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Haloacetic Acid Water Disinfection Byproducts Affect Pyruvate Dehydrogenase Activity and Disrupt Cellular Metabolism
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/(sici)1098-1004(200003)15:3<209::aid-humu1>3.0.co;2-kopenalex-snapshot
Mutations in the X-linked pyruvate dehydrogenase (E1) ? subunit gene (PDHA1) in patients with a pyruvate dehydrogenase complex deficiency
inferredcites →https://doi.org/10.1002/(sici)1098-2280(1998)32:4<360::aid-em10>3.0.co;2-topenalex-snapshot
Analysis of mutagens with single cell gel electrophoresis, flow cytometry, and forward mutation assays in an isolated clone of Chinese hamster ovary cells
inferredcites →https://doi.org/10.1002/1097-4547(20000815)61:4<409::aid-jnr7>3.0.co;2-mopenalex-snapshot
Requirement of glycolytic and mitochondrial energy supply for loading of Ca2+ stores and InsP3-mediated Ca2+ signaling in rat hippocampus astrocytes
inferredcites →https://doi.org/10.1002/bmb.2003.494031010156openalex-snapshot
The biochemistry of the pyruvate dehydrogenase complex*
inferredcites →https://doi.org/10.1002/em.10092openalex-snapshot
Mammalian cell cytotoxicity and genotoxicity analysis of drinking water disinfection by‐products
inferredcites →https://doi.org/10.1002/em.20585openalex-snapshot
Mammalian cell cytotoxicity and genotoxicity of the haloacetic acids, a major class of drinking water disinfection by‐products
inferredcites →https://doi.org/10.1002/em.21795openalex-snapshot
Pyruvate remediation of cell stress and genotoxicity induced by haloacetic acid drinking water disinfection by‐products
inferredcites →https://doi.org/10.1002/ijc.29564openalex-snapshot
The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents
inferredcites →https://doi.org/10.1002/tcm.10010openalex-snapshot
Analysis of the cytotoxicity and mutagenicity of drinking water disinfection by‐products in Salmonella typhimurium
inferredcites →https://doi.org/10.1016/0165-1110(89)90028-6openalex-snapshot
Molecular analysis of spontaneous mutations at the gpt locus in Chinese hamster ovary (AS52) cells
inferredcites →https://doi.org/10.1016/j.bcp.2003.07.002openalex-snapshot
Pharmacologic or genetic ablation of maleylacetoacetate isomerase increases levels of toxic tyrosine catabolites in rodents
inferredcites →https://doi.org/10.1016/j.ccr.2006.10.020openalex-snapshot
A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth
inferredcites →https://doi.org/10.1016/j.jes.2017.04.021openalex-snapshot
CHO cell cytotoxicity and genotoxicity analyses of disinfection by-products: An updated review
inferredcites →https://doi.org/10.1016/j.mrgentox.2010.08.014openalex-snapshot
Assessment of the cytotoxicity and genotoxicity of haloacetic acids using microplate-based cytotoxicity test and CHO/HGPRT gene mutation assay
inferredcites →https://doi.org/10.1016/j.mrrev.2007.09.001openalex-snapshot
Occurrence, genotoxicity, and carcinogenicity of regulated and emerging disinfection by-products in drinking water: A review and roadmap for research
inferredcites →https://doi.org/10.1016/j.reprotox.2010.08.002openalex-snapshot
Pregnancy loss and eye malformations in offspring of F344 rats following gestational exposure to mixtures of regulated trihalomethanes and haloacetic acids
inferredcites →https://doi.org/10.1016/j.str.2007.07.001openalex-snapshot
Distinct Structural Mechanisms for Inhibition of Pyruvate Dehydrogenase Kinase Isoforms by AZD7545, Dichloroacetate, and Radicicol
inferredcites →https://doi.org/10.1016/j.watres.2015.12.047openalex-snapshot
Fingerprinting the reactive toxicity pathways of 50 drinking water disinfection by-products
inferredcites →https://doi.org/10.1016/j.ymgme.2012.03.017openalex-snapshot
The spectrum of pyruvate dehydrogenase complex deficiency: Clinical, biochemical and genetic features in 371 patients
inferredcites →https://doi.org/10.1016/s0021-9258(17)36021-0openalex-snapshot
Properties of a newly characterized protein of the bovine kidney pyruvate dehydrogenase complex.
inferredcites →https://doi.org/10.1021/bk-2015-1190.ch011openalex-snapshot
Formation of DBPs: State of the Science
inferredcites →https://doi.org/10.1021/es049971vopenalex-snapshot
Chemical and Biological Characterization of Newly Discovered Iodoacid Drinking Water Disinfection Byproducts
inferredcites →https://doi.org/10.1021/es051602ropenalex-snapshot
Modulation of the Cytotoxicity and Genotoxicity of the Drinking Water Disinfection Byproduct Iodoacetic Acid by Suppressors of Oxidative Stress
inferredcites →https://doi.org/10.1021/es060353jopenalex-snapshot
Occurrence of a New Generation of Disinfection Byproducts
inferredcites →https://doi.org/10.1021/es2008159openalex-snapshot
Biological Mechanism for the Toxicity of Haloacetic Acid Drinking Water Disinfection Byproducts
inferredcites →https://doi.org/10.1021/es403171bopenalex-snapshot
Human Cell Toxicogenomic Analysis Linking Reactive Oxygen Species to the Toxicity of Monohaloacetic Acid Drinking Water Disinfection Byproducts
inferredcites →https://doi.org/10.1021/tx034099+openalex-snapshot
Glutathione Transferase Zeta-Catalyzed Bioactivation of Dichloroacetic Acid: Reaction of Glyoxylate with Amino Acid Nucleophiles
inferredcites →https://doi.org/10.1021/tx980144fopenalex-snapshot
Glutathione Transferase Zeta-Catalyzed Biotransformation of Dichloroacetic Acid and Other α-Haloacids
inferredcites →https://doi.org/10.1021/tx990085lopenalex-snapshot
Inactivation of Glutathione Transferase Zeta by Dichloroacetic Acid and Other Fluorine-Lacking α-Haloalkanoic Acids
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A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence
inferredcites →https://doi.org/10.1038/sj.emboj.7600663openalex-snapshot
Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex
inferredcites →https://doi.org/10.1042/bj1410761openalex-snapshot
Mechanism of activation of pyruvate dehydrogenase by dichloroacetate and other halogenated carboxylic acids
inferredcites →https://doi.org/10.1042/bj1540327openalex-snapshot
Regulation of pyruvate dehydrogenase in rat heart. Mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme A, acetyl-coenzyme A and reduced and oxidized nicotinamide-adenine…
inferredcites →https://doi.org/10.1056/nejm197803092981002openalex-snapshot
Metabolic Effects of Dichloroacetate in Patients with Diabetes Mellitus and Hyperlipoproteinemia
inferredcites →https://doi.org/10.1073/pnas.0831078100openalex-snapshot
Dichloroacetate effects on glucose and lactate oxidation by neurons and astroglia in vitro and on glucose utilization by brain in vivo
inferredcites →https://doi.org/10.1073/pnas.0912276106openalex-snapshot
Mitaplatin, a potent fusion of cisplatin and the orphan drug dichloroacetate
inferredcites →https://doi.org/10.1093/aje/kwj364openalex-snapshot
Bladder Cancer and Exposure to Water Disinfection By-Products through Ingestion, Bathing, Showering, and Swimming in Pools
inferredcites →https://doi.org/10.1093/mutage/13.1.81openalex-snapshot
Calibration of the single cell gel electrophoresis assay, flow cytometry analysis and forward mutation in Chinese hamster ovary cells
inferredcites →https://doi.org/10.1097/00001648-199803000-00006openalex-snapshot
Trihalomethanes in Drinking Water and Spontaneous Abortion
inferredcites →https://doi.org/10.1098/rsta.2009.0108openalex-snapshot
The formation and control of emerging disinfection by-products of health concern
inferredcites →https://doi.org/10.1107/s0907444905042289openalex-snapshot
High-resolution structure of human D -glyceraldehyde-3-phosphate dehydrogenase
inferredcites →https://doi.org/10.1111/j.1749-6632.1989.tb14984.xopenalex-snapshot
Intermediates in Reductive Transacetylation Catalyzed by Pyruvate Dehydrogenase Complexa
inferredcites →https://doi.org/10.1124/mol.105.018911openalex-snapshot
Deficiency of Glutathione Transferase Zeta Causes Oxidative Stress and Activation of Antioxidant Response Pathways
inferredcites →https://doi.org/10.1203/01.pdr.0000057987.46622.64openalex-snapshot
Differential Effect of DCA Treatment on the Pyruvate Dehydrogenase Complex in Patients with Severe PDHC Deficiency
inferredcites →https://doi.org/10.1353/dem.2005.0002openalex-snapshot
The role of public health improvements in health advances: The twentieth-century United States
inferredcites →https://doi.org/10.18632/oncotarget.2838openalex-snapshot
Dichloroacetate blocks aerobic glycolytic adaptation to attenuated measles virus and promotes viral replication leading to enhanced oncolysis in glioblastoma
inferredcites →https://doi.org/10.3233/jad-2010-1375openalex-snapshot
Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer's Disease: Many Pathways to Neurodegeneration
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Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1016/j.chemosphere.2020.127476openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.chemosphere.2023.140182openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ecoenv.2019.109981openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.115598openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ecoenv.2023.115925openalex-snapshot
Exposure to disinfection by-products and risk of cancer: A systematic review and dose-response meta-analysis
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Impact of perfluorooctanoic acid (PFOA) and perfluorobutanoic acid (PFBA) on oxidative stress and metabolic biomarkers in human neuronal cells (SH-SY5Y)
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Rapid enzymatic activity model (REAM) to decipher the toxic action of per- and polyfluoroalkyl substances
inferred← citeshttps://doi.org/10.1016/j.hazl.2021.100041openalex-snapshot
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Investigation on toxicity and mechanism to Daphnia magna for 14 disinfection by-products: Enzyme activity and molecular docking
inferred← citeshttps://doi.org/10.1016/j.watres.2019.114930openalex-snapshot
Amorphous nickel phosphide as a noble metal-free cathode for electrochemical dechlorination
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Comparative cytotoxicity of halogenated aromatic DBPs and implications of the corresponding developed QSAR model to toxicity mechanisms of those DBPs: Binding interactions between aromatic DBPs and catalase play an important role
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inferred← citeshttps://doi.org/10.1021/acs.est.0c03144openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.est.1c03292openalex-snapshot
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inferred← citeshttps://doi.org/10.1021/acs.est.1c07725openalex-snapshot
Associations of Urinary Trichloroacetic Acid Concentrations with Spermatozoa Apoptosis and DNA Damage in a Chinese Population
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Iodoacetic acid affects estrous cyclicity, ovarian gene expression, and hormone levels in mice
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