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Endoplasmic Reticulum Stress and the Hallmarks of Cancer

https://doi.org/10.1016/j.trecan.2016.03.007

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Hypoxic regulation of the PERK/ATF4/LAMP3‐arm of the unfolded protein response in head and neck squamous cell carcinoma

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IRE1α controls cyclin A1 expression and promotes cell proliferation through XBP-1

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Anticancer drugs for the modulation of endoplasmic reticulum stress and oxidative stress

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When ER stress reaches a dead end

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Immunological Effects of Conventional Chemotherapy and Targeted Anticancer Agents

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The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis

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Endoplasmic Reticulum Stress in Malignancy

inferredcites →https://doi.org/10.1016/j.cell.2011.02.013openalex-snapshot

Hallmarks of Cancer: The Next Generation

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Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

inferredcites →https://doi.org/10.1016/j.cell.2014.08.012openalex-snapshot

The Unfolded Protein Response Triggers Selective mRNA Release from the Endoplasmic Reticulum

inferredcites →https://doi.org/10.1016/j.cell.2015.05.025openalex-snapshot

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

inferredcites →https://doi.org/10.1016/j.celrep.2012.12.007openalex-snapshot

Proteostasis Modulators Prolong Missense VHL Protein Activity and Halt Tumor Progression

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Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells

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ER Stress and Angiogenesis

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Transformation‐associated gene regulation by ATF6α during hepatocarcinogenesis

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ATM blocks tunicamycin‐induced endoplasmic reticulum stress

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The Stress-Response Sensor Chop Regulates the Function and Accumulation of Myeloid-Derived Suppressor Cells in Tumors

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XBP1 Controls Diverse Cell Type- and Condition-Specific Transcriptional Regulatory Networks

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p58IPK-Mediated Attenuation of the Proapoptotic PERK-CHOP Pathway Allows Malignant Progression upon Low Glucose

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VEGF Signals through ATF6 and PERK to Promote Endothelial Cell Survival and Angiogenesis in the Absence of ER Stress

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A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB

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Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing

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Inducing apoptosis of cancer cells using small-molecule plant compounds that bind to GRP78

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Patterns of somatic mutation in human cancer genomes

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XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway

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Anti-oncogenic role of the endoplasmic reticulum differentially activated by mutations in the MAPK pathway

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Proteostasis control by the unfolded protein response

inferredcites →https://doi.org/10.1038/ni.2808openalex-snapshot

The unfolded-protein-response sensor IRE-1α regulates the function of CD8α+ dendritic cells

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Molecular regulation of vessel maturation

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The role of the unfolded protein response in tumour development: friend or foe?

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Models, mechanisms and clinical evidence for cancer dormancy

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Glucose-regulated proteins in cancer: molecular mechanisms and therapeutic potential

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The impact of the endoplasmic reticulum protein-folding environment on cancer development

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Targeting the unfolded protein response in disease

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The unfolded protein response: controlling cell fate decisions under ER stress and beyond

inferredcites →https://doi.org/10.1038/onc.2010.153openalex-snapshot

PERK promotes cancer cell proliferation and tumor growth by limiting oxidative DNA damage

inferredcites →https://doi.org/10.1038/onc.2015.178openalex-snapshot

Tumor progression and the different faces of the PERK kinase

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ER stress‐regulated translation increases tolerance to extreme hypoxia and promotes tumor growth

inferredcites →https://doi.org/10.1038/sj.emboj.7601210openalex-snapshot

HDAC6–p97/VCP controlled polyubiquitin chain turnover

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PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation

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ATF6α-Rheb-mTOR signaling promotes survival of dormant tumor cells in vivo

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Inositol-requiring enzyme 1α is a key regulator of angiogenesis and invasion in malignant glioma

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Transmission of endoplasmic reticulum stress and pro-inflammation from tumor cells to myeloid cells

inferredcites →https://doi.org/10.1073/pnas.1400958111openalex-snapshot

Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia

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Multiclass cancer diagnosis using tumor gene expression signatures

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PERK mediates cell-cycle exit during the mammalian unfolded protein response

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A Conserved Structural Determinant Located at the Interdomain Region of Mammalian Inositol-requiring Enzyme 1α

inferredcites →https://doi.org/10.1074/jbc.m113.507194openalex-snapshot

Endoplasmic Reticulum (ER) Stress and Hypoxia Response Pathways Interact to Potentiate Hypoxia-inducible Factor 1 (HIF-1) Transcriptional Activity on Targets Like Vascular Endothelial Growth Factor (VEGF)

inferredcites →https://doi.org/10.1080/10428190500312196openalex-snapshot

Activation of the endoplasmic reticulum stress pathway is associated with survival of myeloma cells

inferredcites →https://doi.org/10.1084/jem.20070525openalex-snapshot

The transcription factor XBP-1 is essential for the development and survival of dendritic cells

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Keeping up the balance: role of HDACs in cardiac proteostasis and therapeutic implications for atrial fibrillation

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Translational Control in Cancer Etiology

inferredcites →https://doi.org/10.1101/gad.1250704openalex-snapshot

CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulum

inferredcites →https://doi.org/10.1101/gad.201731.112openalex-snapshot

ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

inferredcites →https://doi.org/10.1101/gad.207407.112openalex-snapshot

Aneuploidy causes proteotoxic stress in yeast

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Selective Inhibition of a Regulatory Subunit of Protein Phosphatase 1 Restores Proteostasis

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The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

inferredcites →https://doi.org/10.1128/mcb.01145-06openalex-snapshot

Perk-Dependent Translational Regulation Promotes Tumor Cell Adaptation and Angiogenesis in Response to Hypoxic Stress

inferredcites →https://doi.org/10.1128/mcb.01484-13openalex-snapshot

Endoplasmic Reticulum Stress-Activated Transcription Factor ATF6α Requires the Disulfide Isomerase PDIA5 To Modulate Chemoresistance

inferredcites →https://doi.org/10.1128/mcb.23.20.7198-7209.2003openalex-snapshot

Nrf2 Is a Direct PERK Substrate and Effector of PERK-Dependent Cell Survival

inferredcites →https://doi.org/10.1152/ajpcell.00258.2014openalex-snapshot

Cellular Mechanisms of Endoplasmic Reticulum Stress Signaling in Health and Disease. 1. An overview

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Identification of a Gene Expression Signature Associated with Recurrent Disease in Squamous Cell Carcinoma of the Head and Neck

inferredcites →https://doi.org/10.1158/0008-5472.can-05-3092openalex-snapshot

Functional Coupling of p38-Induced Up-regulation of BiP and Activation of RNA-Dependent Protein Kinase–Like Endoplasmic Reticulum Kinase to Drug Resistance of Dormant Carcinoma Cells

inferredcites →https://doi.org/10.1158/0008-5472.can-06-3235openalex-snapshot

IRE1 Signaling Is Essential for Ischemia-Induced Vascular Endothelial Growth Factor-A Expression and Contributes to Angiogenesis and Tumor Growth In vivo

inferredcites →https://doi.org/10.1158/0008-5472.can-07-0325openalex-snapshot

GRP78 Induction in Cancer: Therapeutic and Prognostic Implications

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The Unfolded Protein Response Regulator GRP78/BiP as a Novel Target for Increasing Chemosensitivity in Malignant Gliomas

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PERK–Dependent Regulation of Ceramide Synthase 6 and Thioredoxin Play a Key Role in mda -7/IL-24–Induced Killing of Primary Human Glioblastoma Multiforme Cells

inferredcites →https://doi.org/10.1158/0008-5472.can-12-0474openalex-snapshot

The Unfolded Protein Response Induces the Angiogenic Switch in Human Tumor Cells through the PERK/ATF4 Pathway

inferredcites →https://doi.org/10.1158/0008-5472.can-12-3109openalex-snapshot

Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity

inferredcites →https://doi.org/10.1158/0008-5472.can-12-3989openalex-snapshot

Posttranscriptional Regulation of PER1 Underlies the Oncogenic Function of IREα

inferredcites →https://doi.org/10.1158/0008-5472.can-14-0798openalex-snapshot

SCCA1/SERPINB3 Promotes Oncogenesis and Epithelial–Mesenchymal Transition via the Unfolded Protein Response and IL6 Signaling

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Multiple Gene Expression Classifiers from Different Array Platforms Predict Poor Prognosis of Colorectal Cancer

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Cancer Dormancy: A Model of Early Dissemination and Late Cancer Recurrence

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Hypoxic Activation of the PERK/eIF2α Arm of the Unfolded Protein Response Promotes Metastasis through Induction of LAMP3

inferredcites →https://doi.org/10.1158/2159-8290.cd-13-0945openalex-snapshot

Epithelial-to-Mesenchymal Transition Activates PERK–eIF2α and Sensitizes Cells to Endoplasmic Reticulum Stress

inferredcites →https://doi.org/10.1158/2159-8290.cd-14-1490openalex-snapshot

Endoplasmic Reticulum Stress–Activated Cell Reprogramming in Oncogenesis

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Vascular Endothelial Cell Growth–Activated XBP1 Splicing in Endothelial Cells Is Crucial for Angiogenesis

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The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5

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Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

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Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma

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Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response

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Autocrine control of glioma cells adhesion/migration through Inositol Requiring enzyme 1α (IRE1α)-mediated cleavage of Secreted Protein Acidic Rich in Cysteine (SPARC) mRNA

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p53 antagonizes the unfolded protein response and inhibits ground glass hepatocyte development during endoplasmic reticulum stress

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The role of X-box binding protein-1 in tumorigenicity

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De-Differentiation Confers Multidrug Resistance Via Noncanonical PERK-Nrf2 Signaling

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Transcriptional and Post-Transcriptional Regulation of Proangiogenic Factors by the Unfolded Protein Response

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The Unfolded Protein Response Is Not Necessary for the G1/S Transition, but It Is Required for Chromosome Maintenance in Saccharomyces cerevisiae

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Cell-Extrinsic Effects of Tumor ER Stress Imprint Myeloid Dendritic Cells and Impair CD8+ T Cell Priming

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A Dual Role for SAGA-Associated Factor 29 (SGF29) in ER Stress Survival by Coordination of Both Histone H3 Acetylation and Histone H3 Lysine-4 Trimethylation

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Activating Transcription Factor 4 Promotes Esophageal Squamous Cell Carcinoma Invasion and Metastasis in Mice and Is Associated with Poor Prognosis in Human Patients

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Genome‐wide screen identifies a novel p97/CDC‐48‐dependent pathway regulating ER‐stress‐induced gene transcription

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Glioblastoma invasion and cooption depend on IRE1α endoribonuclease activity

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inferred← citeshttps://doi.org/10.1007/s10565-025-10072-0openalex-snapshot

METTL1 promotes cadmium-induced stress granules formation via enhancing translation of G3BP1 and expression of m7G- 3' tiRNA MetCAT

inferred← citeshttps://doi.org/10.1007/s10637-022-01306-7openalex-snapshot

TRIM59 guards ER proteostasis and prevents Bortezomib-mediated colorectal cancer (CRC) cells’ killing

inferred← citeshttps://doi.org/10.1007/s10930-025-10264-xopenalex-snapshot

Endoplasmic Reticulum Stress: Implications in Diseases

inferred← citeshttps://doi.org/10.1007/s11033-022-07673-xopenalex-snapshot

Prognostic significance of CHAC1 expression in breast cancer

inferred← citeshttps://doi.org/10.1007/s11033-026-12428-zopenalex-snapshot

TP53 status is associated with differential stress-marker expression and APP maturation in colon cancer cells

inferred← citeshttps://doi.org/10.1007/s11356-025-36593-zopenalex-snapshot

Carcinogenic effects of paraquat-based herbicides: a comprehensive review

inferred← citeshttps://doi.org/10.1007/s11596-025-00161-wopenalex-snapshot

ATF6 Identification Sensitizes B-Cell Precursor Acute Lymphoblastic Leukemia Cells to Doxorubicin

inferred← citeshttps://doi.org/10.1007/s11596-026-00223-7openalex-snapshot

Prognostic Value of Endoplasmic Reticulum Stress-Related Gene Signature in Thyroid Cancer

inferred← citeshttps://doi.org/10.1007/s12031-020-01598-5openalex-snapshot

Knockdown of Amphiregulin Triggers Doxorubicin-Induced Autophagic and Apoptotic Death by Regulating Endoplasmic Reticulum Stress in Glioblastoma Cells

inferred← citeshttps://doi.org/10.1007/s12032-025-02622-7openalex-snapshot

Gefitinib induces apoptosis in Caco-2 cells via ER stress-mediated mitochondrial pathways and the IRE1α/JNK/p38 MAPK signaling axis

inferred← citeshttps://doi.org/10.1007/s12192-022-01267-zopenalex-snapshot

Role of endoplasmic reticulum stress in apoptosis induced by HK2 inhibitor and its potential as a new drug combination strategy

inferred← citeshttps://doi.org/10.1007/s12672-024-01485-0openalex-snapshot

ATF4/NUPR1 axis promotes cancer cell survival and mediates immunosuppression in clear cell renal cell carcinoma

inferred← citeshttps://doi.org/10.1007/s12672-026-05126-6openalex-snapshot

Integration of 117 machine learning algorithms and single-cell transcriptomics identifies macrophage polarization and ER stress signatures for cancer prognosis and precision therapy

inferred← citeshttps://doi.org/10.1007/s13105-023-00986-wopenalex-snapshot

DERL2 (derlin 2) stabilizes BAG6 (BAG cochaperone 6) in chemotherapy resistance of cholangiocarcinoma

inferred← citeshttps://doi.org/10.1007/s13402-023-00789-7openalex-snapshot

Dipyridamole enhances the anti-cancer ability of aspirin against colorectal cancer by inducing apoptosis in an unfolded protein response-dependent manner

inferred← citeshttps://doi.org/10.1016/b978-0-12-819404-1.00022-1openalex-snapshot

Lipid metabolism and signaling in cancer

inferred← citeshttps://doi.org/10.1016/b978-0-12-821567-8.00016-6openalex-snapshot

Role of apoptosis, autophagy, and the unfolded protein response in glioblastoma chemoresistance

inferred← citeshttps://doi.org/10.1016/b978-2-294-77967-1.00003-6openalex-snapshot

Oncogenèse

inferred← citeshttps://doi.org/10.1016/bs.apcsb.2025.08.006openalex-snapshot

Protein misfolding and cancer - proteomics as an approach for biomarker discovery

inferred← citeshttps://doi.org/10.1016/bs.host.2017.09.003openalex-snapshot

Asymptotic Approaches to Discovering Cancer Genomic Signatures

inferred← citeshttps://doi.org/10.1016/bs.vh.2022.10.006openalex-snapshot

Antioxidants affect endoplasmic reticulum stress-related diseases

inferred← citeshttps://doi.org/10.1016/j.apmt.2021.101149openalex-snapshot

Cancer immunotherapy: Classification, therapeutic mechanisms, and nanomaterial-based synergistic therapy

inferred← citeshttps://doi.org/10.1016/j.arr.2026.103342openalex-snapshot

Immunogenic cell death in CNS diseases: From bench to bedside

inferred← citeshttps://doi.org/10.1016/j.bbadis.2019.04.007openalex-snapshot

The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response

inferred← citeshttps://doi.org/10.1016/j.bbadis.2026.168229openalex-snapshot

Securinine suppresses pancreatic cancer progression by activating the p38 MAPK pathway to upregulate CHOP and induce endoplasmic reticulum stress

inferred← citeshttps://doi.org/10.1016/j.bbamcr.2024.119869openalex-snapshot

Endoplasmic reticulum stress induced autophagy in cancer and its potential interactions with apoptosis and ferroptosis

inferred← citeshttps://doi.org/10.1016/j.bbcan.2022.188839openalex-snapshot

Unfolded protein response and angiogenesis in malignancies

inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.08.043openalex-snapshot

QSOX1 promotes mitochondrial apoptosis of hepatocellular carcinoma cells during anchorage-independent growth by inhibiting lipid synthesis

inferred← citeshttps://doi.org/10.1016/j.bbrc.2020.10.052openalex-snapshot

ACP-5862 suppresses esophageal squamous cell carcinoma growth through inducing apoptosis via activation of endoplasmic reticulum stress and ROS production

inferred← citeshttps://doi.org/10.1016/j.bbrc.2023.07.029openalex-snapshot

Metformin combined with glucose starvation synergistically suppress triple-negative breast cancer by enhanced unfolded protein response

inferred← citeshttps://doi.org/10.1016/j.bbrep.2024.101891openalex-snapshot

An integrated machine learning framework for developing and validating a prognostic risk model of gastric cancer based on endoplasmic reticulum stress-associated genes

inferred← citeshttps://doi.org/10.1016/j.bcp.2021.114737openalex-snapshot

The unfolded protein response as regulator of cancer stemness and differentiation: Mechanisms and implications for cancer therapy

inferred← citeshttps://doi.org/10.1016/j.bcp.2022.115254openalex-snapshot

Diterpenoid DGA induces apoptosis via endoplasmic reticulum stress caused by changes in glycosphingolipid composition and inhibition of STAT3 in glioma cells

inferred← citeshttps://doi.org/10.1016/j.bej.2024.109434openalex-snapshot

The role of endoplasmic reticulum stress on reducing recombinant protein production in mammalian cells

inferred← citeshttps://doi.org/10.1016/j.biocel.2019.105572openalex-snapshot

Knockdown of IRE1ɑ suppresses metastatic potential of colon cancer cells through inhibiting FN1-Src/FAK-GTPases signaling

inferred← citeshttps://doi.org/10.1016/j.biochi.2019.06.017openalex-snapshot

Implication of homocysteine in protein quality control processes

inferred← citeshttps://doi.org/10.1016/j.biochi.2022.01.017openalex-snapshot

The unfolded protein response and the biology of uveal melanoma

inferred← citeshttps://doi.org/10.1016/j.biomaterials.2021.121156openalex-snapshot

Tonsil-derived mesenchymal stem cells incorporated in reactive oxygen species-releasing hydrogel promote bone formation by increasing the translocation of cell surface GRP78

inferred← citeshttps://doi.org/10.1016/j.bioorg.2018.11.013openalex-snapshot

Artemisianins A-D, new stereoisomers of seco-guaianolide involved heterodimeric [4+2] adducts from Artemisia argyi induce apoptosis via enhancement of endoplasmic reticulum stress

inferred← citeshttps://doi.org/10.1016/j.bmc.2024.117969openalex-snapshot

Discovery and optimization of anthraquinone derivatives containing substituted bisbenzyloxy groups as a novel scaffold damaged endoplasmic reticulum and against hepatocellular carcinoma cells

inferred← citeshttps://doi.org/10.1016/j.bmcl.2021.128058openalex-snapshot

Discovery of 2-amino-3-amido-5-aryl-pyridines as highly potent, orally bioavailable, and efficacious PERK kinase inhibitors

inferred← citeshttps://doi.org/10.1016/j.cancergen.2023.06.001openalex-snapshot

Unfolded protein response signature unveils novel insights into breast cancer prognosis and tumor microenvironment

inferred← citeshttps://doi.org/10.1016/j.canlet.2019.01.034openalex-snapshot

Endoplasmic reticulum proteostasis control and gastric cancer

inferred← citeshttps://doi.org/10.1016/j.canlet.2020.05.020openalex-snapshot

Targeting the IRE1-XBP1 axis to overcome endocrine resistance in breast cancer: Opportunities and challenges

inferred← citeshttps://doi.org/10.1016/j.canlet.2020.07.009openalex-snapshot

The IRE1 and PERK arms of the unfolded protein response promote survival of rhabdomyosarcoma cells

inferred← citeshttps://doi.org/10.1016/j.canlet.2020.08.019openalex-snapshot

Nuclear protein 1 imparts oncogenic potential and chemotherapeutic resistance in cancer

inferred← citeshttps://doi.org/10.1016/j.canlet.2021.05.021openalex-snapshot

PERK-eIF2α-ERK1/2 axis drives mesenchymal-endothelial transition of cancer-associated fibroblasts in pancreatic cancer

inferred← citeshttps://doi.org/10.1016/j.canlet.2021.06.011openalex-snapshot

Induction of EnR stress by Melatonin enhances the cytotoxic effect of Lapatinib in HER2-positive breast cancer

inferred← citeshttps://doi.org/10.1016/j.canlet.2024.216678openalex-snapshot

ER stress and the unfolded protein response in gastrointestinal stem cells and carcinogenesis

inferred← citeshttps://doi.org/10.1016/j.canlet.2024.217075openalex-snapshot

Novel SERCA2 inhibitor Diphyllin displays anti-tumor effect in non-small cell lung cancer by promoting endoplasmic reticulum stress and mitochondrial dysfunction

inferred← citeshttps://doi.org/10.1016/j.cbi.2018.06.001openalex-snapshot

Antiproliferative effect of p-Coumaric acid targets UPR activation by downregulating Grp78 in colon cancer

inferred← citeshttps://doi.org/10.1016/j.cca.2016.10.006openalex-snapshot

Alpha-foetoprotein (AFP): A multi-purpose marker in hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1016/j.ccell.2022.08.016openalex-snapshot

Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

inferred← citeshttps://doi.org/10.1016/j.ccr.2021.214129openalex-snapshot

Targeting translation: a promising strategy for anticancer metallodrugs

inferred← citeshttps://doi.org/10.1016/j.cej.2026.178420openalex-snapshot

Ion exchange and coordination substitution-mediated low-dose 225Ac-labeled MOFs induce enhanced endoplasmic reticulum stress to boost antitumor immunity

inferred← citeshttps://doi.org/10.1016/j.cell.2021.08.036openalex-snapshot

ERα is an RNA-binding protein sustaining tumor cell survival and drug resistance

inferred← citeshttps://doi.org/10.1016/j.cellsig.2024.111560openalex-snapshot

Inhibition of ERO1L induces autophagy and apoptosis via endoplasmic reticulum stress in colorectal cancer

inferred← citeshttps://doi.org/10.1016/j.cellsig.2025.111657openalex-snapshot

UFMylation in tumorigenesis: Mechanistic insights and therapeutic opportunities

inferred← citeshttps://doi.org/10.1016/j.celrep.2019.02.025openalex-snapshot

A Systematic Investigation of the Malignant Functions and Diagnostic Potential of the Cancer Secretome

inferred← citeshttps://doi.org/10.1016/j.celrep.2021.109312openalex-snapshot

Identification of a class of non-conventional ER-stress-response-derived immunogenic peptides

inferred← citeshttps://doi.org/10.1016/j.celrep.2022.110490openalex-snapshot

On the origin of metastases: Induction of pro-metastatic states after impending cell death via ER stress, reprogramming, and a cytokine storm

inferred← citeshttps://doi.org/10.1016/j.celrep.2026.117612openalex-snapshot

Histone lactylation-driven intratumoral IGFBP2+ NK cells promote tumor immune evasion

inferred← citeshttps://doi.org/10.1016/j.colsurfb.2021.112046openalex-snapshot

Research on endoplasmic reticulum–targeting fluorescent probes and endoplasmic reticulum stress–mediated nanoanticancer strategies: A review

inferred← citeshttps://doi.org/10.1016/j.cstres.2025.100113openalex-snapshot

TBX5-AS1 induces ER stress and suppresses lung cancer growth and tumor stemness via the miR-494-3p/ATF6 axis

inferred← citeshttps://doi.org/10.1016/j.devcel.2018.04.023openalex-snapshot

The UPR Activator ATF6 Responds to Proteotoxic and Lipotoxic Stress by Distinct Mechanisms

inferred← citeshttps://doi.org/10.1016/j.drup.2022.100853openalex-snapshot

Understanding ER homeostasis and the UPR to enhance treatment efficacy of acute myeloid leukemia

inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.119201openalex-snapshot

The thiocarbonyl analog of chrysin induces apoptosis and oxidative stress-mediated unfolded protein response in breast cancer cells

inferred← citeshttps://doi.org/10.1016/j.ejmhg.2017.07.004openalex-snapshot

The endoplasmic reticulum stress response in disease pathogenesis and pathophysiology

inferred← citeshttps://doi.org/10.1016/j.ejphar.2023.176013openalex-snapshot

Cancer chemotherapy resistance: Mechanisms and recent breakthrough in targeted drug delivery

inferred← citeshttps://doi.org/10.1016/j.ejps.2020.105538openalex-snapshot

In silico toxicity evaluation of Salubrinal and its analogues

inferred← citeshttps://doi.org/10.1016/j.eng.2023.11.022openalex-snapshot

The Anticancer Potential of Quassinoids—A Mini-Review

inferred← citeshttps://doi.org/10.1016/j.freeradbiomed.2021.10.022openalex-snapshot

High-fat diet aggravates colitis-associated carcinogenesis by evading ferroptosis in the ER stress-mediated pathway

inferred← citeshttps://doi.org/10.1016/j.heliyon.2020.e05000openalex-snapshot

Secretion of pro-oncogenic AGR2 protein in cancer

inferred← citeshttps://doi.org/10.1016/j.ijpharm.2026.127427openalex-snapshot

Cholesterol-mediated endoplasmic reticulum targeting to enhance the immune-activating capability of doxorubicin for hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1016/j.intimp.2024.112763openalex-snapshot

Secretory Nogo-B regulates Th2 differentiation in the lung cancer microenvironment

inferred← citeshttps://doi.org/10.1016/j.it.2018.12.001openalex-snapshot

Endoplasmic Reticulum Stress Responses in Intratumoral Immune Cells: Implications for Cancer Immunotherapy

inferred← citeshttps://doi.org/10.1016/j.jbc.2022.101644openalex-snapshot

HBXIP is a novel regulator of the unfolded protein response that sustains tamoxifen resistance in ER+ breast cancer

inferred← citeshttps://doi.org/10.1016/j.jbc.2022.101719openalex-snapshot

Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives

inferred← citeshttps://doi.org/10.1016/j.jbc.2022.101890openalex-snapshot

Spirocyclic dimer SpiD7 activates the unfolded protein response to selectively inhibit growth and induce apoptosis of cancer cells

inferred← citeshttps://doi.org/10.1016/j.jbc.2023.105124openalex-snapshot

CARM1 arginine methyltransferase as a therapeutic target for cancer

inferred← citeshttps://doi.org/10.1016/j.jcmgh.2023.04.006openalex-snapshot

Identification of a Transmembrane Protein Involved in Shear Stress Signaling and Hepatocarcinogenesis After a Sustained Virological Response to Hepatitis C Virus

inferred← citeshttps://doi.org/10.1016/j.jep.2017.04.025openalex-snapshot

Taraxacum mongolicum extract induced endoplasmic reticulum stress associated-apoptosis in triple-negative breast cancer cells

inferred← citeshttps://doi.org/10.1016/j.jgeb.2025.100548openalex-snapshot

Transcriptome profiling by RNA sequencing reveals novel targets of Gemini nano curcumin on p53-mutant HT-29 colorectal cancer cells

inferred← citeshttps://doi.org/10.1016/j.jhip.2024.05.002openalex-snapshot

Liujunzi decoction attenuates cisplatin-induced anorexia in rats via inhibiting PERK/eIF2α/ATF4/CHOP pathway and GDF15/GFRAL expression

inferred← citeshttps://doi.org/10.1016/j.jprot.2024.105284openalex-snapshot

Construction of a prognostic model for colon cancer by combining endoplasmic reticulum stress responsive genes

inferred← citeshttps://doi.org/10.1016/j.jsbmb.2024.106599openalex-snapshot

OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer

inferred← citeshttps://doi.org/10.1016/j.jtha.2024.03.015openalex-snapshot

Microtubule interacting and trafficking domain containing 1 deficiency leads to poor survival via tissue factor-mediated coagulation in bladder cancer

inferred← citeshttps://doi.org/10.1016/j.leukres.2022.106883openalex-snapshot

Clinical and biological relevance of CREB3L1 in Philadelphia chromosome-negative myeloproliferative neoplasms

inferred← citeshttps://doi.org/10.1016/j.lfs.2017.08.029openalex-snapshot

Autophagy: The spotlight for cellular stress responses

inferred← citeshttps://doi.org/10.1016/j.lfs.2019.01.046openalex-snapshot

Honokiol induces endoplasmic reticulum stress-mediated apoptosis in human lung cancer cells

inferred← citeshttps://doi.org/10.1016/j.lfs.2021.119470openalex-snapshot

Selective AMPK activator leads to unfolded protein response downregulation and induces breast cancer cell death and autophagy

inferred← citeshttps://doi.org/10.1016/j.lfs.2024.122681openalex-snapshot

GRP78 blockade overcomes acquired resistance to EGFR-tyrosine kinase inhibitors in non-small cell lung cancer

inferred← citeshttps://doi.org/10.1016/j.mce.2020.110932openalex-snapshot

Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival

inferred← citeshttps://doi.org/10.1016/j.mcn.2021.103658openalex-snapshot

Interleukin-15 modulates the response of cortical neurons to ischemia

inferred← citeshttps://doi.org/10.1016/j.medp.2025.100099openalex-snapshot

tRNA methylation in cancer

inferred← citeshttps://doi.org/10.1016/j.mehy.2017.09.013openalex-snapshot

Anastasis and the ER stress response: Solving the paradox of the unfolded protein response in cancer

inferred← citeshttps://doi.org/10.1016/j.molcel.2017.06.017openalex-snapshot

The Unfolded Protein Response and Cell Fate Control

inferred← citeshttps://doi.org/10.1016/j.mrrev.2020.108321openalex-snapshot

Oncogenic BRAF, endoplasmic reticulum stress, and autophagy: Crosstalk and therapeutic targets in cutaneous melanoma

inferred← citeshttps://doi.org/10.1016/j.nano.2019.102083openalex-snapshot

Gold nanourchins induce cellular stress, impair proteostasis and damage RNA

inferred← citeshttps://doi.org/10.1016/j.neo.2026.101297openalex-snapshot

PRAS40 activates the IRE1α-XBP-1-mediated unfolded protein response to exacerbate colorectal cancer by enhancing ST6Gal1-dependent α-2, 6 sialylation of GRP78

inferred← citeshttps://doi.org/10.1016/j.omto.2019.09.003openalex-snapshot

Calcium Influx Caused by ER Stress Inducers Enhances Oncolytic Adenovirus Enadenotucirev Replication and Killing through PKCα Activation

inferred← citeshttps://doi.org/10.1016/j.omto.2020.09.009openalex-snapshot

hsa_circ_0085539 Promotes Osteosarcoma Progression by Regulating miR-526b-5p and SERP1

inferred← citeshttps://doi.org/10.1016/j.pan.2021.10.007openalex-snapshot

The unfolded protein response: An emerging therapeutic target for pancreatitis and pancreatic ductal adenocarcinoma

inferred← citeshttps://doi.org/10.1016/j.pbiomolbio.2022.08.006openalex-snapshot

An overview of the intracellular localization of high-Z nanoradiosensitizers

inferred← citeshttps://doi.org/10.1016/j.pharmthera.2024.108604openalex-snapshot

Protein-rich foods, sea foods, and gut microbiota amplify immune responses in chronic diseases and cancers – Targeting PERK as a novel therapeutic strategy for chronic inflammatory diseases, neurodegenerative disorders, and cancer

inferred← citeshttps://doi.org/10.1016/j.phrs.2021.105654openalex-snapshot

Unfolded protein response in the activation-induced biological processes of CD8+ T cells

inferred← citeshttps://doi.org/10.1016/j.phrs.2024.107355openalex-snapshot

ATF family members as therapeutic targets in cancer: From mechanisms to pharmacological interventions

inferred← citeshttps://doi.org/10.1016/j.phrs.2026.108328openalex-snapshot

Targeting androgen receptor transcriptionally represses VCP and enhances the efficacy of oncolytic-immunotherapy in hepatocellular carcinoma

inferred← citeshttps://doi.org/10.1016/j.pneurobio.2017.08.005openalex-snapshot

Progressing neurobiological strategies against proteostasis failure: Challenges in neurodegeneration

inferred← citeshttps://doi.org/10.1016/j.prp.2023.154905openalex-snapshot

The role of endoplasmic reticulum stress in promoting aerobic glycolysis in cancer cells: An overview

inferred← citeshttps://doi.org/10.1016/j.prp.2025.155900openalex-snapshot

XBP1: A key regulator in breast cancer development and treatment

inferred← citeshttps://doi.org/10.1016/j.redox.2022.102243openalex-snapshot

ER-stress promotes VHL-independent degradation of hypoxia-inducible factors via FBXW1A/βTrCP

inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.175040openalex-snapshot

Exposure to trichloromethane via drinking water promotes progression of colorectal cancer by activating IRE1α/XBP1 pathway of endoplasmic reticulum stress

inferred← citeshttps://doi.org/10.1016/j.semcancer.2018.01.011openalex-snapshot

Homeostatic interplay between FoxO proteins and ER proteostasis in cancer and other diseases

inferred← citeshttps://doi.org/10.1016/j.stemcr.2019.02.012openalex-snapshot

Stearoyl CoA Desaturase Is Essential for Regulation of Endoplasmic Reticulum Homeostasis and Tumor Growth in Glioblastoma Cancer Stem Cells

inferred← citeshttps://doi.org/10.1016/j.steroids.2024.109450openalex-snapshot

Kuwanon C inhibits proliferation and induction of apoptosis via the intrinsic pathway in MDA-MB231 and T47D breast cancer cells

inferred← citeshttps://doi.org/10.1016/j.tcb.2020.09.002openalex-snapshot

When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response

inferred← citeshttps://doi.org/10.1016/j.tem.2017.07.003openalex-snapshot

Surviving Stress: Modulation of ATF4-Mediated Stress Responses in Normal and Malignant Cells

inferred← citeshttps://doi.org/10.1016/j.tips.2018.03.010openalex-snapshot

ER Stress: A Therapeutic Target in Rheumatoid Arthritis?

inferred← citeshttps://doi.org/10.1016/j.tips.2019.07.003openalex-snapshot

Small Molecules to Improve ER Proteostasis in Disease

inferred← citeshttps://doi.org/10.1016/j.tiv.2024.105974openalex-snapshot

Polyamine-modified naphthalimide derivative 9C inhibits colorectal cancer through ROS-mediated ER stress, migration and invasion

inferred← citeshttps://doi.org/10.1016/j.trecan.2017.07.002openalex-snapshot

The Unfolded Protein Response in Immunogenic Cell Death and Cancer Immunotherapy

inferred← citeshttps://doi.org/10.1016/j.trecan.2019.12.001openalex-snapshot

Targeting the Unfolded Protein Response in Hormone-Regulated Cancers

inferred← citeshttps://doi.org/10.1016/j.trecan.2020.07.006openalex-snapshot

Pharmacological Targeting of IRE1 in Cancer

inferred← citeshttps://doi.org/10.1016/j.trecan.2024.09.011openalex-snapshot

The UPRising connection between endoplasmic reticulum stress and the tumor microenvironment

inferred← citeshttps://doi.org/10.1016/j.xcrm.2021.100349openalex-snapshot

Uncoupling of gene expression from copy number presents therapeutic opportunities in aneuploid cancers

inferred← citeshttps://doi.org/10.1016/j.xcrm.2026.102769openalex-snapshot

Overcoming ADC resistance in advanced colorectal cancer by dual targeting of TROP2 and PERK to suppress Wnt/β-catenin signaling

inferred← citeshttps://doi.org/10.1016/j.yexcr.2021.112725openalex-snapshot

Tunicamycin-induced endoplasmic reticulum stress inhibits chemoresistance of FaDu hypopharyngeal carcinoma cells in 3D collagen I cultures and in vivo

inferred← citeshttps://doi.org/10.1016/j.yexcr.2022.113376openalex-snapshot

IRE1α-XBP1 regulates PDK1-dependent induction of epithelial-mesenchymal transition in non-small cell lung cancer cells

inferred← citeshttps://doi.org/10.1016/j.ymthe.2021.01.033openalex-snapshot

Enforced dimerization between XBP1s and ATF6f enhances the protective effects of the UPR in models of neurodegeneration

inferred← citeshttps://doi.org/10.1021/acs.chemrev.3c00062openalex-snapshot

Tumor Abnormality-Oriented Nanomedicine Design

inferred← citeshttps://doi.org/10.1021/acs.inorgchem.2c01375openalex-snapshot

Elucidation of Structure–Activity Relationships in Indolobenzazepine-Derived Ligands and Their Copper(II) Complexes: the Role of Key Structural Components and Insight into the Mechanism of Action

inferred← citeshttps://doi.org/10.1021/acs.jafc.3c00798openalex-snapshot

Heat Stress-Induced Intestinal Barrier Impairment: Current Insights into the Aspects of Oxidative Stress and Endoplasmic Reticulum Stress

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01342openalex-snapshot

Inhibitor Combinations Reveal Wiring of the Proteostasis Network in Prostate Cancer Cells

inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.1c00639openalex-snapshot

IRE-1-Targeting Caged Prodrug with Endoplasmic Reticulum Stress-Inducing and XBP-1S-Inhibiting Activities for Cancer Therapy

inferred← citeshttps://doi.org/10.1021/acsnano.4c01352openalex-snapshot

Endowing Pt(IV) with Perfluorocarbon Chains and Human Serum Albumin Encapsulation for Highly Effective Antitumor Chemoimmunotherapy

inferred← citeshttps://doi.org/10.1038/oncsis.2017.41openalex-snapshot

AKT is indispensable for coordinating Par-4/JNK cross talk in p21 downmodulation during ER stress

inferred← citeshttps://doi.org/10.1038/s12276-025-01486-1openalex-snapshot

C1QL1 inhibits breast cancer through the HSP90α/VCP-ERS/UPR axis

inferred← citeshttps://doi.org/10.1038/s41380-026-03755-5openalex-snapshot

The role of sleep disorders in orchestrating proteomic dysfunction and multi-morbidity

inferred← citeshttps://doi.org/10.1038/s41388-019-0878-3openalex-snapshot

Mutant p53 improves cancer cells’ resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6

inferred← citeshttps://doi.org/10.1038/s41388-019-0890-7openalex-snapshot

Regulation of PERK expression by FOXO3: a vulnerability of drug-resistant cancer cells

inferred← citeshttps://doi.org/10.1038/s41388-021-02108-6openalex-snapshot

Tumor innervation is triggered by endoplasmic reticulum stress

inferred← citeshttps://doi.org/10.1038/s41388-025-03380-6openalex-snapshot

Protein disulfide isomerase-enriched extracellular vesicles from bladder cancer cells support tumor survival and malignant transformation in the bladder

inferred← citeshttps://doi.org/10.1038/s41388-025-03435-8openalex-snapshot

Derlin-3 manipulates the endoplasmic reticulum stress and IgG4 secretion of plasma cells in lung adenocarcinoma

inferred← citeshttps://doi.org/10.1038/s41388-025-03606-7openalex-snapshot

Non-genetic inactivation of caspase-3 and P53 increases cancer cell fitness by PDIA4 redistribution

inferred← citeshttps://doi.org/10.1038/s41388-025-03652-1openalex-snapshot

circSETD3 confers radiotherapy resistance in nasopharyngeal carcinoma by attenuating ER stress-induced autophagy and apoptosis via PDIA6 upregulation

inferred← citeshttps://doi.org/10.1038/s41388-026-03938-yopenalex-snapshot

Complementary intra- and extracellular AGR2 activities support epithelial ovarian cancer cell aggressiveness

inferred← citeshttps://doi.org/10.1038/s41392-021-00761-7openalex-snapshot

XBP1 regulates the protumoral function of tumor-associated macrophages in human colorectal cancer

inferred← citeshttps://doi.org/10.1038/s41416-021-01462-2openalex-snapshot

Biological basis for novel mesothelioma therapies

inferred← citeshttps://doi.org/10.1038/s41416-023-02322-xopenalex-snapshot

Arginine regulates HSPA5/BiP translation through ribosome pausing in triple-negative breast cancer cells

inferred← citeshttps://doi.org/10.1038/s41417-024-00863-8openalex-snapshot

N6-methyladenosine modification of RIMS binding protein 2 promotes head and neck squamous cell carcinoma proliferation and radiotherapy tolerance through endoplasmic reticulum stress

inferred← citeshttps://doi.org/10.1038/s41418-018-0143-2openalex-snapshot

Strong and sustained activation of the anticipatory unfolded protein response induces necrotic cell death

inferred← citeshttps://doi.org/10.1038/s41418-024-01378-3openalex-snapshot

Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway

inferred← citeshttps://doi.org/10.1038/s41418-025-01443-5openalex-snapshot

Small protein ERSP encoded by LINC02870 promotes triple negative breast cancer progression via IRE1α/XBP1s activation

inferred← citeshttps://doi.org/10.1038/s41419-019-1408-5openalex-snapshot

ER stress sensor, glucose regulatory protein 78 (GRP78) regulates redox status in pancreatic cancer thereby maintaining “stemness”

inferred← citeshttps://doi.org/10.1038/s41419-020-02792-4openalex-snapshot

Caveolin-1 suppresses tumor formation through the inhibition of the unfolded protein response

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