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Advanced human iPSC-based preclinical model for Parkinson’s disease with optogenetic alpha-synuclein aggregation

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/stem.3163openalex-snapshot
Generation of homogeneous midbrain organoids with in vivo-like cellular composition facilitates neurotoxin-based Parkinson's disease modeling
inferredcites →https://doi.org/10.1007/s00401-012-0964-xopenalex-snapshot
An antibody with high reactivity for disease-associated α-synuclein reveals extensive brain pathology
inferredcites →https://doi.org/10.1007/s00401-016-1648-8openalex-snapshot
Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology
inferredcites →https://doi.org/10.1007/s00401-019-01995-0openalex-snapshot
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons
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Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model
inferredcites →https://doi.org/10.1007/s12640-017-9825-7openalex-snapshot
Dexamethasone Inhibits Copper-Induced Alpha-Synuclein Aggregation by a Metallothionein-Dependent Mechanism
inferredcites →https://doi.org/10.1016/j.brainres.2015.11.013openalex-snapshot
Back and forth in time: Directing age in iPSC-derived lineages
inferredcites →https://doi.org/10.1016/j.ceb.2012.08.014openalex-snapshot
iPSC technology to study human aging and aging-related disorders
inferredcites →https://doi.org/10.1016/j.cell.2013.05.057openalex-snapshot
Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
inferredcites →https://doi.org/10.1016/j.cell.2016.04.032openalex-snapshot
Brain-Region-Specific Organoids Using Mini-bioreactors for Modeling ZIKV Exposure
inferredcites →https://doi.org/10.1016/j.celrep.2014.10.023openalex-snapshot
iPSC-Derived Dopamine Neurons Reveal Differences between Monozygotic Twins Discordant for Parkinson’s Disease
inferredcites →https://doi.org/10.1016/j.chembiol.2014.05.013openalex-snapshot
Spatiotemporal Control of Fibroblast Growth Factor Receptor Signals by Blue Light
inferredcites →https://doi.org/10.1016/j.nbd.2014.05.020openalex-snapshot
Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread
inferredcites →https://doi.org/10.1016/j.nbd.2019.104525openalex-snapshot
Time course and magnitude of alpha-synuclein inclusion formation and nigrostriatal degeneration in the rat model of synucleinopathy triggered by intrastriatal α-synuclein preformed fibrils
inferredcites →https://doi.org/10.1016/j.neuron.2006.09.026openalex-snapshot
Mechanisms of Parkinson's Disease Linked to Pathological α-Synuclein: New Targets for Drug Discovery
inferredcites →https://doi.org/10.1016/j.neuron.2011.08.033openalex-snapshot
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
inferredcites →https://doi.org/10.1016/j.neuron.2017.09.047openalex-snapshot
Optogenetic Tools for Subcellular Applications in Neuroscience
inferredcites →https://doi.org/10.1016/j.neuron.2019.05.035openalex-snapshot
Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson’s Disease
inferredcites →https://doi.org/10.1016/j.neuron.2021.09.031openalex-snapshot
TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease
inferredcites →https://doi.org/10.1016/j.stem.2013.11.006openalex-snapshot
Human iPSC-Based Modeling of Late-Onset Disease via Progerin-Induced Aging
inferredcites →https://doi.org/10.1016/j.stem.2016.05.022openalex-snapshot
Stem Cell Models of Human Brain Development
inferredcites →https://doi.org/10.1016/j.stem.2016.07.005openalex-snapshot
Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons
inferredcites →https://doi.org/10.1016/j.stem.2019.08.013openalex-snapshot
Loss of SATB1 Induces p21-Dependent Cellular Senescence in Post-mitotic Dopaminergic Neurons
inferredcites →https://doi.org/10.1016/j.stem.2020.08.002openalex-snapshot
Defects in mRNA Translation in LRRK2-Mutant hiPSC-Derived Dopaminergic Neurons Lead to Dysregulated Calcium Homeostasis
inferredcites →https://doi.org/10.1016/s0197-4580(02)00065-9openalex-snapshot
Staging of brain pathology related to sporadic Parkinson’s disease
inferredcites →https://doi.org/10.1016/s0896-6273(02)00682-7openalex-snapshot
Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein
inferredcites →https://doi.org/10.1016/s0896-6273(03)00568-3openalex-snapshot
Parkinson's Disease
inferredcites →https://doi.org/10.1038/42166openalex-snapshot
α-Synuclein in Lewy bodies
inferredcites →https://doi.org/10.1038/emboj.2012.170openalex-snapshot
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences
inferredcites →https://doi.org/10.1038/nature10648openalex-snapshot
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease
inferredcites →https://doi.org/10.1038/ncb2763openalex-snapshot
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output
inferredcites →https://doi.org/10.1038/ncomms1453openalex-snapshot
Parkinson's disease induced pluripotent stem cells with triplication of the α-synuclein locus
inferredcites →https://doi.org/10.1038/nm.4269openalex-snapshot
α-synuclein toxicity in neurodegeneration: mechanism and therapeutic strategies
inferredcites →https://doi.org/10.1038/nm1747openalex-snapshot
Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease
inferredcites →https://doi.org/10.1038/nmeth.2089openalex-snapshot
NIH Image to ImageJ: 25 years of image analysis
inferredcites →https://doi.org/10.1038/nn1443openalex-snapshot
α-Synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
inferredcites →https://doi.org/10.1038/nrm3025openalex-snapshot
mTOR: from growth signal integration to cancer, diabetes and ageing
inferredcites →https://doi.org/10.1038/s41467-017-00060-2openalex-snapshot
Optogenetic protein clustering through fluorescent protein tagging and extension of CRY2
inferredcites →https://doi.org/10.1038/s41593-019-0457-5openalex-snapshot
Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis
inferredcites →https://doi.org/10.1038/s41598-017-05633-1openalex-snapshot
Expansion of human midbrain floor plate progenitors from induced pluripotent stem cells increases dopaminergic neuron differentiation potential
inferredcites →https://doi.org/10.1038/srep05797openalex-snapshot
Quantitative Measurement of Intact Alpha-Synuclein Proteoforms from Post-Mortem Control and Parkinson's Disease Brain Tissue by Intact Protein Mass Spectrometry
inferredcites →https://doi.org/10.1073/pnas.0908005106openalex-snapshot
Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
inferredcites →https://doi.org/10.1073/pnas.1100976108openalex-snapshot
In vivo demonstration that α-synuclein oligomers are toxic
inferredcites →https://doi.org/10.1073/pnas.1710442114openalex-snapshot
Modeling Parkinson’s disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain
inferredcites →https://doi.org/10.1073/pnas.1913904117openalex-snapshot
The process of Lewy body formation, rather than simply α-synuclein fibrillization, is one of the major drivers of neurodegeneration
inferredcites →https://doi.org/10.1073/pnas.95.7.4013openalex-snapshot
Nurr1 is essential for the induction of the dopaminergic phenotype and the survival of ventral mesencephalic late dopaminergic precursor neurons
inferredcites →https://doi.org/10.1074/jbc.m105326200openalex-snapshot
Formation and Removal of α-Synuclein Aggregates in Cells Exposed to Mitochondrial Inhibitors
inferredcites →https://doi.org/10.1074/jbc.m300227200openalex-snapshot
α-Synuclein Is Degraded by Both Autophagy and the Proteasome
inferredcites →https://doi.org/10.1074/jbc.m508361200openalex-snapshot
mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes
inferredcites →https://doi.org/10.1083/jcb.200907014openalex-snapshot
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes
inferredcites →https://doi.org/10.1093/brain/awm302openalex-snapshot
Axonal -synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
inferredcites →https://doi.org/10.1093/hmg/ddt674openalex-snapshot
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
inferredcites →https://doi.org/10.1093/jnen/62.12.1241openalex-snapshot
Morphogenesis of Lewy Bodies: Dissimilar Incorporation of α-Synuclein, Ubiquitin, and p62
inferredcites →https://doi.org/10.1093/jnen/74.12.1158openalex-snapshot
Transmission of Soluble and Insoluble α-Synuclein to Mice
inferredcites →https://doi.org/10.1111/aor.14503openalex-snapshot
FDA Modernization Act 2.0 allows for alternatives to animal testing
inferredcites →https://doi.org/10.1111/j.1349-7006.2008.00891.xopenalex-snapshot
Phosphatidylinositol 3‐kinase inhibitors: promising drug candidates for cancer therapy
inferredcites →https://doi.org/10.1111/j.1750-3639.2008.00140.xopenalex-snapshot
Three‐Layered Structure Shared Between Lewy Bodies and Lewy Neurites—Three‐Dimensional Reconstruction of Triple‐Labeled Sections
inferredcites →https://doi.org/10.1111/jnc.13731openalex-snapshot
Mitochondrial dysfunction in Parkinson's disease
inferredcites →https://doi.org/10.1111/jnc.14806openalex-snapshot
Cellular models of alpha‐synuclein toxicity and aggregation
inferredcites →https://doi.org/10.1126/science.1090278openalex-snapshot
α-Synuclein Locus Triplication Causes Parkinson's Disease
inferredcites →https://doi.org/10.1126/science.1101738openalex-snapshot
Impaired Degradation of Mutant α-Synuclein by Chaperone-Mediated Autophagy
inferredcites →https://doi.org/10.1126/science.1227157openalex-snapshot
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
inferredcites →https://doi.org/10.1126/science.276.5321.2045openalex-snapshot
Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease
inferredcites →https://doi.org/10.1126/science.290.5497.1717openalex-snapshot
Autophagy as a Regulated Pathway of Cellular Degradation
inferredcites →https://doi.org/10.1126/science.adg6276openalex-snapshot
FDA no longer has to require animal testing for new drugs
inferredcites →https://doi.org/10.1146/annurev.neuro.22.1.123openalex-snapshot
ETIOLOGY AND PATHOGENESIS OF PARKINSON'S DISEASE
inferredcites →https://doi.org/10.1155/2015/628192openalex-snapshot
Insights into Neuroinflammation in Parkinson’s Disease: From Biomarkers to Anti-Inflammatory Based Therapies
inferredcites →https://doi.org/10.1158/0008-5472.can-08-1385openalex-snapshot
NVP-BEZ235, a Dual PI3K/mTOR Inhibitor, Prevents PI3K Signaling and Inhibits the Growth of Cancer Cells with Activating PI3K Mutations
inferredcites →https://doi.org/10.1158/2159-8290.cd-15-0460openalex-snapshot
PtdIns(3,4,5) P 3-Dependent Activation of the mTORC2 Kinase Complex
inferredcites →https://doi.org/10.1159/000373980openalex-snapshot
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
inferredcites →https://doi.org/10.1177/108705719900400206openalex-snapshot
A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays
inferredcites →https://doi.org/10.1186/s12974-019-1646-6openalex-snapshot
CXCL12 is involved in α-synuclein-triggered neuroinflammation of Parkinson’s disease
inferredcites →https://doi.org/10.1186/s13024-016-0072-9openalex-snapshot
Oligomeric and phosphorylated alpha-synuclein as potential CSF biomarkers for Parkinson’s disease
inferredcites →https://doi.org/10.14802/jmd.19046openalex-snapshot
Modeling α-Synuclein Propagation with Preformed Fibril Injections
inferredcites →https://doi.org/10.14802/jmd.19046.eopenalex-snapshot
Modeling α-Synuclein Propagation with Preformed Fibril Injections
inferredcites →https://doi.org/10.1523/jneurosci.4658-15.2016openalex-snapshot
Inhibition of the JAK/STAT Pathway Protects Against α-Synuclein-Induced Neuroinflammation and Dopaminergic Neurodegeneration
inferredcites →https://doi.org/10.31887/dcns.2004.6.3/ahartmannopenalex-snapshot
Postmortem studies in Parkinson's disease
inferredcites →https://doi.org/10.3389/fneur.2019.00035openalex-snapshot
Association of Two Polymorphisms in CCL2 With Parkinson's Disease: A Case-Control Study
inferredcites →https://doi.org/10.3389/fnmol.2019.00299openalex-snapshot
Targeting Alpha-Synuclein as a Therapy for Parkinson’s Disease
inferredcites →https://doi.org/10.3791/53193openalex-snapshot
Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Extracellular LCN2 Binding to 24p3R in Astrocytes Impedes α‐Synuclein Endocytosis in Parkinson's Disease
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Temporal Transcriptional Regulation of Human Neuronal Differentiation via Forward Programming
inferred← citeshttps://doi.org/10.1002/advs.78007openalex-snapshot
Developmentally Guided Differentiation of Ventral Midbrain Dopaminergic Cells Validated in Proteopathy‐Based Parkinson's Disease Models
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Shared Metabolic–Proteinopathy Axis in Alzheimer's Disease and Parkinson's Disease: Evidence for a Convergent but Not Identical Disease Spectrum
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Organoids in Cancer Research and Regenerative Medicine: Current Status, Challenges, and Future Prospects
inferred← citeshttps://doi.org/10.1002/med.70080openalex-snapshot
α‐Synuclein Seeds Amplification Assays for Parkinson's Disease and Related Synucleinopathies
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Navigating α‐Synuclein Aggregation Inhibition: Methods, Mechanisms, and Molecular Targets
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Curcumin Attenuates Cuproptosis via Activating Autophagy Through Inhibition of the AKT/mTOR/P70S6K-Signaling Pathway in Parkinson’s Disease Models
inferred← citeshttps://doi.org/10.1007/s12035-026-06248-2openalex-snapshot
A Live-Cell Imaging System for the Identification of Pro- and Anti-Aggregatory α-Synuclein Modulators
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Atorvastatin Shows Limited Disease-Modifying Effects in an A53T α-Synuclein Mouse Model of Parkinson’s Disease
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inferred← citeshttps://doi.org/10.1016/j.biotechadv.2025.108761openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.brainres.2025.150002openalex-snapshot
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