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Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics

https://doi.org/10.1016/j.tips.2022.07.001

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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DNA‐binding domain as the minimal region driving RNA‐dependent liquid–liquid phase separation of androgen receptor

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Translation inhibition and suppression of stress granules formation by cisplatin

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Connecting Coil-to-Globule Transitions to Full Phase Diagrams for Intrinsically Disordered Proteins

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Intrinsically disordered proteins and biomolecular condensates as drug targets

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Synthetic biomolecular condensates to engineer eukaryotic cells

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A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

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Biomolecular Condensates and Cancer

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The role of liquid–liquid phase separation in regulating enzyme activity

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A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

inferredcites →https://doi.org/10.1016/j.cell.2015.09.015openalex-snapshot

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

inferredcites →https://doi.org/10.1016/j.cell.2016.04.047openalex-snapshot

Coexisting Liquid Phases Underlie Nucleolar Subcompartments

inferredcites →https://doi.org/10.1016/j.cell.2016.06.010openalex-snapshot

Compositional Control of Phase-Separated Cellular Bodies

inferredcites →https://doi.org/10.1016/j.cell.2016.12.029openalex-snapshot

Ligand and Target Discovery by Fragment-Based Screening in Human Cells

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Cancer-Specific Retargeting of BAF Complexes by a Prion-like Domain

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FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions

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Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

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Considerations and Challenges in Studying Liquid-Liquid Phase Separation and Biomolecular Condensates

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Organization of Chromatin by Intrinsic and Regulated Phase Separation

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Phase Separation of Zonula Occludens Proteins Drives Formation of Tight Junctions

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G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

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Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

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Phase Separation of Disease-Associated SHP2 Mutants Underlies MAPK Hyperactivation

inferredcites →https://doi.org/10.1016/j.cell.2020.11.030openalex-snapshot

RNA-Mediated Feedback Control of Transcriptional Condensates

inferredcites →https://doi.org/10.1016/j.cell.2021.03.031openalex-snapshot

Kinase-Mediated RAS Signaling Via Membraneless Cytoplasmic Protein Granules

inferredcites →https://doi.org/10.1016/j.cell.2021.07.018openalex-snapshot

TDP-43 condensation properties specify its RNA-binding and regulatory repertoire

inferredcites →https://doi.org/10.1016/j.cell.2021.09.032openalex-snapshot

Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome

inferredcites →https://doi.org/10.1016/j.celrep.2017.11.093openalex-snapshot

ALS/FTD-Associated C9ORF72 Repeat RNA Promotes Phase Transitions In Vitro and in Cells

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Nuclear Import Receptors Directly Bind to Arginine-Rich Dipeptide Repeat Proteins and Suppress Their Pathological Interactions

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RNA-Targeted Therapeutics

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Genetic variation associated with condensate dysregulation in disease

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Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

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Identification of Small Molecules that Modulate Mutant p53 Condensation

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Enzymatic Reactions inside Biological Condensates

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Biochemical Timekeeping Via Reentrant Phase Transitions

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Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics

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The Stress Granule Transcriptome Reveals Principles of mRNA Accumulation in Stress Granules

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Poly(ADP-Ribose) Prevents Pathological Phase Separation of TDP-43 by Promoting Liquid Demixing and Stress Granule Localization

inferredcites →https://doi.org/10.1016/j.molcel.2018.08.003openalex-snapshot

α-Proteobacterial RNA Degradosomes Assemble Liquid-Liquid Phase-Separated RNP Bodies

inferredcites →https://doi.org/10.1016/j.molcel.2018.08.027openalex-snapshot

Cancer Mutations of the Tumor Suppressor SPOP Disrupt the Formation of Active, Phase-Separated Compartments

inferredcites →https://doi.org/10.1016/j.molcel.2019.03.001openalex-snapshot

Dynamic Recruitment of Single RNAs to Processing Bodies Depends on RNA Functionality

inferredcites →https://doi.org/10.1016/j.molcel.2019.03.019openalex-snapshot

C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function

inferredcites →https://doi.org/10.1016/j.molcel.2019.06.044openalex-snapshot

Nucleo-cytoplasmic Partitioning of ARF Proteins Controls Auxin Responses in Arabidopsis thaliana

inferredcites →https://doi.org/10.1016/j.molcel.2019.07.009openalex-snapshot

Enhancer Features that Drive Formation of Transcriptional Condensates

inferredcites →https://doi.org/10.1016/j.molcel.2020.05.008openalex-snapshot

Sequence-Independent Self-Assembly of Germ Granule mRNAs into Homotypic Clusters

inferredcites →https://doi.org/10.1016/j.molcel.2020.11.041openalex-snapshot

Genomic RNA Elements Drive Phase Separation of the SARS-CoV-2 Nucleocapsid

inferredcites →https://doi.org/10.1016/j.molcel.2021.01.024openalex-snapshot

cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing

inferredcites →https://doi.org/10.1016/j.molcel.2021.03.006openalex-snapshot

p53 mediates target gene association with nuclear speckles for amplified RNA expression

inferredcites →https://doi.org/10.1016/j.molcel.2021.07.024openalex-snapshot

Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation

inferredcites →https://doi.org/10.1016/j.molcel.2021.12.010openalex-snapshot

Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns

inferredcites →https://doi.org/10.1016/j.molcel.2022.01.005openalex-snapshot

Chaperones directly and efficiently disperse stress-triggered biomolecular condensates

inferredcites →https://doi.org/10.1016/j.molcel.2022.01.018openalex-snapshot

Poly(ADP-ribose) drives condensation of FUS via a transient interaction

inferredcites →https://doi.org/10.1016/j.molcel.2022.02.005openalex-snapshot

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

inferredcites →https://doi.org/10.1016/j.molcel.2022.02.035openalex-snapshot

Lipid-mediated phase separation of AGO proteins on the ER controls nascent-peptide ubiquitination

inferredcites →https://doi.org/10.1016/j.neuron.2015.10.030openalex-snapshot

ALS/FTD Mutation-Induced Phase Transition of FUS Liquid Droplets and Reversible Hydrogels into Irreversible Hydrogels Impairs RNP Granule Function

inferredcites →https://doi.org/10.1016/j.neuron.2019.01.048openalex-snapshot

RNA Binding Antagonizes Neurotoxic Phase Transitions of TDP-43

inferredcites →https://doi.org/10.1016/j.neuron.2019.05.048openalex-snapshot

Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD

inferredcites →https://doi.org/10.1016/j.tcb.2021.03.001openalex-snapshot

Phase separation in genome organization across evolution

inferredcites →https://doi.org/10.1016/j.tibs.2020.06.007openalex-snapshot

Biomolecular Condensates in the Nucleus

inferredcites →https://doi.org/10.1016/j.tins.2019.08.005openalex-snapshot

Physiological, Pathological, and Targetable Membraneless Organelles in Neurons

inferredcites →https://doi.org/10.1016/j.tips.2020.08.004openalex-snapshot

Paving the Road for RNA Therapeutics

inferredcites →https://doi.org/10.1016/s0169-409x(00)00129-0openalex-snapshot

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings 1PII of original article: S0169-409X(96)00423-1. The article was originally published in Advanced Drug Delivery Reviews 23 (1997) 3–25. 1

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P-Bodies: Composition, Properties, and Functions

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Glucose as a Protein-Condensing Cellular Solute

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Synthetic Protein Condensates That Inducibly Recruit and Release Protein Activity in Living Cells

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Therapeutic reduction of ataxin-2 extends lifespan and reduces pathology in TDP-43 mice

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RNA phase transitions in repeat expansion disorders

inferredcites →https://doi.org/10.1038/nature22822openalex-snapshot

Liquid droplet formation by HP1α suggests a role for phase separation in heterochromatin

inferredcites →https://doi.org/10.1038/nchembio.546openalex-snapshot

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

inferredcites →https://doi.org/10.1038/nrm.2017.7openalex-snapshot

Biomolecular condensates: organizers of cellular biochemistry

inferredcites →https://doi.org/10.1038/onc.2014.296openalex-snapshot

p53 protein aggregation promotes platinum resistance in ovarian cancer

inferredcites →https://doi.org/10.1038/s41467-020-19211-zopenalex-snapshot

Small molecules as potent biphasic modulators of protein liquid-liquid phase separation

inferredcites →https://doi.org/10.1038/s41467-022-28765-zopenalex-snapshot

Phase separation on cell surface facilitates bFGF signal transduction with heparan sulphate

inferredcites →https://doi.org/10.1038/s41467-022-31220-8openalex-snapshot

Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing

inferredcites →https://doi.org/10.1038/s41551-021-00838-2openalex-snapshot

Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats

inferredcites →https://doi.org/10.1038/s41556-018-0263-4openalex-snapshot

Multicolour single-molecule tracking of mRNA interactions with RNP granules

inferredcites →https://doi.org/10.1038/s41556-019-0376-4openalex-snapshot

The inner centromere is a biomolecular condensate scaffolded by the chromosomal passenger complex

inferredcites →https://doi.org/10.1038/s41556-019-0392-4openalex-snapshot

Functional transcription promoters at DNA double-strand breaks mediate RNA-driven phase separation of damage-response factors

inferredcites →https://doi.org/10.1038/s41556-020-0485-0openalex-snapshot

Phase separation of TAZ compartmentalizes the transcription machinery to promote gene expression

inferredcites →https://doi.org/10.1038/s41556-020-0550-8openalex-snapshot

Biophysical properties of AKAP95 protein condensates regulate splicing and tumorigenesis

inferredcites →https://doi.org/10.1038/s41556-021-00710-0openalex-snapshot

Targeting liquid–liquid phase separation of SARS-CoV-2 nucleocapsid protein promotes innate antiviral immunity by elevating MAVS activity

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A new era for understanding amyloid structures and disease

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A framework for understanding the functions of biomolecular condensates across scales

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Biomolecular condensates at the nexus of cellular stress, protein aggregation disease and ageing

inferredcites →https://doi.org/10.1038/s41580-020-0264-6openalex-snapshot

RNA contributions to the form and function of biomolecular condensates

inferredcites →https://doi.org/10.1038/s41580-020-0272-6openalex-snapshot

The nucleolus as a multiphase liquid condensate

inferredcites →https://doi.org/10.1038/s41586-018-0279-8openalex-snapshot

Kinase-controlled phase transition of membraneless organelles in mitosis

inferredcites →https://doi.org/10.1038/s41586-019-1374-1openalex-snapshot

m6A enhances the phase separation potential of mRNA

inferredcites →https://doi.org/10.1038/s41586-019-1464-0openalex-snapshot

Pol II phosphorylation regulates a switch between transcriptional and splicing condensates

inferredcites →https://doi.org/10.1038/s41586-019-1502-yopenalex-snapshot

DEAD-box ATPases are global regulators of phase-separated organelles

inferredcites →https://doi.org/10.1038/s41586-020-1977-6openalex-snapshot

Phase separation organizes the site of autophagosome formation

inferredcites →https://doi.org/10.1038/s41586-020-2256-2openalex-snapshot

Composition-dependent thermodynamics of intracellular phase separation

inferredcites →https://doi.org/10.1038/s41586-020-2574-4openalex-snapshot

MeCP2 links heterochromatin condensates and neurodevelopmental disease

inferredcites →https://doi.org/10.1038/s41586-020-2942-0openalex-snapshot

Assembly of synaptic active zones requires phase separation of scaffold molecules

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NORAD-induced Pumilio phase separation is required for genome stability

inferredcites →https://doi.org/10.1038/s41586-021-03662-5openalex-snapshot

Phase separation drives aberrant chromatin looping and cancer development

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DAXX represents a new type of protein-folding enabler

inferredcites →https://doi.org/10.1038/s41586-021-03903-7openalex-snapshot

UTX condensation underlies its tumour-suppressive activity

inferredcites →https://doi.org/10.1038/s41587-019-0106-2openalex-snapshot

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

inferredcites →https://doi.org/10.1038/s41588-020-00724-8openalex-snapshot

MLL4-associated condensates counterbalance Polycomb-mediated nuclear mechanical stress in Kabuki syndrome

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Light-based control of metabolic flux through assembly of synthetic organelles

inferredcites →https://doi.org/10.1038/s41589-020-0524-yopenalex-snapshot

m6A-binding YTHDF proteins promote stress granule formation

inferredcites →https://doi.org/10.1038/s41589-021-00801-xopenalex-snapshot

Mechanistic dissection of increased enzymatic rate in a phase-separated compartment

inferredcites →https://doi.org/10.1038/s41589-021-00840-4openalex-snapshot

Designer membraneless organelles sequester native factors for control of cell behavior

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Learning the chemical grammar of biomolecular condensates

inferredcites →https://doi.org/10.1038/s41591-021-01557-6openalex-snapshot

Suppression of mutant C9orf72 expression by a potent mixed backbone antisense oligonucleotide

inferredcites →https://doi.org/10.1038/s41594-019-0193-2openalex-snapshot

A gel phase promotes condensation of liquid P granules in Caenorhabditis elegans embryos

inferredcites →https://doi.org/10.1038/s41594-020-0399-3openalex-snapshot

Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation

inferredcites →https://doi.org/10.1039/d1sc07151copenalex-snapshot

Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells

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Therapeutics—how to treat phase separation-associated diseases

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RNA self-assembly contributes to stress granule formation and defining the stress granule transcriptome

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A general fragment-based approach to identify and optimize bioactive ligands targeting RNA

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Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling

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Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma

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Phosphorothioate Antisense Oligonucleotides Bind P-Body Proteins and Mediate P-Body Assembly

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Solid-Phase Separation of Toxic Phosphorothioate Antisense Oligonucleotide-Protein Nucleolar Aggregates Is Cytoprotective

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Nuclear body phase separation drives telomere clustering in ALT cancer cells

inferredcites →https://doi.org/10.1093/nar/gku579openalex-snapshot

Phosphorothioate oligonucleotides can displaceNEAT1RNA and form nuclear paraspeckle-like structures

inferredcites →https://doi.org/10.1101/2022.02.09.479752openalex-snapshot

The guardian of the genome meets a viral master gene regulator at a biomolecular condensate

inferredcites →https://doi.org/10.1101/gad.331520.119openalex-snapshot

Evaluating phase separation in live cells: diagnosis, caveats, and functional consequences

inferredcites →https://doi.org/10.1103/physrevlett.126.258101openalex-snapshot

Self-Assembly of Biomolecular Condensates with Shared Components

inferredcites →https://doi.org/10.1126/sciadv.abm5149openalex-snapshot

Recruitment and organization of ESCRT-0 and ubiquitinated cargo via condensation

inferredcites →https://doi.org/10.1126/science.aad9964openalex-snapshot

Phase separation of signaling molecules promotes T cell receptor signal transduction

inferredcites →https://doi.org/10.1126/science.aaf4382openalex-snapshot

Liquid phase condensation in cell physiology and disease

inferredcites →https://doi.org/10.1126/science.aaf6846openalex-snapshot

ATP as a biological hydrotrope

inferredcites →https://doi.org/10.1126/science.aar2555openalex-snapshot

Imaging dynamic and selective low-complexity domain interactions that control gene transcription

inferredcites →https://doi.org/10.1126/science.aar3958openalex-snapshot

Coactivator condensation at super-enhancers links phase separation and gene control

inferredcites →https://doi.org/10.1126/science.aar4199openalex-snapshot

Mediator and RNA polymerase II clusters associate in transcription-dependent condensates

inferredcites →https://doi.org/10.1126/science.aar7366openalex-snapshot

RNA buffers the phase separation behavior of prion-like RNA binding proteins

inferredcites →https://doi.org/10.1126/science.aar7432openalex-snapshot

mRNA structure determines specificity of a polyQ-driven phase separation

inferredcites →https://doi.org/10.1126/science.aat1022openalex-snapshot

DNA-induced liquid phase condensation of cGAS activates innate immune signaling

inferredcites →https://doi.org/10.1126/science.aau5721openalex-snapshot

A molecular assembly phase transition and kinetic proofreading modulate Ras activation by SOS

inferredcites →https://doi.org/10.1126/science.aaz4427openalex-snapshot

Partitioning of cancer therapeutics in nuclear condensates

inferredcites →https://doi.org/10.1158/2159-8290.cd-21-0674openalex-snapshot

Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation

inferredcites →https://doi.org/10.1242/jcs.245811openalex-snapshot

TDP-43, a protein central to amyotrophic lateral sclerosis, is destabilized by tankyrase-1 and -2

inferredcites →https://doi.org/10.1242/jcs.258578openalex-snapshot

The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid–liquid phase separation

inferredcites →https://doi.org/10.1242/prelights.13626openalex-snapshot

Small molecules for modulating protein driven liquid-liquid phase separation in treating neurodegenerative disease

inferredcites →https://doi.org/10.1261/rna.078875.121openalex-snapshot

RNA sequence and structure control assembly and function of RNA condensates

inferredcites →https://doi.org/10.1261/rna.079004.121openalex-snapshot

Weak multivalent biomolecular interactions: a strength versus numbers tug of war with implications for phase partitioning

inferredcites →https://doi.org/10.1371/journal.pone.0050134openalex-snapshot

Ataxin-2-Like Is a Regulator of Stress Granules and Processing Bodies

inferredcites →https://doi.org/10.15252/embj.2018101379openalex-snapshot

Phase separation of 53BP1 determines liquid‐like behavior of DNA repair compartments

inferredcites →https://doi.org/10.15252/embj.2021107711openalex-snapshot

Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses

inferredcites →https://doi.org/10.15252/embj.2021108443openalex-snapshot

Disease‐linked TDP‐43 hyperphosphorylation suppresses TDP‐43 condensation and aggregation

inferredcites →https://doi.org/10.15252/emmm.201707850openalex-snapshot

G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo

inferredcites →https://doi.org/10.2139/ssrn.3915880openalex-snapshot

Oxaliplatin Kills Cells via Liquid-Liquid Demixing of Nucleoli

inferredcites →https://doi.org/10.3389/fncel.2021.664151openalex-snapshot

Altered Phase Separation and Cellular Impact in C9orf72-Linked ALS/FTD

inferredcites →https://doi.org/10.3390/ijms222011014openalex-snapshot

m6A Modified Short RNA Fragments Inhibit Cytoplasmic TLS/FUS Aggregation Induced by Hyperosmotic Stress

inferredcites →https://doi.org/10.7554/elife.04251openalex-snapshot

Nup98 FG domains from diverse species spontaneously phase-separate into particles with nuclear pore-like permselectivity

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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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inferred← citeshttps://doi.org/10.1016/j.cej.2025.164551openalex-snapshot

Synthesis and characterization of phase-separated extracellular condensates in interactions with cells

inferred← citeshttps://doi.org/10.1016/j.cej.2025.169228openalex-snapshot

Phase-separated condensates modulate light absorption of small molecules and the application for drug analysis

inferred← citeshttps://doi.org/10.1016/j.cell.2026.05.010openalex-snapshot

Deep learning of functional perturbations from condensate morphology

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.115810openalex-snapshot

Phase separation of TTBK2 and CEP164 is necessary for ciliogenesis

inferred← citeshttps://doi.org/10.1016/j.celrep.2025.116090openalex-snapshot

Identification of CNOT1-CCR4-NOT as a suppressor of 53BP1-p53-p21 signaling

inferred← citeshttps://doi.org/10.1016/j.chembiol.2023.10.022openalex-snapshot

2′-OH as a universal handle for studying intracellular RNAs

inferred← citeshttps://doi.org/10.1016/j.cis.2022.102777openalex-snapshot

Biological colloids: Unique properties of membraneless organelles in the cell

inferred← citeshttps://doi.org/10.1016/j.coviro.2025.101496openalex-snapshot

New directions in the multifunctionality of RNA viruses: insights from the rabies virus P-protein

inferred← citeshttps://doi.org/10.1016/j.drudis.2026.104632openalex-snapshot

Allosteric drugs in biomolecular condensates: ways forward

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2025.149044openalex-snapshot

PhaseNet: A computational framework for identifying phase-separating proteins based on protein language model

inferred← citeshttps://doi.org/10.1016/j.jbc.2023.104800openalex-snapshot

Role of condensates in modulating DNA repair pathways and its implication for chemoresistance

inferred← citeshttps://doi.org/10.1016/j.jbc.2025.108188openalex-snapshot

Recent advances in the synthesis and application of biomolecular condensates

inferred← citeshttps://doi.org/10.1016/j.jmb.2023.168380openalex-snapshot

Biomolecular Condensates as Novel Antiviral Targets

inferred← citeshttps://doi.org/10.1016/j.jmb.2024.168472openalex-snapshot

Physiological functions of ULK1/2

inferred← citeshttps://doi.org/10.1016/j.jmb.2025.169343openalex-snapshot

Elucidating the Roles of Intrinsically Disordered Proteins in Eukaryotic Transcriptional Regulation with Single-Molecule Imaging

inferred← citeshttps://doi.org/10.1016/j.mam.2025.101384openalex-snapshot

Protein and RNA chaperones

inferred← citeshttps://doi.org/10.1016/j.molcel.2026.06.004openalex-snapshot

Translational activation: An unforeseen function of RNP biomolecular condensates

inferred← citeshttps://doi.org/10.1016/j.molstruc.2026.146768openalex-snapshot

Multivalent interactions and emergent properties of biomolecular condensates: A molecular dynamics perspective

inferred← citeshttps://doi.org/10.1016/j.slasd.2025.100220openalex-snapshot

Comparative evaluation of cell-based assay technologies for scoring drug-induced condensation of SARS-CoV-2 nucleocapsid protein

inferred← citeshttps://doi.org/10.1016/j.tcb.2022.11.009openalex-snapshot

Kinase regulation by liquid–liquid phase separation

inferred← citeshttps://doi.org/10.1016/j.tcb.2025.01.010openalex-snapshot

Phase separation of p62: roles and regulations in autophagy

inferred← citeshttps://doi.org/10.1016/j.tips.2024.12.004openalex-snapshot

Boosting CAR-T cell therapy through vaccine synergy

inferred← citeshttps://doi.org/10.1016/j.tips.2025.09.006openalex-snapshot

Targeting BRD4 bromodomains and beyond: exploring new therapeutic frontiers

inferred← citeshttps://doi.org/10.1016/j.trecan.2023.05.006openalex-snapshot

Onco-condensates: formation, multi-component organization, and biological functions

inferred← citeshttps://doi.org/10.1016/j.ymeth.2024.07.002openalex-snapshot

Methodological approaches to studying phase separation and HIV-1 replication: Current and future perspectives

inferred← citeshttps://doi.org/10.1021/acs.chemrev.3c00575openalex-snapshot

RNA: The Unsuspected Conductor in the Orchestra of Macromolecular Crowding

inferred← citeshttps://doi.org/10.1021/acs.jpclett.6c00040openalex-snapshot

Construction of Complete Phase Diagrams for Protein Liquid–Liquid Phase Separation by In Situ Raman Microspectroscopy

inferred← citeshttps://doi.org/10.1021/acschembio.2c00908openalex-snapshot

Screen for Modulation of Nucleocapsid Protein Condensation Identifies Small Molecules with Anti-Coronavirus Activity

inferred← citeshttps://doi.org/10.1021/acsptsci.5c00467openalex-snapshot

Intrinsically Disordered Regions of Zinc Finger Protein 687 in Phase Separation: A Potentially Pathogenic Driver of Paget’s Disease of Bone

inferred← citeshttps://doi.org/10.1021/acssynbio.6c00259openalex-snapshot

Beyond Compartmentalization: Deciphering Reaction Kinetics in Liquid–Liquid Phase Separation for Rational Biotechnological Design

inferred← citeshttps://doi.org/10.1021/jacs.3c00165openalex-snapshot

Global Discovery of Covalent Modulators of Ribonucleoprotein Granules

inferred← citeshttps://doi.org/10.1021/jacsau.5c00291openalex-snapshot

Prediction of Small-Molecule Partitioning into Biomolecular Condensates from Simulation

inferred← citeshttps://doi.org/10.1021/mc-2023-vol58.ch17openalex-snapshot

SMALL-MOLECULE INTERACTIONS WITH BIOMOLECULAR CONDENSATES

inferred← citeshttps://doi.org/10.1038/s41401-026-01757-1openalex-snapshot

Pharmacological targeting of oncogenic condensates in cancer: mechanistic insights and therapeutic opportunities

inferred← citeshttps://doi.org/10.1038/s41419-024-06869-2openalex-snapshot

Phase separation of RNF214 promotes the progression of hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1038/s41467-023-41241-6openalex-snapshot

Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology

inferred← citeshttps://doi.org/10.1038/s41467-024-48496-7openalex-snapshot

Protein Condensate Atlas from predictive models of heteromolecular condensate composition

inferred← citeshttps://doi.org/10.1038/s41467-024-55089-xopenalex-snapshot

PICNIC accurately predicts condensate-forming proteins regardless of their structural disorder across organisms

inferred← citeshttps://doi.org/10.1038/s41467-025-57281-zopenalex-snapshot

Rational design of phytovirucide inhibiting nucleocapsid protein aggregation in tomato spotted wilt virus

inferred← citeshttps://doi.org/10.1038/s41467-025-62242-7openalex-snapshot

SON-dependent nuclear speckle rehabilitation alleviates proteinopathies

inferred← citeshttps://doi.org/10.1038/s41580-024-00739-7openalex-snapshot

Splicing regulation through biomolecular condensates and membraneless organelles

inferred← citeshttps://doi.org/10.1038/s41580-024-00789-xopenalex-snapshot

Transcription regulation by biomolecular condensates

inferred← citeshttps://doi.org/10.1038/s41581-023-00767-0openalex-snapshot

Biomolecular condensates in kidney physiology and disease

inferred← citeshttps://doi.org/10.1038/s41592-023-01831-0openalex-snapshot

CD-CODE: crowdsourcing condensate database and encyclopedia

inferred← citeshttps://doi.org/10.1039/d3sm00706eopenalex-snapshot

The effect of monomer polarizability on the stability and salt partitioning in model coacervates

inferred← citeshttps://doi.org/10.1039/d5sc04657bopenalex-snapshot

Kinase signaling cascades: an updated mechanistic landscape

inferred← citeshttps://doi.org/10.1073/pnas.2425261122openalex-snapshot

Exploring RNA destabilization mechanisms in biomolecular condensates through atomistic simulations

inferred← citeshttps://doi.org/10.1073/pnas.2513371122openalex-snapshot

Transcriptional condensates encode a “golden mean” to optimize enhancer–promoter communication across genomic distances

inferred← citeshttps://doi.org/10.1093/bib/bbae528openalex-snapshot

A two-task predictor for discovering phase separation proteins and their undergoing mechanism

inferred← citeshttps://doi.org/10.1093/gpbjnl/qzaf014openalex-snapshot

PhaSeDis: A Manually Curated Database of Phase Separation–disease Associations and Corresponding Small Molecules

inferred← citeshttps://doi.org/10.1093/nar/gkad621openalex-snapshot

Targeted RNA condensation in living cells via genetically encodable triplet repeat tags

inferred← citeshttps://doi.org/10.1093/plcell/koad127openalex-snapshot

Stress-related biomolecular condensates in plants

inferred← citeshttps://doi.org/10.1101/2023.08.10.552741openalex-snapshot

Sub-nucleolar trafficking of Hendra virus matrix protein is regulated by ubiquitination and oligomerisation

inferred← citeshttps://doi.org/10.1101/2023.11.29.569154openalex-snapshot

miRVim: Three-dimensional miRNA Structure Data Server

inferred← citeshttps://doi.org/10.1101/2024.10.15.618281openalex-snapshot

Human Topoisomerase IIα Promotes Chromatin Condensation Via a Phase Transition

inferred← citeshttps://doi.org/10.1158/0008-5472.can-25-0479openalex-snapshot

Distinct States of Nuclear Speckles Emerge as New Predictors of Cancer Prognosis

inferred← citeshttps://doi.org/10.1158/2159-8290.cd-23-0876openalex-snapshot

Condensate-Promoting ENL Mutation Drives Tumorigenesis In Vivo Through Dynamic Regulation of Histone Modifications and Gene Expression

inferred← citeshttps://doi.org/10.1159/000530250openalex-snapshot

Phase Separation in Kidney Diseases: Autosomal Dominant Polycystic Kidney Disease and Beyond

inferred← citeshttps://doi.org/10.1186/s12915-025-02214-xopenalex-snapshot

Current perspectives in drug targeting intrinsically disordered proteins and biomolecular condensates

inferred← citeshttps://doi.org/10.1186/s12951-025-04019-0openalex-snapshot

Lung-targeted RNA delivery systems: strategies and therapeutic applications

inferred← citeshttps://doi.org/10.1186/s13023-024-03307-6openalex-snapshot

VUS next in rare diseases? Deciphering genetic determinants of biomolecular condensation

inferred← citeshttps://doi.org/10.1186/s13059-025-03666-8openalex-snapshot

Xist condensates: perspectives for therapeutic intervention

inferred← citeshttps://doi.org/10.14218/csp.2023.00018openalex-snapshot

An Insight into Cancer from Biomolecular Condensates

inferred← citeshttps://doi.org/10.21203/rs.3.rs-4398439/v1openalex-snapshot

Rational Design of Phytovirucide that Inhibits the Nucleocapsid Condensates of Tomato Spotted Wilt Virus

inferred← citeshttps://doi.org/10.2174/0122115366307988240809045125openalex-snapshot

miRVim: Three-dimensional miRNA Structure Database

inferred← citeshttps://doi.org/10.3389/fmolb.2022.1007744openalex-snapshot

Principles and functions of condensate modifying drugs

inferred← citeshttps://doi.org/10.3390/ijms26125679openalex-snapshot

Two Peas in a Pod: Retroviral RNA Dimers Organize Gag–RNA Nanoclusters with Novel Biophysical Properties

inferred← citeshttps://doi.org/10.3390/v17060797openalex-snapshot

Sub-Nucleolar Trafficking of Hendra Virus Matrix Protein Is Regulated by Ubiquitination

inferred← citeshttps://doi.org/10.64898/2026.02.14.705909openalex-snapshot

Programmable and Switchable RNA Scaffolds for Synthetic Condensate Engineering in Mammalian Cells

inferred← citeshttps://doi.org/10.64898/2026.02.18.706652openalex-snapshot

Unleashed condensation by recurrent mutations of an epigenetic regulator promotes cancer

inferred← citeshttps://doi.org/10.64898/2026.05.13.724666openalex-snapshot

A tunable aqueous architecture modulates functional output in biomolecular condensates

inferred← citeshttps://doi.org/10.64898/2026.05.23.727301openalex-snapshot

Learning molecular determinants of selective small-molecule partitioning across biomolecular condensates

inferred← citeshttps://doi.org/10.7150/ijbs.81521openalex-snapshot

Liquid‒liquid phase separation: roles and implications in future cancer treatment

inferred← citeshttps://doi.org/10.7554/elife.101626openalex-snapshot

N6-methyladenosine in DNA promotes genome stability

inferred← citeshttps://doi.org/10.7554/elife.101626.1openalex-snapshot

N6-methyladenosine in DNA promotes genome stability

inferred← citeshttps://doi.org/10.7554/elife.101626.2openalex-snapshot

N6-methyladenosine in DNA promotes genome stability

inferred← citeshttps://doi.org/10.7554/elife.101626.3openalex-snapshot

N6-methyladenosine in DNA promotes genome stability

inferred← citeshttps://doi.org/10.7554/elife.106602openalex-snapshot

Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume

inferred← citeshttps://doi.org/10.7554/elife.106602.1openalex-snapshot

Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume

inferred← citeshttps://doi.org/10.7554/elife.106602.2openalex-snapshot

Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume

inferred← citeshttps://doi.org/10.7554/elife.106602.3openalex-snapshot

Multiphase separation in postsynaptic density regulated by membrane geometry via interaction valency and volume

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