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N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.bmcl.2009.11.082openalex-snapshot
Novel substituted (Z)-5-((N-benzyl-1H-indol-3-yl)methylene)imidazolidine-2,4-diones and 5-((N-benzyl-1H-indol-3-yl)methylene)pyrimidine-2,4,6(1H,3H,5H)-triones as potent radio-sensitizing agents
inferredcites →https://doi.org/10.1016/j.bmcl.2012.12.053openalex-snapshot
5-((1-Aroyl-1H-indol-3-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-diones as potential anticancer agents with anti-inflammatory properties
inferredcites →https://doi.org/10.1016/j.canlet.2011.09.019openalex-snapshot
Both XPA and DNA polymerase eta are necessary for the repair of doxorubicin-induced DNA lesions
inferredcites →https://doi.org/10.1016/j.cell.2011.02.013openalex-snapshot
Hallmarks of Cancer: The Next Generation
inferredcites →https://doi.org/10.1016/j.cell.2011.03.044openalex-snapshot
Nucleotide Deficiency Promotes Genomic Instability in Early Stages of Cancer Development
inferredcites →https://doi.org/10.1016/j.dnarep.2005.01.005openalex-snapshot
The overexpression of specialized DNA polymerases in cancer
inferredcites →https://doi.org/10.1016/j.dnarep.2010.07.006openalex-snapshot
The Werner's Syndrome protein collaborates with REV1 to promote replication fork progression on damaged DNA
inferredcites →https://doi.org/10.1016/j.molcel.2008.03.024openalex-snapshot
PCNA Ubiquitination and REV1 Define Temporally Distinct Mechanisms for Controlling Translesion Synthesis in the Avian Cell Line DT40
inferredcites →https://doi.org/10.1016/j.molcel.2009.05.022openalex-snapshot
Highly Transcribed RNA Polymerase II Genes Are Impediments to Replication Fork Progression in Saccharomyces cerevisiae
inferredcites →https://doi.org/10.1021/cb100382mopenalex-snapshot
Small Molecule Inhibitors of Human DNA Polymerase λ
inferredcites →https://doi.org/10.1021/tx300392mopenalex-snapshot
Leukotriene Biosynthesis Inhibitor MK886 Impedes DNA Polymerase Activity
inferredcites →https://doi.org/10.1038/emboj.2010.205openalex-snapshot
ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery
inferredcites →https://doi.org/10.1038/emboj.2011.457openalex-snapshot
Dysregulation of DNA polymerase κ recruitment to replication forks results in genomic instability
inferredcites →https://doi.org/10.1038/nature10760openalex-snapshot
The DNA damage response and cancer therapy
inferredcites →https://doi.org/10.1038/nchembio.139openalex-snapshot
DNA damage tolerance: when it's OK to make mistakes
inferredcites →https://doi.org/10.1038/nrm2450openalex-snapshot
ATR: an essential regulator of genome integrity
inferredcites →https://doi.org/10.1038/onc.2010.249openalex-snapshot
Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas
inferredcites →https://doi.org/10.1038/sj.onc.1210116openalex-snapshot
Characterization of promoter regulatory elements involved in downexpression of the DNA polymerase κ in colorectal cancer
inferredcites →https://doi.org/10.1073/pnas.0704219104openalex-snapshot
What a difference a decade makes: Insights into translesion DNA synthesis
inferredcites →https://doi.org/10.1073/pnas.0808589105openalex-snapshot
Human DNA polymerase η activity and translocation is regulated by phosphorylation
inferredcites →https://doi.org/10.1073/pnas.1202681109openalex-snapshot
Structural basis of human DNA polymerase η-mediated chemoresistance to cisplatin
inferredcites →https://doi.org/10.1074/jbc.m111.258038openalex-snapshot
Roles of the Four DNA Polymerases of the Crenarchaeon Sulfolobus solfataricus and Accessory Proteins in DNA Replication
inferredcites →https://doi.org/10.1074/jbc.m504756200openalex-snapshot
DNA Adduct Bypass Polymerization by Sulfolobus solfataricus DNA Polymerase Dpo4
inferredcites →https://doi.org/10.1083/jcb.201008076openalex-snapshot
ATR-mediated phosphorylation of DNA polymerase η is needed for efficient recovery from UV damage
inferredcites →https://doi.org/10.1093/nar/gkp641openalex-snapshot
A real-time fluorescence method for enzymatic characterization of specialized human DNA polymerases
inferredcites →https://doi.org/10.1093/neuonc/nop074openalex-snapshot
Analysis of specialized DNA polymerases expression in human gliomas: association with prognostic significance
inferredcites →https://doi.org/10.1101/gad.1392506openalex-snapshot
Cycles of chromosome instability are associated with a fragile site and are increased by defects in DNA replication and checkpoint controls in yeast
inferredcites →https://doi.org/10.1101/sqb.2009.74.027openalex-snapshot
Evolving Views of DNA Replication (In)Fidelity
inferredcites →https://doi.org/10.1126/science.1070236openalex-snapshot
Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations
inferredcites →https://doi.org/10.1126/science.1071398openalex-snapshot
ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones
inferredcites →https://doi.org/10.1126/science.1120615openalex-snapshot
Ubiquitin-Binding Domains in Y-Family Polymerases Regulate Translesion Synthesis
inferredcites →https://doi.org/10.1128/mcb.26.9.3527-3540.2006openalex-snapshot
Rad18 Regulates DNA Polymerase κ and Is Required for Recovery from S-Phase Checkpoint-Mediated Arrest
inferredcites →https://doi.org/10.1146/annurev.biochem.71.083101.124707openalex-snapshot
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
inferredcites →https://doi.org/10.1146/annurev.biochem.74.082803.133250openalex-snapshot
EUKARYOTIC TRANSLESION SYNTHESIS DNA POLYMERASES: Specificity of Structure and Function
inferredcites →https://doi.org/10.1158/0008-5472.325.65.1openalex-snapshot
Up-Regulation of the Error-Prone DNA Polymerase κ Promotes Pleiotropic Genetic Alterations and Tumorigenesis
inferredcites →https://doi.org/10.1158/0008-5472.can-04-0603openalex-snapshot
Altered DNA Polymerase ι Expression in Breast Cancer Cells Leads to a Reduction in DNA Replication Fidelity and a Higher Rate of Mutagenesis
inferredcites →https://doi.org/10.1158/0008-5472.can-05-1095openalex-snapshot
A Role for Polymerase η in the Cellular Tolerance to Cisplatin-Induced Damage
inferredcites →https://doi.org/10.1158/1078-0432.ccr-08-1227openalex-snapshot
Polymerase η mRNA Expression Predicts Survival of Non–Small Cell Lung Cancer Patients Treated with Platinum-Based Chemotherapy
inferredcites →https://doi.org/10.1158/1535-7163.mct-12-0448openalex-snapshot
Deficient DNA Damage Signaling Leads to Chemoresistance to Cisplatin in Oral Cancer
inferredcites →https://doi.org/10.1215/15228517-2008-090openalex-snapshot
Induction of MGMT expression is associated with temozolomide resistance in glioblastoma xenografts
inferredcites →https://doi.org/10.1371/journal.pone.0045032openalex-snapshot
A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ
inferredcites →https://doi.org/10.3389/fgene.2012.00174openalex-snapshot
Translesion DNA Polymerases and Cancer
inferredcites →https://doi.org/10.3892/ijo.25.1.161openalex-snapshot
Elevated expression of DNA polymerase κ in human lung cancer is associated with p53 inactivation: Negative regulation of POLK promoter activity by p53
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/j.ab.2015.03.002openalex-snapshot
Quantification of pyrophosphate as a universal approach to determine polymerase activity and assay polymerase inhibitors
inferred← citeshttps://doi.org/10.1016/j.bmcl.2013.12.013openalex-snapshot
Synthesis and anti-proliferative activity of aromatic substituted 5-((1-benzyl-1H-indol-3-yl)methylene)-1,3-dimethylpyrimidine-2,4,6(1H,3H,5H)-trione analogs against human tumor cell lines
inferred← citeshttps://doi.org/10.1016/j.bmcl.2018.12.026openalex-snapshot
N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3
inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.115044openalex-snapshot
Computer-aided identification, synthesis, and biological evaluation of DNA polymerase η inhibitors for the treatment of cancer
inferred← citeshttps://doi.org/10.1016/j.mrrev.2022.108436openalex-snapshot
Current state of knowledge of human DNA polymerase eta protein structure and disease-causing mutations
inferred← citeshttps://doi.org/10.1021/acs.biochem.7b01176openalex-snapshot
A Small-Molecule Inhibitor of Human DNA Polymerase η Potentiates the Effects of Cisplatin in Tumor Cells
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.1c00334openalex-snapshot
Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M1dG, the Genomic Metabolite of M1dG, and Liquid Chromatography–Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ι
inferred← citeshttps://doi.org/10.1021/acs.chemrestox.7b00157openalex-snapshot
Translesion DNA Synthesis in Cancer: Molecular Mechanisms and Therapeutic Opportunities
inferred← citeshttps://doi.org/10.1021/acschembio.7b00919openalex-snapshot
Fluorescent Probes of DNA Repair
inferred← citeshttps://doi.org/10.1021/acschembio.9b00304openalex-snapshot
Inhibition of Human DNA Polymerases Eta and Kappa by Indole-Derived Molecules Occurs through Distinct Mechanisms
inferred← citeshttps://doi.org/10.1021/cb4007562openalex-snapshot
Expanding the Scope of Human DNA Polymerase λ and β Inhibitors
inferred← citeshttps://doi.org/10.1021/ja512547gopenalex-snapshot
Nucleotides with Altered Hydrogen Bonding Capacities Impede Human DNA Polymerase η by Reducing Synthesis in the Presence of the Major Cisplatin DNA Adduct
inferred← citeshttps://doi.org/10.1038/s41568-022-00518-6openalex-snapshot
Leveraging the replication stress response to optimize cancer therapy
inferred← citeshttps://doi.org/10.1039/c4md00478gopenalex-snapshot
Synthesis and evaluation of a series of resveratrol analogues as potent anti-cancer agents that target tubulin
inferred← citeshttps://doi.org/10.1039/d3cb00027copenalex-snapshot
Conservation of the insert-2 motif confers Rev1 from different species with an ability to disrupt G-quadruplexes and stimulate translesion DNA synthesis
inferred← citeshttps://doi.org/10.1080/10409238.2019.1651817openalex-snapshot
Post-replication repair: Rad5/HLTF regulation, activity on undamaged templates, and relationship to cancer
inferred← citeshttps://doi.org/10.1080/13543784.2021.1850692openalex-snapshot
Translesion synthesis inhibitors as a new class of cancer chemotherapeutics
inferred← citeshttps://doi.org/10.1111/bph.70037openalex-snapshot
Inhibition of DNA polymerase eta‐mediated translesion DNA synthesis with small molecule sensitises ovarian cancer stem‐like cells to chemotherapy
inferred← citeshttps://doi.org/10.1134/s0006297920080039openalex-snapshot
Translesion DNA Synthesis and Reinitiation of DNA Synthesis in Chemotherapy Resistance
inferred← citeshttps://doi.org/10.21203/rs.3.rs-3118868/v1openalex-snapshot
Inhibition of DNA polymerase eta-mediated translesion DNA synthesis by small molecule sensitizes ovarian cancer stem-like cells to chemotherapy
inferred← citeshttps://doi.org/10.2217/fon-2019-0458openalex-snapshot
Molecular avenues in targeted doxorubicin cancer therapy
inferred← citeshttps://doi.org/10.3389/fonc.2021.778925openalex-snapshot
Early Drug Discovery and Development of Novel Cancer Therapeutics Targeting DNA Polymerase Eta (POLH)
inferred← citeshttps://doi.org/10.3389/fonc.2021.822500openalex-snapshot
DNA Damage Tolerance Pathways in Human Cells: A Potential Therapeutic Target
inferred← citeshttps://doi.org/10.3390/ijms242316637openalex-snapshot
A New Drug Discovery Platform: Application to DNA Polymerase Eta and Apurinic/Apyrimidinic Endonuclease 1
inferred← citeshttps://doi.org/10.3390/molecules25245847openalex-snapshot
A Facile Semisynthesis and Evaluation of Garcinoic Acid and Its Analogs for the Inhibition of Human DNA Polymerase β
inferred← citeshttps://doi.org/10.34917/7777291openalex-snapshot
Paenibacillus larvae spore germination and American Foulbrood disease development in honey bee larvae
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