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High-Performance Molecular Imaging with MALDI Trapped Ion-Mobility Time-of-Flight (timsTOF) Mass Spectrometry

https://doi.org/10.1021/acs.analchem.9b03612

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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‘On the Spot’ Digital Pathology of Breast Cancer Based on Single-Cell Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/acs.analchem.2c00978openalex-snapshot

Efficient Hydrogen–Deuterium Exchange in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging for Confident Metabolite Identification

inferred← citeshttps://doi.org/10.1021/acs.analchem.2c02694openalex-snapshot

Molecular Networking and On-Tissue Chemical Derivatization for Enhanced Identification and Visualization of Steroid Glycosides by MALDI Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/acs.analchem.2c02866openalex-snapshot

Ion Mobility Mass Spectrometry for the Separation and Characterization of Small Molecules

inferred← citeshttps://doi.org/10.1021/acs.analchem.2c02990openalex-snapshot

Data-Driven Deciphering of Latent Lesions in Heterogeneous Tissue Using Function-Directed t-SNE of Mass Spectrometry Imaging Data

inferred← citeshttps://doi.org/10.1021/acs.analchem.2c03939openalex-snapshot

MALDI TIMS IMS of Disialoganglioside Isomers─GD1a and GD1b in Murine Brain Tissue

inferred← citeshttps://doi.org/10.1021/acs.analchem.2c03953openalex-snapshot

Using the Synergy between HPLC-MS and MALDI-MS Imaging to Explore the Lipidomics of Clear Cell Renal Cell Carcinoma

inferred← citeshttps://doi.org/10.1021/acs.analchem.3c02616openalex-snapshot

High-Throughput Deconvolution of Native Protein Mass Spectrometry Imaging Data Sets for Mass Domain Analysis

inferred← citeshttps://doi.org/10.1021/acs.analchem.3c05252openalex-snapshot

Imaging Mass Spectrometry of Isotopically Resolved Intact Proteins on a Trapped Ion-Mobility Quadrupole Time-of-Flight Mass Spectrometer

inferred← citeshttps://doi.org/10.1021/acs.analchem.4c01553openalex-snapshot

Multimodal Image Fusion Workflow Incorporating MALDI Imaging Mass Spectrometry and Microscopy for the Study of Small Pharmaceutical Compounds

inferred← citeshttps://doi.org/10.1021/acs.analchem.4c02394openalex-snapshot

Desorption Electrospray Ionization Cyclic Ion Mobility-Mass Spectrometry Imaging for Traumatic Brain Injury Spatial Metabolomics

inferred← citeshttps://doi.org/10.1021/acs.analchem.4c05249openalex-snapshot

Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/acs.analchem.4c05538openalex-snapshot

Universal Photosensitizer for Isomer-Selective Lipid Imaging with High Molecular Coverage

inferred← citeshttps://doi.org/10.1021/acs.analchem.5c00157openalex-snapshot

Advances in Tandem Mass Spectrometry Imaging for Next-Generation Spatial Metabolomics

inferred← citeshttps://doi.org/10.1021/acs.analchem.5c02092openalex-snapshot

High-Throughput Fluorescence-Guided Sequential Single-Cell MALDI-ICC Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/acs.analchem.5c06621openalex-snapshot

Resolving sn -Positional Isomers of Docosahexaenoic Acid-Bound Phospholipids in the Mouse Brain by Cyclic Ion Mobility Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/acs.analchem.6c01111openalex-snapshot

Towards Cellular Resolution of Tryptic Peptides in Tissue Sections by MALDI MS Imaging: A Focus on Enzyme Application and Reproducibility

inferred← citeshttps://doi.org/10.1021/acs.analchem.6c01209openalex-snapshot

Tandem Mass Spectrometry Imaging of Low-Abundance Ether Phospholipids Guided by Bulk Lipidomics Analysis

inferred← citeshttps://doi.org/10.1021/acs.analchem.9b04768openalex-snapshot

Ultra-High Mass Resolving Power, Mass Accuracy, and Dynamic Range MALDI Mass Spectrometry Imaging by 21-T FT-ICR MS

inferred← citeshttps://doi.org/10.1021/acs.chemrev.6c00098openalex-snapshot

Computational Mass Spectrometry Imaging in the Era of AI

inferred← citeshttps://doi.org/10.1021/acs.jafc.1c08207openalex-snapshot

Current Knowledge on Intestinal Absorption of Anthocyanins

inferred← citeshttps://doi.org/10.1021/acs.jproteome.2c00714openalex-snapshot

Data-Driven and Machine Learning-Based Framework for Image-Guided Single-Cell Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/acs.jproteome.3c00167openalex-snapshot

A Guide to MALDI Imaging Mass Spectrometry for Tissues

inferred← citeshttps://doi.org/10.1021/acs.jproteome.4c00528openalex-snapshot

MALDI MSI Protocol for Spatial Bottom-Up Proteomics at Single-Cell Resolution

inferred← citeshttps://doi.org/10.1021/acs.jproteome.4c00646openalex-snapshot

Recent Developments in Single-Cell Metabolomics by Mass Spectrometry─A Perspective

inferred← citeshttps://doi.org/10.1021/acs.jproteome.4c01140openalex-snapshot

MSIght: A Modular Platform for Improved Confidence in Global, Untargeted Mass Spectrometry Imaging Annotation

inferred← citeshttps://doi.org/10.1021/acsanm.1c03890openalex-snapshot

Laser Desorption Ionization–Mass Spectrometry with Graphite Carbon Black Nanoparticles for Simultaneous Detection of Taste- and Odor-Active Compounds

inferred← citeshttps://doi.org/10.1021/acschemneuro.4c00199openalex-snapshot

Applying Spatial Metabolomics To Investigate Age- and Drug-Induced Neurochemical Changes

inferred← citeshttps://doi.org/10.1021/acsmeasuresciau.2c00031openalex-snapshot

High-Throughput Mass Spectrometry Imaging with Dynamic Sparse Sampling

inferred← citeshttps://doi.org/10.1021/acsmeasuresciau.6c00074openalex-snapshot

Spatial Lipidomic Profiling of Kidney Functional Units in SIV-Infected and ART-Treated Rhesus Macaques

inferred← citeshttps://doi.org/10.1021/acsmeasuresciau.6c00210openalex-snapshot

Expanding the Measurement Space of Ion Mobility-Mass Spectrometry Using Chemical Derivatizations

inferred← citeshttps://doi.org/10.1021/acsmeasuresciau.6c00282openalex-snapshot

From Pixels to Chemical Knowledge: Interpreting Ion Mobility-Enabled Multidimensional Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/jacs.5c16821openalex-snapshot

Integrated Native Mass Spectrometry Imaging of Soluble and Membrane Proteins

inferred← citeshttps://doi.org/10.1021/jasms.0c00005openalex-snapshot

Rapid and Sensitive Drug Quantification in Tissue Sections Using Matrix Assisted Laser Desorption Ionization-Ion Mobility-Mass Spectrometry Profiling

inferred← citeshttps://doi.org/10.1021/jasms.0c00208openalex-snapshot

Antigen Retrieval and Its Effect on the MALDI-MSI of Lipids in Formalin-Fixed Paraffin-Embedded Tissue

inferred← citeshttps://doi.org/10.1021/jasms.0c00232openalex-snapshot

Multimodal Imaging Mass Spectrometry: Next Generation Molecular Mapping in Biology and Medicine

inferred← citeshttps://doi.org/10.1021/jasms.0c00368openalex-snapshot

Implementation of a High-Repetition-Rate Laser in an AP-SMALDI MSI System for Enhanced Measurement Performance

inferred← citeshttps://doi.org/10.1021/jasms.0c00439openalex-snapshot

Spatially Resolved Mass Spectrometry at the Single Cell: Recent Innovations in Proteomics and Metabolomics

inferred← citeshttps://doi.org/10.1021/jasms.1c00159openalex-snapshot

Molecular Mapping of Neutral Lipids Using Silicon Nanopost Arrays and TIMS Imaging Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/jasms.1c00213openalex-snapshot

Enhancement of Tryptic Peptide Signals from Tissue Sections Using MALDI IMS Postionization (MALDI-2)

inferred← citeshttps://doi.org/10.1021/jasms.1c00300openalex-snapshot

Reduced Hemoglobin Signal and Improved Detection of Endogenous Proteins in Blood-Rich Tissues for MALDI Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/jasms.1c00360openalex-snapshot

Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content

inferred← citeshttps://doi.org/10.1021/jasms.2c00203openalex-snapshot

Transforming a Mid-infrared Laser Profile from Gaussian to a Top-Hat with a Diffractive Optical Element for Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/jasms.3c00033openalex-snapshot

Microscopy-Directed Imaging Mass Spectrometry for Rapid High Spatial Resolution Molecular Imaging of Glomeruli

inferred← citeshttps://doi.org/10.1021/jasms.3c00081openalex-snapshot

Separation of Isobaric Lipids in Imaging Mass Spectrometry Using Gas-Phase Charge Inversion Ion/Ion Reactions

inferred← citeshttps://doi.org/10.1021/jasms.3c00199openalex-snapshot

Nanospray Desorption Electrospray Ionization (Nano-DESI) Mass Spectrometry Imaging with High Ion Mobility Resolution

inferred← citeshttps://doi.org/10.1021/jasms.3c00320openalex-snapshot

Evaluation of a Commercial TIMS-Q-TOF Platform for Native Mass Spectrometry

inferred← citeshttps://doi.org/10.1021/jasms.3c00369openalex-snapshot

Detection, Quantification, and Isomer Differentiation of Per- and Polyfluoroalkyl Substances (PFAS) Using MALDI-TOF with Trapped Ion Mobility

inferred← citeshttps://doi.org/10.1021/jasms.4c00042openalex-snapshot

Visualizing 13C-Labeled Metabolites in Maize Root Tips with Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/jasms.4c00089openalex-snapshot

MALDI TIMS IMS Reveals Ganglioside Molecular Diversity within Murine S. aureus Kidney Tissue Abscesses

inferred← citeshttps://doi.org/10.1021/jasms.4c00178openalex-snapshot

MSIGen: An Open-Source Python Package for Processing and Visualizing Mass Spectrometry Imaging Data

inferred← citeshttps://doi.org/10.1021/jasms.4c00365openalex-snapshot

A Streamlined Workflow for Microscopy-Driven MALDI Imaging Mass Spectrometry Data Collection

inferred← citeshttps://doi.org/10.1021/jasms.5c00090openalex-snapshot

A Spatial Metabolomics Annotation Workflow Leveraging Cyclic Ion Mobility and Machine Learning-Predicted Collision Cross Sections

inferred← citeshttps://doi.org/10.1021/jasms.5c00202openalex-snapshot

High-Specificity and Sensitivity Imaging of Neutral Lipids Using Salt-Enhanced MALDI TIMS

inferred← citeshttps://doi.org/10.1021/jasms.5c00211openalex-snapshot

Investigating the Quantitative Structure–Ionization Efficiency Relationship of Small Molecules and Lipids in the Presence of Ammonium Fluoride in MALDI-TIMS-QTOF Mass Spectrometry Imaging

inferred← citeshttps://doi.org/10.1021/jasms.5c00292openalex-snapshot

Hyphenation of Trapped Ion Mobility to Two-Dimensional Mass Spectrometry for Protein Analysis in Complex Biomixtures

inferred← citeshttps://doi.org/10.1021/jasms.5c00411openalex-snapshot

Chiral α-Hydroxy Acid Discrimination in Tumor Tissues and Food Samples via Derivatization-Assisted MALDI-TIMS-MS

inferred← citeshttps://doi.org/10.1021/jasms.6c00079openalex-snapshot

mspix: A Data Format for High Pixel Count Mass Spectral Images

inferred← citeshttps://doi.org/10.1038/s41467-021-25744-8openalex-snapshot

Peak learning of mass spectrometry imaging data using artificial neural networks

inferred← citeshttps://doi.org/10.1038/s41467-025-58135-4openalex-snapshot

Resolving multi-image spatial lipidomic responses to inhaled toxicants by machine learning

inferred← citeshttps://doi.org/10.1038/s41556-023-01194-wopenalex-snapshot

Advances and prospects for the Human BioMolecular Atlas Program (HuBMAP)

inferred← citeshttps://doi.org/10.1038/s41568-023-00657-4openalex-snapshot

Multiplex protein imaging in tumour biology

inferred← citeshttps://doi.org/10.1038/s41586-025-09734-0openalex-snapshot

iPEX enables micrometre-resolution deep spatial proteomics via tissue expansion

inferred← citeshttps://doi.org/10.1038/s41592-023-01774-6openalex-snapshot

Mass spectrometry imaging: the rise of spatially resolved single-cell omics

inferred← citeshttps://doi.org/10.1038/s41596-023-00864-1openalex-snapshot

Visualization of metabolites and microbes at high spatial resolution using MALDI mass spectrometry imaging and in situ fluorescence labeling

inferred← citeshttps://doi.org/10.1038/s41598-022-06894-1openalex-snapshot

LPS-induced lipid alterations in microglia revealed by MALDI mass spectrometry-based cell fingerprinting in neuroinflammation studies

inferred← citeshttps://doi.org/10.1038/s43586-026-00492-5openalex-snapshot

Matrix-assisted laser desorption/ionization imaging mass spectrometry

inferred← citeshttps://doi.org/10.1039/d1sc04077dopenalex-snapshot

Self-supervised clustering of mass spectrometry imaging data using contrastive learning

inferred← citeshttps://doi.org/10.1039/d3dd00165bopenalex-snapshot

Extended similarity methods for efficient data mining in imaging mass spectrometry

inferred← citeshttps://doi.org/10.1039/d4np00053fopenalex-snapshot

‘Need for speed: high throughput’ – mass spectrometry approaches for high-throughput directed evolution screening of natural product enzymes

inferred← citeshttps://doi.org/10.1039/d5an00466gopenalex-snapshot

Bacterial biofilm sample preparation for spatial metabolomics

inferred← citeshttps://doi.org/10.1053/j.gastro.2020.04.073openalex-snapshot

Use of Single-Cell -Omic Technologies to Study the Gastrointestinal Tract and Diseases, From Single Cell Identities to Patient Features

inferred← citeshttps://doi.org/10.1080/00032719.2023.2173768openalex-snapshot

Monitoring Conformational Changes of Lysozyme–Polyelectrolyte Complexes Using Trapped Ion Mobility-Mass Spectrometry (IM-MS)

inferred← citeshttps://doi.org/10.1080/14789450.2021.1941893openalex-snapshot

Mass Spectrometry Imaging of Fibroblasts: Promise and Challenge

inferred← citeshttps://doi.org/10.1080/14789450.2022.2026218openalex-snapshot

Insights and prospects for ion mobility-mass spectrometry in clinical chemistry

inferred← citeshttps://doi.org/10.1093/bbb/zbae034openalex-snapshot

Application of graphite carbon black assisted-laser desorption ionization-mass spectrometry for soy sauce product discrimination

inferred← citeshttps://doi.org/10.1093/bioinformatics/btaf247openalex-snapshot

Preserving full spectrum information in imaging mass spectrometry data reduction

inferred← citeshttps://doi.org/10.1093/gigascience/giag006openalex-snapshot

SpaceBF: spatial coexpression analysis using Bayesian fused approaches in spatial omics datasets

inferred← citeshttps://doi.org/10.1093/ndt/gfab359openalex-snapshot

Mass spectrometry imaging and its place in nephrology

inferred← citeshttps://doi.org/10.1093/pnasnexus/pgad144openalex-snapshot

Multiplexed neuropeptide mapping in ant brains integrating microtomography and three-dimensional mass spectrometry imaging

inferred← citeshttps://doi.org/10.1094/pbiomes-05-20-0042-rvwopenalex-snapshot

Novel and Emerging Capabilities that Can Provide a Holistic Understanding of the Plant Root Microbiome

inferred← citeshttps://doi.org/10.1094/pbiomes-5-2openalex-snapshot

Full Issue PDF

inferred← citeshttps://doi.org/10.1101/2021.12.13.472421openalex-snapshot

Characterization of metabolic compartmentalization in the liver using spatially resolved metabolomics

inferred← citeshttps://doi.org/10.1101/2023.12.01.569690openalex-snapshot

In situ lipidomics of Staphylococcus aureus osteomyelitis using imaging mass spectrometry

inferred← citeshttps://doi.org/10.1101/2024.02.21.581450openalex-snapshot

Revealing In Situ Molecular Profiles of Glomerular Cell Types and Substructures with Integrated Imaging Mass Spectrometry and Multiplexed Immunofluorescence Microscopy

inferred← citeshttps://doi.org/10.1101/2024.03.12.584673openalex-snapshot

A multi-modal image fusion workflow incorporating MALDI imaging mass spectrometry and microscopy for the study of small pharmaceutical compounds

inferred← citeshttps://doi.org/10.1101/2024.06.01.596997openalex-snapshot

Spatial Multiomics Lipids and Gene expression using MALDI ISH MSI

inferred← citeshttps://doi.org/10.1101/2024.12.03.626022openalex-snapshot

Histology-Guided Single-Cell Mass Spectrometry Imaging using Integrated Bright-field and Fluorescence Microscopy

inferred← citeshttps://doi.org/10.1101/2025.02.04.636486openalex-snapshot

Critical Evaluation of Sphingolipids Detection by MALDI-MSI

inferred← citeshttps://doi.org/10.1101/2025.09.12.675752openalex-snapshot

Mass spectrometry imaging-based explainable machine learning reveals the biochemical landscapes of the mouse brain

inferred← citeshttps://doi.org/10.1101/2025.09.26.678707openalex-snapshot

Cellular and Spatial Drivers of Unresolved Injury and Functional Decline in the Human Kidney

inferred← citeshttps://doi.org/10.1101/2025.10.15.682422openalex-snapshot

LipidQMap - An Open-Source Tool for Quantitative Mass Spectrometry Imaging of Lipids

inferred← citeshttps://doi.org/10.1109/access.2020.3047588openalex-snapshot

Methods for Proteogenomics Data Analysis, Challenges, and Scalability Bottlenecks: A Survey

inferred← citeshttps://doi.org/10.1111/jnc.70315openalex-snapshot

Considerations for Spatial Omics, Metabolite Analyses, and Tissue‐Harvesting Artifacts

inferred← citeshttps://doi.org/10.1111/tpj.16924openalex-snapshot

Advances in mass spectrometry imaging for plant metabolomics—Expanding the analytical toolbox

inferred← citeshttps://doi.org/10.1126/sciadv.adv0741openalex-snapshot

Virtual staining of label-free tissue in imaging mass spectrometry

inferred← citeshttps://doi.org/10.1134/s0036024423110262openalex-snapshot

Express Search and Characterization of Nitro Compounds via Visualization Mass Spectrometry

inferred← citeshttps://doi.org/10.1139/cjc-2025-0279openalex-snapshot

Surgical tissue profiling and computational pipeline using the liquid microjunction surface sampling probe (LMJ-SSP) mass spectrometry: a proof-of-concept study

inferred← citeshttps://doi.org/10.1146/annurev-anchem-061020-022048openalex-snapshot

Mass Spectrometry Measurements of Neuropeptides: From Identification to Quantitation

inferred← citeshttps://doi.org/10.1146/annurev-anchem-083023-024546openalex-snapshot

High-Specificity Imaging Mass Spectrometry

inferred← citeshttps://doi.org/10.1146/annurev-nutr-062024-111053openalex-snapshot

Shaping Human Health and Nutrition Through Innovations in Spatial Metabolism

inferred← citeshttps://doi.org/10.1158/1078-0432.ccr-24-2469openalex-snapshot

The Society for Immunotherapy of Cancer Perspective on Tissue-Based Technologies for Immuno-Oncology Biomarker Discovery and Application

inferred← citeshttps://doi.org/10.1161/circresaha.126.327684openalex-snapshot

Single Cell Proteomics to Spatial Multiomics in Cardiovascular Disease: Foundations, Technologies, and Biological Insights

inferred← citeshttps://doi.org/10.1167/iovs.65.14.24openalex-snapshot

Sphingolipid Levels and Processing of the Retinyl Chromophore in the Retina of a Mouse Model of Niemann-Pick Disease

inferred← citeshttps://doi.org/10.1167/iovs.66.3.18openalex-snapshot

Porcine Sub-Retinal Pigment Epithelium Deposits: A Model for Dry Age-Related Macular Degeneration With Comparison to Human Drusen

inferred← citeshttps://doi.org/10.1186/s40478-026-02361-4openalex-snapshot

Multimodal molecular mapping of the vasculature in human cortex reveals lipid markers of cerebral amyloid angiopathy

inferred← citeshttps://doi.org/10.1186/s40779-024-00537-4openalex-snapshot

Spatiotemporal multi-omics: exploring molecular landscapes in aging and regenerative medicine

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