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Fisetin attenuates isoproterenol-induced cardiac ischemic injury in vivo by suppressing RAGE/NF-κB mediated oxidative stress, apoptosis and inflammation
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/ijc.26178openalex-snapshot
Dual inhibition of phosphatidylinositol 3‐kinase/Akt and mammalian target of rapamycin signaling in human nonsmall cell lung cancer cells by a dietary flavonoid fisetin
inferredcites →https://doi.org/10.1002/jbt.21583openalex-snapshot
Antihyperlipidemic Effect of Fisetin, a Bioflavonoid of Strawberries, Studied in Streptozotocin‐Induced Diabetic Rats
inferredcites →https://doi.org/10.1006/abio.1976.9999openalex-snapshot
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
inferredcites →https://doi.org/10.1007/s00395-016-0583-0openalex-snapshot
The spleen contributes importantly to myocardial infarct exacerbation during post-ischemic reperfusion in mice via signaling between cardiac HMGB1 and splenic RAGE
inferredcites →https://doi.org/10.1007/s10495-014-1083-zopenalex-snapshot
5-HT2B receptor blockade attenuates β-adrenergic receptor-stimulated myocardial remodeling in rats via inhibiting apoptosis: role of MAPKs and HSPs
inferredcites →https://doi.org/10.1007/s10571-015-0272-9openalex-snapshot
Fisetin Imparts Neuroprotection in Experimental Diabetic Neuropathy by Modulating Nrf2 and NF-κB Pathways
inferredcites →https://doi.org/10.1007/s10753-014-9883-4openalex-snapshot
Anti-septic Effects of Fisetin In Vitro and In Vivo
inferredcites →https://doi.org/10.1007/s11897-012-0089-5openalex-snapshot
Receptor for Advanced Glycation End Products (RAGE) and Implications for the Pathophysiology of Heart Failure
inferredcites →https://doi.org/10.1016/0003-2697(79)90738-3openalex-snapshot
Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
inferredcites →https://doi.org/10.1016/0304-4165(79)90289-7openalex-snapshot
Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver
inferredcites →https://doi.org/10.1016/j.ejphar.2010.06.065openalex-snapshot
Cardioprotective effect of melatonin against isoproterenol induced myocardial infarction in rats: A biochemical, electrocardiographic and histoarchitectural evaluation
inferredcites →https://doi.org/10.1016/j.etp.2010.11.013openalex-snapshot
Crocus sativus L. (saffron) attenuates isoproterenol-induced myocardial injury via preserving cardiac functions and strengthening antioxidant defense system
inferredcites →https://doi.org/10.1016/j.hlc.2015.11.005openalex-snapshot
Improvement of Left Ventricular Remodelling by Inhibition of NF-κB in a Rat Model of Myocardial Infarction
inferredcites →https://doi.org/10.1016/j.intimp.2015.11.014openalex-snapshot
Fisetin inhibits TNF-α-induced inflammatory action and hydrogen peroxide-induced oxidative damage in human keratinocyte HaCaT cells through PI3K/AKT/Nrf-2-mediated heme oxygenase-1 expression
inferredcites →https://doi.org/10.1016/j.jnutbio.2015.10.004openalex-snapshot
Fisetin, a dietary flavonoid, ameliorates experimental colitis in mice: Relevance of NF-κB signaling
inferredcites →https://doi.org/10.1016/j.phymed.2016.07.015openalex-snapshot
Kampeferol protects against oxidative stress and apoptotic damage in experimental model of isoproterenol-induced cardiac toxicity in rats
inferredcites →https://doi.org/10.1016/s0140-6736(12)61689-4openalex-snapshot
Disability-adjusted life years (DALYs) for 291 diseases and injuries in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
inferredcites →https://doi.org/10.1021/jp907071vopenalex-snapshot
Electrochemical and Density Functional Theory Study on the Reactivity of Fisetin and Its Radicals: Implications on in Vitro Antioxidant Activity
inferredcites →https://doi.org/10.1080/10286020.2014.932351openalex-snapshot
Anti-inflammatory activity of fisetin in human gingival fibroblasts treated with lipopolysaccharide
inferredcites →https://doi.org/10.1089/jmf.2012.2191openalex-snapshot
Maslinic Acid Protects Against Isoproterenol-Induced Cardiotoxicity in Albino Wistar Rats
inferredcites →https://doi.org/10.1093/carcin/bgn078openalex-snapshot
Fisetin, a novel dietary flavonoid, causes apoptosis and cell cycle arrest in human prostate cancer LNCaP cells
inferredcites →https://doi.org/10.1093/eurjhf/hfq231openalex-snapshot
Increased Serum High-Mobility Group Box-1 and Cleaved Receptor for Advanced Glycation Endproducts Levels and Decreased Endogenous Secretory Receptor for Advanced Glycation Endproducts Levels in Diabetic and Non-Diabetic Patients with Heart Failure
inferredcites →https://doi.org/10.1093/jn/130.9.2243openalex-snapshot
Dietary Intakes of Flavonols, Flavones and Isoflavones by Japanese Women and the Inverse Correlation between Quercetin Intake and Plasma LDL Cholesterol Concentration
inferredcites →https://doi.org/10.1093/jn/135.3.525openalex-snapshot
Low Concentrations of Flavonoids Are Protective in Rat H4IIE Cells Whereas High Concentrations Cause DNA Damage and Apoptosis,
inferredcites →https://doi.org/10.1111/j.1432-1033.1974.tb03714.xopenalex-snapshot
Involvement of the Superoxide Anion Radical in the Autoxidation of Pyrogallol and a Convenient Assay for Superoxide Dismutase
inferredcites →https://doi.org/10.1139/cjpp-2015-0135openalex-snapshot
Cardioprotective effect of pioglitazone in diabetic and non-diabetic rats subjected to acute myocardial infarction involves suppression of AGE-RAGE axis and inhibition of apoptosis
inferredcites →https://doi.org/10.1139/cjpp-2016-0147openalex-snapshot
Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia
inferredcites →https://doi.org/10.1161/circulationaha.105.575993openalex-snapshot
Receptor for Advanced-Glycation End Products
inferredcites →https://doi.org/10.1161/circulationaha.113.004046openalex-snapshot
The Global Burden of Ischemic Heart Disease in 1990 and 2010
inferredcites →https://doi.org/10.1177/1753944714531638openalex-snapshot
Exploration of pharmacological interventions to prevent isoproterenol-induced myocardial infarction in experimental models
inferredcites →https://doi.org/10.1186/s12986-015-0004-7openalex-snapshot
Inhibition of TGF-β by a novel PPAR-γ agonist, chrysin, salvages β-receptor stimulated myocardial injury in rats through MAPKs-dependent mechanism
inferredcites →https://doi.org/10.1371/journal.pone.0021226openalex-snapshot
Fisetin Lowers Methylglyoxal Dependent Protein Glycation and Limits the Complications of Diabetes
inferredcites →https://doi.org/10.1371/journal.pone.0105070openalex-snapshot
Ameliorative Effect of Fisetin on Cisplatin-Induced Nephrotoxicity in Rats via Modulation of NF-κB Activation and Antioxidant Defence
inferredcites →https://doi.org/10.2174/1871527313666140806144831openalex-snapshot
Receptor for AGEs (RAGE) as Mediator of NF-kB Pathway Activation in Neuroinflammation and Oxidative Stress
inferredcites →https://doi.org/10.2188/jea.8.168openalex-snapshot
Japanese Intake of Flavonoids and Isoflavonoids from Foods
inferredcites →https://doi.org/10.22074/cellj.2016.4148openalex-snapshot
Lavandula Reduces Heart Injury via Attenuating Tumor Necrosis Factor-Alpha and Oxidative Stress in A Rat Model of Infarct-Like Myocardial Injury.
inferredcites →https://doi.org/10.3109/08923973.2011.648270openalex-snapshot
Inhibition of c-Jun N-terminal kinase and nuclear factor κ B pathways mediates fisetin-exerted anti-inflammatory activity in lipopolysccharide-treated RAW264.7 cells
inferredcites →https://doi.org/10.3390/ijms161126040openalex-snapshot
Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats
inferredcites →https://doi.org/10.3390/ijms18040852openalex-snapshot
Fisetin Protects PC12 Cells from Tunicamycin-Mediated Cell Death via Reactive Oxygen Species Scavenging and Modulation of Nrf2-Driven Gene Expression, SIRT1 and MAPK Signaling in PC12 Cells
inferredcites →https://doi.org/10.3892/ijmm.2016.2474openalex-snapshot
HMGB1 induces apoptosis and EMT in association with increased autophagy following H/R injury in cardiomyocytes
inferredcites →https://doi.org/10.3892/ijmm.2017.2987openalex-snapshot
Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells
inferredcites →https://doi.org/10.3892/ijo.18.6.1175openalex-snapshot
Fisetin induces transcription of NADPH:quinone oxidoreductase gene through an antioxidant responsive element-involved activation
inferredcites →https://doi.org/10.3892/ijo.2011.1116openalex-snapshot
The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells
inferredcites →https://doi.org/10.3892/ijo.2017.3970openalex-snapshot
Carnosic acid and fisetin combination therapy enhances inhibition of lung cancer through apoptosis induction
inferredcites →https://doi.org/10.3892/or.2017.5676openalex-snapshot
Fisetin inhibits liver cancer growth in a mouse model: Relation to dopamine receptor
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4673402openalex-extracted
Shengxian Decoction Protects Against Obesity-Induced Cardiac Injuryin Rats by Regulating the Hk1/Nlrp3 Signalling Pathway
inferred← citeshttps://doi.org/10.1002/adfm.202108630openalex-snapshot
Combined Methylglyoxal Scavenger and Collagen Hydrogel Therapy Prevents Adverse Remodeling and Improves Cardiac Function Post‐Myocardial Infarction
inferred← citeshttps://doi.org/10.1002/jat.70358openalex-snapshot
PM2.5 Exacerbates Airway Inflammation and Epithelial Barrier Disruption in Chronic Obstructive Pulmonary Disease Mice Through the RAGE‐Dependent PERK/eIF2α/ATF4/CHOP Pathway
inferred← citeshttps://doi.org/10.1002/jbt.22785openalex-snapshot
Cardioprotective effects of azilsartan compared with that of telmisartan on an in vivo model of myocardial ischemia‐reperfusion injury
inferred← citeshttps://doi.org/10.1002/tox.23456openalex-snapshot
Platelet‐rich plasma exhibits anti‐inflammatory effect and attenuates cardiomyocyte damage by reducing NF‐κB and enhancing VEGF expression in isoproterenol induced cardiotoxicity model
inferred← citeshttps://doi.org/10.1007/978-3-030-94753-8_23-1openalex-snapshot
Fisetin: Advances on Resources, Biosynthesis Pathway, Bioavailability, Bioactivity, and Pharmacology
inferred← citeshttps://doi.org/10.1007/978-3-031-37534-7_15openalex-snapshot
Potential Benefits of Bioactive Functional Components of Citrus Fruits for Health Promotion and Disease Prevention
inferred← citeshttps://doi.org/10.1007/978-981-13-1745-3_4-1openalex-snapshot
Dietary Flavonols and O-Glycosides
inferred← citeshttps://doi.org/10.1007/978-981-15-4148-3_4openalex-snapshot
Dietary Flavonols and O-Glycosides
inferred← citeshttps://doi.org/10.1007/s00210-025-04912-3openalex-snapshot
Fisetin: a multitarget flavonol bridging oxidative stress, inflammation, aging, and cancer
inferred← citeshttps://doi.org/10.1007/s10522-025-10230-1openalex-snapshot
Fisetin: hormesis accounts for many of its chemoprotective effects
inferred← citeshttps://doi.org/10.1007/s10557-022-07362-8openalex-snapshot
NF-κB, A Potential Therapeutic Target in Cardiovascular Diseases
inferred← citeshttps://doi.org/10.1007/s10561-021-09915-xopenalex-snapshot
Human amniotic membrane mesenchymal stem cells exert cardioprotective effects against isoproterenol (ISO)-induced myocardial injury through suppression of inflammation and modulation of inflammatory MAPK/NF-κB pathway
inferred← citeshttps://doi.org/10.1007/s10787-019-00680-8openalex-snapshot
Therapeutic potential of IKK-β inhibitors from natural phenolics for inflammation in cardiovascular diseases
inferred← citeshttps://doi.org/10.1007/s10787-020-00708-4openalex-snapshot
Gentianella acuta prevents acute myocardial infarction induced by isoproterenol in rats via inhibition of galectin-3/TLR4/MyD88/NF-кB inflammatory signalling
inferred← citeshttps://doi.org/10.1007/s12013-021-01026-4openalex-snapshot
FIsetin Preserves Interfibrillar Mitochondria to Protect Against Myocardial Ischemia-Reperfusion Injury
inferred← citeshttps://doi.org/10.1007/s13659-020-00286-6openalex-snapshot
Sesamol Alleviates the Cytotoxic Effect of Cyclophosphamide on Normal Human Lung WI-38 Cells via Suppressing RAGE/NF-κB/Autophagy Signaling
inferred← citeshttps://doi.org/10.1007/s40200-024-01502-7openalex-snapshot
The protective effects of fisetin in metabolic disorders: a focus on oxidative stress and associated events
inferred← citeshttps://doi.org/10.1007/s43032-021-00615-1openalex-snapshot
Protective Effects of Fisetin in the Mice Induced by Long-Term Scrotal Hyperthermia
inferred← citeshttps://doi.org/10.1016/j.abb.2020.108572openalex-snapshot
The molecular mechanism involved in cardioprotection by the dietary flavonoid fisetin as an agonist of PPAR-γ in a murine model of myocardial infarction
inferred← citeshttps://doi.org/10.1016/j.abb.2025.110716openalex-snapshot
Fisetin promotes ischemic flap survival by enhancing autophagy via inhibition of the PI3K/Akt/mTOR signaling pathway
inferred← citeshttps://doi.org/10.1016/j.arcmed.2020.10.009openalex-snapshot
Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress
inferred← citeshttps://doi.org/10.1016/j.biopha.2024.117367openalex-snapshot
Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-κB pathway in heart failure
inferred← citeshttps://doi.org/10.1016/j.cbi.2022.109869openalex-snapshot
Harnessing the therapeutic potential of fisetin and its nanoparticles: Journey so far and road ahead
inferred← citeshttps://doi.org/10.1016/j.cbi.2024.110890openalex-snapshot
Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting sirtuin 6
inferred← citeshttps://doi.org/10.1016/j.cbi.2025.111489openalex-snapshot
Flavonoids and their role in oxidative stress, inflammation, and human diseases
inferred← citeshttps://doi.org/10.1016/j.cpcardiol.2026.103400openalex-snapshot
Flavonoids as potential modulators targeting lipoprotein lipase in combating cardiovascular disorders: Mechanistic insights, pharmacological activity and drug delivery approaches
inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.176298openalex-snapshot
Fisetin suppresses ferroptosis through Nrf2 and attenuates intervertebral disc degeneration in rats
inferred← citeshttps://doi.org/10.1016/j.exger.2020.111006openalex-snapshot
Fisetin prevents the aging-associated decline in relative spectral power of α, β and linked MUA in the cortex and behavioral alterations
inferred← citeshttps://doi.org/10.1016/j.ijpharm.2023.123673openalex-snapshot
PEG-modified nano liposomes co-deliver Apigenin and RAGE-siRNA to protect myocardial ischemia injury
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Exploring nanoformulation drug delivery of herbal actives for enhanced therapeutic efficacy: A comprehensive review
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2019.108253openalex-snapshot
Oral flavonoid fisetin treatment protects against prolonged high-fat-diet-induced cardiac dysfunction by regulation of multicombined signaling
inferred← citeshttps://doi.org/10.1016/j.lfs.2021.120106openalex-snapshot
Catecholamine-induced cardiotoxicity: A critical element in the pathophysiology of stroke-induced heart injury
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The use of geroprotectors to prevent multimorbidity: Opportunities and challenges
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Roles of flavonoids in ischemic heart disease: Cardioprotective effects and mechanisms against myocardial ischemia and reperfusion injury
inferred← citeshttps://doi.org/10.1038/s41598-020-74246-yopenalex-snapshot
The cardioprotective effects of the new crystal form of puerarin in isoproterenol-induced myocardial ischemia rats based on metabolomics
inferred← citeshttps://doi.org/10.1038/s41598-021-87257-0openalex-snapshot
Fisetin inhibits lipopolysaccharide-induced inflammatory response by activating β-catenin, leading to a decrease in endotoxic shock
inferred← citeshttps://doi.org/10.1080/09603123.2025.2609876openalex-snapshot
Bioinformatic and chemoinformatic insights into mRNA and lncRNA dysregulation in metabolically associated fatty liver disease: the role of exercise and antioxidants following air pollution exposure
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D‐pinitol attenuates isoproterenol‐induced myocardial infarction by alleviating cardiac inflammation, oxidative stress and ultrastructural changes in Swiss albino mice
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(E)-N ′ -(1-(7-Hydroxy-2-Oxo-2H-Chromen-3-Yl) Ethylidene) Benzohydrazide, a Novel Synthesized Coumarin, Ameliorates Isoproterenol-Induced Myocardial Infarction in Rats through Attenuating Oxidative Stress, Inflammation, and Apoptosis
inferred← citeshttps://doi.org/10.1186/s42826-024-00218-2openalex-snapshot
Flavonoids as therapeutics for myocardial ischemia-reperfusion injury: a comprehensive review on preclinical studies
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Cardioprotection of cortistatin against isoproterenol-induced myocardial injury in rats
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Fisetin suppresses chondrocyte senescence and attenuates osteoarthritis progression by targeting SIRT6
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Flavonoids as Potential Cardioprotective Agents against Myocarditis
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Therapeutic Potential and Molecular Mechanisms of the Multitargeted Flavonoid Fisetin
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Sympathetic overactivation and catecholamine toxicity: mechanisms and therapeutic strategies for neurogenic heart injury following acute ischemic stroke
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Flavonoids as Natural Anti-Inflammatory Agents Targeting Nuclear Factor-Kappa B (NFκB) Signaling in Cardiovascular Diseases: A Mini Review
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Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy
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Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability
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Natural Products Acting as Senolytics and Senomorphics Alleviate Cardiovascular Diseases by Targeting Senescent Cells
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Freeze-Dried Powder of Rubus coreanus Miquel Ameliorates Isoproterenol-Induced Oxidative Stress and Tissue Damage in Rats
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Assessment of the biosafety profile of Galium verum in vitro on myoblasts and in ovo on chorioallantoic membrane
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Additional file 1 of Flavonoids as therapeutics for myocardial ischemia-reperfusion injury: a comprehensive review on preclinical studies
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Biochanin A Mitigates Oxidative Stress and Inflammation in Diabetic Myocardial Infarction: Insights From a Streptozotocin and Isoproterenol Rat Model
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