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Low Concentrations of Flavonoids Are Protective in Rat H4IIE Cells Whereas High Concentrations Cause DNA Damage and Apoptosis,
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/biof.5520120129openalex-snapshot
Metabolic fate of luteolin and its functional activity at focal site
inferredcites →https://doi.org/10.1006/abio.1976.9999openalex-snapshot
A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
inferredcites →https://doi.org/10.1006/mgme.1999.2901openalex-snapshot
Prooxidant Activity of Flavonoids: Copper-Dependent Strand Breaks and the Formation of 8-Hydroxy-2′-Deoxyguanosine in DNA
inferredcites →https://doi.org/10.1007/s00204-002-0346-6openalex-snapshot
Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1
inferredcites →https://doi.org/10.1007/s002280000197openalex-snapshot
Pharmacokinetics of quercetin from quercetin aglycone and rutin in healthy volunteers
inferredcites →https://doi.org/10.1007/s003940050043openalex-snapshot
Dietary flavonoids protect human colonocyte DNA from oxidative attack in vitro
inferredcites →https://doi.org/10.1007/s003940050054openalex-snapshot
Comparative analysis of the effects of flavonoids on proliferation, cytotoxicity, and apoptosis in human colon cancer cell lines
inferredcites →https://doi.org/10.1016/0006-2952(86)90461-2openalex-snapshot
Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids
inferredcites →https://doi.org/10.1016/0014-4827(88)90265-0openalex-snapshot
A simple technique for quantitation of low levels of DNA damage in individual cells
inferredcites →https://doi.org/10.1016/0022-1759(83)90303-4openalex-snapshot
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
inferredcites →https://doi.org/10.1016/0027-5107(84)90118-0openalex-snapshot
Superoxide dismutase acts as an enhancing factor for quercetin mutagenesis in rat-liver cytosol by preventing its decomposition
inferredcites →https://doi.org/10.1016/0147-6513(86)90030-8openalex-snapshot
In vitro cytotoxicity testing of aquatic pollutants (cadmium, copper, zinc, nickel) using established fish cell lines
inferredcites →https://doi.org/10.1016/0278-6915(95)00077-1openalex-snapshot
Review of the biology of quercetin and related bioflavonoids
inferredcites →https://doi.org/10.1016/0891-5849(93)90035-sopenalex-snapshot
A comparative evaluation of thiobarbituric acid methods for the determination of malondialdehyde in biological materials
inferredcites →https://doi.org/10.1016/j.tox.2004.07.022openalex-snapshot
Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells
inferredcites →https://doi.org/10.1016/j.toxlet.2003.12.071openalex-snapshot
The modulating effects of quercetin and rutin on the mitomycin C induced DNA damage
inferredcites →https://doi.org/10.1016/s0014-2999(99)00649-4openalex-snapshot
Exposure of rat thymocytes to hydrogen peroxide increases annexin V binding to membranes: inhibitory actions of deferoxamine and quercetin
inferredcites →https://doi.org/10.1016/s0014-5793(97)00467-5openalex-snapshot
Bioavailability of rutin and quercetin in rats
inferredcites →https://doi.org/10.1016/s0014-5793(97)01367-7openalex-snapshot
Relative bioavailability of the antioxidant flavonoid quercetin from various foods in man
inferredcites →https://doi.org/10.1016/s0027-5107(99)00029-9openalex-snapshot
Mechanism of oxidative DNA damage induced by quercetin in the presence of Cu(II)
inferredcites →https://doi.org/10.1016/s0031-6997(24)01472-8openalex-snapshot
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
inferredcites →https://doi.org/10.1016/s0165-1218(97)00010-4openalex-snapshot
The effect of dietary flavonoids on DNA damage (strand breaks and oxidised pyrimdines) and growth in human cells
inferredcites →https://doi.org/10.1016/s0891-5849(98)00167-1openalex-snapshot
Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product
inferredcites →https://doi.org/10.1016/s0891-5849(98)00315-3openalex-snapshot
Antioxidant activity applying an improved ABTS radical cation decolorization assay
inferredcites →https://doi.org/10.1038/nsmb743openalex-snapshot
A receptor for green tea polyphenol EGCG
inferredcites →https://doi.org/10.1042/0264-6021:3580547openalex-snapshot
Flavonoids protect neurons from oxidized low-density-lipoprotein-induced apoptosis involving c-Jun N-terminal kinase (JNK), c-Jun and caspase-3
inferredcites →https://doi.org/10.1042/bst0240785openalex-snapshot
Role of dietary flavonoids in protection against cancer and coronary heart disease
inferredcites →https://doi.org/10.1042/bst0280022openalex-snapshot
Cytotoxicity, genotoxicity and oxidative reactions in cell-culture models: modulatory effects of phytochemicals
inferredcites →https://doi.org/10.1046/j.1464-410x.2002.02790.xopenalex-snapshot
Polyphenols in red wine inhibit the proliferation and induce apoptosis of LNCaP cells
inferredcites →https://doi.org/10.1080/1071576021000016463openalex-snapshot
Interactions of Flavonoids with Iron and Copper Ions: A Mechanism for their Antioxidant Activity
inferredcites →https://doi.org/10.1080/10715769900301141openalex-snapshot
The sugar moiety is a major determinant of the absorption of dietary flavonoid glycosides in man
inferredcites →https://doi.org/10.1080/15216549900201423openalex-snapshot
Different effects of the constituents of EGb761 on apoptosis in rat cerebellar granule cells induced by hydroxyl radicals
inferredcites →https://doi.org/10.1093/ajcn/76.3.560openalex-snapshot
Flavonoid intake and risk of chronic diseases
inferredcites →https://doi.org/10.1093/carcin/19.9.1583openalex-snapshot
Quercetin inhibits hydrogen peroxide (H2O2)-induced NF-kappaB DNA binding activity and DNA damage in HepG2 cells
inferredcites →https://doi.org/10.1093/jn/128.3.593openalex-snapshot
Supplementation with Quercetin Markedly Increases Plasma Quercetin Concentration without Effect on Selected Risk Factors for Heart Disease in Healthy Subjects
inferredcites →https://doi.org/10.1093/jn/130.5.1200openalex-snapshot
Bioavailabilities of Quercetin-3-Glucoside and Quercetin-4′-Glucoside Do Not Differ in Humans
inferredcites →https://doi.org/10.1093/jn/130.8.2073sopenalex-snapshot
Dietary Intake and Bioavailability of Polyphenols
inferredcites →https://doi.org/10.1093/jn/131.3.745openalex-snapshot
Red Wine Is a Poor Source of Bioavailable Flavonols in Men
inferredcites →https://doi.org/10.1093/jn/134.3.552openalex-snapshot
Quercetin Metabolites Downregulate Cyclooxygenase-2 Transcription in Human Lymphocytes Ex Vivo but Not In Vivo
inferredcites →https://doi.org/10.1093/mutage/9.5.445openalex-snapshot
On the mechanisms of genotoxicity and metabolism of quercetin
inferredcites →https://doi.org/10.1124/jpet.103.050351openalex-snapshot
In Vitro Cytotoxicity of 4-Methylcatechol in Murine Tumor Cells: Induction of Apoptotic Cell Death by Extracellular Pro-Oxidant Action
inferredcites →https://doi.org/10.1152/ajpregu.2000.279.2.r461openalex-snapshot
Accumulation of quercetin conjugates in blood plasma after the short-term ingestion of onion by women
inferredcites →https://doi.org/10.1177/00912700122010366openalex-snapshot
Pharmacokinetics and Bioavailability of Quercetin Glycosides in Humans
inferredcites →https://doi.org/10.1207/s15327914nc340113openalex-snapshot
Quercetin-Induced Apoptosis in Colorectal Tumor Cells: Possible Role of EGF Receptor Signaling
inferredcites →https://doi.org/10.3892/ijo.19.4.837openalex-snapshot
Induction of cell cycle arrest and apoptosis in human breast cancer cells by quercetin
inferredcites →https://doi.org/10.5414/cpp40207openalex-snapshot
Methylation of quercetin and fisetin, flavonoids widely distributed in edible vegetables, fruits and wine, by human liver
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1002/9781444323375.ch6openalex-snapshot
Biological Activity of Phenolics in Plant Cells
inferred← citeshttps://doi.org/10.1002/cbdv.202402342openalex-snapshot
Phytochemical Characterization, Prooxidant, Antiproliferative and Anti‐Inflammatory Potential of Meyna spinosa Roxb. Ex Link Ripe Fruit
inferred← citeshttps://doi.org/10.1002/cbin.10251openalex-snapshot
Effect of photodynamic therapy supplemented with quercetin in HEp‐2 cells
inferred← citeshttps://doi.org/10.1002/cbin.11942openalex-snapshot
Study of quercetin and fisetin synergistic effect on breast cancer and potentially involved signaling pathways
inferred← citeshttps://doi.org/10.1002/ejoc.201100573openalex-snapshot
Redox Properties and Cytotoxicity of Synthetic Isomeric Mitochondriotropic Derivatives of the Natural Polyphenol Quercetin
inferred← citeshttps://doi.org/10.1002/em.20199openalex-snapshot
Quercetin reduces chromosome aberrations induced by atrazine in theAllium cepatest
inferred← citeshttps://doi.org/10.1002/jat.1725openalex-snapshot
Selective apoptotic effects of piceatannol and myricetin in human cancer cells
inferred← citeshttps://doi.org/10.1002/jbt.70736openalex-snapshot
Naringin Mitigates Synergistic Brain Aging Model Induced by D‐Galactose and Gamma Radiation via Targeting Oxidative Stress, Inflammation and Senescence
inferred← citeshttps://doi.org/10.1002/jsfa.70699openalex-snapshot
Neuroprotective effects of quercetin in animal models of neurodegenerative diseases: A systematic review and meta‐analysis
inferred← citeshttps://doi.org/10.1002/mnfr.200700203openalex-snapshot
Time‐course regulation of quercetin on cell survival/proliferation pathways in human hepatoma cells
inferred← citeshttps://doi.org/10.1002/mnfr.201300362openalex-snapshot
Quercetin prevents liver carcinogenesis by inducing cell cycle arrest, decreasing cell proliferation and enhancing apoptosis
inferred← citeshttps://doi.org/10.1002/mnfr.201400592openalex-snapshot
Rooibos flavonoids, orientin and luteolin, stimulate mineralization in human osteoblasts through the Wnt pathway
inferred← citeshttps://doi.org/10.1002/mnfr.202100210openalex-snapshot
Flavonoid‐Like Components of Peanut Stem and Leaf Extract Promote Sleep by Decreasing Neuronal Excitability
inferred← citeshttps://doi.org/10.1002/ptr.2883openalex-snapshot
Antioxidant and antimutagenic effect of quercetin against DEN induced hepatotoxicity in rat
inferred← citeshttps://doi.org/10.1002/tox.22075openalex-snapshot
Dual effects of quercetin in doxorubicin‐induced nephrotoxicity in rats and its modulation of the cytotoxic activity of doxorubicin on human carcinoma cells
inferred← citeshttps://doi.org/10.1002/tox.22265openalex-snapshot
Harmonization of Mangiferin on methylmercury engendered mitochondrial dysfunction
inferred← citeshttps://doi.org/10.1007/978-3-642-30018-9_160openalex-snapshot
Strategies to Target Mitochondria and Oxidative Stress by Antioxidants
inferred← citeshttps://doi.org/10.1007/978-981-15-2874-3_12openalex-snapshot
Nutrigenomics Approaches to Control Metabolic Diseases and Challenges to Personalized Nutritional Intervention
inferred← citeshttps://doi.org/10.1007/s00210-014-1034-9openalex-snapshot
Pharmacologic overview of systemic chlorogenic acid therapy on experimental wound healing
inferred← citeshttps://doi.org/10.1007/s00394-011-0204-5openalex-snapshot
In vitro activity of dietary flavonol congeners against human cancer cell lines
inferred← citeshttps://doi.org/10.1007/s10068-021-00899-8openalex-snapshot
Anticancer activity of flavonoids accompanied by redox state modulation and the potential for a chemotherapeutic strategy
inferred← citeshttps://doi.org/10.1007/s10517-022-05626-9openalex-snapshot
Suppression of the Antioxidant System and PI3K/Akt/mTOR Signaling Pathway in Cisplatin-Resistant Cancer Cells by Quercetin
inferred← citeshttps://doi.org/10.1007/s10522-025-10230-1openalex-snapshot
Fisetin: hormesis accounts for many of its chemoprotective effects
inferred← citeshttps://doi.org/10.1007/s10787-018-00561-6openalex-snapshot
The citrus flavanone naringenin attenuates zymosan-induced mouse joint inflammation: induction of Nrf2 expression in recruited CD45+ hematopoietic cells
inferred← citeshttps://doi.org/10.1007/s10863-009-9198-6openalex-snapshot
The flavonoid quercetin induces changes in mitochondrial permeability by inhibiting adenine nucleotide translocase
inferred← citeshttps://doi.org/10.1007/s11033-012-1621-0openalex-snapshot
Quercetin-induced apoptosis of HL-60 cells by reducing PI3K/Akt
inferred← citeshttps://doi.org/10.1007/s11033-018-4275-8openalex-snapshot
Vicenin-2: a potential radiosensitizer of non-small cell lung cancer cells
inferred← citeshttps://doi.org/10.1007/s11033-021-06779-yopenalex-snapshot
Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson’s disease
inferred← citeshttps://doi.org/10.1007/s11094-023-02896-zopenalex-snapshot
Histopathological and Enzymological Evaluation of Opium Tincture and Protective Effects of Chicory Extract on Liver Structure in Adult Male Rats
inferred← citeshttps://doi.org/10.1007/s11095-011-0587-2openalex-snapshot
Strategies to Target Mitochondria and Oxidative Stress by Antioxidants: Key Points and Perspectives
inferred← citeshttps://doi.org/10.1007/s11626-013-9681-6openalex-snapshot
Fisetin attenuates hydrogen peroxide-induced cell damage by scavenging reactive oxygen species and activating protective functions of cellular glutathione system
inferred← citeshttps://doi.org/10.1007/s12011-008-8289-2openalex-snapshot
Biosafety of Flavonoids in Rats: Effects on Copper and Zinc Homeostasis and Interaction with Low-Level Pesticide Exposure
inferred← citeshttps://doi.org/10.1007/s12013-012-9447-xopenalex-snapshot
Isoliquiritigenin Enhances Radiosensitivity of HepG2 Cells via Disturbance of Redox Status
inferred← citeshttps://doi.org/10.1007/s12013-015-0549-0openalex-snapshot
Combination Approach: the Future of the War Against Cancer
inferred← citeshttps://doi.org/10.1007/s12263-011-0255-5openalex-snapshot
Do polyphenols enter the brain and does it matter? Some theoretical and practical considerations
inferred← citeshttps://doi.org/10.1007/s12640-016-9604-xopenalex-snapshot
An In Vitro Study of the Neurotoxic Effects of N-Benzylpiperazine: A Designer Drug of Abuse
inferred← citeshttps://doi.org/10.1007/s13273-011-0044-7openalex-snapshot
ERK1/2 activation in quercetin-treated BEAS-2B cell plays a role in Nrf2-driven HO-1 expression
inferred← citeshttps://doi.org/10.1007/s13668-022-00423-2openalex-snapshot
The Underexplored Dimensions of Nutritional Hormesis
inferred← citeshttps://doi.org/10.1007/s13765-013-4201-7openalex-snapshot
Standardized Rhus verniciflua stokes extract and its major flavonoid fustin attenuate oxidative stress induced by tert-butyl hydroperoxide via activation of nuclear factor erythroid 2-related factor
inferred← citeshttps://doi.org/10.1016/b978-0-12-409517-5.00011-5openalex-snapshot
Generating Biomedical Polyphenolic Compounds from Spent Coffee or Silverskin
inferred← citeshttps://doi.org/10.1016/j.ajt.2024.01.001openalex-snapshot
Utilizing pathophysiological concepts of ischemia-reperfusion injury to design renoprotective strategies and therapeutic interventions for normothermic ex vivo kidney perfusion
inferred← citeshttps://doi.org/10.1016/j.animal.2024.101287openalex-snapshot
Review: Herbivory and the power of phytochemical diversity on animal health
inferred← citeshttps://doi.org/10.1016/j.arabjc.2012.05.001openalex-snapshot
A quest for staunch effects of flavonoids: Utopian protection against hepatic ailments
inferred← citeshttps://doi.org/10.1016/j.bbabio.2009.06.002openalex-snapshot
Quercetin can act either as an inhibitor or an inducer of the mitochondrial permeability transition pore: A demonstration of the ambivalent redox character of polyphenols
inferred← citeshttps://doi.org/10.1016/j.bcp.2008.03.013openalex-snapshot
Role of Bax in quercetin-induced apoptosis in human prostate cancer cells
inferred← citeshttps://doi.org/10.1016/j.biochi.2006.09.006openalex-snapshot
Role of quercetin and its in vivo metabolites in protecting H9c2 cells against oxidative stress
inferred← citeshttps://doi.org/10.1016/j.biopha.2017.02.075openalex-snapshot
Polyalthia longifolia Methanolic Leaf Extracts (PLME) induce apoptosis, cell cycle arrest and mitochondrial potential depolarization by possibly modulating the redox status in hela cells
inferred← citeshttps://doi.org/10.1016/j.biopha.2018.03.136openalex-snapshot
Dose- dependent ameliorative effects of quercetin and l-Carnitine against atrazine- induced reproductive toxicity in adult male Albino rats
inferred← citeshttps://doi.org/10.1016/j.brainres.2008.01.089openalex-snapshot
Lack of robust protective effect of quercetin in two types of 6-hydroxydopamine-induced parkinsonian models in rats and dopaminergic cell cultures
inferred← citeshttps://doi.org/10.1016/j.brainres.2008.02.018openalex-snapshot
Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons
inferred← citeshttps://doi.org/10.1016/j.canlet.2008.10.036openalex-snapshot
Cytotoxic effects of flavonoids against a human colon cancer derived cell line, COLO 201: A potential natural anti-cancer substance
inferred← citeshttps://doi.org/10.1016/j.cbi.2011.12.005openalex-snapshot
Quercetin modulates Nrf2 and glutathione-related defenses in HepG2 cells: Involvement of p38
inferred← citeshttps://doi.org/10.1016/j.cbi.2017.07.026openalex-snapshot
Flavonoids from persimmon (Diospyros kaki L.) leaves inhibit proliferation and induce apoptosis in PC-3 cells by activation of oxidative stress and mitochondrial apoptosis
inferred← citeshttps://doi.org/10.1016/j.cbpa.2012.09.007openalex-snapshot
Effects of quercetin and menadione on intestinal calcium absorption and the underlying mechanisms
inferred← citeshttps://doi.org/10.1016/j.cbpb.2007.10.004openalex-snapshot
Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin
inferred← citeshttps://doi.org/10.1016/j.ejphar.2018.02.018openalex-snapshot
The cytogenetic effects of silibinin alone and in combination with methotrexate in mouse bone marrow
inferred← citeshttps://doi.org/10.1016/j.exger.2005.08.008openalex-snapshot
Effects of Chamomilla recutita flavonoids on age-related liver sphingolipid turnover in rats
inferred← citeshttps://doi.org/10.1016/j.fbio.2021.101376openalex-snapshot
Polyphenolic bioactives as an emerging group of nutraceuticals for promotion of gut health: A review
inferred← citeshttps://doi.org/10.1016/j.fct.2006.08.008openalex-snapshot
Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells
inferred← citeshttps://doi.org/10.1016/j.fct.2008.06.006openalex-snapshot
The changes of antioxidant defense system caused by quercetin administration do not lead to DNA damage and apoptosis in the spleen and bone marrow cells of rats
inferred← citeshttps://doi.org/10.1016/j.fct.2009.07.033openalex-snapshot
Quercetin inhibits hydrogen peroxide-induced DNA damage and enhances DNA repair in Caco-2 cells
inferred← citeshttps://doi.org/10.1016/j.fct.2010.05.058openalex-snapshot
Fisetin induces apoptosis in Huh-7 cells via downregulation of BIRC8 and Bcl2L2
inferred← citeshttps://doi.org/10.1016/j.fct.2011.06.055openalex-snapshot
Cytoprotective activity against peroxide-induced oxidative damage and cytotoxicity of flavonoids in C6 rat glioma cells
inferred← citeshttps://doi.org/10.1016/j.fct.2011.12.015openalex-snapshot
Fisetin prevents fluoride- and dexamethasone-induced oxidative damage in osteoblast and hippocampal cells
inferred← citeshttps://doi.org/10.1016/j.fct.2014.02.004openalex-snapshot
High concentrations of genistein exhibit pro-oxidant effects in primary muscle cells through mechanisms involving 5-lipoxygenase-mediated production of reactive oxygen species
inferred← citeshttps://doi.org/10.1016/j.fct.2015.04.001openalex-snapshot
In vivo systemic chlorogenic acid therapy under diabetic conditions: Wound healing effects and cytotoxicity/genotoxicity profile
inferred← citeshttps://doi.org/10.1016/j.foodchem.2017.06.034openalex-snapshot
Interactions between macromolecule-bound antioxidants and Trolox during liposome autoxidation: A multivariate approach
inferred← citeshttps://doi.org/10.1016/j.foodres.2006.01.001openalex-snapshot
Effects of phenolic compounds in blueberries and muscadine grapes on HepG2 cell viability and apoptosis
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2008.11.017openalex-snapshot
Influence of polyphenols on Escherichia coli resistance to oxidative stress
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2016.12.046openalex-snapshot
Linking lipid peroxidation and neuropsychiatric disorders: focus on 4-hydroxy-2-nonenal
inferred← citeshttps://doi.org/10.1016/j.genrep.2019.100416openalex-snapshot
Sustained DDB-2 and TRX transcriptional response of quercetin-treated lymphocytes exposed to Co-60 radiation
inferred← citeshttps://doi.org/10.1016/j.heliyon.2023.e20020openalex-snapshot
Alteration of the aortic vascular reactivity associated to excessive consumption of Hibiscus sabdariffa Linnaeus: Preliminary findings
inferred← citeshttps://doi.org/10.1016/j.jarmap.2017.02.001openalex-snapshot
Analysis of phenolic compounds in Greek plants of Lamiaceae family by HPLC
inferred← citeshttps://doi.org/10.1016/j.jclepro.2022.131489openalex-snapshot
Textile colouration with natural colourants: A review
inferred← citeshttps://doi.org/10.1016/j.jddst.2019.101477openalex-snapshot
Development and optimization of stealth liposomal system for enhanced in vitro cytotoxic effect of quercetin
inferred← citeshttps://doi.org/10.1016/j.jep.2020.112728openalex-snapshot
Maternal-fetal repercussions of Phyllanthus niruri L. treatment during rat pregnancy
inferred← citeshttps://doi.org/10.1016/j.jep.2020.112922openalex-snapshot
Ethanolic extract of Moringa oleifera leaves alleviate cyclophosphamide-induced testicular toxicity by improving endocrine function and modulating cell specific gene expression in mouse testis
inferred← citeshttps://doi.org/10.1016/j.jesf.2022.06.001openalex-snapshot
Potential harms of supplementation with high doses of antioxidants in athletes
inferred← citeshttps://doi.org/10.1016/j.jff.2016.01.041openalex-snapshot
Isoquercitrin, isolated from Aster yomena triggers ROS-mediated apoptosis in Candida albicans
inferred← citeshttps://doi.org/10.1016/j.jff.2020.103988openalex-snapshot
Polyphenolic composition of extracts from winery by-products and effects on cellular cytotoxicity and mitochondrial functions in HepG2 cells
inferred← citeshttps://doi.org/10.1016/j.jff.2022.105345openalex-snapshot
Differential Uridyl-diphosphate-Glucuronosyl Transferase 1A enzymatic arsenal explains the specific cytotoxicity of resveratrol towards tumor colorectal cells
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2006.11.004openalex-snapshot
Effects of dietary flavonoids on apoptotic pathways related to cancer chemoprevention
inferred← citeshttps://doi.org/10.1016/j.jnutbio.2015.11.006openalex-snapshot
The role of natural polyphenols in cell signaling and cytoprotection against cancer development
inferred← citeshttps://doi.org/10.1016/j.jphotobiol.2019.111771openalex-snapshot
Abilities of protocatechuic acid and its alkyl esters, ethyl and heptyl protocatechuates, to counteract UVB-induced oxidative injuries and photoaging in fibroblasts L929 cell line
inferred← citeshttps://doi.org/10.1016/j.jprot.2014.05.017openalex-snapshot
The flavonoid (−)-epicatechin affects cytoskeleton proteins and functions in Entamoeba histolytica
inferred← citeshttps://doi.org/10.1016/j.jtemb.2020.126655openalex-snapshot
Pomegranate juice rescues developmental, neurobehavioral and biochemical disorders in aluminum chloride-treated male mice
inferred← citeshttps://doi.org/10.1016/j.lwt.2014.12.023openalex-snapshot
Bioprospecting Davidson's plum and quandong: Cytoprotective and proapoptotic activities
inferred← citeshttps://doi.org/10.1016/j.mce.2013.11.021openalex-snapshot
Quercetin supplementation restores testicular function and augments germ cell survival in the estrogenized rats
inferred← citeshttps://doi.org/10.1016/j.meatsci.2020.108269openalex-snapshot
Influence of adding cinnamon bark oil on meat quality of ground lamb during storage at 4 °C
inferred← citeshttps://doi.org/10.1016/j.molbiopara.2015.11.004openalex-snapshot
Kaempferol inhibits Entamoeba histolytica growth by altering cytoskeletal functions
inferred← citeshttps://doi.org/10.1016/j.mrgentox.2014.07.002openalex-snapshot
Evaluation of potential antigenotoxic, cytotoxic and proapoptotic effects of the olive oil by-product “alperujo”, hydroxytyrosol, tyrosol and verbascoside
inferred← citeshttps://doi.org/10.1016/j.nano.2013.12.010openalex-snapshot
Novel self-nanoemulsifying formulation of quercetin: Implications of pro-oxidant activity on the anticancer efficacy
inferred← citeshttps://doi.org/10.1016/j.neurobiolaging.2013.10.077openalex-snapshot
Pomegranate juice exacerbates oxidative stress and nigrostriatal degeneration in Parkinson's disease
inferred← citeshttps://doi.org/10.1016/j.nxbio.2025.100004openalex-snapshot
Gold nanoparticles derived from Selaginella bryopteris extract provide neuroprotection and ameliorate oxidative stress induced neurodegeneration in human neuronal cells (SH-SY5Y) model
inferred← citeshttps://doi.org/10.1016/j.phrs.2017.07.016openalex-snapshot
Potential anti-cancer activity of 7-O-pentyl quercetin: Efficient, membrane-targeted kinase inhibition and pro-oxidant effect
inferred← citeshttps://doi.org/10.1016/j.phymed.2018.09.187openalex-snapshot
Fisetin attenuates isoproterenol-induced cardiac ischemic injury in vivo by suppressing RAGE/NF-κB mediated oxidative stress, apoptosis and inflammation
inferred← citeshttps://doi.org/10.1016/j.reprotox.2016.02.012openalex-snapshot
Effect of Quercetin-loaded liposomes on induced oxidative stress in human spermatozoa
inferred← citeshttps://doi.org/10.1016/j.semcancer.2016.04.003openalex-snapshot
Exploring the molecular targets of dietary flavonoid fisetin in cancer
inferred← citeshttps://doi.org/10.1016/j.taap.2005.04.004openalex-snapshot
Protective and detrimental effects of kaempferol in rat H4IIE cells: Implication of oxidative stress and apoptosis
inferred← citeshttps://doi.org/10.1016/j.tifs.2017.10.003openalex-snapshot
Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies
inferred← citeshttps://doi.org/10.1016/j.tiv.2014.01.005openalex-snapshot
Acrylamide-induced apoptosis in rat primary astrocytes and human astrocytoma cell lines
inferred← citeshttps://doi.org/10.1016/j.tox.2007.09.010openalex-snapshot
Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompanied by inhibition of ERK phosphorylation
inferred← citeshttps://doi.org/10.1016/j.toxrep.2015.07.004openalex-snapshot
Fisetin targets phosphatidylinositol-3-kinase and induces apoptosis of human B lymphoma Raji cells
inferred← citeshttps://doi.org/10.1017/s0007114510000346openalex-snapshot
Quercetin, the active phenolic component in kiwifruit, prevents hydrogen peroxide-induced inhibition of gap-junction intercellular communication
inferred← citeshttps://doi.org/10.1017/s0029665116000719openalex-snapshot
Phytochemicals in animal health: diet selection and trade-offs between costs and benefits
inferred← citeshttps://doi.org/10.1021/acs.jafc.4c09069openalex-snapshot
Carbon Monoxide-Releasing Activity of Plant Flavonoids
inferred← citeshttps://doi.org/10.1021/jf060563fopenalex-snapshot
Induction of Cell Death in Caco-2 Human Colon Carcinoma Cells by Ellagic Acid Rich Fractions from Muscadine Grapes (Vitis rotundifolia)
inferred← citeshttps://doi.org/10.1021/jf500080zopenalex-snapshot
Pro-oxidative and Antioxidative Controls and Signaling Modification of Polyphenolic Phytochemicals: Contribution to Health Promotion and Disease Prevention?
inferred← citeshttps://doi.org/10.1021/tx300171uopenalex-snapshot
Carnosic Acid Prevents 6-Hydroxydopamine-Induced Cell Death in SH-SY5Y Cells via Mediation of Glutathione Synthesis
inferred← citeshttps://doi.org/10.1038/s41526-021-00162-8openalex-snapshot
Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions
inferred← citeshttps://doi.org/10.1038/s41598-017-01888-wopenalex-snapshot
Physicochemical properties of dietary phytochemicals can predict their passive absorption in the human small intestine
inferred← citeshttps://doi.org/10.1038/s41598-025-09053-4openalex-snapshot
Atopic dermatitis-related anti-inflammatory in vitro effects of a plant extract mixture
inferred← citeshttps://doi.org/10.1039/c4fo00413bopenalex-snapshot
The pleiotropic flavonoid quercetin: from its metabolism to the inhibition of protein kinases in chronic lymphocytic leukemia
inferred← citeshttps://doi.org/10.1039/c4tx00162aopenalex-snapshot
Eugenia uniflora leaves essential oil induces toxicity in Drosophila melanogaster: involvement of oxidative stress mechanisms
inferred← citeshttps://doi.org/10.1039/d2mo00267aopenalex-snapshot
A transcriptome based approach to predict candidate drug targets and drugs for Parkinson's disease using an in vitro 6-OHDA model
inferred← citeshttps://doi.org/10.1042/bst20140073openalex-snapshot
Novel flavonoids as anti-cancer agents: mechanisms of action and promise for their potential application in breast cancer
inferred← citeshttps://doi.org/10.1080/01635580903441196openalex-snapshot
Quercetin Modulates NF-κ B and AP-1/JNK Pathways to Induce Cell Death in Human Hepatoma Cells
inferred← citeshttps://doi.org/10.1080/01635581.2011.523806openalex-snapshot
Quercetin Inhibits Diethylnitrosamine-Induced Hepatic Preneoplastic Lesions in Rats
inferred← citeshttps://doi.org/10.1080/01635581.2014.864418openalex-snapshot
Site-Specific Anticancer Effects of Dietary Flavonoid Quercetin
inferred← citeshttps://doi.org/10.1080/03601230902801034openalex-snapshot
Short- and long-term exposure to low levels of pesticide and flavonoid mixtures modify endogenous antioxidants in tissues of rats
inferred← citeshttps://doi.org/10.1080/03610470.2019.1686572openalex-snapshot
Protective Roles of Hop Proanthocyanidins on Alcohol-Induced SH-SY5Y Cell Damage
inferred← citeshttps://doi.org/10.1080/10715760802626535openalex-snapshot
Inhibition of reactive oxygen species and pre-neoplastic lesions by quercetin through an antioxidant defense mechanism
inferred← citeshttps://doi.org/10.1080/13510002.2022.2101832openalex-snapshot
Beneficial role of naringin against methotrexate-induced injury to rat testes: biochemical and ultrastructural analyses
inferred← citeshttps://doi.org/10.1080/15287390802538964openalex-snapshot
Induction of DNA Double-Strand Breaks in the H4IIE Cell Line Exposed to Environmentally Relevant Concentrations of Copper, Cadmium, and Zinc, Singly and in Combinations
inferred← citeshttps://doi.org/10.1080/15287394.2016.1190675openalex-snapshot
Antimutagenic and antioxidant properties of the aqueous extracts of organic and conventional grapevineVitis labruscacv. Isabella leaves in V79 cells
inferred← citeshttps://doi.org/10.1080/15287394.2018.1562392openalex-snapshot
Toxicological aspects ofCampomanesia xanthocarpaBerg. associated with its phytochemical profile
inferred← citeshttps://doi.org/10.1089/bio.2022.0081openalex-snapshot
Does Rainbow Trout Seminal Plasma-Cysteine Combination Affect the Cryo-Survivability and Post-Thaw Incubation Resilience of Ram Semen?
inferred← citeshttps://doi.org/10.1093/carcin/bgm133openalex-snapshot
Induction of death receptor 5 and suppression of survivin contribute to sensitization of TRAIL-induced cytotoxicity by quercetin in non-small cell lung cancer cells
inferred← citeshttps://doi.org/10.1093/jn/136.11.2715openalex-snapshot
Quercetin Induces Apoptosis via Caspase Activation, Regulation of Bcl-2, and Inhibition of PI-3-Kinase/Akt and ERK Pathways in a Human Hepatoma Cell Line (HepG2)
inferred← citeshttps://doi.org/10.1093/mutage/geq004openalex-snapshot
The impact of quercetin on cisplatin-induced clastogenesis and apoptosis in murine marrow cells
inferred← citeshttps://doi.org/10.1093/nutrit/nuag144openalex-snapshot
Dose-Dependent Effects, Metabolic Paradoxes, and Nutritional Implications of Flavonoids and Cancer
inferred← citeshttps://doi.org/10.1096/fasebj.24.1_supplement.921.9openalex-snapshot
Delphinidin Alters Hydrogen Peroxide Induced Cytotoxicity and Apoptosis in Human Colon Adenocarcinoma Cells
inferred← citeshttps://doi.org/10.1097/01.cad.0000215063.23932.02openalex-snapshot
Antiproliferative effect of quercetin in the human U138MG glioma cell line
inferred← citeshttps://doi.org/10.1111/j.1742-7843.2007.00173.xopenalex-snapshot
Increased Expression of Catalase in Human Hepatoma Cells by the Soy Isoflavone, Daidzein
inferred← citeshttps://doi.org/10.1111/j.1753-4887.2010.00301.xopenalex-snapshot
Hormesis and synergy: pathways and mechanisms of quercetin in cancer prevention and management
inferred← citeshttps://doi.org/10.1111/nbu.70039openalex-snapshot
Flavonoids and Their Influence on the Gut Microbiome: Implications for Cardiovascular Health
inferred← citeshttps://doi.org/10.1155/2010/851589openalex-snapshot
The Investigation of Effects of Quercetin and Its Combination with Cisplatin on Malignant Mesothelioma Cells In Vitro
inferred← citeshttps://doi.org/10.1155/2012/282570openalex-snapshot
Chemotherapy and Dietary Phytochemical Agents
inferred← citeshttps://doi.org/10.1155/2014/838101openalex-snapshot
Phytochemical Constituents and Toxicity of Duguetia furfuracea Hydroalcoholic Extract in Drosophila melanogaster
inferred← citeshttps://doi.org/10.1155/2016/6943053openalex-snapshot
Cytoprotective and Cytotoxic Effects of Rice Bran Extracts in Rat H9c2(2‐1) Cardiomyocytes
inferred← citeshttps://doi.org/10.1155/2016/8252741openalex-snapshot
Antidiabetic Effect of Young and Old Ethanolic Leaf Extracts of Vernonia amygdalina : A Comparative Study
inferred← citeshttps://doi.org/10.1155/2021/3157867openalex-snapshot
Quercetin as a Novel Therapeutic Approach for Lymphoma
inferred← citeshttps://doi.org/10.1158/1940-6207.capr-13-0355openalex-snapshot
Piper Betel Leaf: A Reservoir of Potential Xenohormetic Nutraceuticals with Cancer-Fighting Properties
inferred← citeshttps://doi.org/10.11606/t.60.2014.tde-17042015-151957openalex-snapshot
Avaliação fotoquimiopreventiva do extrato de maçã e da rutina em modelos de pele in vitro e in vivo
inferred← citeshttps://doi.org/10.1177/0960327111426585openalex-snapshot
Influence of flavonoid extracts from celery on oxidative stress induced by dichlorvos in rats
inferred← citeshttps://doi.org/10.1177/0960327113499048openalex-snapshot
Effect of flavonoids and hyperthermal intraperitoneal chemotherapy on tumour growth and micronucleus induction in mouse tumour model
inferred← citeshttps://doi.org/10.1186/1472-6882-12-153openalex-snapshot
Antioxidant, genotoxic and antigenotoxic activities of daphne gnidium leaf extracts
inferred← citeshttps://doi.org/10.1186/1472-6882-13-242openalex-snapshot
Antioxidant and pro-oxidant effects of oil palm (Elaeis guineensis) leaves extract in experimental diabetic nephropathy: a duration-dependent outcome
inferred← citeshttps://doi.org/10.1186/1743-7075-11-26openalex-snapshot
Alcohol consumption and hormonal alterations related to muscle hypertrophy: a review
inferred← citeshttps://doi.org/10.1186/1743-7075-11-43openalex-snapshot
Retraction Note: Alcohol consumption and hormonal alterations related to muscle hypertrophy: a review
inferred← citeshttps://doi.org/10.1186/s12906-019-2581-xopenalex-snapshot
The effects of Centella asiatica (L.) Urban on neural differentiation of human mesenchymal stem cells in vitro
inferred← citeshttps://doi.org/10.1186/s13048-019-0530-4openalex-snapshot
Quercetin: a natural compound for ovarian cancer treatment
inferred← citeshttps://doi.org/10.1186/s13104-017-2601-1openalex-snapshot
Comparison of the polyphenolic profile and antibacterial activity of the leaves, fruits and flowers of Rhododendron ambiguum and Rhododendron cinnabarinum
inferred← citeshttps://doi.org/10.1201/9781420006186.ch5openalex-snapshot
Grape Wine and Tea Polyphenols in the Modulation of Atherosclerosis and Heart Disease
inferred← citeshttps://doi.org/10.1201/9781420073522.ch14openalex-snapshot
Modulation of Multiple Pathways Involved in the Maintenance of Neuronal Function by Fisetin
inferred← citeshttps://doi.org/10.1207/s15327914nc5401_9openalex-snapshot
Ellagic Acid and Natural Sources of Ellagitannins as Possible Chemopreventive Agents Against Intestinal Tumorigenesis in the Min Mouse
inferred← citeshttps://doi.org/10.1207/s15327914nc5502_12openalex-snapshot
Reactive Oxygen Species Production Is Involved in Quercetin-Induced Apoptosis in Human Hepatoma Cells
inferred← citeshttps://doi.org/10.1208/s12249-019-1457-1openalex-snapshot
Pharmaceutical Topical Delivery of Poorly Soluble Polyphenols: Potential Role in Prevention and Treatment of Melanoma
inferred← citeshttps://doi.org/10.1248/bpb.b12-01004openalex-snapshot
Quercetin Potentiates Apoptosis by Inhibiting Nuclear Factor-kappaB Signaling in H460 Lung Cancer Cells
inferred← citeshttps://doi.org/10.12691/ajfst-5-4-7openalex-snapshot
Olive Leaf Extract as Natural Antioxidant Additive of Fresh Hamburger Stored at 4°C Running Title: Antioxidants from Olive Leaves in Hamburger
inferred← citeshttps://doi.org/10.1371/journal.pone.0089365openalex-snapshot
Dietary Quercetin Supplementation in Mice Increases Skeletal Muscle PGC1α Expression, Improves Mitochondrial Function and Attenuates Insulin Resistance in a Time-Specific Manner
inferred← citeshttps://doi.org/10.1371/journal.pone.0105725openalex-snapshot
Purification and Characterization of Flavonoids from the Leaves of Zanthoxylum bungeanum and Correlation between Their Structure and Antioxidant Activity
inferred← citeshttps://doi.org/10.1371/journal.pone.0171325openalex-snapshot
Taxifolin synergizes Andrographolide-induced cell death by attenuation of autophagy and augmentation of caspase dependent and independent cell death in HeLa cells
inferred← citeshttps://doi.org/10.14235/bs.2016.704openalex-snapshot
Exogenous Antioxidants are Double-edged Swords
inferred← citeshttps://doi.org/10.1515/pac-2023-1201openalex-snapshot
3-(4-methoxyphenyl) acrylic acid halts redox imbalance and modulate purinergic enzyme activity in iron-induced testicular injury
inferred← citeshttps://doi.org/10.15406/jnhfe.2017.06.00200openalex-snapshot
Effect of Chronic Treatment with Grape Juice during Pregnancy and Nursing in Central Nervous System of Female Wistar Rats
inferred← citeshttps://doi.org/10.1590/0001-3765202120190479openalex-snapshot
Toxicological, biochemical and morphophysiological effects of Serjania erecta leaf aqueous extract on Piaractus mesopotamicus
inferred← citeshttps://doi.org/10.18586/msufbd.1681215openalex-snapshot
GLAUCIUM FLAVUM BİTKİSİNİN TOPRAK ÜSTÜ KISIMLARINDA BULUNAN FENOLİK BİLEŞİKLERİN, UÇUCU BİLEŞENLERİN VE ANTİOKSİDAN KAPASİTENİN ANALİZİ
inferred← citeshttps://doi.org/10.18869/acadpub.hms.22.2.95openalex-snapshot
Teratogenic Effects of Hydroalcoholic Extract of Capparis spinosa Leaf on Balb/c Mice
inferred← citeshttps://doi.org/10.20883/jms.2016.119openalex-snapshot
Polyphenol‑rich extract of Aronia melanocarpa inhibits TNF‑α induced apoptosis in H9c2 cells
inferred← citeshttps://doi.org/10.21037/tcr-21-629openalex-snapshot
The interplay between reactive oxygen species and antioxidants in cancer progression and therapy: a narrative review
inferred← citeshttps://doi.org/10.21048/ijnd.2021.58.2.26592openalex-snapshot
A Scoping Review on the Impact of Nutrition and Counseling in the Prevention and Management of Cancer
inferred← citeshttps://doi.org/10.21203/rs.3.rs-1824875/v1openalex-snapshot
Modulation of vascular reactivity by reductive stress associated with excessive consumption of Hibiscus Sabdariffa Linnaeus
inferred← citeshttps://doi.org/10.21203/rs.3.rs-8295668/v1openalex-snapshot
Influence of Dietary Quercetin and Stocking Density on Stress Indicators and Meat Quality of Broiler Chickens in Tropical Production Systems
inferred← citeshttps://doi.org/10.2147/ott.s211904openalex-snapshot
Methyloleanolate Induces Apoptotic And Autophagic Cell Death Via Reactive Oxygen Species Generation And c-Jun N-terminal Kinase Phosphorylation
inferred← citeshttps://doi.org/10.2174/1567201816666191002102353openalex-snapshot
pH-Sensitive Magnetite Nanoparticles Modified with Hyperbranched Polymers and Folic Acid for Targeted Imaging and Therapy
inferred← citeshttps://doi.org/10.2174/157340109787314721openalex-snapshot
A Cell Culture Model for the Assessment of the Chemopreventive Potential of Dietary Compounds.
inferred← citeshttps://doi.org/10.2174/2589977515666230120144852openalex-snapshot
A Review on Anticancer Profile of Flavonoids: Sources, Chemistry, Mechanisms, Structure-activity Relationship and Anticancer Activity
inferred← citeshttps://doi.org/10.2174/2665978601999200807160528openalex-snapshot
Hydrogen Peroxide and Quercetin Induced Changes on Cell Viability, Apoptosis and Oxidative Stress in HepG2 Cells
inferred← citeshttps://doi.org/10.31083/fbl46289openalex-snapshot
Integration of Meta-Analysis and Network Pharmacology to Investigate the Pharmacological Mechanisms of Quercetin on Hepatocellular Carcinoma
inferred← citeshttps://doi.org/10.3109/15376516.2011.631196openalex-snapshot
Grape juice concentrate modulates p16 expression in high fat diet-induced liver steatosis in Wistar rats
inferred← citeshttps://doi.org/10.31390/gradschool_theses.1716openalex-snapshot
The Economic Burden of Gluten-Free Products and the Potential of Dietary Inhibitors of Transglutaminase-2
inferred← citeshttps://doi.org/10.31390/gradschool_theses.73openalex-snapshot
The effects of quercetin on skeletal muscle mitochondrial biogenesis and OXPHOS regulation
inferred← citeshttps://doi.org/10.31665/jfb.2018.4162openalex-snapshot
Bioaccessibility and bioavailability of phenolic compounds
inferred← citeshttps://doi.org/10.3341/jkos.2016.57.1.106openalex-snapshot
Cytoprotective Effect of Polyphenolic Compounds against Oxidative Stress in Cultured Retinal Pigment Epithelial Cells
inferred← citeshttps://doi.org/10.3341/jkos.2021.62.1.77openalex-snapshot
Effects of Blue Light on Eye of Zebra Fish and Protective Role of Polyphenolic Compounds
inferred← citeshttps://doi.org/10.3389/fgene.2018.00160openalex-snapshot
Quercetin-Induced Lifespan Extension in Podospora anserina Requires Methylation of the Flavonoid by the O-Methyltransferase PaMTH1
inferred← citeshttps://doi.org/10.3389/fnut.2016.00048openalex-snapshot
Quercetin as an Emerging Anti-Melanoma Agent: A Four-Focus Area Therapeutic Development Strategy
inferred← citeshttps://doi.org/10.3389/fphar.2022.950109openalex-snapshot
Exploring the recent trends in perturbing the cellular signaling pathways in cancer by natural products
inferred← citeshttps://doi.org/10.3390/beverages4040099openalex-snapshot
In Vitro Antioxidant Activity of Purple Grape Juice (Vitis Labrusca) against Temozolamide Treatment in Rat Brains
inferred← citeshttps://doi.org/10.3390/cells12010071openalex-snapshot
The Major Stilbene Compound Accumulated in the Roots of a Resistant Variety of Phoenix dactylifera L. Activates Proteasome for a Path in Anti-Aging Strategy
inferred← citeshttps://doi.org/10.3390/ecsoc-17-e013openalex-snapshot
Influence of thermodynamic parameters on the genotoxicity of bioactive phenolic compounds present in food
inferred← citeshttps://doi.org/10.3390/ecsoc-18-e015openalex-snapshot
Natural Coumarins: QSTR Approaches Regarding Their Genotoxicity
inferred← citeshttps://doi.org/10.3390/ijms18102098openalex-snapshot
Reductive Stress in Inflammation-Associated Diseases and the Pro-Oxidant Effect of Antioxidant Agents
inferred← citeshttps://doi.org/10.3390/ijms242417358openalex-snapshot
Fisetin Inhibits UVA-Induced Expression of MMP-1 and MMP-3 through the NOX/ROS/MAPK Pathway in Human Dermal Fibroblasts and Human Epidermal Keratinocytes
inferred← citeshttps://doi.org/10.3390/ijms25010500openalex-snapshot
Oleuropein Stimulates Migration of Human Trophoblast Cells and Expression of Invasion-Associated Markers
inferred← citeshttps://doi.org/10.3390/ijms25137063openalex-snapshot
Comparative Study of Condensed and Hydrolysable Tannins during the Early Stages of Zebrafish Development
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