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NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Krebs cycle rewired for macrophage and dendritic cell effector functions
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Mitochondrial DNA copy number in human disease: the more the better?
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Role of NCoR1 in mitochondrial function and energy metabolism
inferredcites →https://doi.org/10.1002/cpmo.21openalex-snapshot
Analysis of mtDNA/nDNA Ratio in Mice
inferredcites →https://doi.org/10.1002/eji.201142053openalex-snapshot
Influence of hypoxia‐inducible factor 1α on dendritic cell differentiation and migration
inferredcites →https://doi.org/10.1007/978-3-540-71029-5_12openalex-snapshot
Induction of Tolerogenic Dendritic Cells by Vitamin D Receptor Agonists
inferredcites →https://doi.org/10.1007/s00018-013-1539-2openalex-snapshot
Regulation of pyruvate metabolism and human disease
inferredcites →https://doi.org/10.1007/s00018-022-04424-wopenalex-snapshot
Epigenomics of conventional type-I dendritic cells depicted preferential control of TLR9 versus TLR3 response by NCoR1 through differential IRF3 activation
inferredcites →https://doi.org/10.1007/s00109-018-01740-2openalex-snapshot
IDH-1 deficiency induces growth defects and metabolic alterations in GSPD-1-deficient Caenorhabditis elegans
inferredcites →https://doi.org/10.1007/s00281-016-0587-8openalex-snapshot
Tolerogenic dendritic cells
inferredcites →https://doi.org/10.1016/j.cell.2011.10.017openalex-snapshot
NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function
inferredcites →https://doi.org/10.1016/j.celrep.2015.01.013openalex-snapshot
Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways
inferredcites →https://doi.org/10.1016/j.cels.2015.12.004openalex-snapshot
The Molecular Signatures Database Hallmark Gene Set Collection
inferredcites →https://doi.org/10.1016/j.cmet.2019.11.011openalex-snapshot
Human Tolerogenic Dendritic Cells Regulate Immune Responses through Lactate Synthesis
inferredcites →https://doi.org/10.1016/j.cmet.2020.08.002openalex-snapshot
The Role of HIF in Immunity and Inflammation
inferredcites →https://doi.org/10.1016/j.immuni.2017.12.004openalex-snapshot
Paracrine Wnt5a-β-Catenin Signaling Triggers a Metabolic Program that Drives Dendritic Cell Tolerization
inferredcites →https://doi.org/10.1016/j.intimp.2018.07.031openalex-snapshot
The impact of metabolic reprogramming on dendritic cell function
inferredcites →https://doi.org/10.1016/j.isci.2019.08.024openalex-snapshot
NCoR1: Putting the Brakes on the Dendritic Cell Immune Tolerance
inferredcites →https://doi.org/10.1016/j.jim.2007.03.005openalex-snapshot
Generation and maturation of bone marrow-derived DCs under serum-free conditions
inferredcites →https://doi.org/10.1016/j.jsbmb.2018.11.011openalex-snapshot
Vitamin D controls the capacity of human dendritic cells to induce functional regulatory T cells by regulation of glucose metabolism
inferredcites →https://doi.org/10.1016/j.molmet.2021.101315openalex-snapshot
Nuclear Receptor CoRepressors, NCOR1 and SMRT, are required for maintaining systemic metabolic homeostasis
inferredcites →https://doi.org/10.1016/j.neo.2021.10.003openalex-snapshot
STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications
inferredcites →https://doi.org/10.1016/j.redox.2018.03.004openalex-snapshot
Sorting cells alters their redox state and cellular metabolome
inferredcites →https://doi.org/10.1016/j.redox.2020.101674openalex-snapshot
Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement
inferredcites →https://doi.org/10.1016/s0005-2728(99)00025-0openalex-snapshot
Nitric oxide and mitochondrial respiration
inferredcites →https://doi.org/10.1038/cddiscovery.2016.22openalex-snapshot
Hypoxia and classical activation limits Mycobacterium tuberculosis survival by Akt-dependent glycolytic shift in macrophages
inferredcites →https://doi.org/10.1038/cmi.2017.88openalex-snapshot
Innate immunity in tuberculosis: host defense vs pathogen evasion
inferredcites →https://doi.org/10.1038/cr.2015.68openalex-snapshot
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
inferredcites →https://doi.org/10.1038/ni.2833openalex-snapshot
TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation
inferredcites →https://doi.org/10.1038/ni1112openalex-snapshot
Toll-like receptor control of the adaptive immune responses
inferredcites →https://doi.org/10.1038/nri.2016.70openalex-snapshot
A guide to immunometabolism for immunologists
inferredcites →https://doi.org/10.1038/nri3771openalex-snapshot
Dendritic cell metabolism
inferredcites →https://doi.org/10.1038/s41423-021-00753-1openalex-snapshot
Metabolic programming in dendritic cells tailors immune responses and homeostasis
inferredcites →https://doi.org/10.1038/s41467-018-04804-6openalex-snapshot
Glycolytic metabolism is essential for CCR7 oligomerization and dendritic cell migration
inferredcites →https://doi.org/10.1038/s41467-019-08829-3openalex-snapshot
Autophagy regulates lipid metabolism through selective turnover of NCoR1
inferredcites →https://doi.org/10.1038/s41467-019-13668-3openalex-snapshot
Mitochondrial TCA cycle metabolites control physiology and disease
inferredcites →https://doi.org/10.1038/s41587-019-0201-4openalex-snapshot
Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype
inferredcites →https://doi.org/10.1038/s41598-018-33248-7openalex-snapshot
Comparative transcriptomic profile of tolerogenic dendritic cells differentiated with vitamin D3, dexamethasone and rapamycin
inferredcites →https://doi.org/10.1038/s42255-019-0043-xopenalex-snapshot
NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism
inferredcites →https://doi.org/10.1084/jem.20151570openalex-snapshot
Immunometabolism governs dendritic cell and macrophage function
inferredcites →https://doi.org/10.1093/nar/gkz114openalex-snapshot
The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads
inferredcites →https://doi.org/10.1101/gad.1529107openalex-snapshot
The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
inferredcites →https://doi.org/10.1101/gad.214023.113openalex-snapshot
Emerging roles of the corepressors NCoR1 and SMRT in homeostasis
inferredcites →https://doi.org/10.1111/imm.12610openalex-snapshot
Vitamin D immunoregulation through dendritic cells
inferredcites →https://doi.org/10.1111/j.1365-2567.2011.03482.xopenalex-snapshot
Vitamin D3: a helpful immuno-modulator
inferredcites →https://doi.org/10.1111/j.1365-3083.2005.01640.xopenalex-snapshot
Dexamethasone Induces IL‐10‐Producing Monocyte‐Derived Dendritic Cells with Durable Immaturity
inferredcites →https://doi.org/10.1113/jp280572openalex-snapshot
Regulation of glycolysis by the hypoxia‐inducible factor (HIF): implications for cellular physiology
inferredcites →https://doi.org/10.1155/2016/2636701openalex-snapshot
Metabolism Is Central to Tolerogenic Dendritic Cell Function
inferredcites →https://doi.org/10.1155/2017/5134760openalex-snapshot
Metabolic Plasticity in Dendritic Cell Responses: Implications in Allergic Asthma
inferredcites →https://doi.org/10.1158/0008-5472.can-17-3155openalex-snapshot
ME1 Regulates NADPH Homeostasis to Promote Gastric Cancer Growth and Metastasis
inferredcites →https://doi.org/10.1186/s13059-014-0550-8openalex-snapshot
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
inferredcites →https://doi.org/10.1194/jlr.m021485openalex-snapshot
Major involvement of mTOR in the PPARγ-induced stimulation of adipose tissue lipid uptake and fat accretion
inferredcites →https://doi.org/10.12997/jla.2020.9.3.313openalex-snapshot
Mitochondrial Fatty Acid Oxidation Disorders: Laboratory Diagnosis, Pathogenesis, and the Complicated Route to Treatment
inferredcites →https://doi.org/10.1371/journal.pbio.1001759openalex-snapshot
Direct Type I IFN but Not MDA5/TLR3 Activation of Dendritic Cells Is Required for Maturation and Metabolic Shift to Glycolysis after Poly IC Stimulation
inferredcites →https://doi.org/10.1371/journal.pone.0244366openalex-snapshot
Hypoxia-inducible factor 1 alpha limits dendritic cell stimulation of CD8 T cell immunity
inferredcites →https://doi.org/10.21203/rs.3.rs-1204554/v1openalex-snapshot
NCoR1 and SMRT Fine-Tune Inflammatory Versus Tolerogenic Balance in Dendritic Cells By Differentially Regulating STAT3 Signaling
inferredcites →https://doi.org/10.2147/ott.s256970openalex-snapshot
Malic Enzyme 1 Indicates Worse Prognosis in Breast Cancer and Promotes Metastasis by Manipulating Reactive Oxygen Species
inferredcites →https://doi.org/10.2337/db19-0508openalex-snapshot
RNF20 Functions as a Transcriptional Coactivator for PPARγ by Promoting NCoR1 Degradation in Adipocytes
inferredcites →https://doi.org/10.3349/ymj.2018.59.7.807openalex-snapshot
Generation, Characteristics and Clinical Trials of Ex Vivo Generated Tolerogenic Dendritic Cells
inferredcites →https://doi.org/10.3389/fendo.2018.00129openalex-snapshot
The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues
inferredcites →https://doi.org/10.3389/fimmu.2012.00331openalex-snapshot
Novel Murine Dendritic Cell Lines: A Powerful Auxiliary Tool for Dendritic Cell Research
inferredcites →https://doi.org/10.3389/fimmu.2014.00203openalex-snapshot
Metabolic control of dendritic cell activation and function: recent advances and clinical implications
inferredcites →https://doi.org/10.3389/fimmu.2016.00009openalex-snapshot
Tolerogenic IDO+ Dendritic Cells Are Induced by PD-1-Expressing Mast Cells
inferredcites →https://doi.org/10.3389/fimmu.2017.01764openalex-snapshot
Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity
inferredcites →https://doi.org/10.3389/fimmu.2018.02489openalex-snapshot
Human Dendritic Cell Subsets Undergo Distinct Metabolic Reprogramming for Immune Response
inferredcites →https://doi.org/10.3389/fimmu.2019.00775openalex-snapshot
Metabolic Control of Dendritic Cell Functions: Digesting Information
inferredcites →https://doi.org/10.3389/fimmu.2019.00868openalex-snapshot
Increased Akt-Driven Glycolysis Is the Basis for the Higher Potency of CD137L-DCs
inferredcites →https://doi.org/10.3389/fimmu.2020.552988openalex-snapshot
Tolerogenic Dendritic Cells: The Pearl of Immunotherapy in Organ Transplantation
inferredcites →https://doi.org/10.3389/fimmu.2020.569358openalex-snapshot
Role of the Nuclear Receptor Corepressor 1 (NCOR1) in Atherosclerosis and Associated Immunometabolic Diseases
inferredcites →https://doi.org/10.3389/fimmu.2021.649475openalex-snapshot
Genome-Wide Gene Expression Analysis of Mtb-Infected DC Highlights the Rapamycin-Driven Modulation of Regulatory Cytokines via the mTOR/GSK-3β Axis
inferredcites →https://doi.org/10.3389/fphar.2011.00049openalex-snapshot
Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review
inferredcites →https://doi.org/10.3390/ijms19040949openalex-snapshot
Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis
inferredcites →https://doi.org/10.3390/ijms19072124openalex-snapshot
PPARs and Metabolic Disorders Associated with Challenged Adipose Tissue Plasticity
inferredcites →https://doi.org/10.3858/emm.2008.40.5.479openalex-snapshot
STAT3 inhibits the degradation of HIF-1α by pVHL-mediated ubiquitination
inferredcites →https://doi.org/10.4049/jimmunol.0802560openalex-snapshot
Kinetic of RelA Activation Controls Magnitude of TLR-Mediated IL-12p40 Induction
inferredcites →https://doi.org/10.4049/jimmunol.1000296openalex-snapshot
A Versatile Role of Mammalian Target of Rapamycin in Human Dendritic Cell Function and Differentiation
inferredcites →https://doi.org/10.4049/jimmunol.1200069openalex-snapshot
Cutting Edge: mTORC1 in Intestinal CD11c+CD11b+ Dendritic Cells Regulates Intestinal Homeostasis by Promoting IL-10 Production
inferredcites →https://doi.org/10.4049/jimmunol.1303316openalex-snapshot
High Mitochondrial Respiration and Glycolytic Capacity Represent a Metabolic Phenotype of Human Tolerogenic Dendritic Cells
inferredcites →https://doi.org/10.4049/jimmunol.162.11.6473openalex-snapshot
Glucocorticoids Affect Human Dendritic Cell Differentiation and Maturation
inferredcites →https://doi.org/10.4049/jimmunol.180.7.4697openalex-snapshot
Hypoxia and Hypoxia-Inducible Factor-1α Modulate Lipopolysaccharide-Induced Dendritic Cell Activation and Function
inferredcites →https://doi.org/10.4161/21645515.2014.979640openalex-snapshot
Mechanisms and pathways of innate immune activation and regulation in health and cancer
inferredcites →https://doi.org/10.4254/wjh.v7.i8.1012openalex-snapshot
Peroxisome proliferator-activated receptors as targets to treat non-alcoholic fatty liver disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Cholesterol Metabolism-Mediated Immune Regulation and Cancer Immunotherapy
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PFKFB2‐Driven Glycolysis Promotes Dendritic Cell Maturation and Exacerbates Acute Lung Injury
inferred← citeshttps://doi.org/10.1002/cam4.71185openalex-snapshot
Glucose Metabolic Reprogramming in Colorectal Cancer: From Mechanisms to Targeted Therapy Approaches
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RetSat Knockout Mitigates Hypoxia‐Induced Microglial Activation by Enhancing Lipid Droplets Degradation
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Metabolic reprogramming of immune cells in the battle against intracellular bacterial chronic infections: novel mechanisms and breakthroughs
inferred← citeshttps://doi.org/10.1007/s11357-023-00849-8openalex-snapshot
Coordinated transcriptional upregulation of oxidative metabolism proteins in long-lived endocrine mutant mice
inferred← citeshttps://doi.org/10.1007/s11357-024-01466-9openalex-snapshot
Downregulation of the NF-κB protein p65 is a shared phenotype among most anti-aging interventions
inferred← citeshttps://doi.org/10.1016/b978-0-443-27735-1.00001-0openalex-snapshot
Unraveling NCoR1's role in Mycobacterium tuberculosis pathogenicity
inferred← citeshttps://doi.org/10.1016/j.bbcan.2025.189416openalex-snapshot
Targeting lipid metabolism to enhance cancer immunotherapy
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Mitochondrial isocitrate dehydrogenase impedes CAR T cell function by restraining antioxidant metabolism and histone acetylation
inferred← citeshttps://doi.org/10.1016/j.gendis.2024.101491openalex-snapshot
Emerging roles for fatty acid oxidation in cancer
inferred← citeshttps://doi.org/10.1016/j.jri.2023.104087openalex-snapshot
Glutamine metabolism shapes the phenotypic adaptation of uterine dendritic cells in response to early allogeneic pregnancy
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Baicalin inhibits macrophage glycolysis and succinate-driven HIF-1α signaling by targeting PKM2 to alleviate RSV-induced inflammation
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inferred← citeshttps://doi.org/10.1038/s41419-024-07125-3openalex-snapshot
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The emerging role of dendritic cells in the tumor microenvironment: from antigen presentation to targeted immunotherapy
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Senescence-induced p21high macrophages contributed to CD8+ T cells-related immune hyporesponsiveness in kidney transplantation via Zfp36/IL-27 axis
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Prediction of the risk of transplant rejection based on RNA sequencing data of PBMCs before transplantation
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SMRT-depleted conventional DCs maintain inflammation despite lower glycolysis via mTOR signalling and succinate oxidation
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inferred← citeshttps://doi.org/10.1097/mot.0000000000001127openalex-snapshot
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AMPK activation induces RALDH high tolerogenic dendritic cells through rewiring of glucose and lipid metabolism
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Tretinoin, a Vitamin A derivative, exerts antiviral effects against Chikungunya virus infection through the nuclear retinoid receptor signaling pathways
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Functional and Metabolic Heterogeneity of Dendritic Cells in Self‐Tolerance and Autoimmunity
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Dendritic cell immunometabolism - a potential therapeutic target for allergic diseases
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