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Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities

https://doi.org/10.1021/acs.chemrestox.7b00157

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Outgoing claims: the papers this work cites, builds on, or argues with.

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Translesion synthesis: Y-family polymerases and the polymerase switch

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Polk mutant mice have a spontaneous mutator phenotype

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PCNA ubiquitination-independent activation of polymerase η during somatic hypermutation and DNA damage tolerance

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Pol kappa partially rescues MMR-dependent cytotoxicity of O6-methylguanine

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DNA Synthesis across an Abasic Lesion by Yeast Rev1 DNA Polymerase

inferredcites →https://doi.org/10.1016/j.jmb.2013.05.029openalex-snapshot

NMR Mapping of PCNA Interaction with Translesion Synthesis DNA Polymerase Rev1 Mediated by Rev1-BRCT Domain

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Human DNA Polymerase η Promotes DNA Synthesis from Strand Invasion Intermediates of Homologous Recombination

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PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40

inferredcites →https://doi.org/10.1016/j.molcel.2009.01.024openalex-snapshot

Single-Stranded DNA Orchestrates an ATM-to-ATR Switch at DNA Breaks

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Regulation of Translesion Synthesis DNA Polymerase η by Monoubiquitination

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Epigenetic Instability due to Defective Replication of Structured DNA

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SHPRH and HLTF Act in a Damage-Specific Manner to Coordinate Different Forms of Postreplication Repair and Prevent Mutagenesis

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Expression of an X-family DNA polymerase, pol lambda, in the respiratory epithelium of non-small cell lung cancer patients with habitual smoking

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Human Translesion Polymerase κ Exhibits Enhanced Activity and Reduced Fidelity Two Nucleotides from G-Quadruplex DNA

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Leukotriene Biosynthesis Inhibitor MK886 Impedes DNA Polymerase Activity

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Instability and decay of the primary structure of DNA

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Two‐polymerase mechanisms dictate error‐free and error‐prone translesion DNA synthesis in mammals

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Replication by human DNA polymerase-ι occurs by Hoogsteen base-pairing

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Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor

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Regulation of monoubiquitinated PCNA by DUB autocleavage

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Causes and consequences of replication stress

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A selective USP1–UAF1 inhibitor links deubiquitination to DNA damage responses

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A Polymerase Theta-dependent repair pathway suppresses extensive genomic instability at endogenous G4 DNA sites

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Balancing repair and tolerance of DNA damage caused by alkylating agents

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Replication stress and cancer

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Mechanisms of DNA replication termination

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Regulation of DNA repair by ubiquitylation

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ATR: an essential regulator of genome integrity

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Y-family DNA polymerases and their role in tolerance of cellular DNA damage

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A ‘DNA replication’ signature of progression and negative outcome in colorectal cancer

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Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas

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DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients

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Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase κ in colorectal cancer

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Expression of human and mouse genes encoding polκ: testis‐specific developmental regulation and AhR‐dependent inducible transcription

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Accuracy of thymine-thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase eta

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DNA polymerase θ contributes to the generation of C/G mutations during somatic hypermutation of Ig genes

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What a difference a decade makes: Insights into translesion DNA synthesis

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Reconstitution of a human ATR-mediated checkpoint response to damaged DNA

inferredcites →https://doi.org/10.1073/pnas.0805685105openalex-snapshot

Polyubiquitination of proliferating cell nuclear antigen by HLTF and SHPRH prevents genomic instability from stalled replication forks

inferredcites →https://doi.org/10.1073/pnas.0910759107openalex-snapshot

DNA polymerase θ up-regulation is associated with poor survival in breast cancer, perturbs DNA replication, and promotes genetic instability

inferredcites →https://doi.org/10.1073/pnas.1011412107openalex-snapshot

Error-prone translesion synthesis mediates acquired chemoresistance

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Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin

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Enhancing tumor cell response to chemotherapy through nanoparticle-mediated codelivery of siRNA and cisplatin prodrug

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Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells

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Mechanism of nucleotide incorporation opposite a thymine-thymine dimer by yeast DNA polymerase η

inferredcites →https://doi.org/10.1073/pnas.222377899openalex-snapshot

Polκ protects mammalian cells against the lethal and mutagenic effects of benzo[ a ]pyrene

inferredcites →https://doi.org/10.1073/pnas.72.1.219openalex-snapshot

Xeroderma pigmentosum cells with normal levels of excision repair have a defect in DNA synthesis after UV-irradiation.

inferredcites →https://doi.org/10.1073/pnas.97.7.3094openalex-snapshot

Accuracy of thymine–thymine dimer bypass by Saccharomyces cerevisiae DNA polymerase η

inferredcites →https://doi.org/10.1074/jbc.275.11.7447openalex-snapshot

Fidelity of Human DNA Polymerase η

inferredcites →https://doi.org/10.1074/jbc.m111.324947openalex-snapshot

Human POLB Gene Is Mutated in High Percentage of Colorectal Tumors

inferredcites →https://doi.org/10.1074/jbc.m112.351122openalex-snapshot

DNA Polymerase δ and ζ Switch by Sharing Accessory Subunits of DNA Polymerase δ

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Structural Basis of Rev1-mediated Assembly of a Quaternary Vertebrate Translesion Polymerase Complex Consisting of Rev1, Heterodimeric Polymerase (Pol) ζ, and Pol κ

inferredcites →https://doi.org/10.1074/jbc.m112.396838openalex-snapshot

Structural Basis of Recruitment of DNA Polymerase ζ by Interaction between REV1 and REV7 Proteins

inferredcites →https://doi.org/10.1074/jbc.m112.407825openalex-snapshot

In Vitro Analysis of the Role of Replication Protein A (RPA) and RPA Phosphorylation in ATR-mediated Checkpoint Signaling

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The Interaction between Checkpoint Kinase 1 (Chk1) and the Minichromosome Maintenance (MCM) Complex Is Required for DNA Damage-induced Chk1 Phosphorylation

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The Proliferating Cell Nuclear Antigen (PCNA)-interacting Protein (PIP) Motif of DNA Polymerase η Mediates Its Interaction with the C-terminal Domain of Rev1

inferredcites →https://doi.org/10.1074/jbc.m211838200openalex-snapshot

Role of DNA Polymerase η in the UV Mutation Spectrum in Human Cells

inferredcites →https://doi.org/10.1074/jbc.m409155200openalex-snapshot

Quantitative Analysis of Translesion DNA Synthesis across a Benzo[a]pyrene-Guanine Adduct in Mammalian Cells

inferredcites →https://doi.org/10.1074/jbc.m501562200openalex-snapshot

DNA Polymerase κ Is Specifically Required for Recovery from the Benzo[a]pyrene-Dihydrodiol Epoxide (BPDE)-induced S-phase Checkpoint

inferredcites →https://doi.org/10.1074/jbc.r400006200openalex-snapshot

DNA Replication Fidelity

inferredcites →https://doi.org/10.1080/23723556.2015.1012976openalex-snapshot

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy

inferredcites →https://doi.org/10.1080/23723556.2015.1043482openalex-snapshot

Targeting translesion synthesis to facilitate the eradication of ovarian cancer stem cells by platinum-based therapy

inferredcites →https://doi.org/10.1083/jcb.201207066openalex-snapshot

DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis

inferredcites →https://doi.org/10.1084/jem.20032022openalex-snapshot

Absence of DNA Polymerase η Reveals Targeting of C Mutations on the Nontranscribed Strand in Immunoglobulin Switch Regions

inferredcites →https://doi.org/10.1093/ajhp/33.4.373aopenalex-snapshot

The Pharmacological Basis of Therapeutics

inferredcites →https://doi.org/10.1093/emboj/18.12.3491openalex-snapshot

Xeroderma pigmentosum variant (XP‐V) correcting protein from HeLa cells has a thymine dimer bypass DNA polymerase activity

inferredcites →https://doi.org/10.1093/emboj/19.12.3100openalex-snapshot

Mechanisms of accurate translesion synthesis by human DNA polymerase η

inferredcites →https://doi.org/10.1093/emboj/cdg308openalex-snapshot

Multiple roles of Rev3, the catalytic subunit of polζ in maintaining genome stability in vertebrates

inferredcites →https://doi.org/10.1093/genetics/147.3.1017openalex-snapshot

A Role for REV3 in Mutagenesis During Double-Strand Break Repair in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1093/genetics/68.1.21openalex-snapshot

MUTANTS OF YEAST DEFECTIVE IN MUTATION INDUCED BY ULTRAVIOLET LIGHT

inferredcites →https://doi.org/10.1093/nar/gkl380openalex-snapshot

The DNA polymerase is required for the repair of non-compatible DNA double strand breaks by NHEJ in mammalian cells

inferredcites →https://doi.org/10.1093/nar/gkn651openalex-snapshot

REV1 restrains DNA polymerase ζ to ensure frame fidelity during translesion synthesis of UV photoproducts in vivo

inferredcites →https://doi.org/10.1093/nar/gkp641openalex-snapshot

A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases

inferredcites →https://doi.org/10.1093/nar/gkq403openalex-snapshot

Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts

inferredcites →https://doi.org/10.1093/nar/gkr769openalex-snapshot

REV1 and polymerase ζ facilitate homologous recombination repair

inferredcites →https://doi.org/10.1093/nar/gkr868openalex-snapshot

FANCJ coordinates two pathways that maintain epigenetic stability at G-quadruplex DNA

inferredcites →https://doi.org/10.1093/nar/gkr889openalex-snapshot

Beyond translesion synthesis: polymerase κ fidelity as a potential determinant of microsatellite stability

inferredcites →https://doi.org/10.1093/nar/gkt1314openalex-snapshot

Human Rev1 polymerase disrupts G-quadruplex DNA

inferredcites →https://doi.org/10.1093/nar/gku1301openalex-snapshot

Roles of PCNA ubiquitination and TLS polymerases κ and η in the bypass of methyl methanesulfonate-induced DNA damage

inferredcites →https://doi.org/10.1093/neuonc/nop074openalex-snapshot

Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance

inferredcites →https://doi.org/10.1093/neuonc/nor011openalex-snapshot

N-methylpurine DNA glycosylase and DNA polymerase β modulate BER inhibitor potentiation of glioma cells to temozolomide

inferredcites →https://doi.org/10.1096/fasebj.13.9.1107openalex-snapshot

Overexpression of DNA polymerase β: a genomic instability enhancer process

inferredcites →https://doi.org/10.1096/fj.99-1063comopenalex-snapshot

Nucleotide excision repair DNA synthesis by excess DNA polymerase β: a potential source of genetic instability in cancer cells

inferredcites →https://doi.org/10.1101/gad.1666208openalex-snapshot

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

inferredcites →https://doi.org/10.1101/gad.882301openalex-snapshot

Roles of yeast DNA polymerases δ and ζ and of Rev1 in the bypass of abasic sites

inferredcites →https://doi.org/10.1101/sqb.2000.65.143openalex-snapshot

DNA Polymerase and Mammalian Base Excision Repair

inferredcites →https://doi.org/10.1111/j.1356-9597.2004.00747.xopenalex-snapshot

Interaction of hREV1 with three human Y‐family DNA polymerases

inferredcites →https://doi.org/10.1124/mol.104.010579openalex-snapshot

Suppression of hREV1 Expression Reduces the Rate at Which Human Ovarian Carcinoma Cells Acquire Resistance to Cisplatin

inferredcites →https://doi.org/10.1124/mol.105.020446openalex-snapshot

Human REV1 Modulates the Cytotoxicity and Mutagenicity of Cisplatin in Human Ovarian Carcinoma Cells

inferredcites →https://doi.org/10.1126/science.1083430openalex-snapshot

Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

inferredcites →https://doi.org/10.1126/science.1120615openalex-snapshot

Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis

inferredcites →https://doi.org/10.1126/science.272.5268.1646openalex-snapshot

Thymine-Thymine Dimer Bypass by Yeast DNA Polymerase ζ

inferredcites →https://doi.org/10.1128/mcb.00071-09openalex-snapshot

Separate Domains of Rev1 Mediate Two Modes of DNA Damage Bypass in Mammalian Cells

inferredcites →https://doi.org/10.1128/mcb.00115-09openalex-snapshot

Human DNA Polymerase η Is Required for Common Fragile Site Stability during Unperturbed DNA Replication

inferredcites →https://doi.org/10.1128/mcb.00237-17openalex-snapshot

DNA Polymerase Beta Participates in Mitochondrial DNA Repair

inferredcites →https://doi.org/10.1128/mcb.00993-09openalex-snapshot

Differential Roles for DNA Polymerases Eta, Zeta, and REV1 in Lesion Bypass of Intrastrand versus Interstrand DNA Cross-Links

inferredcites →https://doi.org/10.1128/mcb.01478-07openalex-snapshot

Complex Formation of Yeast Rev1 with DNA Polymerase η

inferredcites →https://doi.org/10.1128/mcb.24.10.4267-4274.2004openalex-snapshot

Opposing Effects of Ubiquitin Conjugation and SUMO Modification of PCNA on Replicational Bypass of DNA Lesions in Saccharomyces cerevisiae

inferredcites →https://doi.org/10.1158/0008-5472.325.65.1openalex-snapshot

Up-Regulation of the Error-Prone DNA Polymerase κ Promotes Pleiotropic Genetic Alterations and Tumorigenesis

inferredcites →https://doi.org/10.1158/0008-5472.can-03-3942openalex-snapshot

DNA Polymerase ζ Regulates Cisplatin Cytotoxicity, Mutagenicity, and The Rate of Development of Cisplatin Resistance

inferredcites →https://doi.org/10.1158/0008-5472.can-04-0603openalex-snapshot

Altered DNA Polymerase ι Expression in Breast Cancer Cells Leads to a Reduction in DNA Replication Fidelity and a Higher Rate of Mutagenesis

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PrimPol—Prime Time to Reprime

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Replication stress activates DNA polymerase alpha-associated Chk1

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