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N6-Methyladenosine in DNA Promotes Genome Stability

https://doi.org/10.2139/ssrn.4682264
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Mutagenesis Studies in Diploid Human Cells with Different DNA-Repair Capacities
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Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination
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Spatiotemporal Control of Intracellular Phase Transitions Using Light-Activated optoDroplets
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Functional partitioning of transcriptional regulators by patterned charge blocks
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Functional Analysis of the Replication Fork Proteome Identifies BET Proteins as PCNA Regulators
inferredcites →https://doi.org/10.1016/j.celrep.2023.112279openalex-extracted
The N6-methyladenine DNA demethylase ALKBH1 promotes gastric carcinogenesis by disrupting NRF1 binding capacity
inferredcites →https://doi.org/10.1016/j.chembiol.2023.09.001openalex-extracted
Targeting METTL3 reprograms the tumor microenvironment to improve cancer immunotherapy
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Uracil in DNA—General mutagen, but normal intermediate in acquired immunity
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The UNG2 Arg88Cys variant abrogates RPA-mediated recruitment of UNG2 to single-stranded DNA
inferredcites →https://doi.org/10.1016/j.dnarep.2020.102866openalex-extracted
New insights into abasic site repair and tolerance
inferredcites →https://doi.org/10.1016/j.molcel.2018.06.015openalex-extracted
N6-Methyladenine DNA Modification in the Human Genome
inferredcites →https://doi.org/10.1016/j.molcel.2019.03.018openalex-extracted
An Adversarial DNA N6-Methyladenine-Sensor Network Preserves Polycomb Silencing
inferredcites →https://doi.org/10.1016/j.molcel.2020.06.017openalex-extracted
METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation
inferredcites →https://doi.org/10.1016/j.tibs.2020.06.007openalex-extracted
Biomolecular Condensates in the Nucleus
inferredcites →https://doi.org/10.1016/j.tibs.2020.09.007openalex-extracted
A Role for N6-Methyladenine in DNA Damage Repair
inferredcites →https://doi.org/10.1016/j.tips.2022.07.001openalex-extracted
Biomolecular condensates: new opportunities for drug discovery and RNA therapeutics
inferredcites →https://doi.org/10.1038/nature21671openalex-extracted
RNA m6A methylation regulates the ultraviolet-induced DNA damage response
inferredcites →https://doi.org/10.1038/nchembio.1432openalex-extracted
A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
inferredcites →https://doi.org/10.1038/nmeth.3179openalex-extracted
Directed evolution of APEX2 for electron microscopy and proximity labeling
inferredcites →https://doi.org/10.1038/nprot.2016.018openalex-extracted
Spatially resolved proteomic mapping in living cells with the engineered peroxidase APEX2
inferredcites →https://doi.org/10.1038/nrm.2017.7openalex-extracted
Biomolecular condensates: organizers of cellular biochemistry
inferredcites →https://doi.org/10.1038/s41392-020-00450-xopenalex-extracted
The role of m6A modification in the biological functions and diseases
inferredcites →https://doi.org/10.1038/s41419-022-04661-8openalex-extracted
Reducing N6AMT1-mediated 6mA DNA modification promotes breast tumor progression via transcriptional repressing cell cycle inhibitors
inferredcites →https://doi.org/10.1038/s41421-018-0019-0openalex-extracted
VIRMA mediates preferential m6A mRNA methylation in 3′UTR and near stop codon and associates with alternative polyadenylation
inferredcites →https://doi.org/10.1038/s41421-019-0136-4openalex-extracted
Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro
inferredcites →https://doi.org/10.1038/s41421-022-00484-1openalex-extracted
High-precision mapping reveals rare N6-deoxyadenosine methylation in the mammalian genome
inferredcites →https://doi.org/10.1038/s41422-019-0237-5openalex-extracted
Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA
inferredcites →https://doi.org/10.1038/s41422-020-0317-6openalex-extracted
N6-methyladenine is incorporated into mammalian genome by DNA polymerase
inferredcites →https://doi.org/10.1038/s41586-021-03536-wopenalex-extracted
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
inferredcites →https://doi.org/10.1038/sj.emboj.7601958openalex-extracted
Cell cycle‐specific UNG2 phosphorylations regulate protein turnover, activity and association with RPA
inferredcites →https://doi.org/10.1053/j.gastro.2007.09.003openalex-extracted
5-Fluorouracil Is Efficiently Removed From DNA by the Base Excision and Mismatch Repair Systems
inferredcites →https://doi.org/10.1074/jbc.m412105200openalex-extracted
DNA Mismatch Repair-dependent Response to Fluoropyrimidine-generated Damage
inferredcites →https://doi.org/10.1093/biolre/ioad136openalex-extracted
YTHDF2 promotes DNA damage repair by positively regulating the histone methyltransferase SETDB1 in spermatogonia
inferredcites →https://doi.org/10.1093/carcin/19.11.1931openalex-extracted
Resistance to 6-thioguanine in mismatch repair-deficient human cancer cell lines correlates with an increase in induced mutations at the HPRT locus
inferredcites →https://doi.org/10.1093/nar/gkab195openalex-extracted
RPA2 winged-helix domain facilitates UNG-mediated removal of uracil from ssDNA; implications for repair of mutagenic uracil at the replication fork
inferredcites →https://doi.org/10.1093/nar/gkab460openalex-extracted
Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions
inferredcites →https://doi.org/10.1101/cshperspect.a012583openalex-extracted
Base Excision Repair
inferredcites →https://doi.org/10.1101/cshperspect.a012633openalex-extracted
Postreplicative Mismatch Repair
inferredcites →https://doi.org/10.1124/molpharm.120.000191openalex-extracted
Inhibition of Human Uracil DNA Glycosylase Sensitizes a Large Fraction of Colorectal Cancer Cells to 5-Fluorodeoxyuridine and Raltitrexed but Not Fluorouracil
inferredcites →https://doi.org/10.1126/science.aaf4382openalex-extracted
Liquid phase condensation in cell physiology and disease
inferredcites →https://doi.org/10.1186/s13059-022-02819-3openalex-extracted
METTL4-mediated nuclear N6-deoxyadenosine methylation promotes metastasis through activating multiple metastasis-inducing targets
inferredcites →https://doi.org/10.1371/journal.pbio.3001535openalex-extracted
Dynamic assembly of the mRNA m6A methyltransferase complex is regulated by METTL3 phase separation
inferredcites →https://doi.org/10.1371/journal.pone.0017151openalex-extracted
Uracil DNA N-Glycosylase Promotes Assembly of Human Centromere Protein A
inferredcites →https://doi.org/10.15252/embj.2020106309openalex-extracted
m6A deposition is regulated by PRMT1‐mediated arginine methylation of METTL14 in its disordered C‐terminal region
inferredcites →https://doi.org/10.3389/fonc.2020.616098openalex-extracted
DNA N6-Methyladenine (6mA) Modification Regulates Drug Resistance in Triple Negative Breast Cancer
inferredcites →https://doi.org/10.3389/fonc.2022.824190openalex-extracted
METTL3 Is Associated With the Malignancy of Esophageal Squamous Cell Carcinoma and Serves as a Potential Immunotherapy Biomarker
inferredcites →https://doi.org/10.3390/ijms241814186openalex-extracted
Base Excision Repair: Mechanisms and Impact in Biology, Disease, and Medicine
inferredcites →https://doi.org/10.3892/ijo.2022.5396openalex-extracted
METTL3 antagonizes 5‑FU chemotherapy and confers drug resistance in colorectal carcinoma
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