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Toward an AOP Network-Based Tiered Testing Strategy for the Assessment of Thyroid Hormone Disruption
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/dvg.23000openalex-snapshot
Frogs model man: In vivo thyroid hormone signaling during development
inferredcites →https://doi.org/10.1002/etc.2403openalex-snapshot
Investigating Alternatives to the fish early-life stage test: A strategy for discovering and annotating adverse outcome pathways for early fish development
inferredcites →https://doi.org/10.1002/etc.34openalex-snapshot
Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment
inferredcites →https://doi.org/10.1002/etc.3855openalex-snapshot
Impaired swim bladder inflation in early life stage fathead minnows exposed to a deiodinase inhibitor, iopanoic acid
inferredcites →https://doi.org/10.1002/etc.4055openalex-snapshot
Applicability of the fish embryo acute toxicity (FET) test (OECD 236) in the regulatory context of Registration, Evaluation, Authorisation, and Restriction of Chemicals (REACH)
inferredcites →https://doi.org/10.1002/etc.4124openalex-snapshot
Adverse outcome pathway networks II: Network analytics
inferredcites →https://doi.org/10.1002/etc.4125openalex-snapshot
Adverse outcome pathway networks I: Development and applications
inferredcites →https://doi.org/10.1002/etc.4682openalex-snapshot
Critical Review of Read-Across Potential in Testing for Endocrine-Related Effects in Vertebrate Ecological Receptors
inferredcites →https://doi.org/10.1002/ieam.1703openalex-snapshot
Advancing the 3Rs in regulatory ecotoxicology: A pragmatic cross-sector approach
inferredcites →https://doi.org/10.1002/ieam.1862openalex-snapshot
Current limitations and recommendations to improve testing for the environmental assessment of endocrine active substances
inferredcites →https://doi.org/10.1002/ieam.1885openalex-snapshot
Recommended approaches to the scientific evaluation of ecotoxicological hazards and risks of endocrine-active substances
inferredcites →https://doi.org/10.1002/ieam.4153openalex-snapshot
When Are Adverse Outcome Pathways and Associated Assays “Fit for Purpose” for Regulatory Decision-Making and Management of Chemicals?
inferredcites →https://doi.org/10.1002/jmor.10558openalex-snapshot
Development of the swimbladder and its innervation in the zebrafish, Danio rerio
inferredcites →https://doi.org/10.1016/j.aquatox.2014.10.017openalex-snapshot
PFOS affects posterior swim bladder chamber inflation and swimming performance of zebrafish larvae
inferredcites →https://doi.org/10.1016/j.aquatox.2015.12.015openalex-snapshot
Thyroid disruption in zebrafish (Danio rerio) larvae: Different molecular response patterns lead to impaired eye development and visual functions
inferredcites →https://doi.org/10.1016/j.aquatox.2015.12.023openalex-snapshot
Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part II: Zebrafish
inferredcites →https://doi.org/10.1016/j.aquatox.2015.12.024openalex-snapshot
Impaired anterior swim bladder inflation following exposure to the thyroid peroxidase inhibitor 2-mercaptobenzothiazole part I: Fathead minnow
inferredcites →https://doi.org/10.1016/j.aquatox.2017.10.024openalex-snapshot
Thyroid disrupting effects of halogenated and next generation chemicals on the swim bladder development of zebrafish
inferredcites →https://doi.org/10.1016/j.aquatox.2018.04.009openalex-snapshot
An AOP-based alternative testing strategy to predict the impact of thyroid hormone disruption on swim bladder inflation in zebrafish
inferredcites →https://doi.org/10.1016/j.cotox.2018.03.004openalex-snapshot
The adverse outcome pathway: A multifaceted framework supporting 21st century toxicology
inferredcites →https://doi.org/10.1016/j.reprotox.2015.04.003openalex-snapshot
The potential of AOP networks for reproductive and developmental toxicity assay development
inferredcites →https://doi.org/10.1016/j.tiv.2013.02.012openalex-snapshot
Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals
inferredcites →https://doi.org/10.1016/j.tiv.2017.01.014openalex-snapshot
Application of a nonradioactive assay for high throughput screening for inhibition of thyroid hormone uptake via the transmembrane transporter MCT8
inferredcites →https://doi.org/10.1016/j.tiv.2019.104692openalex-snapshot
Vision of a near future: Bridging the human health–environment divide. Toward an integrated strategy to understand mechanisms across species for chemical safety assessment
inferredcites →https://doi.org/10.1016/j.toxlet.2012.03.020openalex-snapshot
State-of-the-science of endocrine disrupting chemicals, 2012
inferredcites →https://doi.org/10.1016/j.ygcen.2009.09.011openalex-snapshot
Combined antisense knockdown of type 1 and type 2 iodothyronine deiodinases disrupts embryonic development in zebrafish (Danio rerio)
inferredcites →https://doi.org/10.1016/j.ygcen.2018.05.001openalex-snapshot
Gene transcription ontogeny of hypothalamic-pituitary-thyroid axis development in early-life stage fathead minnow and zebrafish
inferredcites →https://doi.org/10.1016/s1532-0456(01)00271-xopenalex-snapshot
Thyroid hormones in growth and development of fish
inferredcites →https://doi.org/10.1021/acs.est.7b06145openalex-snapshot
High-Throughput Screening and Quantitative Chemical Ranking for Sodium-Iodide Symporter Inhibitors in ToxCast Phase I Chemical Library
inferredcites →https://doi.org/10.1021/acs.est.8b04587openalex-snapshot
Evidence for Cross Species Extrapolation of Mammalian-Based High-Throughput Screening Assay Results
inferredcites →https://doi.org/10.1021/acs.est.9b07204openalex-snapshot
Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish
inferredcites →https://doi.org/10.1021/es050972copenalex-snapshot
Effects of the Antithyroid Agent Propylthiouracil in a Partial Life Cycle Assay with Zebrafish
inferredcites →https://doi.org/10.1021/es202248hopenalex-snapshot
Zebrafish Eleutheroembryos Provide a Suitable Vertebrate Model for Screening Chemicals that Impair Thyroid Hormone Synthesis
inferredcites →https://doi.org/10.1038/s41574-019-0273-8openalex-snapshot
Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification
inferredcites →https://doi.org/10.1093/toxsci/kfu199openalex-snapshot
Adverse Outcome Pathway (AOP) Development I: Strategies and Principles
inferredcites →https://doi.org/10.1093/toxsci/kfv181openalex-snapshot
Adverse Outcome Pathways for Regulatory Applications: Examination of Four Case Studies With Different Degrees of Completeness and Scientific Confidence
inferredcites →https://doi.org/10.1093/toxsci/kfw034openalex-snapshot
Tiered High-Throughput Screening Approach to Identify Thyroperoxidase Inhibitors Within the ToxCast Phase I and II Chemical Libraries
inferredcites →https://doi.org/10.1093/toxsci/kfx163openalex-snapshot
Neurodevelopment and Thyroid Hormone Synthesis Inhibition in the Rat: Quantitative Understanding Within the Adverse Outcome Pathway Framework
inferredcites →https://doi.org/10.1093/toxsci/kfy302openalex-snapshot
Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases
inferredcites →https://doi.org/10.1111/j.1365-2605.2007.00857.xopenalex-snapshot
Thyroid disrupting chemicals: mechanisms and mixtures
inferredcites →https://doi.org/10.1210/en.2008-0457openalex-snapshot
Type 2 Iodothyronine Deiodinase Is Essential for Thyroid Hormone-Dependent Embryonic Development and Pigmentation in Zebrafish
inferredcites →https://doi.org/10.1210/en.2013-1660openalex-snapshot
Knockdown of Type 3 Iodothyronine Deiodinase Severely Perturbs Both Embryonic and Early Larval Development in Zebrafish
inferredcites →https://doi.org/10.1210/en.2016-1077openalex-snapshot
Permanent Deiodinase Type 2 Deficiency Strongly Perturbs Zebrafish Development, Growth, and Fertility
inferredcites →https://doi.org/10.1289/ehp.1306638openalex-snapshot
Current Perspectives on the Use of Alternative Species in Human Health and Ecological Hazard Assessments
inferredcites →https://doi.org/10.1289/ehp1304openalex-snapshot
Application of Adverse Outcome Pathways to U.S. EPA’s Endocrine Disruptor Screening Program
inferredcites →https://doi.org/10.1289/ehp5297openalex-snapshot
Evaluating Chemicals for Thyroid Disruption: Opportunities and Challenges with in Vitro Testing and Adverse Outcome Pathway Approaches
inferredcites →https://doi.org/10.1371/journal.pone.0123285openalex-snapshot
Deiodinase Knockdown during Early Zebrafish Development Affects Growth, Development, Energy Metabolism, Motility and Phototransduction
inferredcites →https://doi.org/10.14573/altex.1402011openalex-snapshot
Developmental toxicity of thyroid-active compounds in a zebrafish embryotoxicity test
inferredcites →https://doi.org/10.1787/20777876openalex-snapshot
OECD Series on Testing and Assessment
inferredcites →https://doi.org/10.2903/j.efsa.2013.3132openalex-snapshot
Scientific Opinion on the hazard assessment of endocrine disruptors: Scientific criteria for identification of endocrine disruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the environment
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.12688/openreseurope.18739.1zenodo-depositor-declared
A 2024 inventory of test methods relevant to thyroid hormone system disruption for human health and environmental regulatory hazard assessment
inferred← citeshttps://doi.org/10.1002/etc.4869openalex-snapshot
Assessing the Ecological Risks of Per- and Polyfluoroalkyl Substances: Current State-of-the Science and a Proposed Path Forward
inferred← citeshttps://doi.org/10.1002/etc.5287openalex-snapshot
A Multidimensional Matrix Model for Predicting the Effects of Male-Biased Sex Ratios on Fish Populations
inferred← citeshttps://doi.org/10.1002/etc.5452openalex-snapshot
AOP Report: Thyroperoxidase Inhibition Leading to Altered Visual Function in Fish Via Altered Retinal Layer Structure
inferred← citeshttps://doi.org/10.1002/etc.5581openalex-snapshot
AOP Report: Adverse Outcome Pathways for Aromatase Inhibition or Androgen Receptor Agonism Leading to Male-Biased Sex Ratio and Population Decline in Fish
inferred← citeshttps://doi.org/10.1002/etc.5584openalex-snapshot
New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians
inferred← citeshttps://doi.org/10.1002/etc.5741openalex-snapshot
Challenges and Recommendations in Assessing Potential Endocrine-Disrupting Properties of Metals in Aquatic Organisms
inferred← citeshttps://doi.org/10.1002/etc.5930openalex-snapshot
Effects of Metabolic Disruption on Lipid Metabolism and Yolk Retention in Zebrafish Embryos
inferred← citeshttps://doi.org/10.1002/ieam.4828openalex-snapshot
Development of the integrated fish endocrine disruptor test—Part B: Implementation of thyroid-related endpoints
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Effect of thyroid hormone‐disrupting chemicals on swim bladder inflation and thyroid hormone‐related gene expression in Japanese medaka and zebrafish
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Effects of plasticizer diisobutyl adipate on the Japanese medaka ( Oryzias latipes ) endocrine system
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Quantum-Catalyst Materials and Their Application in Air Purification
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General Challenges and Recommendations for the Water Quality Criteria of Endocrine Disrupting Chemicals (EDCs)
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G × E interactions as a basis for toxicological uncertainty
inferred← citeshttps://doi.org/10.1007/s00204-024-03766-7openalex-snapshot
In vitro assessment of thyroid peroxidase inhibition by chemical exposure: comparison of cell models and detection methods
inferred← citeshttps://doi.org/10.1007/s00204-025-04258-yopenalex-snapshot
In vitro thyroperoxidase inhibition assessment by LC-ICP-MS-based L-tyrosine iodination assay: comparison with Amplex Ultrared assay and its modifications
inferred← citeshttps://doi.org/10.1007/s10311-022-01531-9openalex-snapshot
Effects of pollutant toxicity on the eyes of aquatic life monitored by visual dysfunction in zebrafish: a review
inferred← citeshttps://doi.org/10.1007/s12672-023-00840-xopenalex-snapshot
The adverse outcome pathway for breast cancer: a knowledge management framework bridging biomedicine and toxicology
inferred← citeshttps://doi.org/10.1016/b978-0-323-85713-0.00027-xopenalex-snapshot
How to integrate the “small and big” data into a complex adverse outcome pathway?
inferred← citeshttps://doi.org/10.1016/j.aquatox.2023.106607openalex-snapshot
Putative adverse outcome pathway development based on physiological responses of female fathead minnows to model estrogen versus androgen receptor agonists
inferred← citeshttps://doi.org/10.1016/j.aquatox.2023.106632openalex-snapshot
Deiodinase inhibition impairs the formation of the three posterior swim bladder tissue layers during early embryonic development in zebrafish
inferred← citeshttps://doi.org/10.1016/j.aquatox.2024.106969openalex-snapshot
The generation gap in endocrine disruption: Can the integrated fish endocrine disruptor test (iFEDT) bridge the gap by assessing intergenerational effects of thyroid hormone system disruption?
inferred← citeshttps://doi.org/10.1016/j.cbi.2023.110565openalex-snapshot
A metabolomics approach to reveal the mechanism of developmental toxicity in zebrafish embryos exposed to 6-propyl-2-thiouracil
inferred← citeshttps://doi.org/10.1016/j.cbpc.2022.109502openalex-snapshot
Adverse effects of thyroid-hormone-disrupting chemicals 6-propyl-2-thiouracil and tetrabromobisphenol A on Japanese medaka (Oryzias latipes)
inferred← citeshttps://doi.org/10.1016/j.cbpc.2026.110677openalex-snapshot
Impact of propylthiouracil-induced thyroid hormone deficiency on reproduction and larval development in Japanese medaka (Oryzias latipes)
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2021.132419openalex-snapshot
Toxicity pathways of lipid metabolic disorders induced by typical replacement flame retardants via data-driven analysis, in silico and in vitro approaches
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2022.135929openalex-snapshot
High-throughput screening paradigms in ecotoxicity testing: Emerging prospects and ongoing challenges
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2022.136860openalex-snapshot
Effects of the synthetic progestin levonorgestrel on some aspects of thyroid physiology in common carp (Cyprinus carpio)
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2023.140776openalex-snapshot
Bisphenol A alters retinal morphology, visually guided behavior, and thyroid hormone levels in zebrafish larvae
inferred← citeshttps://doi.org/10.1016/j.chemosphere.2024.143287openalex-snapshot
Gene biomarkers for the assessment of thyroid-disrupting activity in zebrafish embryos
inferred← citeshttps://doi.org/10.1016/j.comtox.2026.100429openalex-snapshot
Computational approaches to adverse outcome pathway networks: advances in construction, quantification, and regulatory decision support
inferred← citeshttps://doi.org/10.1016/j.cotox.2023.100391openalex-snapshot
Adverse outcome pathway network approach to identify endocrine disruptor-induced reproductive toxicity
inferred← citeshttps://doi.org/10.1016/j.cotox.2025.100517openalex-snapshot
The European Partnership PARC’s role in actively promoting the uptake of new approach methodologies and next-generation risk assessment into regulatory risk assessment practice
inferred← citeshttps://doi.org/10.1016/j.crtox.2023.100124openalex-snapshot
Enhancing developmental and reproductive toxicity knowledge: A new AOP stemming from glutathione depletion
inferred← citeshttps://doi.org/10.1016/j.ecoenv.2024.116995openalex-snapshot
The thyroid hormone system disrupting potential of resorcinol in fish
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New insight into the adverse effect and molecular mechanism of thyroid disrupting chemicals on retinal cone differentiation: A case study of bisphenol S.
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Organophosphate esters cause thyroid dysfunction via multiple signaling pathways in zebrafish brain
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Polyquaternium polymers cause inflammatory response and alterations of the lipidome in Danio rerio larvae
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Toxicological Mechanism of Individual Susceptibility to Formaldehyde-Induced Respiratory Effects
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6PPD, Not 6PPD-Quinone, Induced Serious Zebrafish Eye Damage by Disrupting the Thyroid Signaling Pathway
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inferred← citeshttps://doi.org/10.1021/acs.est.9b07204openalex-snapshot
Effect of Thyroperoxidase and Deiodinase Inhibition on Anterior Swim Bladder Inflation in the Zebrafish
inferred← citeshttps://doi.org/10.1021/envhealth.3c00140openalex-snapshot
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inferred← citeshttps://doi.org/10.1093/etojnl/vgaf028openalex-snapshot
Development of the fish invitrome for animal-free environmental risk assessment of chemicals
inferred← citeshttps://doi.org/10.1093/jrsssc/qlac005openalex-snapshot
Bayesian matrix completion for hypothesis testing
inferred← citeshttps://doi.org/10.1093/toxsci/kfad063openalex-snapshot
Cross-species applicability of an adverse outcome pathway network for thyroid hormone system disruption
inferred← citeshttps://doi.org/10.14573/altex.2202141openalex-snapshot
Application of evidence-based methods to construct mechanism-driven chemical assessment frameworks
inferred← citeshttps://doi.org/10.1787/9f651c16-enopenalex-snapshot
Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation
inferred← citeshttps://doi.org/10.1787/dc406014-enopenalex-snapshot
Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation
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Hierarchical Causal Validation Framework for Explainable Bias Mitigation in LLM-Powered Recommendation Systems
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inferred← citeshttps://doi.org/10.3389/ftox.2023.1189303openalex-snapshot
New approach methods to improve human health risk assessment of thyroid hormone system disruption–a PARC project
inferred← citeshttps://doi.org/10.3389/ftox.2026.1733477openalex-snapshot
Zebrafish neuromast development: a target for endocrine disrupting chemicals?
inferred← citeshttps://doi.org/10.3390/fishes10080365openalex-snapshot
Bisphenols: Endocrine Disruptors and Their Impact on Fish: A Review
inferred← citeshttps://doi.org/10.70675/11ee966az2d84z47a4z99b1z77e79bf324ebopenalex-snapshot
Identification of biomarkers of effect following exposure to endocrine disrupting chemicals in Xenopus laevis and their relevance for human health
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