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Covalent DNA–Protein Cross-Linking by Phosphoramide Mustard and Nornitrogen Mustard in Human Cells

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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The Gene Ontology Annotation (GOA) project — application of GO in SWISS‐PROT, TrEMBL and InterPro
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Sequence Conservation of therad21 Schizosaccharomyces pombeDNA Double-Strand Break Repair Gene in Human and Mouse
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DNA–Protein Crosslinks Induced by Nickel Compounds in Isolated Rat Renal Cortical Cells and Its Antagonism by Specific Amino Acids and Magnesium Ion
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Replication-Coupled DNA Interstrand Cross-Link Repair in Xenopus Egg Extracts
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Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy
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N-(2-hydroxyethyl)-N-[2-(7-guaninyl)ethyl]amine, the putative major DNA adduct of cyclophosphamide in vitro and in vivo in the rat
inferredcites →https://doi.org/10.1016/0009-2797(87)90020-2openalex-snapshot
DNA-binding products of nornitrogen mustard, a metabolite of cyclophosphamide
inferredcites →https://doi.org/10.1016/0165-1218(91)90057-sopenalex-snapshot
1,3-Butadiene and its epoxides induce sister-chromatid exchanges in human lymphocytes in vitro
inferredcites →https://doi.org/10.1016/0167-8817(84)90035-xopenalex-snapshot
DNA-DNA and DNA-protein crosslinking and repair in Neurospora crassa following exposure to nitrogen mustard
inferredcites →https://doi.org/10.1016/0300-483x(96)03462-2openalex-snapshot
Metabolism of 1,3-butadiene: inhalation pharmacokinetics and tissue dosimetry of butadiene epoxides in rats and mice
inferredcites →https://doi.org/10.1016/j.cell.2014.04.053openalex-snapshot
A DNA-Dependent Protease Involved in DNA-Protein Crosslink Repair
inferredcites →https://doi.org/10.1016/j.cell.2014.09.024openalex-snapshot
Repair of a DNA-Protein Crosslink by Replication-Coupled Proteolysis
inferredcites →https://doi.org/10.1016/j.gde.2004.02.004openalex-snapshot
Facts about FACT and transcript elongation through chromatin
inferredcites →https://doi.org/10.1016/j.immuni.2013.11.011openalex-snapshot
S100A8-S100A9 Protein Complex Mediates Psoriasis by Regulating the Expression of Complement Factor C3
inferredcites →https://doi.org/10.1016/j.molcel.2007.07.029openalex-snapshot
Nucleotide Excision Repair and Homologous Recombination Systems Commit Differentially to the Repair of DNA-Protein Crosslinks
inferredcites →https://doi.org/10.1016/j.mrrev.2004.11.003openalex-snapshot
DNA?protein crosslinks: their induction, repair, and biological consequences
inferredcites →https://doi.org/10.1016/j.yexcr.2004.08.004openalex-snapshot
Desmin: a major intermediate filament protein essential for the structural integrity and function of muscle
inferredcites →https://doi.org/10.1016/s0092-8674(00)80903-4openalex-snapshot
FACT, a Factor that Facilitates Transcript Elongation through Nucleosomes
inferredcites →https://doi.org/10.1016/s0092-8674(00)81402-6openalex-snapshot
Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor
inferredcites →https://doi.org/10.1016/s1097-2765(00)80272-5openalex-snapshot
FACT Relieves DSIF/NELF-Mediated Inhibition of Transcriptional Elongation and Reveals Functional Differences between P-TEFb and TFIIH
inferredcites →https://doi.org/10.1016/s1097-2765(01)00176-9openalex-snapshot
A DNA Damage–Induced p53 Serine 392 Kinase Complex Contains CK2, hSpt16, and SSRP1
inferredcites →https://doi.org/10.1016/s1383-5718(99)00189-8openalex-snapshot
Age-related increases of 8-hydroxy-2′-deoxyguanosine and DNA–protein crosslinks in mouse organs
inferredcites →https://doi.org/10.1021/ac00114a016openalex-snapshot
Mining Genomes: Correlating Tandem Mass Spectra of Modified and Unmodified Peptides to Sequences in Nucleotide Databases
inferredcites →https://doi.org/10.1021/acs.accounts.5b00056openalex-snapshot
DNA–Protein Cross-Links: Formation, Structural Identities, and Biological Outcomes
inferredcites →https://doi.org/10.1021/bi030243eopenalex-snapshot
Trifunctional Dinuclear Platinum Complexes as DNA−Protein Cross-Linking Agents
inferredcites →https://doi.org/10.1021/bi400273mopenalex-snapshot
DNA-Reactive Protein Monoepoxides Induce Cell Death and Mutagenesis in Mammalian Cells
inferredcites →https://doi.org/10.1021/bi970928copenalex-snapshot
The Human LON Protease Binds to Mitochondrial Promoters in a Single-Stranded, Site-Specific, Strand-Specific Manner
inferredcites →https://doi.org/10.1021/cb5001795openalex-snapshot
Synthesis of Site-Specific DNA–Protein Conjugates and Their Effects on DNA Replication
inferredcites →https://doi.org/10.1021/pr200042uopenalex-snapshot
Mechlorethamine-Induced DNA–Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells
inferredcites →https://doi.org/10.1021/pr3011974openalex-snapshot
1,2,3,4-Diepoxybutane-Induced DNA–Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells
inferredcites →https://doi.org/10.1021/tx049897uopenalex-snapshot
Activation of bis-Electrophiles to Mutagenic Conjugates by Human O6-Alkylguanine-DNA Alkyltransferase
inferredcites →https://doi.org/10.1021/tx7004508openalex-snapshot
Cross-Linking of the DNA Repair Protein O6-Alkylguanine DNA Alkyltransferase to DNA in the Presence of Antitumor Nitrogen Mustards
inferredcites →https://doi.org/10.1038/22350openalex-snapshot
The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins
inferredcites →https://doi.org/10.1038/ncomms6744openalex-snapshot
Spartan deficiency causes genomic instability and progeroid phenotypes
inferredcites →https://doi.org/10.1038/nrclinonc.2009.146openalex-snapshot
Cyclophosphamide and cancer: golden anniversary
inferredcites →https://doi.org/10.1046/j.1432-1327.2000.01606.xopenalex-snapshot
Investigation of the Alamar Blue (resazurin) fluorescent dye for the assessment of mammalian cell cytotoxicity
inferredcites →https://doi.org/10.1073/pnas.75.3.1106openalex-snapshot
Mammalian cytoplasmic actins are the products of at least two genes and differ in primary structure in at least 25 identified positions from skeletal muscle actins
inferredcites →https://doi.org/10.1074/jbc.m109.019174openalex-snapshot
Homologous Recombination but Not Nucleotide Excision Repair Plays a Pivotal Role in Tolerance of DNA-Protein Cross-links in Mammalian Cells
inferredcites →https://doi.org/10.1074/jbc.m111.287037openalex-snapshot
Chromodomain Helicase DNA-binding Protein 4 (CHD4) Regulates Homologous Recombination DNA Repair, and Its Deficiency Sensitizes Cells to Poly(ADP-ribose) Polymerase (PARP) Inhibitor Treatment
inferredcites →https://doi.org/10.1074/jbc.m112.419358openalex-snapshot
Translocation and Stability of Replicative DNA Helicases upon Encountering DNA-Protein Cross-links
inferredcites →https://doi.org/10.1074/jbc.m114.613638openalex-snapshot
Error-prone Translesion Synthesis Past DNA-Peptide Cross-links Conjugated to the Major Groove of DNA via C5 of Thymidine
inferredcites →https://doi.org/10.1074/jbc.m502477200openalex-snapshot
Identification of Mammalian Proteins Cross-linked to DNA by Ionizing Radiation
inferredcites →https://doi.org/10.1074/jbc.m702856200openalex-snapshot
Nucleotide Excision Repair Eliminates Unique DNA-Protein Cross-links from Mammalian Cells
inferredcites →https://doi.org/10.1083/jcb.105.3.1183openalex-snapshot
Amino acid sequence of the human fibronectin receptor.
inferredcites →https://doi.org/10.1093/carcin/12.2.269openalex-snapshot
Complexing of actin and other nuclear proteins to DNA by cis-diamminedichloroplatinum(II) and chromium compounds
inferredcites →https://doi.org/10.1093/carcin/15.4.713openalex-snapshot
Mutagenicity of butadiene and its epoxide metabolites: I. Mutagenic potential of 1,2-epoxybutene, 1,2,3,4-diepoxybutane and 3,4-epoxy-1,2-butanediol in cultured human lymphoblasts
inferredcites →https://doi.org/10.1093/carcin/21.5.573openalex-snapshot
Loss of DNA–protein crosslinks from formaldehyde-exposed cells occurs through spontaneous hydrolysis and an active repair process linked to proteosome function
inferredcites →https://doi.org/10.1093/nar/gkm032openalex-snapshot
Mechanism of the formation of DNA–protein cross-links by antitumor cisplatin
inferredcites →https://doi.org/10.1100/tsw.2002.863openalex-snapshot
High Dose Cyclophosphamide Treatment for Autoimmune Disorders
inferredcites →https://doi.org/10.1101/cshperspect.a012732openalex-snapshot
Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link Repair
inferredcites →https://doi.org/10.1101/gad.351205openalex-snapshot
NIR is a novel INHAT repressor that modulates the transcriptional activity of p53
inferredcites →https://doi.org/10.1111/j.1432-1033.1995.473zz.xopenalex-snapshot
A Nuclear Protein, Synthesized in Growth-Arrested Human Hepatoblastoma Cells, is a Novel Member of the Short-Chain Alcohol Dehydrogenase Family
inferredcites →https://doi.org/10.1111/micc.12111openalex-snapshot
Vimentin as an Integral Regulator of Cell Adhesion and Endothelial Sprouting
inferredcites →https://doi.org/10.1128/mcb.01290-07openalex-snapshot
p160 Myb-Binding Protein Interacts with Prep1 and Inhibits Its Transcriptional Activity
inferredcites →https://doi.org/10.1152/physrev.00018.2013openalex-snapshot
Actin Dynamics, Architecture, and Mechanics in Cell Motility
inferredcites →https://doi.org/10.1200/jco.1997.15.10.3258openalex-snapshot
High-dose cyclophosphamide for poor-prognosis and recurrent pediatric brain tumors: a dose-escalation study.
inferredcites →https://doi.org/10.1289/ehp.98106s4969openalex-snapshot
Utilization of DNA-Protein Cross-Links as a Biomarker of Chromium Exposure
inferredcites →https://doi.org/10.1371/journal.pone.0039723openalex-snapshot
Myb-Binding Protein 1A (MYBBP1A) Is Essential for Early Embryonic Development, Controls Cell Cycle and Mitosis, and Acts as a Tumor Suppressor
inferredcites →https://doi.org/10.4161/cc.5.13.2892openalex-snapshot
Repair of DNA–Protein Cross-links in Mammalian Cells

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Synthesis and Antitumor Effect of Sophoridine Derivatives Bearing an Acyclic Aryloxy Phosphoramidate Mustard Functionality
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A quantitative PCR-based assay reveals that nucleotide excision repair plays a predominant role in the removal of DNA-protein crosslinks from plasmids transfected into mammalian cells
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Cross-linking of the DNA repair protein O6-alkylguanine DNA alkyltransferase to DNA in the presence of cisplatin
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Radiation-induced DNA–protein cross-links: Mechanisms and biological significance
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Nitrogen mustard induces dynamic nuclear protein spectrum change and DNA-protein crosslinking, with p97 mediating repair
inferred← citeshttps://doi.org/10.1016/j.intimp.2024.113976openalex-snapshot
Acute exposure to nitrogen mustard induces rapid nuclear component regulation and delayed stress to exogenous stimuli
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Investigation of the immunomodulatory effects and molecular mechanisms of cichoric acid on cyclophosphamide-induced immunosuppression in mice
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Enzymatic bypass of an N6-deoxyadenosine DNA–ethylene dibromide–peptide cross-link by translesion DNA polymerases
inferred← citeshttps://doi.org/10.1016/j.preteyeres.2025.101413openalex-snapshot
Current progress in research on ocular injury caused by exposure to vesicants
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Cross-linking by epichlorohydrin and diepoxybutane correlates with cytotoxicity and leads to apoptosis in human leukemia (HL-60) cells
inferred← citeshttps://doi.org/10.1016/j.tibs.2017.03.005openalex-snapshot
DNA–Protein Crosslink Proteolysis Repair
inferred← citeshttps://doi.org/10.1016/j.toxlet.2017.12.014openalex-snapshot
Mass spectrometric analysis of sulfur mustard-induced biomolecular adducts: Are DNA adducts suitable biomarkers of exposure?
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Chromatographic analysis of chemical warfare agents and their metabolites in biological samples
inferred← citeshttps://doi.org/10.1021/acs.analchem.1c03356openalex-snapshot
DNA–Protein Cross-Links Formed by Reacting Lysine with Apurinic/Apyrimidinic Sites in DNA and Human Cells: Quantitative Analysis by Liquid Chromatography–Tandem Mass Spectrometry Coupled with Stable Isotope Dilution
inferred← citeshttps://doi.org/10.1021/acs.analchem.5c06852openalex-snapshot
Isotope Dilution NanoLC-MS/MS Quantitation of Methylglyoxal DNA–Protein Cross-Links: Formation and Repair in Human Cells
inferred← citeshttps://doi.org/10.1021/acs.analchem.7b04247openalex-snapshot
Chemical Analysis of DNA Damage
inferred← citeshttps://doi.org/10.1021/acs.bioconjchem.6b00342openalex-snapshot
Chloroacetamide-Linked Nucleotides and DNA for Cross-Linking with Peptides and Proteins
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.1c00111openalex-snapshot
Novel 4-Hydroxybenzyl Adducts in Human Hemoglobin: Structures and Mechanisms of Formation
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.4c00076openalex-snapshot
Quantification of Intracellular DNA–Protein Cross-Links with N7-Methyl-2′-Deoxyguanosine and Their Contribution to Cytotoxicity
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00389openalex-snapshot
Mass Spectrometry Based Proteomics Study of Cisplatin-Induced DNA–Protein Cross-Linking in Human Fibrosarcoma (HT1080) Cells
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6b00397openalex-snapshot
Mutagenicity of a Model DNA-Peptide Cross-Link in Human Cells: Roles of Translesion Synthesis DNA Polymerases
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.6c00196openalex-snapshot
Uncovering the DNA Adduct Interactome: Experimental Strategies to Identify Binding Proteins and Repair Pathways
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.8b00040openalex-snapshot
Accurate Measurement of Formaldehyde-Induced DNA–Protein Cross-Links by High-Resolution Orbitrap Mass Spectrometry
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.8b00417openalex-snapshot
Sulfur Mustard Analog Mechlorethamine (Bis(2-chloroethyl)methylamine) Modulates Cell Cycle Progression via the DNA Damage Response in Human Lung Epithelial A549 Cells
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.9b00057openalex-snapshot
Effect of Nucleosome Assembly on Alkylation by a Dynamic Electrophile
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c02476openalex-snapshot
DNA Adducts in Cancer Chemotherapy
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DNA–Protein Cross-Link Formation and Cellular Toxicity by Chimeric Bis-Electrophiles
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.0c00232openalex-snapshot
A Novel Model System for Understanding Anticancer Activity of Hypoxia-Activated Prodrugs
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inferred← citeshttps://doi.org/10.1021/acschembio.9b00365openalex-snapshot
Transcriptional Bypass of DNA–Protein and DNA–Peptide Conjugates by T7 RNA Polymerase
inferred← citeshttps://doi.org/10.1021/jacs.5c09293openalex-snapshot
Examination of a Chimeric Bis-Electrophile for Selective DNA–Protein Cross-Linking and Mechlorethamine Reveals an Unknown Source of Nitrogen Mustard Cytotoxicity
inferred← citeshttps://doi.org/10.1021/jacsau.2c00625openalex-snapshot
Chemical RNA Cross-Linking: Mechanisms, Computational Analysis, and Biological Applications
inferred← citeshttps://doi.org/10.1038/s41598-024-81799-9openalex-snapshot
SPRTN metalloprotease participates in repair of ROS-mediated DNA-protein crosslinks
inferred← citeshttps://doi.org/10.1039/c7nj00270jopenalex-snapshot
Synthesis, structural studies and stability of model cysteine containing DNA–protein cross-links
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Site-specific cross-linking of proteins to DNA via a new bioorthogonal approach employing oxime ligation
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Histone tails decrease N7-methyl-2′-deoxyguanosine depurination and yield DNA–protein cross-links in nucleosome core particles and cells
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Bypass of DNA-Protein Cross-links Conjugated to the 7-Deazaguanine Position of DNA by Translesion Synthesis Polymerases
inferred← citeshttps://doi.org/10.1080/00498254.2021.1975060openalex-snapshot
Intracellular activation of 4-hydroxycyclophosphamide into a DNA-alkylating agent in human leucocytes
inferred← citeshttps://doi.org/10.1093/nar/gkad1178openalex-snapshot
Isolation and detection of DNA–protein crosslinks in mammalian cells
inferred← citeshttps://doi.org/10.1093/nar/gkad860openalex-snapshot
Ubiquitin signaling and the proteasome drive human DNA–protein crosslink repair
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5-Formylcytosine mediated DNA–protein cross-links block DNA replication and induce mutations in human cells
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Cellular pathways in the repair and tolerance of formaldehyde-induced DNA damage
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