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The transcription factor HIF-1α plays a critical role in the growth factor-dependent regulation of both aerobic and anaerobic glycolysis
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1 of the 49 references listed on this page is in the Retraction Watch database as retracted (export 2026-11-04): 10.1074/jbc.m308197200 (notice 2025-07-05).
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.ccr.2004.11.022openalex-snapshot
Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase
inferredcites →https://doi.org/10.1016/j.ccr.2005.06.017openalex-snapshot
HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability
inferredcites →https://doi.org/10.1016/j.ccr.2005.09.008openalex-snapshot
ATP citrate lyase inhibition can suppress tumor cell growth
inferredcites →https://doi.org/10.1016/j.ccr.2006.04.023openalex-snapshot
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance
inferredcites →https://doi.org/10.1016/j.cell.2004.11.046openalex-snapshot
Growth Factor Regulation of Autophagy and Cell Survival in the Absence of Apoptosis
inferredcites →https://doi.org/10.1016/j.cmet.2005.05.001openalex-snapshot
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
inferredcites →https://doi.org/10.1016/j.cmet.2005.05.002openalex-snapshot
Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation
inferredcites →https://doi.org/10.1016/j.cmet.2005.05.003openalex-snapshot
Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation
inferredcites →https://doi.org/10.1016/j.cmet.2006.01.012openalex-snapshot
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
inferredcites →https://doi.org/10.1016/j.cmet.2006.02.002openalex-snapshot
HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
inferredcites →https://doi.org/10.1016/s1074-7613(02)00323-0openalex-snapshot
The CD28 Signaling Pathway Regulates Glucose Metabolism
inferredcites →https://doi.org/10.1016/s1097-2765(00)00066-6openalex-snapshot
In the Absence of Extrinsic Signals, Nutrient Utilization by Lymphocytes Is Insufficient to Maintain Either Cell Size or Viability
inferredcites →https://doi.org/10.1038/20459openalex-snapshot
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
inferredcites →https://doi.org/10.1038/28867openalex-snapshot
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
inferredcites →https://doi.org/10.1038/nature04871openalex-snapshot
Hypoxia signalling in cancer and approaches to enforce tumour regression
inferredcites →https://doi.org/10.1038/sj.emboj.7600196openalex-snapshot
HIF‐1α induces cell cycle arrest by functionally counteracting Myc
inferredcites →https://doi.org/10.1038/sj.onc.1208986openalex-snapshot
Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1α and vascular endothelial growth factor
inferredcites →https://doi.org/10.1042/bj2280353openalex-snapshot
Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism
inferredcites →https://doi.org/10.1073/pnas.181341498openalex-snapshot
HIF-1α binding to VHL is regulated by stimulus-sensitive proline hydroxylation
inferredcites →https://doi.org/10.1074/jbc.270.36.21021openalex-snapshot
Hypoxic Regulation of Lactate Dehydrogenase A
inferredcites →https://doi.org/10.1074/jbc.271.51.32529openalex-snapshot
Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1
inferredcites →https://doi.org/10.1074/jbc.274.46.32631openalex-snapshot
p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1
inferredcites →https://doi.org/10.1074/jbc.m003325200openalex-snapshot
Non-hypoxic pathway mediates the induction of hypoxia inducible factor 1 alpha (HIF-1 alpha ) in vascular smooth muscle cells
inferredcites →https://doi.org/10.1074/jbc.m111162200openalex-snapshot
Phosphatidylinositol 3-Kinase/Akt Signaling Is Neither Required for Hypoxic Stabilization of HIF-1α nor Sufficient for HIF-1-dependent Target Gene Transcription
inferredcites →https://doi.org/10.1074/jbc.m203781200openalex-snapshot
Insulin-like Growth Factor 1 Induces Hypoxia-inducible Factor 1-mediated Vascular Endothelial Growth Factor Expression, Which is Dependent on MAP Kinase and Phosphatidylinositol 3-Kinase Signaling in Colon Cancer Cells
inferredcites →https://doi.org/10.1074/jbc.m204733200openalex-snapshot
Hsp90 Regulates a von Hippel Lindau-independent Hypoxia-inducible Factor-1α-degradative Pathway
inferredcites →https://doi.org/10.1074/jbc.m206141200openalex-snapshot
Activated pp60c-Src Leads to Elevated Hypoxia-inducible Factor (HIF)-1α Expression under Normoxia
inferredcites →https://doi.org/10.1074/jbc.m305689200openalex-snapshot
Interleukin-3-mediated Cell Survival Signals Include Phosphatidylinositol 3-Kinase-dependent Translocation of the Glucose Transporter GLUT1 to the Cell Surface
inferredcites →https://doi.org/10.1074/jbc.m308013200openalex-snapshot
Ras Induction of Superoxide Activates ERK-dependent Angiogenic Transcription Factor HIF-1α and VEGF-A Expression in Shock Wave-stimulated Osteoblasts
inferredcites →https://doi.org/10.1074/jbc.m308197200openalex-snapshot
Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling
inferredcites →https://doi.org/10.1074/jbc.m508718200openalex-snapshot
Reversible Inactivation of HIF-1 Prolyl Hydroxylases Allows Cell Metabolism to Control Basal HIF-1
inferredcites →https://doi.org/10.1074/jbc.m608372200openalex-snapshot
Phosphatidylinositol 3-Kinase-dependent Modulation of Carnitine Palmitoyltransferase 1A Expression Regulates Lipid Metabolism during Hematopoietic Cell Growth
inferredcites →https://doi.org/10.1093/emboj/17.11.3005openalex-snapshot
HIF‐1α is required for solid tumor formation and embryonic vascularization
inferredcites →https://doi.org/10.1096/fj.03-1001fjeopenalex-snapshot
Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand
inferredcites →https://doi.org/10.1101/gad.12.2.149openalex-snapshot
Cellular and developmental control of O 2 homeostasis by hypoxia-inducible factor 1α
inferredcites →https://doi.org/10.1101/gad.1471106openalex-snapshot
HIF1α delays premature senescence through the activation of MIF
inferredcites →https://doi.org/10.1126/science.1059796openalex-snapshot
Targeting of HIF-α to the von Hippel-Lindau Ubiquitylation Complex by O 2 -Regulated Prolyl Hydroxylation
inferredcites →https://doi.org/10.1128/mcb.21.10.3436-3444.2001openalex-snapshot
Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells
inferredcites →https://doi.org/10.1128/mcb.21.12.3995-4004.2001openalex-snapshot
HER2 (neu) Signaling Increases the Rate of Hypoxia-Inducible Factor 1α (HIF-1α) Synthesis: Novel Mechanism for HIF-1-Mediated Vascular Endothelial Growth Factor Expression
inferredcites →https://doi.org/10.1128/mcb.21.17.5899-5912.2001openalex-snapshot
Growth Factors Can Influence Cell Growth and Survival through Effects on Glucose Metabolism
inferredcites →https://doi.org/10.1128/mcb.23.24.9361-9374.2003openalex-snapshot
Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation
inferredcites →https://doi.org/10.1128/mcb.24.7.2905-2914.2004openalex-snapshot
Growth Factor-Mediated Induction of HDM2 Positively Regulates Hypoxia-Inducible Factor 1α Expression
inferredcites →https://doi.org/10.1152/ajpendo.1999.276.1.e1openalex-snapshot
Malonyl-CoA, fuel sensing, and insulin resistance
inferredcites →https://doi.org/10.1158/0008-5472.999.65.3openalex-snapshot
Ras Inhibition in Glioblastoma Down-regulates Hypoxia-Inducible Factor-1α, Causing Glycolysis Shutdown and Cell Death
inferredcites →https://doi.org/10.1158/0008-5472.can-04-1284openalex-snapshot
A Hypoxia-Independent Hypoxia-Inducible Factor-1 Activation Pathway Induced by Phosphatidylinositol-3 Kinase/Akt in HER2 Overexpressing Cells
inferredcites →https://doi.org/10.1158/0008-5472.can-04-4130openalex-snapshot
Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T Cells
inferredcites →https://doi.org/10.1159/000373980openalex-snapshot
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.2139/ssrn.4186473openalex-extracted
Hypoxia/Inflammation-Induced Upregulation of HIF-1α and C/EBPβ, Promoted Nephroblastoma EMT by Improving HOXA11-AS Transcription
inferred← citeshttps://doi.org/10.1002/biot.202100214openalex-snapshot
Molecular analysis of sugar transporters and glycolysis pathways in Ettlia sp. under heterotrophy using fructose and glucose
inferred← citeshttps://doi.org/10.1002/btm2.10255openalex-snapshot
Area light source‐triggered latent angiogenic molecular mechanisms intensify therapeutic efficacy of adult stem cells
inferred← citeshttps://doi.org/10.1002/cac2.12361openalex-snapshot
An update on the molecular biology of glioblastoma, with clinical implications and progress in its treatment
inferred← citeshttps://doi.org/10.1002/cphy.c150032openalex-snapshot
Hyperbaric Environment: Oxygen and Cellular Damage versus Protection
inferred← citeshttps://doi.org/10.1002/cyto.a.20469openalex-snapshot
Cytometric assessment of DNA damage by exogenous and endogenous oxidants reports aging‐related processes
inferred← citeshttps://doi.org/10.1002/ijc.28623openalex-snapshot
Transglutaminase 2 reprogramming of glucose metabolism in mammary epithelial cells via activation of inflammatory signaling pathways
inferred← citeshttps://doi.org/10.1002/iub.70092openalex-snapshot
Hypoxia‐Inducible Factors as Guardians of Cancer Stem Cell Fate: Implications for Novel Therapies
inferred← citeshttps://doi.org/10.1002/j.2040-4603.2017.tb00735.xopenalex-snapshot
Hyperbaric Environment: Oxygen and Cellular Damage versus Protection
inferred← citeshttps://doi.org/10.1002/jat.3749openalex-snapshot
The use of cobalt chloride as a chemical hypoxia model
inferred← citeshttps://doi.org/10.1002/jcb.29240openalex-snapshot
Glutathione peroxidase 3 (GPX3) suppresses the growth of melanoma cells through reactive oxygen species (ROS)‐dependent stabilization of hypoxia‐inducible factor 1‐α and 2‐α
inferred← citeshttps://doi.org/10.1002/jmv.28018openalex-snapshot
Interplay between cellular metabolism and DNA viruses
inferred← citeshttps://doi.org/10.1002/mc.23460openalex-snapshot
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas
inferred← citeshttps://doi.org/10.1002/tox.22869openalex-snapshot
p,p′‐Dichlorodiphenyltrichloroethane promotes aerobic glycolysis via reactive oxygen species–mediated extracellular signal‐regulated kinase/M2 isoform of pyruvate kinase (PKM2) signaling in colorectal cancer cells
inferred← citeshttps://doi.org/10.1002/wnan.1766openalex-snapshot
Modulating hypoxia inducible factor‐1 by nanomaterials for effective cancer therapy
inferred← citeshttps://doi.org/10.1007/978-1-4419-6448-9_22openalex-snapshot
Von Hippel Lindau Syndrome
inferred← citeshttps://doi.org/10.1007/978-1-4614-2400-0_4openalex-snapshot
Tissue Biomarkers in Renal Cell Carcinoma: Intermediate Endpoints in the Selection of Targeted Agents for RCC
inferred← citeshttps://doi.org/10.1007/978-1-4614-5847-0_2openalex-snapshot
The Warburg Effect and Beyond: Metabolic Dependencies for Cancer Cells
inferred← citeshttps://doi.org/10.1007/978-1-60327-227-8_18openalex-snapshot
Stem Cells, Hypoxia and Hypoxia-Inducible Factors
inferred← citeshttps://doi.org/10.1007/978-3-030-47336-5_8openalex-snapshot
The Roles of HIFs in the Complications of Diabetes
inferred← citeshttps://doi.org/10.1007/978-3-030-56905-1_4openalex-snapshot
HIF-1α as a Potential Therapeutic Target for Tuberculosis Treatment
inferred← citeshttps://doi.org/10.1007/978-981-99-0313-9_19openalex-snapshot
Hypoxia in Drug Resistance and Radioresistance
inferred← citeshttps://doi.org/10.1007/s00018-026-06299-7openalex-snapshot
Chronic hypoxia protects the mouse heart from oxidative stress via HIF-1α-mitochondria crosstalk
inferred← citeshttps://doi.org/10.1007/s00424-017-1935-9openalex-snapshot
Hypoxia and aerobic metabolism adaptations of human endothelial cells
inferred← citeshttps://doi.org/10.1007/s00432-019-02847-wopenalex-snapshot
Prognostic role of glycolysis for cancer outcome: evidence from 86 studies
inferred← citeshttps://doi.org/10.1007/s00604-019-3791-0openalex-snapshot
Amperometric lactate nanobiosensor based on reduced graphene oxide, carbon nanotube and gold nanoparticle nanocomposite
inferred← citeshttps://doi.org/10.1007/s10147-025-02906-yopenalex-snapshot
The role of hypoxia-inducible factor-1α on colon cancer progression and metastasis
inferred← citeshttps://doi.org/10.1007/s10499-025-02059-9openalex-snapshot
Hypoxia inducible factor HIF-1α regulates anaerobic metabolism after hypoxia stress in Pacific oyster Crassostrea gigas
inferred← citeshttps://doi.org/10.1007/s10522-013-9478-8openalex-snapshot
SIRT6, a protein with many faces
inferred← citeshttps://doi.org/10.1007/s10689-014-9725-4openalex-snapshot
Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies
inferred← citeshttps://doi.org/10.1007/s10719-013-9515-5openalex-snapshot
Regulation of cancer metabolism by O-GlcNAcylation
inferred← citeshttps://doi.org/10.1007/s10811-023-03132-7openalex-snapshot
A review of the representative microalgal-derived reactive oxygen species: Possible formation, ecophysiological implications, and metabolomic-based evaluations
inferred← citeshttps://doi.org/10.1007/s10911-012-9271-3openalex-snapshot
Impaired Mitochondrial Metabolism and Mammary Carcinogenesis
inferred← citeshttps://doi.org/10.1007/s12031-017-0947-4openalex-snapshot
Aerobic Glycolysis Hypothesis Through WNT/Beta-Catenin Pathway in Exudative Age-Related Macular Degeneration
inferred← citeshttps://doi.org/10.1007/s12031-020-01630-8openalex-snapshot
Naringin Targets NFKB1 to Alleviate Oxygen-Glucose Deprivation/Reoxygenation–Induced Injury in PC12 Cells Via Modulating HIF-1α/AKT/mTOR-Signaling Pathway
inferred← citeshttps://doi.org/10.1007/s12032-022-01699-8openalex-snapshot
Alterations in cellular metabolisms after Imatinib therapy: a review
inferred← citeshttps://doi.org/10.1007/s12033-013-9668-2openalex-snapshot
Glucose Metabolism, Hyperosmotic Stress, and Reprogramming of Somatic Cells
inferred← citeshttps://doi.org/10.1007/s12094-009-0407-xopenalex-snapshot
Inhibiting PI3K as a therapeutic strategy against cancer
inferred← citeshttps://doi.org/10.1007/s12264-018-0219-5openalex-snapshot
Opposite Interplay Between the Canonical WNT/β-Catenin Pathway and PPAR Gamma: A Potential Therapeutic Target in Gliomas
inferred← citeshttps://doi.org/10.1007/s12311-022-01415-2openalex-snapshot
A Survey of the Metabolic Landscape of the Developing Cerebellum at Single-Cell Resolution
inferred← citeshttps://doi.org/10.1007/s12640-009-9039-8openalex-snapshot
The Brain Uncoupling Protein UCP4 Attenuates Mitochondrial Toxin-Induced Cell Death: Role of Extracellular Signal-Regulated Kinases in Bioenergetics Adaptation and Cell Survival
inferred← citeshttps://doi.org/10.1007/s13105-014-0325-4openalex-snapshot
Saponin as regulator of biofuel: implication for ethnobotanical management of diabetes
inferred← citeshttps://doi.org/10.1007/s13277-014-2617-2openalex-snapshot
A lentiviral sponge for miRNA-21 diminishes aerobic glycolysis in bladder cancer T24 cells via the PTEN/PI3K/AKT/mTOR axis
inferred← citeshttps://doi.org/10.1007/s40336-017-0231-1openalex-snapshot
Molecular mechanisms of hypoxia in cancer
inferred← citeshttps://doi.org/10.1007/s44411-026-00669-0openalex-snapshot
Mitochondrial Transfer Enhances The Antiproliferative Effects of 3-Bromopyruvate in Prostate Cancer Cells with Reduced mTOR/HIF-1α Protein Levels
inferred← citeshttps://doi.org/10.1016/b978-0-12-814118-2.00002-1openalex-snapshot
Sirtuins in the biology of aging
inferred← citeshttps://doi.org/10.1016/b978-0-12-814879-2.00008-xopenalex-snapshot
Regenerative Potential Across Species: An Eco-Evo-Devo Perspective
inferred← citeshttps://doi.org/10.1016/b978-0-12-820583-9.00031-2openalex-snapshot
T-cell biology, tolerance, and regulation
inferred← citeshttps://doi.org/10.1016/b978-0-12-821666-8.00064-5openalex-snapshot
Dormancy in cancer bone metastasis
inferred← citeshttps://doi.org/10.1016/b978-0-443-13212-4.00029-5openalex-snapshot
An altered metabolic landscape drives quiescence to the reawakening of cancer stem cells
inferred← citeshttps://doi.org/10.1016/b978-0-443-23881-9.00005-0openalex-snapshot
Regulation of pentose phosphate pathway in bladder cancer
inferred← citeshttps://doi.org/10.1016/b978-1-4557-4066-6.00013-5openalex-snapshot
The Metabolism of Cell Growth and Proliferation
inferred← citeshttps://doi.org/10.1016/bs.ircmb.2017.07.012openalex-snapshot
Altered Metabolism of Leukemic Cells: New Therapeutic Opportunity
inferred← citeshttps://doi.org/10.1016/j.abb.2025.110344openalex-snapshot
Roles of selenium-containing glutathione peroxidases and thioredoxin reductases in the regulation of processes associated with glioblastoma progression
inferred← citeshttps://doi.org/10.1016/j.advms.2015.09.003openalex-snapshot
The role of sirtuins in aging and age-related diseases
inferred← citeshttps://doi.org/10.1016/j.bbabio.2010.02.011openalex-snapshot
Hypoxia and mitochondrial oxidative metabolism
inferred← citeshttps://doi.org/10.1016/j.bbabio.2017.02.001openalex-snapshot
Cancer metabolism in space and time: Beyond the Warburg effect
inferred← citeshttps://doi.org/10.1016/j.bbadis.2017.07.017openalex-snapshot
Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1
inferred← citeshttps://doi.org/10.1016/j.bbadis.2019.06.005openalex-snapshot
Human steroid sulfatase enhances aerobic glycolysis through induction of HIF1α and glycolytic enzymes
inferred← citeshttps://doi.org/10.1016/j.bbadis.2025.167691openalex-snapshot
The curious case of mitochondrial sirtuin in rewiring breast cancer metabolism: Mr Hyde or Dr Jekyll?
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2016.02.011openalex-snapshot
Hypoxia-driven glycolytic and fructolytic metabolic programs: Pivotal to hypertrophic heart disease
inferred← citeshttps://doi.org/10.1016/j.bbamcr.2020.118733openalex-snapshot
Role of the HIF oxygen sensing pathway in cell defense and proliferation through the control of amino acid metabolism
inferred← citeshttps://doi.org/10.1016/j.bbcan.2014.07.011openalex-snapshot
Deconstructing breast cancer cell biology and the mechanisms of multidrug resistance
inferred← citeshttps://doi.org/10.1016/j.bbcan.2017.04.002openalex-snapshot
Linking tumor glycolysis and immune evasion in cancer: Emerging concepts and therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.bbrc.2015.09.125openalex-snapshot
Extracellular polysaccharide from Bordetella species reduces high glucose-induced macrophage apoptosis via regulating interaction between caveolin-1 and TLR4
inferred← citeshttps://doi.org/10.1016/j.bbrc.2024.150483openalex-snapshot
STAT3 drives the expression of HIF1alpha in cancer cells through a novel super-enhancer
inferred← citeshttps://doi.org/10.1016/j.biocel.2009.10.012openalex-snapshot
The role of HIF in immunity
inferred← citeshttps://doi.org/10.1016/j.biocel.2009.11.008openalex-snapshot
Distinctions and similarities of cell bioenergetics and the role of mitochondria in hypoxia, cancer, and embryonic development
inferred← citeshttps://doi.org/10.1016/j.biocel.2010.05.003openalex-snapshot
Waves of gene regulation suppress and then restore oxidative phosphorylation in cancer cells
inferred← citeshttps://doi.org/10.1016/j.biopha.2017.01.019openalex-snapshot
Interplay between cancer cell cycle and metabolism: Challenges, targets and therapeutic opportunities
inferred← citeshttps://doi.org/10.1016/j.biortech.2019.122248openalex-snapshot
Enhancement of pyruvic acid production in Candida glabrata by engineering hypoxia-inducible factor 1
inferred← citeshttps://doi.org/10.1016/j.brainres.2012.06.055openalex-snapshot
Decreased VEGF expression and microvascular density, but increased HIF-1 and 2α accumulation and EPO expression in chronic moderate hyperoxia in the mouse brain
inferred← citeshttps://doi.org/10.1016/j.brainres.2014.04.035openalex-snapshot
HIF-1α/COX-2 expression and mouse brain capillary remodeling during prolonged moderate hypoxia and subsequent re-oxygenation
inferred← citeshttps://doi.org/10.1016/j.brainresbull.2022.11.002openalex-snapshot
Enhanced BPGM/2,3-DPG pathway activity suppresses glycolysis in hypoxic astrocytes via FIH-1 and TET2
inferred← citeshttps://doi.org/10.1016/j.canlet.2014.01.032openalex-snapshot
Hypoxia and hypoxia inducible factors in tumor metabolism
inferred← citeshttps://doi.org/10.1016/j.canlet.2020.05.034openalex-snapshot
Beyond glycolysis: Hypoxia signaling as a master regulator of alternative metabolic pathways and the implications in clear cell renal cell carcinoma
inferred← citeshttps://doi.org/10.1016/j.cbd.2023.101136openalex-snapshot
Sex differences in antioxidant ability and energy metabolism level resulting in the difference of hypoxia tolerance in red swamp crayfish (Procambarus clarkii)
inferred← citeshttps://doi.org/10.1016/j.cbi.2021.109602openalex-snapshot
Metabolic reprograming confers tamoxifen resistance in breast cancer
inferred← citeshttps://doi.org/10.1016/j.cbi.2025.111393openalex-snapshot
Prostate cancer-selective anticancer action of an oxindole derivative via HO-1-mediated disruption of metabolic reprogramming
inferred← citeshttps://doi.org/10.1016/j.ccell.2016.09.006openalex-snapshot
Enhanced Fructose Utilization Mediated by SLC2A5 Is a Unique Metabolic Feature of Acute Myeloid Leukemia with Therapeutic Potential
inferred← citeshttps://doi.org/10.1016/j.ccell.2020.09.004openalex-snapshot
Immunometabolic Interplay in the Tumor Microenvironment
inferred← citeshttps://doi.org/10.1016/j.ccr.2007.02.006openalex-snapshot
HIF-2α Promotes Hypoxic Cell Proliferation by Enhancing c-Myc Transcriptional Activity
inferred← citeshttps://doi.org/10.1016/j.ccr.2007.07.006openalex-snapshot
HIF and c-Myc: Sibling Rivals for Control of Cancer Cell Metabolism and Proliferation
inferred← citeshttps://doi.org/10.1016/j.ccr.2008.10.016openalex-snapshot
HIF-α Effects on c-Myc Distinguish Two Subtypes of Sporadic VHL-Deficient Clear Cell Renal Carcinoma
inferred← citeshttps://doi.org/10.1016/j.ccr.2012.02.014openalex-snapshot
Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate
inferred← citeshttps://doi.org/10.1016/j.cell.2007.06.009openalex-snapshot
AKT/PKB Signaling: Navigating Downstream
inferred← citeshttps://doi.org/10.1016/j.cell.2009.12.041openalex-snapshot
The Histone Deacetylase Sirt6 Regulates Glucose Homeostasis via Hif1α
inferred← citeshttps://doi.org/10.1016/j.cell.2023.08.037openalex-snapshot
Human microglial state dynamics in Alzheimer’s disease progression
inferred← citeshttps://doi.org/10.1016/j.cellsig.2014.11.004openalex-snapshot
ECM1 promotes the Warburg effect through EGF-mediated activation of PKM2
inferred← citeshttps://doi.org/10.1016/j.celrep.2017.04.012openalex-snapshot
STAT3 Regulation of Citrate Synthase Is Essential during the Initiation of Lymphocyte Cell Growth
inferred← citeshttps://doi.org/10.1016/j.celrep.2023.112155openalex-snapshot
Limiting Mrs2-dependent mitochondrial Mg2+ uptake induces metabolic programming in prolonged dietary stress
inferred← citeshttps://doi.org/10.1016/j.cmet.2007.10.002openalex-snapshot
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
inferred← citeshttps://doi.org/10.1016/j.cmet.2012.12.001openalex-snapshot
AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo
inferred← citeshttps://doi.org/10.1016/j.cmet.2019.01.015openalex-snapshot
Cancer Metabolism Drives a Stromal Regenerative Response
inferred← citeshttps://doi.org/10.1016/j.cytogfr.2018.11.001openalex-snapshot
Potential roles of IL-1 subfamily members in glycolysis in disease
inferred← citeshttps://doi.org/10.1016/j.devcel.2023.08.015openalex-snapshot
Mitochondrial leak metabolism induces the Spemann-Mangold Organizer via Hif-1α in Xenopus
inferred← citeshttps://doi.org/10.1016/j.drudis.2015.03.001openalex-snapshot
Restoration of mitochondria function as a target for cancer therapy
inferred← citeshttps://doi.org/10.1016/j.drup.2020.100703openalex-snapshot
Genetic biomarkers of drug resistance: A compass of prognosis and targeted therapy in acute myeloid leukemia
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.117341openalex-snapshot
Hexavalent chromium induced metabolic reprogramming, carcinogenesis and tumor progression through PDK1 upregulation
inferred← citeshttps://doi.org/10.1016/j.envint.2019.105428openalex-snapshot
PI3K/Akt/FoxO pathway mediates glycolytic metabolism in HepG2 cells exposed to triclosan (TCS)
inferred← citeshttps://doi.org/10.1016/j.exphem.2009.01.007openalex-snapshot
Low oxygen concentration as a general physiologic regulator of erythropoiesis beyond the EPO-related downstream tuning and a tool for the optimization of red blood cell production ex vivo
inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2025.10.007openalex-snapshot
p66Shc silencing promotes aerobic glycolysis via signalling between the transcription factors NRF2 and HIF1-α
inferred← citeshttps://doi.org/10.1016/j.gde.2008.02.003openalex-snapshot
Brick by brick: metabolism and tumor cell growth
inferred← citeshttps://doi.org/10.1016/j.gde.2009.01.002openalex-snapshot
The molecular determinants of de novo nucleotide biosynthesis in cancer cells
inferred← citeshttps://doi.org/10.1016/j.heliyon.2024.e27654openalex-snapshot
Hypoxia/inflammation-induced upregulation of HIF-1α and C/EBPβ promotes nephroblastoma cell EMT by improving HOXA11-AS transcription
inferred← citeshttps://doi.org/10.1016/j.isci.2020.101979openalex-snapshot
Increasing neuronal glucose uptake attenuates brain aging and promotes life span under dietary restriction in Drosophila
inferred← citeshttps://doi.org/10.1016/j.isci.2022.104625openalex-snapshot
Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism
inferred← citeshttps://doi.org/10.1016/j.isci.2024.108821openalex-snapshot
Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes
inferred← citeshttps://doi.org/10.1016/j.isci.2025.114211openalex-snapshot
Oxygen-dependent regulation of serotonin receptor 5-HT1A in hypoxic response and flight performance in bumblebees, Bombus terrestris
inferred← citeshttps://doi.org/10.1016/j.jconrel.2011.03.032openalex-snapshot
Multi-modal strategies for overcoming tumor drug resistance: Hypoxia, the Warburg effect, stem cells, and multifunctional nanotechnology
inferred← citeshttps://doi.org/10.1016/j.jep.2009.09.027openalex-snapshot
Involvement of the PI3K/AKT pathway in the hypoglycemic effects of saponins from Helicteres isora
inferred← citeshttps://doi.org/10.1016/j.jfma.2021.03.019openalex-snapshot
Immunometabolism in systemic lupus erythematosus: Relevant pathogenetic mechanisms and potential clinical applications
inferred← citeshttps://doi.org/10.1016/j.jhep.2021.09.020openalex-snapshot
HIF-1α modulates sex-specific Th17/Treg responses during hepatic amoebiasis
inferred← citeshttps://doi.org/10.1016/j.lfs.2016.11.016openalex-snapshot
Satellite cell activation induced by aerobic muscle adaptation in response to endurance exercise in humans and rodents
inferred← citeshttps://doi.org/10.1016/j.lfs.2017.09.008openalex-snapshot
PPARγ agonists: Potential treatments for exudative age-related macular degeneration
inferred← citeshttps://doi.org/10.1016/j.lfs.2019.116952openalex-snapshot
Hypoxia inducible factors in the tumor microenvironment as therapeutic targets of cancer stem cells
inferred← citeshttps://doi.org/10.1016/j.mambio.2016.07.004openalex-snapshot
Coping with environmental stress: The effects of wastewater pollutants on energy stores and leptin levels in insectivorous bats
inferred← citeshttps://doi.org/10.1016/j.mce.2018.05.002openalex-snapshot
Curcumin inhibits hepatic stellate cell activation via suppression of succinate-associated HIF-1α induction
inferred← citeshttps://doi.org/10.1016/j.molcel.2007.10.035openalex-snapshot
FOXO3a Is Activated in Response to Hypoxic Stress and Inhibits HIF1-Induced Apoptosis via Regulation of CITED2
inferred← citeshttps://doi.org/10.1016/j.molcel.2010.05.007openalex-snapshot
Glucose Addiction of TSC Null Cells Is Caused by Failed mTORC1-Dependent Balancing of Metabolic Demand with Supply
inferred← citeshttps://doi.org/10.1016/j.molcel.2010.10.030openalex-snapshot
mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α
inferred← citeshttps://doi.org/10.1016/j.molmed.2022.10.005openalex-snapshot
Engineering of the microenvironment to accelerate vascular regeneration
inferred← citeshttps://doi.org/10.1016/j.niox.2022.11.003openalex-snapshot
Glutamine-dependent effects of nitric oxide on cancer cells subjected to hypoxia-reoxygenation
inferred← citeshttps://doi.org/10.1016/j.pharmthera.2018.11.004openalex-snapshot
Altered cancer metabolism in mechanisms of immunotherapy resistance
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2025.101403openalex-snapshot
Keeping the lights on: a new role for an old drug to support cone survival in Retinitis Pigmentosa
inferred← citeshttps://doi.org/10.1016/j.redox.2022.102575openalex-snapshot
NCoR1 controls immune tolerance in conventional dendritic cells by fine-tuning glycolysis and fatty acid oxidation
inferred← citeshttps://doi.org/10.1016/j.redox.2023.102831openalex-snapshot
Cellular and exosomal GPx1 are essential for controlling hydrogen peroxide balance and alleviating oxidative stress in hypoxic glioblastoma
inferred← citeshttps://doi.org/10.1016/j.smim.2016.09.002openalex-snapshot
Immunometabolic circuits in trained immunity
inferred← citeshttps://doi.org/10.1016/j.stem.2012.10.011openalex-snapshot
Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells
inferred← citeshttps://doi.org/10.1016/j.surg.2011.06.006openalex-snapshot
Systemic pretreatment with dimethyloxalylglycine increases myocardial HIF-1α and VEGF production and improves functional recovery after acute ischemia/reperfusion
inferred← citeshttps://doi.org/10.1016/j.tcb.2012.08.001openalex-snapshot
The nuclear factor kappa B signaling pathway: integrating metabolism with inflammation
inferred← citeshttps://doi.org/10.1016/j.tice.2026.103914openalex-snapshot
KDM1A promotes colorectal cancer growth by regulating the HIF-1α/PDK4-mediated glycolysis
inferred← citeshttps://doi.org/10.1016/j.tips.2024.07.001openalex-snapshot
Role of hypoxia-inducible factor 1 in type 1 diabetes
inferred← citeshttps://doi.org/10.1016/j.trsl.2022.06.015openalex-snapshot
Associations between local acidosis induced by renal LDHA and renal fibrosis and mitochondrial abnormalities in patients with diabetic kidney disease
inferred← citeshttps://doi.org/10.1016/j.yjmcc.2019.05.024openalex-snapshot
Metabolic reprogramming in atherosclerosis: Opposed interplay between the canonical WNT/β-catenin pathway and PPARγ
inferred← citeshttps://doi.org/10.1017/cbo9780511979811.012openalex-snapshot
Functional networks of events that modulate phenotypic manifestation of cancer
inferred← citeshttps://doi.org/10.1017/s0007114511000614openalex-snapshot
Beneficial effects of dietary fibre supplementation of a high-fat diet on fetal development in rats
inferred← citeshttps://doi.org/10.1021/mp1002653openalex-snapshot
Development of EGFR-Targeted Polymer Blend Nanocarriers for Combination Paclitaxel/Lonidamine Delivery To Treat Multi-Drug Resistance in Human Breast and Ovarian Tumor Cells
inferred← citeshttps://doi.org/10.1038/cdd.2014.95openalex-snapshot
Tumor suppressor WWOX regulates glucose metabolism via HIF1α modulation
inferred← citeshttps://doi.org/10.1038/cddis.2014.565openalex-snapshot
The role of hypoxia-inducible factor-2 in digestive system cancers
inferred← citeshttps://doi.org/10.1038/clpt.2009.48openalex-snapshot
Biomarker Discovery: Identification of a Growth Factor Gene Signature
inferred← citeshttps://doi.org/10.1038/nature06667openalex-snapshot
Pyruvate kinase M2 is a phosphotyrosine-binding protein
inferred← citeshttps://doi.org/10.1038/nature22379openalex-snapshot
Nutrient acquisition strategies of mammalian cells
inferred← citeshttps://doi.org/10.1038/nrc2468openalex-snapshot
Hypoxia, HIF1 and glucose metabolism in the solid tumour
inferred← citeshttps://doi.org/10.1038/nrg2665openalex-snapshot
Generating specificity and diversity in the transcriptional response to hypoxia
inferred← citeshttps://doi.org/10.1038/onc.2009.112openalex-snapshot
c-Myc activates multiple metabolic networks to generate substrates for cell-cycle entry
inferred← citeshttps://doi.org/10.1038/onc.2009.252openalex-snapshot
Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α
inferred← citeshttps://doi.org/10.1038/onc.2010.67openalex-snapshot
Imatinib resistance associated with BCR-ABL upregulation is dependent on HIF-1α-induced metabolic reprograming
inferred← citeshttps://doi.org/10.1038/onc.2013.115openalex-snapshot
STAT3 and HIF1α cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells
inferred← citeshttps://doi.org/10.1038/onc.2017.36openalex-snapshot
Cytosolic malate dehydrogenase activity helps support glycolysis in actively proliferating cells and cancer
inferred← citeshttps://doi.org/10.1038/s41366-024-01604-5openalex-snapshot
The rs2341471-G/G genotype of activating transcription factor 6 (ATF6) is the risk factor of type 2 diabetes in subjects with obesity or overweight
inferred← citeshttps://doi.org/10.1038/s41388-018-0582-8openalex-snapshot
The ERK and JNK pathways in the regulation of metabolic reprogramming
inferred← citeshttps://doi.org/10.1038/s41398-020-01086-9openalex-snapshot
The influence of circadian rhythms and aerobic glycolysis in autism spectrum disorder
inferred← citeshttps://doi.org/10.1038/s41419-020-02768-4openalex-snapshot
HIF-1α regulates cellular metabolism, and Imatinib resistance by targeting phosphogluconate dehydrogenase in gastrointestinal stromal tumors
inferred← citeshttps://doi.org/10.1038/s41420-023-01695-5openalex-snapshot
Cigarette smoke causes a bioenergetic crisis in RPE cells involving the downregulation of HIF-1α under normoxia
inferred← citeshttps://doi.org/10.1038/s41423-024-01222-1openalex-snapshot
Ubiquitin regulatory X (UBX) domain-containing protein 6 is essential for autophagy induction and inflammation control in macrophages
inferred← citeshttps://doi.org/10.1038/s41467-020-16504-1openalex-snapshot
A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism
inferred← citeshttps://doi.org/10.1038/s41467-025-64360-8openalex-snapshot
Alpha-ketoglutarate mitigates insulin resistance and metabolic inflexibility in a mouse model of Ataxia-Telangiectasia
inferred← citeshttps://doi.org/10.1038/s41540-025-00525-xopenalex-snapshot
Computational modeling of cancer cell metabolism along the catabolic-anabolic axes
inferred← citeshttps://doi.org/10.1038/s41598-017-00508-xopenalex-snapshot
IL-1β induced HIF-1α inhibits the differentiation of human FOXP3+ T cells
inferred← citeshttps://doi.org/10.1038/s41598-017-13330-2openalex-snapshot
Mechanistic Evaluation and Translational Signature of Gemcitabine-induced Chemoresistance by Quantitative Phosphoproteomics Analysis with iTRAQ Labeling Mass Spectrometry
inferred← citeshttps://doi.org/10.1038/s41598-020-66059-wopenalex-snapshot
Computational modeling to determine key regulators of hypoxia effects on the lactate production in the glycolysis pathway
inferred← citeshttps://doi.org/10.1038/s41598-021-89792-2openalex-snapshot
Effect of hypoxia factors gene silencing on ROS production and metabolic status of A375 malignant melanoma cells
inferred← citeshttps://doi.org/10.1038/s42003-025-07880-9openalex-snapshot
HIF1A facilitates hypoxia-induced changes in H3K27ac modification to promote myometrial contractility
inferred← citeshttps://doi.org/10.1038/sj.bjc.6604547openalex-snapshot
Poorer outcome in stromal HIF-2α- and CA9-positive colorectal adenocarcinomas is associated with wild-type TP53 but not with BNIP3 promoter hypermethylation or apoptosis
inferred← citeshttps://doi.org/10.1038/srep25929openalex-snapshot
The developmental effects of pentachlorophenol on zebrafish embryos during segmentation: A systematic view
inferred← citeshttps://doi.org/10.1038/srep40830openalex-snapshot
Hypoxia inducible factors are dispensable for myeloid cell migration into the inflamed mouse eye
inferred← citeshttps://doi.org/10.1053/j.semnuclmed.2007.11.006openalex-snapshot
Fundamentals of Molecular Imaging: Rationale and Applications With Relevance for Radiation Oncology
inferred← citeshttps://doi.org/10.1073/pnas.0801376105openalex-snapshot
The splicing-factor oncoprotein SF2/ASF activates mTORC1
inferred← citeshttps://doi.org/10.1073/pnas.0810199105openalex-snapshot
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
inferred← citeshttps://doi.org/10.1073/pnas.0900465106openalex-snapshot
mTOR and HIF-1α-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome
inferred← citeshttps://doi.org/10.1073/pnas.0909570107openalex-snapshot
Hypoxia converts the myogenic action of insulin-like growth factors into mitogenic action by differentially regulating multiple signaling pathways
inferred← citeshttps://doi.org/10.1073/pnas.1001296107openalex-snapshot
HIF-2α deletion promotes Kras-driven lung tumor development
inferred← citeshttps://doi.org/10.1073/pnas.1108856108openalex-snapshot
Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation
inferred← citeshttps://doi.org/10.1073/pnas.1117773108openalex-snapshot
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
inferred← citeshttps://doi.org/10.1073/pnas.1608198113openalex-snapshot
Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopy
inferred← citeshttps://doi.org/10.1074/jbc.aw119.008146openalex-snapshot
Growth factors stimulate anabolic metabolism by directing nutrient uptake
inferred← citeshttps://doi.org/10.1074/jbc.m112.396796openalex-snapshot
Cofactor Balance by Nicotinamide Nucleotide Transhydrogenase (NNT) Coordinates Reductive Carboxylation and Glucose Catabolism in the Tricarboxylic Acid (TCA) Cycle
inferred← citeshttps://doi.org/10.1074/jbc.m116.715797openalex-snapshot
Activation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1α Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium
inferred← citeshttps://doi.org/10.1074/jbc.m710079200openalex-snapshot
Hypoxia-mediated Selective mRNA Translation by an Internal Ribosome Entry Site-independent Mechanism
inferred← citeshttps://doi.org/10.1074/jbc.m800102200openalex-snapshot
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
inferred← citeshttps://doi.org/10.1074/jbc.m805056200openalex-snapshot
Hypoxic Reactive Oxygen Species Regulate the Integrated Stress Response and Cell Survival
inferred← citeshttps://doi.org/10.1074/jbc.ra119.012175openalex-snapshot
Hypoxia drives the assembly of the multienzyme purinosome complex
inferred← citeshttps://doi.org/10.1089/ars.2018.7673openalex-snapshot
Focus on Early Events: Pathogenesis of Pulmonary Arterial Hypertension Development
inferred← citeshttps://doi.org/10.1089/ars.2020.8161openalex-snapshot
Interplay Between Reactive Oxygen/Reactive Nitrogen Species and Metabolism in Vascular Biology and Disease
inferred← citeshttps://doi.org/10.1093/bjd/ljad305openalex-snapshot
Metformin has anti-inflammatory effects and induces immunometabolic reprogramming via multiple mechanisms in hidradenitis suppurativa
inferred← citeshttps://doi.org/10.1093/hropen/hoae028openalex-snapshot
Effects of chemical in vitro activation versus fragmentation on human ovarian tissue and follicle growth in culture
inferred← citeshttps://doi.org/10.1093/intimm/dxp112openalex-snapshot
IL-21 and T follicular helper cells
inferred← citeshttps://doi.org/10.1093/intimm/dxs110openalex-snapshot
Hypoxia-mediated regulation of macrophage functions in pathophysiology
inferred← citeshttps://doi.org/10.1093/jleuko/qiae025openalex-snapshot
Metabolic regulation of neutrophil functions in homeostasis and diseases
inferred← citeshttps://doi.org/10.1093/jleuko/qiae215openalex-snapshot
Intracellular methylglyoxal accumulation in classically activated mouse macrophages is mediated by HIF-1α
inferred← citeshttps://doi.org/10.1093/nar/gkn620openalex-snapshot
Stra13/DEC1 and DEC2 inhibit sterol regulatory element binding protein-1c in a hypoxia-inducible factor-dependent mechanism
inferred← citeshttps://doi.org/10.1093/ndt/gfaa091openalex-snapshot
Hypoxia in chronic kidney disease: towards a paradigm shift?
inferred← citeshttps://doi.org/10.1093/neuonc/noac041openalex-snapshot
Imipridones affect tumor bioenergetics and promote cell lineage differentiation in diffuse midline gliomas
inferred← citeshttps://doi.org/10.1093/neuonc/nov125openalex-snapshot
Metabolic reprogramming in glioblastoma: the influence of cancer metabolism on epigenetics and unanswered questions
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