/s-2004-825760openalex-snapshot

α-lipoic Acid Mitigates Insulin Resistance in Goto-Kakizaki Rats

inferredcites →https://doi.org/10.1056/nejmra040223openalex-snapshot

Alzheimer's Disease

inferredcites →https://doi.org/10.1073/pnas.0400282101openalex-snapshot

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

inferredcites →https://doi.org/10.1073/pnas.261709098openalex-snapshot

Age-associated mitochondrial oxidative decay: Improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl- l - carnitine and/or R -α-lipoic acid

inferredcites →https://doi.org/10.1073/pnas.261709299openalex-snapshot

Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl- l -carnitine and/or R -α-lipoic acid

inferredcites →https://doi.org/10.1073/pnas.94.10.5296openalex-snapshot

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

inferredcites →https://doi.org/10.1074/jbc.272.28.17810openalex-snapshot

Activation of the Receptor for Advanced Glycation End Products Triggers a p21 -dependent Mitogen-activated Protein Kinase Pathway Regulated by Oxidant Stress

inferredcites →https://doi.org/10.1089/ars.2005.7.1040openalex-snapshot

The Molecular Basis for Oxidative Stress-Induced Insulin Resistance

inferredcites →https://doi.org/10.1093/jn/127.9.1776openalex-snapshot

Lipoic Acid Reduces the Activities of Biotin-Dependent Carboxylases in Rat Liver ,

inferredcites →https://doi.org/10.1096/fasebj.13.2.411openalex-snapshot

( R )‐α‐Lipoic acid‐supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate

inferredcites →https://doi.org/10.1096/fj.02-0186fjeopenalex-snapshot

β‐Amyloid inhibits NOS activity by subtracting NADPH availability

inferredcites →https://doi.org/10.1097/00005072-199503000-00014openalex-snapshot

Interleukin-1 Expression in Different Plaque Types in Alzheimerʼs Disease

inferredcites →https://doi.org/10.1111/j.1365-2990.1988.tb00864.xopenalex-snapshot

Neuropil Threads Occur in Dendrites of Tangle—Bearing Nerve Cells

inferredcites →https://doi.org/10.1111/j.1464-5491.2004.01109.xopenalex-snapshot

Treatment of symptomatic diabetic polyneuropathy with the antioxidant α‐lipoic acid: a meta‐analysis

inferredcites →https://doi.org/10.1136/jnnp.74.9.1200openalex-snapshot

Intrathecal inflammation precedes development of Alzheimer's disease

inferredcites →https://doi.org/10.1159/000054469openalex-snapshot

Insulin Metabolism in Alzheimer’s Disease Differs According to Apolipoprotein E Genotype and Gender

inferredcites →https://doi.org/10.1176/appi.ajp.159.5.738openalex-snapshot

Longitudinal PET Evaluation of Cerebral Metabolic Decline in Dementia: A Potential Outcome Measure in Alzheimer’s Disease Treatment Studies

inferredcites →https://doi.org/10.1179/016164101101198758openalex-snapshot

Physiological levels ofβ-amyloid induce cerebral vessel dysfunction and reduce endothelial nitric oxide production

inferredcites →https://doi.org/10.1179/135100002125000190openalex-snapshot

The Haber-Weiss cycle—70 years later: an alternative view

inferredcites →https://doi.org/10.1179/135100002125000604openalex-snapshot

Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status

inferredcites →https://doi.org/10.1179/135100004225003923openalex-snapshot

Dihydrolipoic acid lowers the redox activity of transition metal ions but does not remove them from the active site of enzymes

inferredcites →https://doi.org/10.1179/135100005x21624openalex-snapshot

Dietary supplementation with (R)-α-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex

inferredcites →https://doi.org/10.1196/annals.1333.026openalex-snapshot

Methylglyoxal, Glyoxal, and Their Detoxification in Alzheimer's Disease

inferredcites →https://doi.org/10.1517/13543784.11.9.1205openalex-snapshot

Advanced glycation end products and diabetic complications

inferredcites →https://doi.org/10.2165/00023210-200317010-00003openalex-snapshot

The Role of Insulin Resistance in the Pathogenesis of Alzheimer??s Disease

inferredcites →https://doi.org/10.2174/0929867043365387openalex-snapshot

Lipoic Acid as a Potential Therapy for Chronic Diseases Associated with Oxidative Stress

inferredcites →https://doi.org/10.2337/diab.46.9.1481openalex-snapshot

Advanced Glycation End Product-Induced Activation of NF-κB is Suppressed by α-Lipoic Acid in Cultured Endothelial Cells

inferredcites →https://doi.org/10.2337/diabetes.46.9.1481openalex-snapshot

Advanced glycation end product-induced activation of NF-kappaB is suppressed by alpha-lipoic acid in cultured endothelial cells

inferredcites →https://doi.org/10.2337/diacare.19.3.257openalex-snapshot

Oxidative Stress and Diabetic Vascular Complications

inferredcites →https://doi.org/10.3233/jad-2001-3206openalex-snapshot

The severity of cortical Alzheimer's type changes is positively correlated with increased amyloid-β Levels: Resolubilization of amyloid-β with transition metal ion chelators

inferredcites →https://doi.org/10.3233/jad-2003-5104openalex-snapshot

Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y

inferredcites →https://doi.org/10.3233/jad-2003-5306openalex-snapshot

Protection against amyloid beta peptide and iron/hydrogen peroxide toxicity by alpha lipoic acid

inferredcites →https://doi.org/10.3892/ijmm.10.3.245openalex-snapshot

Additive effects of amyloid β fragment and interleukin-1β on interleukin-6 secretion in rat primary glial cultures

inferredcites →https://doi.org/10.4049/jimmunol.170.10.5281openalex-snapshot

Amyloid Peptide-Induced Cytokine and Chemokine Expression in THP-1 Monocytes Is Blocked by Small Inhibitory RNA Duplexes for Early Growth Response-1 Messenger RNA

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Alpha‐lipoic acid: A promising adjuvant for nonsteroidal anti‐inflammatory drugs therapy with improved efficacy and gastroprotection

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Determination of α‐Lipoic acid on a Pyrolytic Graphite Electrode Modified with Cobalt Phthalocyanine

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Lipoic Acid Ameliorates Lipopolysaccharide‐Induced Inflammation via Inhibition of Glycolysis in RAW264.7 Macrophages

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Is α‐lipoic acid a scavenger of reactive oxygen species in vivo? Evidence for its initiation of stress signaling pathways that promote endogenous antioxidant capacity

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Antioxidant dihydrolipolic acid protects against in vitro aluminum‐induced toxicity

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α‐Lipoic acid inhibits testicular and epididymal oxidative damage and improves fertility efficacy in arsenic‐intoxicated rats

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inferred← citeshttps://doi.org/10.1007/s40828-019-0091-6openalex-snapshot

Lipoic acid

inferred← citeshttps://doi.org/10.1007/s43188-019-00036-yopenalex-snapshot

α-lipoic acid protects testis and epididymis against linuron-induced oxidative toxicity in adult rats

inferred← citeshttps://doi.org/10.1016/b978-0-12-394816-8.00010-6openalex-snapshot

Estrogen regulation of mitochondrial bioenergetics: implications for prevention of Alzheimer's disease.

inferred← citeshttps://doi.org/10.1016/b978-0-12-407824-6.00088-4openalex-snapshot

Role of α-Lipoid Acid and Acetyl-L-Carnitine in Dementia

inferred← citeshttps://doi.org/10.1016/b978-0-12-411462-3.00035-7openalex-snapshot

Antioxidants for the Prevention and Treatment of Multiple Sclerosis

inferred← citeshttps://doi.org/10.1016/b978-0-443-18951-7.00026-8openalex-snapshot

Role of protein-rich diet in brain functions

inferred← citeshttps://doi.org/10.1016/b978-0-443-29839-4.00002-0openalex-snapshot

How to accomplish brain fitness: The five brain rules

inferred← citeshttps://doi.org/10.1016/bs.mie.2018.06.006openalex-snapshot

Biochemical Approaches for Understanding Iron–Sulfur Cluster Regeneration in Escherichia coli Lipoyl Synthase During Catalysis

inferred← citeshttps://doi.org/10.1016/j.addr.2008.04.015openalex-snapshot

Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.addr.2008.06.003openalex-snapshot

Estrogen regulation of glucose metabolism and mitochondrial function: Therapeutic implications for prevention of Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.ancard.2008.02.018openalex-snapshot

Un dithiol endogène aux propriétés antioxydantes : l’acide alpha-lipoïque, utilisation potentielle dans les pathologies cardiovasculaires

inferred← citeshttps://doi.org/10.1016/j.antiviral.2008.11.001openalex-snapshot

Ethacrynic and α-lipoic acids inhibit vaccinia virus late gene expression

inferred← citeshttps://doi.org/10.1016/j.arr.2023.102035openalex-snapshot

Research on ferroptosis as a therapeutic target for the treatment of neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.07.033openalex-snapshot

A novel DSC approach for evaluating protectant drugs efficacy against dementia

inferred← citeshttps://doi.org/10.1016/j.bbadis.2025.168034openalex-snapshot

Alpha-lipoic acid attenuates cardiac inflammation of CVB3 induced viral myocarditis via neutrophil-derived YM-1

inferred← citeshttps://doi.org/10.1016/j.biochi.2011.02.015openalex-snapshot

General oxidative stress during doxorubicin-induced cardiotoxicity in rats: Absence of cardioprotection and low antioxidant efficiency of alpha-lipoic acid

inferred← citeshttps://doi.org/10.1016/j.biopha.2018.06.147openalex-snapshot

A molecular approach in drug development for Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/j.bmcl.2009.01.102openalex-snapshot

Preparation and characterization of antioxidant nanospheres from multiple α-lipoic acid-containing compounds

inferred← citeshttps://doi.org/10.1016/j.bmcl.2011.03.010openalex-snapshot

Proflavine derivatives as fluorescent imaging agents of amyloid deposits

inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.04.068openalex-snapshot

Synthesis of novel bis(pyrimido[5,4-c]quinoline-2,4(1H,3H)-dione) and its derivatives: Evaluation of their antioxidant properties

inferred← citeshttps://doi.org/10.1016/j.bmcl.2020.127709openalex-snapshot

Novel molecular hybrids of indoline spiropyrans and α-lipoic acid as potential photopharmacological agents: Synthesis, structure, photochromic and biological properties

inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.129938openalex-snapshot

Synthesis and evaluation of lipoic acid – donepezil hybrids for Alzheimer’s disease using a straightforward strategy

inferred← citeshttps://doi.org/10.1016/j.brainres.2008.11.025openalex-snapshot

Distribution study of orally administered lipoic acid in rat brain tissues

inferred← citeshttps://doi.org/10.1016/j.brainres.2011.07.022openalex-snapshot

Ibuprofen and lipoic acid codrug 1 control Alzheimer's disease progression by down-regulating protein kinase C ε-mediated metalloproteinase 2 and 9 levels in β-amyloid infused Alzheimer's disease rat model

inferred← citeshttps://doi.org/10.1016/j.brainres.2013.01.054openalex-snapshot

Alpha-lipoic acid protects against 6-hydroxydopamine-induced neurotoxicity in a rat model of hemi-parkinsonism

inferred← citeshttps://doi.org/10.1016/j.brainresbull.2016.02.014openalex-snapshot

Alpha-lipoic acid-mediated activation of muscarinic receptors improves hippocampus- and amygdala-dependent memory

inferred← citeshttps://doi.org/10.1016/j.brainresbull.2018.05.019openalex-snapshot

α-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis

inferred← citeshttps://doi.org/10.1016/j.cej.2026.182033openalex-snapshot

Rational engineering of ginseng polysaccharide-based composite nanoparticles for orchestrating microglial homeostasis and suppressing complement-mediated synaptic injury in Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2012.04.018openalex-snapshot

Alfa-Lipoic acid protects testosterone secretion pathway and sperm quality against 4-tert-octylphenol induced reproductive toxicity

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2013.01.022openalex-snapshot

Pesticide-induced decrease in rat testicular steroidogenesis is differentially prevented by lipoate and tocopherol

inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.115533openalex-snapshot

α-lipoic acid ameliorates hepatotoxicity induced by chronic ammonia toxicity in crucian carp (Carassius auratus gibelio) by alleviating oxidative stress, inflammation and inhibiting ERS pathway

inferred← citeshttps://doi.org/10.1016/j.ejmech.2010.10.028openalex-snapshot

Synthesis of a novel ester of hydroxytyrosol and α-lipoic acid exhibiting an antiproliferative effect on human colon cancer HT-29 cells

inferred← citeshttps://doi.org/10.1016/j.ejmech.2011.09.001openalex-snapshot

Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/j.ejmech.2016.03.023openalex-snapshot

Novel benzylidenephenylpyrrolizinones with pleiotropic activities potentially useful in Alzheimer's disease treatment

inferred← citeshttps://doi.org/10.1016/j.ejmech.2018.03.057openalex-snapshot

Success stories of natural product-based hybrid molecules for multi-factorial diseases

inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116174openalex-snapshot

Exploring structural determinants of neuroprotection bias on novel glypromate conjugates with bioactive amines

inferred← citeshttps://doi.org/10.1016/j.etp.2010.11.012openalex-snapshot

Modulatory effects of vitamin E, acetyl-l-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model

inferred← citeshttps://doi.org/10.1016/j.foodchem.2017.09.028openalex-snapshot

Stabilization of alpha-lipoic acid by complex formation with octenylsuccinylated high amylose starch

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2008.01.004openalex-snapshot

Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2019.10.410openalex-snapshot

Are the beneficial effects of ‘antioxidant’ lipoic acid mediated through metabolism of reactive sulfur species?

inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e32755openalex-snapshot

Computational and spectroscopic insight into the binding of citral with human transferrin: Targeting neurodegenerative diseases

inferred← citeshttps://doi.org/10.1016/j.ijpharm.2022.122201openalex-snapshot

Review of lipoic acid: From a clinical therapeutic agent to various emerging biomaterials

inferred← citeshttps://doi.org/10.1016/j.intimp.2013.03.024openalex-snapshot

α-Lipoic acid attenuates LPS-induced cardiac dysfunction through a PI3K/Akt-dependent mechanism

inferred← citeshttps://doi.org/10.1016/j.intimp.2021.107741openalex-snapshot

The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review

inferred← citeshttps://doi.org/10.1016/j.intimp.2023.111326openalex-snapshot

Dry and wet experiments reveal diagnostic clustering and immune landscapes of cuproptosis patterns in patients with ankylosing spondylitis

inferred← citeshttps://doi.org/10.1016/j.jbc.2023.105228openalex-snapshot

Crystal structure of histone deacetylase 6 complexed with (R)-lipoic acid, an essential cofactor in central carbon metabolism

inferred← citeshttps://doi.org/10.1016/j.jff.2017.12.051openalex-snapshot

Isolation of activating factors of serotonin N-acetyltransferase from rice peptides

inferred← citeshttps://doi.org/10.1016/j.jinorgbio.2019.03.019openalex-snapshot

Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology

inferred← citeshttps://doi.org/10.1016/j.jmhi.2012.03.004openalex-snapshot

Gold nanoparticles and lipoic acid as a novel anti-inflammatory treatment for autism, a hypothesis

inferred← citeshttps://doi.org/10.1016/j.jphotochem.2020.112438openalex-snapshot

Nitrogen-doped carbon quantum dots as a “turn off-on” fluorescence sensor based on the redox reaction mechanism for the sensitive detection of dopamine and alpha lipoic acid

inferred← citeshttps://doi.org/10.1016/j.lfs.2010.03.019openalex-snapshot

Inflammation and apoptosis in aortic tissues of aged type II diabetes: Amelioration with α-lipoic acid through phosphatidylinositol 3-kinase/Akt- dependent mechanism

inferred← citeshttps://doi.org/10.1016/j.lfs.2017.01.001openalex-snapshot

α-Lipoic acid ameliorates oral mucositis and oxidative stress induced by methotrexate in rats. Histological and immunohistochemical study

inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119766openalex-snapshot

Investigation of alpha-lipoic acid effect on memory impairment considering strain-dependent differences in mice

inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119899openalex-snapshot

RETRACTED: Decrypting the potential role of α-lipoic acid in Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.mehy.2008.09.058openalex-snapshot

High-dose folate and dietary purines promote scavenging of peroxynitrite-derived radicals – Clinical potential in inflammatory disorders

inferred← citeshttps://doi.org/10.1016/j.mehy.2009.01.050openalex-snapshot

Emerging hypotheses regarding the influences of butyrylcholinesterase-K variant, APOE ε4, and hyperhomocysteinemia in neurodegenerative dementias

inferred← citeshttps://doi.org/10.1016/j.neuint.2012.09.003openalex-snapshot

The oxidative damage and inflammation caused by pesticides are reverted by lipoic acid in rat brain

inferred← citeshttps://doi.org/10.1016/j.neuint.2015.10.011openalex-snapshot

Novel promising therapeutics against chronic neuroinflammation and neurodegeneration in Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.neuint.2017.06.003openalex-snapshot

Alpha-lipoic acid attenuates acute neuroinflammation and long-term cognitive impairment after polymicrobial sepsis

inferred← citeshttps://doi.org/10.1016/j.neuint.2020.104806openalex-snapshot

The effect of three polyphenols and some other antioxidant substances on amyloid fibril formation by Human cystatin C

inferred← citeshttps://doi.org/10.1016/j.neulet.2014.12.037openalex-snapshot

Effects of alpha-lipoic acid on spatial learning and memory, oxidative stress, and central cholinergic system in a rat model of vascular dementia

inferred← citeshttps://doi.org/10.1016/j.pbb.2010.11.001openalex-snapshot

Lipoic acid inhibits caspase-dependent and -independent cell death pathways and is neuroprotective against hippocampal damage after pilocarpine-induced seizures

inferred← citeshttps://doi.org/10.1016/j.phrs.2017.12.023openalex-snapshot

An overview of the possible therapeutic role of SUMOylation in the treatment of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/j.phyplu.2021.100146openalex-snapshot

Comparative study on the effect of EGCG and wheat grass together with mental and physical activities against induction of Alzheimer's disease in both isolated and socialized rats

inferred← citeshttps://doi.org/10.1016/j.pnpbp.2015.08.002openalex-snapshot

Evidence for protective effect of lipoic acid and desvenlafaxine on oxidative stress in a model depression in mice

inferred← citeshttps://doi.org/10.1016/j.talanta.2007.08.008openalex-snapshot

Novel lipoate-selective membrane sensor for the flow injection determination of α-lipoic acid in pharmaceutical preparations and urine

inferred← citeshttps://doi.org/10.1016/j.tetasy.2014.10.011openalex-snapshot

Efficient synthesis of an ε-hydroxy ester in a space–time yield of 1580 g L−1d−1 by a newly identified reductase RhCR

inferred← citeshttps://doi.org/10.1016/j.theriogenology.2020.10.017openalex-snapshot

Dietary alpha-lipoic acid supplementation improves spermatogenesis and semen quality via antioxidant and anti-apoptotic effects in aged breeder roosters

inferred← citeshttps://doi.org/10.1016/j.tice.2026.103459openalex-snapshot

Neuroprotective potentials of alpha-lipoic acid against multi-walled carbon nanotubes-induced neurotoxicity and behavioral deficits in male albino rats: Role of antioxidant and anti-apoptotic pathways

inferred← citeshttps://doi.org/10.1016/j.tips.2008.12.006openalex-snapshot

Estrogen-induced plasticity from cells to circuits: predictions for cognitive function

inferred← citeshttps://doi.org/10.1016/j.toxrep.2017.06.009openalex-snapshot

α-lipoic acid inhibits oxidative stress in testis and attenuates testicular toxicity in rats exposed to carbimazole during embryonic period

inferred← citeshttps://doi.org/10.1016/j.yfrne.2013.08.001openalex-snapshot

Estrogen: A master regulator of bioenergetic systems in the brain and body

inferred← citeshttps://doi.org/10.1016/s1734-1140(11)70600-4openalex-snapshot

Lipoic acid – biological activity and therapeutic potential

inferred← citeshttps://doi.org/10.1017/cbo9780511635700.002openalex-snapshot

Estrogens and cognition: perspectives and opportunities in the wake of the Women's Health Initiative Memory Study

inferred← citeshttps://doi.org/10.1017/cbo9780511635700.007openalex-snapshot

The healthy cell bias of estrogen action through regulating glucose metabolism and mitochondrial function: implications for prevention of Alzheimer's disease

inferred← citeshttps://doi.org/10.1021/acs.jafc.7b02569openalex-snapshot

Soyasapogenol B and Genistein Attenuate Lipopolysaccharide-Induced Memory Impairment in Mice by the Modulation of NF-κB-Mediated BDNF Expression

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b00115openalex-snapshot

Novel Multitarget-Directed Ligands (MTDLs) with Acetylcholinesterase (AChE) Inhibitory and Serotonergic Subtype 4 Receptor (5-HT4R) Agonist Activities As Potential Agents against Alzheimer’s Disease: The Design of Donecopride

inferred← citeshttps://doi.org/10.1021/acschemneuro.0c00105openalex-snapshot

Novel α-Lipoic Acid/3-n-Butylphthalide Conjugate Enhances Protective Effects against Oxidative Stress and 6-OHDA Induced Neuronal Damage

inferred← citeshttps://doi.org/10.1021/acschemneuro.2c00675openalex-snapshot

Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences

inferred← citeshttps://doi.org/10.1021/acsomega.3c06799openalex-snapshot

Experimental and Computational Insights into the Molecular Interactions between Human Transferrin and Apigenin: Implications of Natural Compounds in Targeting Neuroinflammation

inferred← citeshttps://doi.org/10.1021/cr300009xopenalex-snapshot

Bioinorganic Chemistry of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1021/jm7009364openalex-snapshot

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1021/jm901123nopenalex-snapshot

Toward a Rational Design of Multitarget-Directed Antioxidants: Merging Memoquin and Lipoic Acid Molecular Frameworks

inferred← citeshttps://doi.org/10.1038/ajh.2011.196openalex-snapshot

Role of AMP-Activated Protein Kinase in -Lipoic Acid-Induced Vasodilatation in Spontaneously Hypertensive Rats

inferred← citeshttps://doi.org/10.1038/cr.2007.75openalex-snapshot

Metabolic enzymes link morphine withdrawal with metabolic disorder

inferred← citeshttps://doi.org/10.1038/nrn2421openalex-snapshot

Brain foods: the effects of nutrients on brain function

inferred← citeshttps://doi.org/10.1038/s41392-023-01546-wopenalex-snapshot

Mitochondrial heterogeneity in diseases

inferred← citeshttps://doi.org/10.1038/srep46065openalex-snapshot

Alpha-lipoic acid ameliorates the epithelial mesenchymal transition induced by unilateral ureteral obstruction in mice

inferred← citeshttps://doi.org/10.1039/9781837676989-00032openalex-snapshot

Emerging Drug Candidates from Plants

inferred← citeshttps://doi.org/10.1039/c3md00041aopenalex-snapshot

Design, synthesis and biological evaluation of novel indano- and thiaindano-pyrazoles with potential interest for Alzheimer's disease

inferred← citeshttps://doi.org/10.1039/d1md00177aopenalex-snapshot

Boron-based hybrids as novel scaffolds for the development of drugs with neuroprotective properties

inferred← citeshttps://doi.org/10.1039/d6cs00825aopenalex-snapshot

α-Lipoic acid: from a mitochondrial cofactor to a versatile platform for dynamic biomaterials and translational biomedicine

inferred← citeshttps://doi.org/10.1074/jbc.m114.622555openalex-snapshot

Interaction of α-Lipoic Acid with the Human Na+/Multivitamin Transporter (hSMVT)

inferred← citeshttps://doi.org/10.1080/1028415x.2017.1386755openalex-snapshot

α-Lipoic acid, functional fatty acid, as a novel therapeutic alternative for central nervous system diseases: A review

inferred← citeshttps://doi.org/10.1080/10641960701744111openalex-snapshot

Comparative Crossover, Randomized, Open-Label Bioequivalence Study on the Bioequivalence of Two Formulations of Thioctic Acid in Healthy Volunteers

inferred← citeshttps://doi.org/10.1080/10715760802644694openalex-snapshot

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

inferred← citeshttps://doi.org/10.1080/15376516.2020.1771803openalex-snapshot

Manganese-induced neurotoxicity and the potential protective effects of lipoic acid andSpirulina platensis

inferred← citeshttps://doi.org/10.1080/15376516.2023.2266027openalex-snapshot

Alpha-Lipoic acid alleviates imidacloprid-induced neuro-behavioral deficits in rats via Nrf2/HO-1 pathway

inferred← citeshttps://doi.org/10.1080/21678707.2018.1462696openalex-snapshot

Alpha lipoic acid as a novel therapeutic approach to cystinuria

inferred← citeshttps://doi.org/10.1089/ars.2020.8132openalex-snapshot

Are Reactive Sulfur Species the New Reactive Oxygen Species?

inferred← citeshttps://doi.org/10.1089/ars.2022.0077openalex-snapshot

The Effects of Antioxidant Nutraceuticals on Cellular Sulfur Metabolism and Signaling

inferred← citeshttps://doi.org/10.1089/jmf.2017.0056openalex-snapshot

Effect of Alpha-Lipoic Acid on Clinical and Neurophysiologic Recovery of Carpal Tunnel Syndrome: A Double-Blind, Randomized Clinical Trial

inferred← citeshttps://doi.org/10.1093/pnasnexus/pgac050openalex-snapshot

Cross-species metabolomic analysis of tau- and DDT-related toxicity

inferred← citeshttps://doi.org/10.1097/00767537-201003000-00010openalex-snapshot

Influence of Alpha-Lipoic Acid on Streptozotocin Induced Diabetic Cardiomyopathy in Adult Male Albino Rats

inferred← citeshttps://doi.org/10.1097/fjc.0b013e3181be7554openalex-snapshot

Antioxidant Properties of an Endogenous Thiol: Alpha-lipoic Acid, Useful in the Prevention of Cardiovascular Diseases

inferred← citeshttps://doi.org/10.1097/gme.0b013e31820db576openalex-snapshot

Reciprocal effects of α-lipoic acid on adenosine monophosphate-activated protein kinase activity in obesity induced by ovariectomy in rats

inferred← citeshttps://doi.org/10.1097/jcp.0b013e31816777f7openalex-snapshot

A Preliminary Investigation of α-Lipoic Acid Treatment of Antipsychotic Drug-Induced Weight Gain in Patients With Schizophrenia

inferred← citeshttps://doi.org/10.1097/yic.0000000000000132openalex-snapshot

Adjunctive α-lipoic acid reduces weight gain compared with placebo at 12 weeks in schizophrenic patients treated with atypical antipsychotics

inferred← citeshttps://doi.org/10.1100/2012/509838openalex-snapshot

Alfa-Lipoic Acid Controls Tumor Growth and Modulates Hepatic Redox State in Ehrlich-Ascites-Carcinoma-Bearing Mice

inferred← citeshttps://doi.org/10.1101/2021.06.14.448355openalex-snapshot

Cross-species metabolomic analysis of DDT and Alzheimer’s disease-associated tau toxicity

inferred← citeshttps://doi.org/10.1107/s0108768112004284openalex-snapshot

Structure of the inclusion complex of β-cyclodextrin with lipoic acid from laboratory powder diffraction data

inferred← citeshttps://doi.org/10.1111/1440-1681.13373openalex-snapshot

Alpha‐lipoic acid: A possible pharmacological agent for treating dry eye disease and retinopathy in diabetes

inferred← citeshttps://doi.org/10.1111/j.1399-5618.2012.01046.xopenalex-snapshot

Effects of alpha‐lipoic acid in an animal model of mania induced by d ‐amphetamine

inferred← citeshttps://doi.org/10.1111/j.1476-4431.2009.00460.xopenalex-snapshot

Therapy and outcome of suspected alpha lipoic acid toxicity in two dogs

inferred← citeshttps://doi.org/10.1111/j.1601-183x.2011.00728.xopenalex-snapshot

Genetic variants in the choline acetyltransferase (ChAT) gene are modestly associated with normal cognitive function in the elderly

inferred← citeshttps://doi.org/10.1134/s1990519x10020082openalex-snapshot

Effect of alpha-lipoic acid on 3T3 and 3T3-SV40 fibroblasts: Comparison with N-acetylcysteine

inferred← citeshttps://doi.org/10.1155/2013/454253openalex-snapshot

The Effect of Lipoic Acid Therapy on Cognitive Functioning in Patients with Alzheimer's Disease

inferred← citeshttps://doi.org/10.1155/2013/985093openalex-snapshot

Neuroprotective Activity of Thioctic Acid in Central Nervous System Lesions Consequent to Peripheral Nerve Injury

inferred← citeshttps://doi.org/10.1155/2020/5850865openalex-snapshot

The Beneficial Effects of Alpha Lipoic Acid Supplementation on Lp-PLA2 Mass and Its Distribution between HDL and apoB-Containing Lipoproteins in Type 2 Diabetic Patients: A Randomized, Double-Blind, Placebo-Controlled Trial

inferred← citeshttps://doi.org/10.1155/2023/4999306openalex-snapshot

Protective Potentials of Alpha-Lipoic Acid against Ionizing Radiation-Induced Brain Damage in Rats

inferred← citeshttps://doi.org/10.1159/000336378openalex-snapshot

Antioxidant Therapies: A Potential Role in Perinatal Medicine

inferred← citeshttps://doi.org/10.1159/000346445openalex-snapshot

Ibuprofen and Lipoic Acid Conjugate Neuroprotective Activity Is Mediated by Ngb/Akt Intracellular Signaling Pathway in Alzheimer's Disease Rat Model

inferred← citeshttps://doi.org/10.11606/d.97.2011.tde-27082013-103058openalex-snapshot

Avaliação de amidos hidrolisados, aniônico e catiônico, como tensoativos nas formulações de nanopartículas poliméricas para aplicação em filtros solares

inferred← citeshttps://doi.org/10.11606/t.74.2017.tde-03042017-104320openalex-snapshot

Parâmetros zootécnicos e perfil de ácidos graxos de juvenis de pacu (Piaractus mesopotamicus) alimentados com dietas contendo sesamina e ácido alfa-lipoico

inferred← citeshttps://doi.org/10.1176/appi.books.9798894551913.lg13openalex-snapshot

Chapter 13. Nutraceuticals and Phytoceuticals

inferred← citeshttps://doi.org/10.1177/039463201002300221openalex-snapshot

Ibuprofen and Lipoic Acid Diamide as Co-Drug with Neuroprotective Activity: Pharmacological Properties and Effects in β-Amyloid (1–40) Infused Alzheimer's Disease Rat Model

inferred← citeshttps://doi.org/10.1177/0748233712462473openalex-snapshot

Second-hand tobacco smoke and children

inferred← citeshttps://doi.org/10.1186/1755-8794-2-2openalex-snapshot

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

inferred← citeshttps://doi.org/10.1186/s12974-018-1111-yopenalex-snapshot

Early alpha-lipoic acid therapy protects from degeneration of the inner retinal layers and vision loss in an experimental autoimmune encephalomyelitis-optic neuritis model

inferred← citeshttps://doi.org/10.1186/s13059-015-0847-2openalex-snapshot

Transcriptome analysis in calorie-restricted rats implicates epigenetic and post-translational mechanisms in neuroprotection and aging

inferred← citeshttps://doi.org/10.1186/s13063-019-3431-3openalex-snapshot

Efficacy of Cognition Support Formula® on cognitive function in older adults with subjective cognitive impairment: a protocol for a 26-week, randomised, double-blind, placebo-controlled trial

inferred← citeshttps://doi.org/10.1186/s40303-016-0018-8openalex-snapshot

Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy

inferred← citeshttps://doi.org/10.1201/9780429243462-9openalex-snapshot

Micronutrients in the Prevention and Improvement of the Standard Therapy for Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1201/9781420045390.ch10openalex-snapshot

An Evaluation of the Stability and Pharmacokinetics of R-Lipoic Acid and R-Dihydrolipoic Acid Dosage Forms in Human Plasma from Healthy Subjects

inferred← citeshttps://doi.org/10.1201/9781420073522.ch10openalex-snapshot

Lipoic Acid as a Novel Treatment for Mild Cognitive Impairment and Early-Stage Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1242/dmm.049492openalex-snapshot

Integrated multi-omics analysis of Huntington disease identifies pathways that modulate protein aggregation

inferred← citeshttps://doi.org/10.12794/metadc1248456openalex-snapshot

Revisiting the Neuroprotective Role of 17B-Estradiol (E2): A Multi-Omics Based Analysis of the Rat Brain and Serum

inferred← citeshttps://doi.org/10.1515/cclm.2011.079openalex-snapshot

Advanced glycation endproducts as gerontotoxins and biomarkers for carbonyl-based degenerative processes in Alzheimer's disease

inferred← citeshttps://doi.org/10.15157/ea.v0i0.10570openalex-snapshot

Antioksüdandid Alzheimeri tõve ennetuses ja ravis

inferred← citeshttps://doi.org/10.1517/13543776.18.4.387openalex-snapshot

Progress in acetylcholinesterase inhibitors for Alzheimer's disease: an update

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Therapeutic applications of lipoic acid: a patent review (2011 – 2014)

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α-Lipoic acid: physiologic mechanisms and indications for the treatment of metabolic syndrome

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Acetyl- L -carnitine and α-lipoic acid: possible neurotherapeutic agents for mood disorders?

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