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ER stress potentiates insulin resistance through PERK-mediated FOXO phosphorylation

https://doi.org/10.1101/gad.201731.112

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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A Conserved MST-FOXO Signaling Pathway Mediates Oxidative-Stress Responses and Extends Life Span

inferredcites →https://doi.org/10.1016/j.cell.2006.05.043openalex-snapshot

Distinct Ubiquitin-Ligase Complexes Define Convergent Pathways for the Degradation of ER Proteins

inferredcites →https://doi.org/10.1016/j.cmet.2007.11.010openalex-snapshot

Nutritional Control of Protein Biosynthetic Capacity by Insulin via Myc in Drosophila

inferredcites →https://doi.org/10.1016/j.jhep.2010.11.005openalex-snapshot

Endoplasmic reticulum stress in liver disease

inferredcites →https://doi.org/10.1016/s1534-5807(02)00401-xopenalex-snapshot

The Forkhead Transcription Factor Foxo1 Regulates Adipocyte Differentiation

inferredcites →https://doi.org/10.1038/35008115openalex-snapshot

AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

inferredcites →https://doi.org/10.1038/ncb2069openalex-snapshot

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

inferredcites →https://doi.org/10.1038/ng890openalex-snapshot

Regulation of insulin action and pancreatic β-cell function by mutated alleles of the gene encoding forkhead transcription factor Foxo1

inferredcites →https://doi.org/10.1038/nprot.2006.468openalex-snapshot

In-gel digestion for mass spectrometric characterization of proteins and proteomes

inferredcites →https://doi.org/10.1038/nrg2102openalex-snapshot

Network motifs: theory and experimental approaches

inferredcites →https://doi.org/10.1038/sj.cdd.4401840openalex-snapshot

From acute ER stress to physiological roles of the Unfolded Protein Response

inferredcites →https://doi.org/10.1038/sj.onc.1209086openalex-snapshot

FOXO transcription factors at the interface between longevity and tumor suppression

inferredcites →https://doi.org/10.1055/s-0028-1091980openalex-snapshot

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

inferredcites →https://doi.org/10.1073/pnas.0803022105openalex-snapshot

RNAi screening for kinases and phosphatases identifies FoxO regulators

inferredcites →https://doi.org/10.1091/mbc.e05-03-0268openalex-snapshot

PERK and GCN2 Contribute to eIF2α Phosphorylation and Cell Cycle Arrest after Activation of the Unfolded Protein Response Pathway

inferredcites →https://doi.org/10.1101/gad.1098703openalex-snapshot

Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway

inferredcites →https://doi.org/10.1101/gad.1340505openalex-snapshot

Transcriptional feedback control of insulin receptor by dFOXO/FOXO1

inferredcites →https://doi.org/10.1101/gad.416307openalex-snapshot

Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth

inferredcites →https://doi.org/10.1111/j.1600-0854.2008.00729.xopenalex-snapshot

The Recognition and Retrotranslocation of Misfolded Proteins from the Endoplasmic Reticulum

inferredcites →https://doi.org/10.1126/science.1103160openalex-snapshot

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

inferredcites →https://doi.org/10.1126/science.1128294openalex-snapshot

Chemical Chaperones Reduce ER Stress and Restore Glucose Homeostasis in a Mouse Model of Type 2 Diabetes

inferredcites →https://doi.org/10.1126/science.1130512openalex-snapshot

CDK2-Dependent Phosphorylation of FOXO1 as an Apoptotic Response to DNA Damage

inferredcites →https://doi.org/10.1126/science.1152337openalex-snapshot

Activation of FOXO1 by Cdk1 in Cycling Cells and Postmitotic Neurons

inferredcites →https://doi.org/10.1126/science.1209235openalex-snapshot

Road to Ruin: Targeting Proteins for Degradation in the Endoplasmic Reticulum

inferredcites →https://doi.org/10.1126/scisignal.2001630openalex-snapshot

Akt Determines Cell Fate Through Inhibition of the PERK-eIF2α Phosphorylation Pathway

inferredcites →https://doi.org/10.1128/mcb.00063-12openalex-snapshot

PERK Utilizes Intrinsic Lipid Kinase Activity To Generate Phosphatidic Acid, Mediate Akt Activation, and Promote Adipocyte Differentiation

inferredcites →https://doi.org/10.1128/mcb.24.5.2181-2189.2004openalex-snapshot

Control of Cyclin G2 mRNA Expression by Forkhead Transcription Factors: Novel Mechanism for Cell Cycle Control by Phosphoinositide 3-Kinase and Forkhead

inferredcites →https://doi.org/10.1128/mcb.25.11.4529-4540.2005openalex-snapshot

Endoplasmic Reticulum Stress Induction of the Grp78/BiP Promoter: Activating Mechanisms Mediated by YY1 and Its Interactive Chromatin Modifiers

inferredcites →https://doi.org/10.1186/1475-4924-2-20openalex-snapshot

The Drosophila Forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling

inferredcites →https://doi.org/10.1242/jcs.001222openalex-snapshot

Dynamic FoxO transcription factors

inferredcites →https://doi.org/10.1242/jcs.113.21.3697openalex-snapshot

IRE1 and efferent signaling from the endoplasmic reticulum

inferredcites →https://doi.org/10.1371/journal.pgen.1002429openalex-snapshot

MAPK/ERK Signaling Regulates Insulin Sensitivity to Control Glucose Metabolism in Drosophila

inferredcites →https://doi.org/10.2337/db08-1001openalex-snapshot

FoxO1 Haploinsufficiency Protects Against High-Fat Diet–Induced Insulin Resistance With Enhanced Peroxisome Proliferator–Activated Receptor γ Activation in Adipose Tissue

inferredcites →https://doi.org/10.2337/db10-1433openalex-snapshot

Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Forkhead box protein FOXK1 disrupts the circadian rhythm to promote breast tumorigenesis in response to insulin resistance

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Feedback regulation on PTEN/AKT pathway by the ER stress kinase PERK mediated by interaction with the Vault complex

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Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

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inferred← citeshttps://doi.org/10.1016/j.cmet.2019.08.021openalex-snapshot

Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

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Association of changes in ER stress-mediated signaling pathway with lead-induced insulin resistance and apoptosis in rats and their prevention by A-type dimeric epigallocatechin-3-gallate

inferred← citeshttps://doi.org/10.1016/j.fct.2020.111329openalex-snapshot

Impaired ferritinophagy flux induced by high fat diet mediates hepatic insulin resistance via endoplasmic reticulum stress

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Endoplasmic reticulum stress and autophagy contributed to cadmium nephrotoxicity in HK-2 cells and Sprague-Dawley rats

inferred← citeshttps://doi.org/10.1016/j.ibmb.2021.103667openalex-snapshot

Halofuginone triggers a transcriptional program centered on ribosome biogenesis and function in honey bees

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2019.07.043openalex-snapshot

In vitro induction of endoplasmic reticulum stress in human cervical adenocarcinoma HeLa cells by fucoidan

inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2023.125995openalex-snapshot

Role of forkhead box proteins in regulation of doxorubicin and paclitaxel responses in tumor cells: A comprehensive review

inferred← citeshttps://doi.org/10.1016/j.jsbmb.2015.07.015openalex-snapshot

Forkhead box O transcription factors in chondrocytes regulate endochondral bone formation

inferred← citeshttps://doi.org/10.1016/j.lfs.2018.11.041openalex-snapshot

Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes

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Preferential effect of Montelukast on Dapagliflozin: Modulation of IRS-1/AKT/GLUT4 and ER stress response elements improves insulin sensitivity in soleus muscle of a type-2 diabetic rat model

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The rules and regulatory mechanisms of FOXO3 on inflammation, metabolism, cell death and aging in hosts

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Plasma from pre-pubertal obese children impairs insulin stimulated Nitric Oxide (NO) bioavailability in endothelial cells: Role of ER stress

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ER stress and cancer: The FOXO forkhead transcription factor link

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Reciprocal regulation between GCN2 (eIF2AK4) and PERK (eIF2AK3) through the JNK-FOXO3 axis to modulate cancer drug resistance and clonal survival

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Specific PERK inhibitors enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes

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Intestinal FoxO signaling is required to survive oral infection in Drosophila

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Advanced glycation end products induce skeletal muscle atrophy and insulin resistance via activating ROS-mediated ER stress PERK/FOXO1 signaling

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Boolean network modeling of β-cell apoptosis and insulin resistance in type 2 diabetes mellitus

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inferred← citeshttps://doi.org/10.1371/journal.pone.0317971openalex-snapshot

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inferred← citeshttps://doi.org/10.1515/hmbci-2015-0033openalex-snapshot

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Attenuation of PERK enhances glucose-stimulated insulin secretion in islets

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Insulin/insulin-like growth factor signaling in C. elegans

inferred← citeshttps://doi.org/10.21203/rs.3.rs-1683406/v1openalex-snapshot

Effect of chitooligosaccharides with a specific degree of polymerization on multiple targets in T2DM mice

inferred← citeshttps://doi.org/10.21203/rs.3.rs-3896719/v1openalex-snapshot

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Metabolomic Analysis Unfolds Connection of Obesity and Endometrial Cancer

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Trimethylamine N-oxide—a marker for atherosclerotic vascular disease

inferred← citeshttps://doi.org/10.31219/osf.io/6jnxvopenalex-snapshot

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Computational modelling of the biological and social factors of type 2 diabetes

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Emerging role of UFMylation in secretory cells involved in the endocrine system by maintaining ER proteostasis

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Protective Properties of FOXO1 Inhibition in a Murine Model of Non-alcoholic Fatty Liver Disease Are Associated With Attenuation of ER Stress and Necroptosis

inferred← citeshttps://doi.org/10.3389/fphys.2022.935195openalex-snapshot

The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders

inferred← citeshttps://doi.org/10.3389/fphys.2024.1337442openalex-snapshot

Potential molecular mechanism of exercise reversing insulin resistance and improving neurodegenerative diseases

inferred← citeshttps://doi.org/10.3390/biom15020248openalex-snapshot

PERK-Olating Through Cancer: A Brew of Cellular Decisions

inferred← citeshttps://doi.org/10.3390/biomedicines11020431openalex-snapshot

Contribution of Trimethylamine N-Oxide (TMAO) to Chronic Inflammatory and Degenerative Diseases

inferred← citeshttps://doi.org/10.3390/cancers12092385openalex-snapshot

Proteotoxic Stress and Cell Death in Cancer Cells

inferred← citeshttps://doi.org/10.3390/cancers17223639openalex-snapshot

The Unfolded Protein Response—Novel Mechanisms, Challenges, and Key Considerations for Therapeutic Intervention

inferred← citeshttps://doi.org/10.3390/cells9030540openalex-snapshot

Translational Regulations in Response to Endoplasmic Reticulum Stress in Cancers

inferred← citeshttps://doi.org/10.3390/genes13040668openalex-snapshot

Integrated Analysis of the ceRNA Network and M-7474 Function in Testosterone-Mediated Fat Deposition in Pigs

inferred← citeshttps://doi.org/10.3390/ijms19071989openalex-snapshot

Impact of Drosophila Models in the Study and Treatment of Friedreich’s Ataxia

inferred← citeshttps://doi.org/10.3390/ijms19103020openalex-snapshot

Protein Quality Control in the Endoplasmic Reticulum and Cancer

inferred← citeshttps://doi.org/10.3390/ijms20184354openalex-snapshot

Dual role of Endoplasmic Reticulum Stress-Mediated Unfolded Protein Response Signaling Pathway in Carcinogenesis

inferred← citeshttps://doi.org/10.3390/ijms27041959openalex-snapshot

Effect Modification of Trimethylamine N-Oxide and Lipoprotein Insulin Resistance with Post-Transplantation Diabetes After Liver Transplant

inferred← citeshttps://doi.org/10.3390/molecules23092098openalex-snapshot

Mechanism of Action of Magnesium Lithospermate B against Aging and Obesity-Induced ER Stress, Insulin Resistance, and Inflammsome Formation in the Liver

inferred← citeshttps://doi.org/10.3390/molecules25030599openalex-snapshot

Baicalein Alleviates Liver Oxidative Stress and Apoptosis Induced by High-Level Glucose through the Activation of the PERK/Nrf2 Signaling Pathway

inferred← citeshttps://doi.org/10.37175/stemedicine.v1i4.63openalex-snapshot

Misfolded protein aggregation and altered cellular pathways in neurodegenerative diseases

inferred← citeshttps://doi.org/10.3748/wjg.v20.i7.1768openalex-snapshot

Role of endoplasmic reticulum stress in the pathogenesis of nonalcoholic fatty liver disease

inferred← citeshttps://doi.org/10.3803/enm.2023.1738openalex-snapshot

Partial Deletion of Perk Improved High-Fat Diet-Induced Glucose Intolerance in Mice

inferred← citeshttps://doi.org/10.3892/mmr.2016.5867openalex-snapshot

Post-translational modifications of FOXO family proteins

inferred← citeshttps://doi.org/10.4049/jimmunol.1501707openalex-snapshot

Survival of Igα-Deficient Mature B Cells Requires BAFF-R Function

inferred← citeshttps://doi.org/10.4093/dmj.2017.41.1.10openalex-snapshot

Nuclear Receptors Resolve Endoplasmic Reticulum Stress to Improve Hepatic Insulin Resistance

inferred← citeshttps://doi.org/10.4172/2327-4638.1000105openalex-snapshot

Endoplasmic Reticulum Stress and Related Pathological Processes

inferred← citeshttps://doi.org/10.4251/wjgo.v13.i10.1367openalex-snapshot

Diverse roles of FOXO family members in gastric cancer

inferred← citeshttps://doi.org/10.47749/t/unicamp.2021.1265511openalex-snapshot

Efeitos de diferentes protocolos de treinamento físico em vias biomoleculares de controle de produção hepática de glicose e metabolismo lipídico no fígado de roedores obesos

inferred← citeshttps://doi.org/10.6084/m9.figshare.20933472openalex-snapshot

Additional file 1 of Effect of chitooligosaccharides with a specific degree of polymerization on multiple targets in T2DM mice

inferred← citeshttps://doi.org/10.64898/2026.02.17.706443openalex-snapshot

A PERK-FOXO1 AXIS LINKS DNA DAMAGE TO FIBROBLAST SURVIVAL IN DIFFUSE CUTANEOUS SYSTEMIC SCLEROSIS

inferred← citeshttps://doi.org/10.70675/34bdea7fz8e7bz4ba1z997ez5d01dd3c712eopenalex-snapshot

Protéostase cellulaire et tumeurs solides

inferred← citeshttps://doi.org/10.70675/50aa6a06zc458z48e5z9416z7682f49fb7f3openalex-snapshot

Fine-tuning UPR signals and subsequent cellular outputs

inferred← citeshttps://doi.org/10.70675/a7f68586zb194z4f22z9adbz62a1d34b7bc0openalex-snapshot

Stress du réticulum endoplasmique dans les leucémies aiguës myéloïdes : rôle et régulation du facteur de transcription XBP1

inferred← citeshttps://doi.org/10.70675/de500ab2z3c59z484dz8f58z7c3173626c42openalex-snapshot

The roles of endoplasmic reticulum stress and Bax inhibitor-1 in non-alcoholic fatty liver disease

inferred← citeshttps://doi.org/10.7554/elife.53159openalex-snapshot

FoxO suppresses endoplasmic reticulum stress to inhibit growth of Tsc1-deficient tissues under nutrient restriction

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