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Depressing Antidepressant: Fluoxetine Affects Serotonin Neurons Causing Adverse Reproductive Responses in Daphnia magna
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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NTP‐CERHR Expert Panel Report on the reproductive and developmental toxicity of fluoxetine
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Ion transport peptide splice forms in central and peripheral neurons throughout postembryogenesis of Drosophila melanogaster
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Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed
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Olfactory Centers in the Brain of Freshwater Crayfish
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Distribution of monoaminergic neurons in the nervous system of non-malacostracan crustaceans
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Serotonin and aggression: insights gained from a lobster model system and speculations on the role of amine neurons in a complex behavior
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Crustacean hyperglycaemic hormone in the nervous system of the primitive crustacean species Daphnia magna and Artemia salina (Crustacea: Branchiopoda)
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Determination of biogenic amines in the water flea, Daphnia magna (Cladocera, Crustacea) and their diurnal variations using ion-pair reversed phase hplc with electrochemical detection
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The role of biogenic amines in the control of blood glucose level in the decapod crustacean, Carcinus maenas L.
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Ecotoxicology of human pharmaceuticals
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Enhanced offspring production in Daphnia magna clones exposed to serotonin reuptake inhibitors and 4-nonylphenol. Stage- and food-dependent effects
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The biological effects of antidepressants on the molluscs and crustaceans: A review
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Fish on Prozac (and Zoloft): Ten years later
inferredcites →https://doi.org/10.1016/j.asd.2014.11.003openalex-snapshot
Conserved patterns of axogenesis in the panarthropod brain
inferredcites →https://doi.org/10.1016/j.cbd.2011.10.005openalex-snapshot
Genomic analyses of aminergic signaling systems (dopamine, octopamine and serotonin) in Daphnia pulex
inferredcites →https://doi.org/10.1016/j.chroma.2008.01.063openalex-snapshot
Occurrence of selective serotonin reuptake inhibitors in sewage and receiving waters at Spitsbergen and in Norway
inferredcites →https://doi.org/10.1016/j.cmet.2006.11.004openalex-snapshot
Serotonin targets the DAF-16/FOXO signaling pathway to modulate stress responses
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Exposures to a selective serotonin reuptake inhibitor (SSRI), sertraline hydrochloride, over multiple generations: Changes in life history traits in Ceriodaphnia dubia
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Low-dose paroxetine exposure causes lifetime declines in male mouse body weight, reproduction and competitive ability as measured by the novel organismal performance assay
inferredcites →https://doi.org/10.1016/j.ygcen.2011.11.035openalex-snapshot
The CHH-superfamily of multifunctional peptide hormones controlling crustacean metabolism, osmoregulation, moulting, and reproduction
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Determining the ecotoxicological mode of action of chemicals from measurements made on individuals: results from instar-based tests with Daphnia magna Straus
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Big houses, big cars, superfleas and the costs of reproduction
inferredcites →https://doi.org/10.1016/s0378-4274(03)00066-3openalex-snapshot
Aquatic ecotoxicology of fluoxetine
inferredcites →https://doi.org/10.1021/es202248hopenalex-snapshot
Zebrafish Eleutheroembryos Provide a Suitable Vertebrate Model for Screening Chemicals that Impair Thyroid Hormone Synthesis
inferredcites →https://doi.org/10.1021/es203157fopenalex-snapshot
Mechanisms of Action of Selective Serotonin Reuptake Inhibitors in Daphnia magna
inferredcites →https://doi.org/10.1021/es4012299openalex-snapshot
Identification of Metabolic Pathways in Daphnia magna Explaining Hormetic Effects of Selective Serotonin Reuptake Inhibitors and 4-Nonylphenol Using Transcriptomic and Phenotypic Responses
inferredcites →https://doi.org/10.1021/es9012454openalex-snapshot
Simple, Rapid Zebrafish Larva Bioassay for Assessing the Potential of Chemical Pollutants and Drugs to Disrupt Thyroid Gland Function
inferredcites →https://doi.org/10.1021/jm00054a006openalex-snapshot
Further insights into the molecular mechanisms of action of the serotonergic neurotoxin 5,7-dihydroxytryptamine
inferredcites →https://doi.org/10.1023/a:1018484824003openalex-snapshot
Offspring size and parental fitness in Daphnia magna
inferredcites →https://doi.org/10.1023/b:ectx.0000037188.09072.deopenalex-snapshot
Experimental Designs to Assess Endocrine Disrupting Effects in Invertebrates A Review
inferredcites →https://doi.org/10.1038/35007534openalex-snapshot
Central nervous system control of food intake
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Phenotypic plasticity and constancy of life‐history traits in laboratory clones of Daphnia magna Straus: effects of neonatal length
inferredcites →https://doi.org/10.1080/10937404.2011.578559openalex-snapshot
Pharmaceuticals as Neuroendocrine Disruptors: Lessons Learned from Fish on Prozac
inferredcites →https://doi.org/10.1126/science.1197761openalex-snapshot
The Ecoresponsive Genome of Daphnia pulex
inferredcites →https://doi.org/10.1126/science.1248811openalex-snapshot
Anxiety-like behavior in crayfish is controlled by serotonin
inferredcites →https://doi.org/10.1201/9781420058376openalex-snapshot
Insect Physiology and Biochemistry
inferredcites →https://doi.org/10.1590/s0100-879x2001000100009openalex-snapshot
Effects of serotonin and fluoxetine on blood glucose regulation in two decapod species
inferredcites →https://doi.org/10.1897/06-219r.1openalex-snapshot
Mixture and single-substance toxicity of selective serotonin reuptake inhibitors toward algae and crustaceans
inferredcites →https://doi.org/10.2147/ndt.s12531openalex-snapshot
Comparative efficacy of escitalopram in the treatment of major depressive disorder
inferredcites →https://doi.org/10.4081/jlimnol.2011.222openalex-snapshot
Anticipatory maternal effects in two different clones of Daphnia magna in response to food shortage
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Ecotoxicological Assessment of the Effects of Fluoxetine on Daphnia Magna Based on Acute Toxicity, Multigenerational Reproduction Effects, and Attraction Repellence Responses
inferred← citeshttps://doi.org/10.1002/bcp.70046openalex-snapshot
Assessing the environmental impact of medicines in Italy using data from the Italian Medicines Agency
inferred← citeshttps://doi.org/10.1002/etc.5600openalex-snapshot
Genes-to-Pathways Species Conservation Analysis: Enabling the Exploration of Conservation of Biological Pathways and Processes Across Species
inferred← citeshttps://doi.org/10.1002/etc.5646openalex-snapshot
Enantioselectivity in the Ecotoxicity of Amphetamine Using Daphnia magna as the Aquatic Model Organism: Morphophysiological, Behavioral, Reproductive and Biochemical Parameters
inferred← citeshttps://doi.org/10.1007/s00216-019-01968-yopenalex-snapshot
Characterization of neurotransmitter profiles in Daphnia magna juveniles exposed to environmental concentrations of antidepressants and anxiolytic and antihypertensive drugs using liquid chromatography–tandem mass spectrometry
inferred← citeshttps://doi.org/10.1007/s10646-017-1803-6openalex-snapshot
Assessing the environmental hazard of individual and combined pharmaceuticals: acute and chronic toxicity of fluoxetine and propranolol in the crustacean Daphnia magna
inferred← citeshttps://doi.org/10.1007/s11356-021-14693-wopenalex-snapshot
Environmental risk assessments of multiclass pharmaceutical active compounds: selection of high priority concern pharmaceuticals using entropy-utility functions
inferred← citeshttps://doi.org/10.1007/s11356-023-26169-0openalex-snapshot
Freshwater crustacean exposed to active pharmaceutical ingredients: ecotoxicological effects and mechanisms
inferred← citeshttps://doi.org/10.1007/s11356-024-32846-5openalex-snapshot
Binary effects of fluoxetine and zinc on the biomarker responses of the non-target model organism Daphnia magna
inferred← citeshttps://doi.org/10.1016/b978-0-443-13417-3.00012-3openalex-snapshot
Pharmaceutical sciences and sustainability
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Functional Data Analysis: Omics for Environmental Risk Assessment
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Determining lower threshold concentrations for synergistic effects
inferred← citeshttps://doi.org/10.1016/j.aquatox.2017.12.017openalex-snapshot
Novel approach for evaluating pharmaceuticals toxicity using Daphnia model: analysis of the mode of cytochrome P450-generated metabolite action after acetaminophen exposure
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Effects of environmental antidepressants on colour change and locomotor behaviour in juvenile shore crabs, Carcinus maenas
inferred← citeshttps://doi.org/10.1016/j.aquatox.2021.105877openalex-snapshot
Neurochemical exposure disrupts sex-specific trade-offs between body length and behaviour in a freshwater crustacean
inferred← citeshttps://doi.org/10.1016/j.aquatox.2024.106924openalex-snapshot
Ecotoxicological effects of ketoprofen and fluoxetine and their mixture in an aquatic microcosm
inferred← citeshttps://doi.org/10.1016/j.aquatox.2024.107082openalex-snapshot
Effects of long-term fluoxetine exposure on morphology, but not behaviour or metabolic rate, in male guppies (Poecilia reticulata)
inferred← citeshttps://doi.org/10.1016/j.aquatox.2024.107134openalex-snapshot
Developmental, behavioral, and biochemical effects of chronic exposure to sublethal concentrations of organic UV-filter compounds on a freshwater model species
inferred← citeshttps://doi.org/10.1016/j.aquatox.2024.107161openalex-snapshot
Maternal Daphnia magna exposure to the antidepressant sertraline causes molting disorder, multi-generational reproductive and serotonergic dysfunction
inferred← citeshttps://doi.org/10.1016/j.aquatox.2025.107664openalex-snapshot
The effects of fluoxetine and metformin pollution on phenotypic traits and gene expression in Daphnia magna
inferred← citeshttps://doi.org/10.1016/j.biortech.2020.123436openalex-snapshot
Fate of typical endocrine active compounds in full-scale wastewater treatment plants: Distribution, removal efficiency and potential risks
inferred← citeshttps://doi.org/10.1016/j.cbd.2022.100983openalex-snapshot
Genome-wide identification of 194 G protein-coupled receptor (GPCR) genes from the water flea Daphnia magna
inferred← citeshttps://doi.org/10.1016/j.cbpc.2020.108875openalex-snapshot
Transgenerational reproductive effects of two serotonin reuptake inhibitors after acute exposure in Daphnia magna embryos
inferred← citeshttps://doi.org/10.1016/j.cbpc.2022.109322openalex-snapshot
Levels and effects of antidepressant drugs to aquatic organisms
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2021.130169openalex-snapshot
Alteration of predatory behaviour and growth in juvenile cuttlefish by fluoxetine and venlafaxine
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2022.136671openalex-snapshot
Acute and chronic ecotoxicological effects of pharmaceuticals and their mixtures in Daphnia similis
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2022.137028openalex-snapshot
Ecotoxicological assessment of the effects of fluoxetine on Daphnia magna based on acute toxicity, multigenerational reproduction effects, and attraction-repellence responses
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2023.138446openalex-snapshot
Widespread psychoactive pollutant augments daytime restfulness and disrupts diurnal activity rhythms in fish
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2017.03.042openalex-snapshot
Bioconcentration of the antidepressant fluoxetine and its effects on the physiological and biochemical status in Daphnia magna
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2019.109738openalex-snapshot
Hidden in the sand: Alteration of burying behaviour in shore crabs and cuttlefish by antidepressant exposure
inferred← citeshttps://doi.org/10.1016/j.envpol.2017.07.088openalex-snapshot
Evidence of low dose effects of the antidepressant fluoxetine and the fungicide prochloraz on the behavior of the keystone freshwater invertebrate Gammarus pulex
inferred← citeshttps://doi.org/10.1016/j.envpol.2019.112999openalex-snapshot
Effects of antidepressants with different modes of action on early life stages of fish and amphibians
inferred← citeshttps://doi.org/10.1016/j.envpol.2019.113029openalex-snapshot
Analysis of neurotransmitters in Daphnia magna affected by neuroactive pharmaceuticals using liquid chromatography-high resolution mass spectrometry
inferred← citeshttps://doi.org/10.1016/j.envpol.2020.114450openalex-snapshot
Chronic exposure to a pervasive pharmaceutical pollutant erodes among-individual phenotypic variation in a fish
inferred← citeshttps://doi.org/10.1016/j.envpol.2024.123355openalex-snapshot
Daphnia magna an emerging environmental model of neuro and cardiotoxicity of illicit drugs.
inferred← citeshttps://doi.org/10.1016/j.envpol.2025.126690openalex-snapshot
Micro-bioplastic impact on gut microbiome, cephalic transcription and cognitive function in the aquatic invertebrate Daphnia magna
inferred← citeshttps://doi.org/10.1016/j.envpol.2026.128203openalex-snapshot
Post-embryonic consequences of embryonic exposure: Mechanisms of Developmental Toxicity Induced by selective serotonin re-uptake inhibitors and tributyltin in Daphnia magna
inferred← citeshttps://doi.org/10.1016/j.etap.2022.103964openalex-snapshot
Transcriptomic responses to cytotoxic drug cisplatin in water flea Daphnia magna
inferred← citeshttps://doi.org/10.1016/j.jece.2024.112228openalex-snapshot
Design of porous spherical biomaterials from carboxymethyl chitosan for removal of fluoxetine in aqueous medium
inferred← citeshttps://doi.org/10.1016/j.jhazmat.2024.137023openalex-snapshot
Transgenerational combined toxicity effects of neonicotinoids and triazole pesticides at environmentally relevant concentrations on D. magna: From individual to population level
inferred← citeshttps://doi.org/10.1016/j.mce.2024.112155openalex-snapshot
Antidepressants – The new endocrine disruptors? The case of crustaceans
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2018.03.076openalex-snapshot
Effects of waterborne antidepressants on non-target animals living in the aquatic environment: A review
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2018.06.333openalex-snapshot
Effect of psychiatric drugs on Daphnia magna oxylipin profiles
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Foraging behaviour of top predators mediated by pollution of psychoactive pharmaceuticals and effects on ecosystem stability
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2020.139029openalex-snapshot
Changes in lipid profiles in Daphnia magna individuals exposed to low environmental levels of neuroactive pharmaceuticals
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2020.141932openalex-snapshot
Effect of emerging pollutant fluoxetine on the excess sludge anaerobic digestion
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Long-term effects of lithium and lithium-microplastic mixtures on the model species Daphnia magna: Toxicological interactions and implications to ‘One Health’
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.157353openalex-snapshot
Pharmaceutical pollution of hospital effluents and municipal wastewaters of Eastern Canada
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2022.159042openalex-snapshot
The Role of Serotonergic Signaling on Phototactic and Locomotor Behavior in Daphnia Magna
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.164984openalex-snapshot
Impact of the antidepressant Bupropion on the Dynamic Energy Budget of Daphnia magna
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2023.169866openalex-snapshot
Concentration-dependent effects of lithium on Daphnia magna: Life-history profiles and integrated biomarker response implementation
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Developmental defects in cognition, metabolic and cardiac function following maternal exposures to low environmental levels of selective serotonin re-uptake inhibitors and tributyltin in Daphnia magna
inferred← citeshttps://doi.org/10.1016/j.scitotenv.2024.175431openalex-snapshot
A short-term exposure to saxitoxin triggers a multitude of deleterious effects in Daphnia magna at levels deemed safe for human health
inferred← citeshttps://doi.org/10.1016/j.watres.2023.120388openalex-snapshot
Flushing away the future: The effects of wastewater treatment plants on aquatic invertebrates
inferred← citeshttps://doi.org/10.1021/acs.est.5c15302openalex-snapshot
From Gut to Brain: Glyphosate and Triclosan Impair Microbiome Composition, Neuroactive Metabolites, and Cognitive and Ecological Fitness in Daphnia magna
inferred← citeshttps://doi.org/10.1021/acs.est.9b03228openalex-snapshot
Effects of Single and Combined Low Concentrations of Neuroactive Drugs on Daphnia magna Reproduction and Transcriptomic Responses
inferred← citeshttps://doi.org/10.1021/acssuschemeng.5c01939openalex-snapshot
Long-Term Exposure to Hydrogen Nanobubbles Enhances Daphnia magna Resilience Against Copper Stress: Sustainable Molecular Strategies for Growth, Reproduction, and Aquatic Health
inferred← citeshttps://doi.org/10.1038/s41598-018-19778-0openalex-snapshot
Tryptophan hydroxylase (TRH) loss of function mutations induce growth and behavioral defects in Daphnia magna
inferred← citeshttps://doi.org/10.1038/s41598-019-39987-5openalex-snapshot
Tryptophan hydroxylase (TRH) loss of function mutations in Daphnia deregulated growth, energetic, serotoninergic and arachidonic acid metabolic signalling pathways
inferred← citeshttps://doi.org/10.1038/s41598-021-98886-wopenalex-snapshot
Pharmacological modulation of fish-induced depth selection in D. magna: the role of cholinergic and GABAergic signalling
inferred← citeshttps://doi.org/10.1039/c8ew00278aopenalex-snapshot
Emerging investigators series: occurrence and fate of emerging organic contaminants in wastewater treatment plants with an enhanced nitrification step
inferred← citeshttps://doi.org/10.1071/mf24275openalex-snapshot
Interspecific variation in cyanobacteria–temperature interaction on life history and gut microbiota of water fleas
inferred← citeshttps://doi.org/10.1080/02705060.2019.1629546openalex-snapshot
Influences of the antidepressant fluoxetine on stream ecosystem function and aquatic insect emergence at environmentally realistic concentrations
inferred← citeshttps://doi.org/10.1080/10934529.2017.1394722openalex-snapshot
Assessment of long term ecotoxicity of urban stormwaters using a multigenerational bioassay on Ceriodaphnia dubia: A preliminary study
inferred← citeshttps://doi.org/10.1093/etojnl/vgaf135openalex-snapshot
Aquatic toxicity of synthetic cannabinoid: multisystem impacts of 5F-ADB on neurodevelopment in Daphnia magna
inferred← citeshttps://doi.org/10.1101/2022.11.30.518590openalex-snapshot
A high-cholesterol diet leads to faster induction of general anesthesia in two model animals: D. magna and C. elegans
inferred← citeshttps://doi.org/10.1149/1945-7111/adf35fopenalex-snapshot
Electrochemical Determination of Paroxetine in the Presence of Non-Steroidal Anti-Inflammatory Drugs
inferred← citeshttps://doi.org/10.1787/3854026c-enopenalex-snapshot
Management of Pharmaceutical Household Waste
inferred← citeshttps://doi.org/10.2478/aiht-2020-71-3473openalex-snapshot
Oxidative and apoptotic effects of fluoxetine and its metabolite norfluoxetine in Daphnia magna
inferred← citeshttps://doi.org/10.3389/fendo.2021.587608openalex-snapshot
A Crab Is Not a Fish: Unique Aspects of the Crustacean Endocrine System and Considerations for Endocrine Toxicology
inferred← citeshttps://doi.org/10.3389/fphar.2024.1412188openalex-snapshot
The reprotoxic adverse side effects of neurogenic and neuroprotective drugs: current use of human organoid modeling as a potential alternative to preclinical models
inferred← citeshttps://doi.org/10.3390/limnolrev25030030openalex-snapshot
Water Monitoring Practices 2.0—Water Fleas as Key Species in Ecotoxicology and Risk Assessment
inferred← citeshttps://doi.org/10.3390/molecules30142952openalex-snapshot
Environmental Antidepressants Disrupt Metabolic Pathways in Spirostomum ambiguum and Daphnia magna: Insights from LC-MS-Based Metabolomics
inferred← citeshttps://doi.org/10.3390/toxics13070532openalex-snapshot
The Effect of the Antidepressant Citalopram on the Bioconcentration and Biomarker Response of Daphnia magna at Environmentally Relevant Concentrations
inferred← citeshttps://doi.org/10.3390/toxics9030064openalex-snapshot
High-Throughput Screening of Psychotropic Compounds: Impacts on Swimming Behaviours in Artemia franciscana
inferred← citeshttps://doi.org/10.3390/toxics9080187openalex-snapshot
Pharmacological Modulation of Behaviour, Serotonin and Dopamine Levels in Daphnia magna Exposed to the Monoamine Oxidase Inhibitor Deprenyl
inferred← citeshttps://doi.org/10.3390/toxins10120527openalex-snapshot
Cyanobacterial Neurotoxin Beta-Methyl-Amino-l-Alanine Affects Dopaminergic Neurons in Optic Ganglia and Brain of Daphnia magna
inferred← citeshttps://doi.org/10.5336/pharmsci.2021-87716openalex-snapshot
Risk of Ecotoxicity Due to Bioaccumulation of Antidepressants: Systematic Review
inferred← citeshttps://doi.org/10.7717/peerj.16472openalex-snapshot
Long-term toxicity of chlorpromazine, diclofenac and two lanthanides on three generations of Ceriodaphnia dubia
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