On the public citation graph

Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice

https://doi.org/10.1021/acs.jmedchem.0c01775

0 signed · 200 inferred · view as graph

Inferred edges come from two machine sources: sweeps of open repository metadata (mostly SSRN and Zenodo), and a bulk OpenAlex citation snapshot. Every row below is labelled with the one it came from. Neither is a complete citation index — absence here is not evidence of absence.

Is this your work? Sign in with ORCID and put your name on the claims that are yours.

Claim with ORCID

Reference health. See whether every reference in this work resolves to a known work and none has been retracted — and get a dated CiteStamped badge you can embed.

See reference health

What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ana.20101openalex-snapshot

Progressive age‐related development of Alzheimer‐like pathology in APP/PS1 mice

inferredcites →https://doi.org/10.1002/cmdc.200800414openalex-snapshot

Tacrine–Melatonin Hybrids as Multifunctional Agents for Alzheimer's Disease, with Cholinergic, Antioxidant, and Neuroprotective Properties

inferredcites →https://doi.org/10.1002/cmdc.201000322openalex-snapshot

Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates

inferredcites →https://doi.org/10.1002/cmdc.201000523openalex-snapshot

New Huprine Derivatives Functionalized at Position 9 as Highly Potent Acetylcholinesterase Inhibitors

inferredcites →https://doi.org/10.1002/cmdc.201100438openalex-snapshot

Huprine Derivatives as Sub‐Nanomolar Human Acetylcholinesterase Inhibitors: From Rational Design to Validation by X‐ray Crystallography

inferredcites →https://doi.org/10.1002/ejoc.201501433openalex-snapshot

Improved Access to Huprine Derivatives Functionalized at Position 9

inferredcites →https://doi.org/10.1002/med.21434openalex-snapshot

Drugs in Clinical Trials for Alzheimer's Disease: The Major Trends

inferredcites →https://doi.org/10.1002/rcm.2718openalex-snapshot

Rapid and sensitive determination of donepezil in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study

inferredcites →https://doi.org/10.1002/slct.201803222openalex-snapshot

Novel Coumarin‐Quinoline Hybrids: Design of Multitarget Compounds for Alzheimer's Disease

inferredcites →https://doi.org/10.1006/jmbi.1997.1245openalex-snapshot

Acetylcholinesterase promotes the aggregation of amyloid-β-peptide fragments by forming a complex with the growing fibrils 1 1Edited by A. R. Fersht

inferredcites →https://doi.org/10.1007/s00044-008-9122-3openalex-snapshot

Evaluation of a new lead for acetylcholinesterase inhibition

inferredcites →https://doi.org/10.1007/s10571-014-0074-5openalex-snapshot

Parallels Between Major Depressive Disorder and Alzheimer’s Disease: Role of Oxidative Stress and Genetic Vulnerability

inferredcites →https://doi.org/10.1007/s12031-013-0183-5openalex-snapshot

Acetylcholinesterase Protein Level Is Preserved in the Alzheimer's Brain

inferredcites →https://doi.org/10.1007/s40266-015-0273-xopenalex-snapshot

The Use of Cholinesterase Inhibitors Across All Stages of Alzheimer’s Disease

inferredcites →https://doi.org/10.1016/0006-2952(61)90145-9openalex-snapshot

A new and rapid colorimetric determination of acetylcholinesterase activity

inferredcites →https://doi.org/10.1016/0022-2836(88)90213-6openalex-snapshot

Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C

inferredcites →https://doi.org/10.1016/c2009-0-22837-6openalex-snapshot

Organic Chemistry of Enzyme-Catalyzed Reactions

inferredcites →https://doi.org/10.1016/j.bbadis.2015.09.009openalex-snapshot

The increased potassium intake improves cognitive performance and attenuates histopathological markers in a model of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.bbadis.2017.01.002openalex-snapshot

Induction of hypothyroidism during early postnatal stages triggers a decrease in cognitive performance by decreasing hippocampal synaptic plasticity

inferredcites →https://doi.org/10.1016/j.biocel.2008.12.015openalex-snapshot

Reassessing the amyloid cascade hypothesis of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.biochi.2011.12.015openalex-snapshot

Alkyl esters of hydroxycinnamic acids with improved antioxidant activity and lipophilicity protect PC12 cells against oxidative stress

inferredcites →https://doi.org/10.1016/j.bioorg.2020.103721openalex-snapshot

Tacrine-hydroxamate derivatives as multitarget-directed ligands for the treatment of Alzheimer’s disease: Design, synthesis, and biological evaluation

inferredcites →https://doi.org/10.1016/j.bmc.2014.07.053openalex-snapshot

Shogaol–huprine hybrids: Dual antioxidant and anticholinesterase agents with β-amyloid and tau anti-aggregating properties

inferredcites →https://doi.org/10.1016/j.bmc.2015.06.010openalex-snapshot

Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents

inferredcites →https://doi.org/10.1016/j.bmc.2020.115374openalex-snapshot

Design, synthesis and evaluation of flurbiprofen-clioquinol hybrids as multitarget-directed ligands against Alzheimer’s disease

inferredcites →https://doi.org/10.1016/j.bmcl.2005.09.018openalex-snapshot

In vitro photo-release of a TRPV1 agonist

inferredcites →https://doi.org/10.1016/j.bmcl.2008.11.005openalex-snapshot

Sulfonamido-aryl ethers as bradykinin B1 receptor antagonists

inferredcites →https://doi.org/10.1016/j.chemphys.2020.110763openalex-snapshot

Combined infrared spectroscopic and computational study on simpler capsaicin derivatives and their anion intermediates in the scavenging of free radicals

inferredcites →https://doi.org/10.1016/j.ejmech.2019.02.076openalex-snapshot

Advancement of multi-target drug discoveries and promising applications in the field of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.ejmech.2019.05.055openalex-snapshot

Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.ejmech.2019.07.051openalex-snapshot

A novel class of multitarget anti-Alzheimer benzohomoadamantane‒chlorotacrine hybrids modulating cholinesterases and glutamate NMDA receptors

inferredcites →https://doi.org/10.1016/j.ejmech.2019.111572openalex-snapshot

The chemistry toolbox of multitarget-directed ligands for Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2013.09.035openalex-snapshot

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

inferredcites →https://doi.org/10.1016/j.neurobiolaging.2016.06.021openalex-snapshot

Andrographolide recovers cognitive impairment in a natural model of Alzheimer's disease (Octodon degus)

inferredcites →https://doi.org/10.1016/j.saa.2019.117570openalex-snapshot

Antioxidant effect of phenolic compounds (PC) at different concentrations in IEC-6 cells: A spectroscopic analysis

inferredcites →https://doi.org/10.1016/s0023-6438(95)80008-5openalex-snapshot

Use of a free radical method to evaluate antioxidant activity

inferredcites →https://doi.org/10.1016/s0026-895x(24)23214-4openalex-snapshot

Huprine X is a Novel High-Affinity Inhibitor of Acetylcholinesterase That Is of Interest for Treatment of Alzheimer’s Disease

inferredcites →https://doi.org/10.1016/s0026-895x(25)13975-8openalex-snapshot

Propidium—a Fluorescence Probe for a Peripheral Anionic Site on Acetylcholinesterase

inferredcites →https://doi.org/10.1016/s0028-3908(03)00071-6openalex-snapshot

Characterisation of the anticholinesterase activity of two new tacrine–huperzine A hybrids

inferredcites →https://doi.org/10.1016/s0223-5234(03)00012-6openalex-snapshot

High throughput artificial membrane permeability assay for blood–brain barrier

inferredcites →https://doi.org/10.1016/s0896-6273(00)80108-7openalex-snapshot

Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme

inferredcites →https://doi.org/10.1016/s1357-2725(02)00027-4openalex-snapshot

Inhibition of acetylcholinesterase from Electrophorus electricus (L.) by tricyclic antidepressants

inferredcites →https://doi.org/10.1021/acs.jafc.8b01686openalex-snapshot

Bioactive Compounds of Kimchi Inhibit Apoptosis by Attenuating Endoplasmic Reticulum Stress in the Brain of Amyloid β-Injected Mice

inferredcites →https://doi.org/10.1021/acs.jmedchem.0c00528openalex-snapshot

Centrally Active Multitarget Anti-Alzheimer Agents Derived from the Antioxidant Lead CR-6

inferredcites →https://doi.org/10.1021/acs.jmedchem.0c00756openalex-snapshot

MicroRNA-Based Multitarget Approach for Alzheimer’s Disease: Discovery of the First-In-Class Dual Inhibitor of Acetylcholinesterase and MicroRNA-15b Biogenesis

inferredcites →https://doi.org/10.1021/acs.jmedchem.0c01129openalex-snapshot

Discovery and Biological Evaluation of a Novel Highly Potent Selective Butyrylcholinsterase Inhibitor

inferredcites →https://doi.org/10.1021/acs.jmedchem.5b01325openalex-snapshot

Tacrine–Trolox Hybrids: A Novel Class of Centrally Active, Nonhepatotoxic Multi-Target-Directed Ligands Exerting Anticholinesterase and Antioxidant Activities with Low In Vivo Toxicity

inferredcites →https://doi.org/10.1021/acs.jmedchem.9b00623openalex-snapshot

Dual-Acting Cholinesterase–Human Cannabinoid Receptor 2 Ligands Show Pronounced Neuroprotection in Vitro and Overadditive and Disease-Modifying Neuroprotective Effects in Vivo

inferredcites →https://doi.org/10.1021/acs.jmedchem.9b00937openalex-snapshot

New Dual Small Molecules for Alzheimer’s Disease Therapy Combining Histamine H 3 Receptor (H3R) Antagonism and Calcium Channels Blockade with Additional Cholinesterase Inhibition

inferredcites →https://doi.org/10.1021/acschemneuro.8b00420openalex-snapshot

Structure-Based Survey of the Binding Modes of BACE1 Inhibitors

inferredcites →https://doi.org/10.1021/acschemneuro.9b00226openalex-snapshot

Novel Multitarget Directed Triazinoindole Derivatives as Anti-Alzheimer Agents

inferredcites →https://doi.org/10.1021/bi00680a029openalex-snapshot

Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

inferredcites →https://doi.org/10.1021/bi011652iopenalex-snapshot

3D Structure of Torpedo californica Acetylcholinesterase Complexed with Huprine X at 2.1 Å Resolution: Kinetic and Molecular Dynamic Correlates,

inferredcites →https://doi.org/10.1021/ja052939wopenalex-snapshot

Prevention of Undesirable Isomerization during Olefin Metathesis

inferredcites →https://doi.org/10.1021/jf030723copenalex-snapshot

The Chemistry behind Antioxidant Capacity Assays

inferredcites →https://doi.org/10.1021/jf0734931openalex-snapshot

Antioxidant and Iron-Binding Properties of Curcumin, Capsaicin, and S-Allylcysteine Reduce Oxidative Stress in Rat Brain Homogenate

inferredcites →https://doi.org/10.1021/jm000980yopenalex-snapshot

New Tacrine−Huperzine A Hybrids (Huprines): Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease

inferredcites →https://doi.org/10.1021/jm0255668openalex-snapshot

Specific Targeting of Acetylcholinesterase and Butyrylcholinesterase Recognition Sites. Rational Design of Novel, Selective, and Highly Potent Cholinesterase Inhibitors

inferredcites →https://doi.org/10.1021/jm070859sopenalex-snapshot

First Gallamine−Tacrine Hybrid: Design and Characterization at Cholinesterases and the M2 Muscarinic Receptor

inferredcites →https://doi.org/10.1021/jm200840copenalex-snapshot

Huprine–Tacrine Heterodimers as Anti-Amyloidogenic Compounds of Potential Interest against Alzheimer’s and Prion Diseases

inferredcites →https://doi.org/10.1021/jm201460yopenalex-snapshot

New Tacrine–4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer’s Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties

inferredcites →https://doi.org/10.1021/jm400970mopenalex-snapshot

Oxidative Stress in Alzheimer’s Disease: Are We Connecting the Dots?

inferredcites →https://doi.org/10.1021/jm401824wopenalex-snapshot

Synthesis and Multitarget Biological Profiling of a Novel Family of Rhein Derivatives As Disease-Modifying Anti-Alzheimer Agents

inferredcites →https://doi.org/10.1021/jm501195eopenalex-snapshot

Discovery, Biological Evaluation, and Crystal Structure of a Novel Nanomolar Selective Butyrylcholinesterase Inhibitor

inferredcites →https://doi.org/10.1021/jm7009364openalex-snapshot

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

inferredcites →https://doi.org/10.1037/0033-2909.83.3.482openalex-snapshot

The open-field test: A critical review.

inferredcites →https://doi.org/10.1038/31508openalex-snapshot

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

inferredcites →https://doi.org/10.1038/35050103openalex-snapshot

A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

inferredcites →https://doi.org/10.1038/nn0805-977openalex-snapshot

The synaptic Aβ hypothesis of Alzheimer disease

inferredcites →https://doi.org/10.1038/nprot.2006.205openalex-snapshot

Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study 'recognition memory'

inferredcites →https://doi.org/10.1038/s41598-020-59805-7openalex-snapshot

Rational design of novel benzisoxazole derivatives with acetylcholinesterase inhibitory and serotoninergic 5-HT4 receptors activities for the treatment of Alzheimer’s disease

inferredcites →https://doi.org/10.1039/c5ra07927fopenalex-snapshot

Reactive oxygen species: friend or foe?

inferredcites →https://doi.org/10.1039/d0fo00351dopenalex-snapshot

Capsaicin—the major bioactive ingredient of chili peppers: bio-efficacy and delivery systems

inferredcites →https://doi.org/10.1042/bj1370143openalex-snapshot

A simple graphical method for determining the inhibition constants of mixed, uncompetitive and non-competitive inhibitors (Short Communication)

inferredcites →https://doi.org/10.1042/bj20130013openalex-snapshot

Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase

inferredcites →https://doi.org/10.1056/nejmoa1312889openalex-snapshot

Phase 3 Trials of Solanezumab for Mild-to-Moderate Alzheimer's Disease

inferredcites →https://doi.org/10.1073/pnas.0508575102openalex-snapshot

Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent

inferredcites →https://doi.org/10.1080/13813455.2019.1669056openalex-snapshot

Capsaicin has potent anti-oxidative effects in vivo through a mechanism which is non-receptor mediated

inferredcites →https://doi.org/10.1080/14756366.2019.1581184openalex-snapshot

New flavonoid – N , N -dibenzyl( N -methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

inferredcites →https://doi.org/10.1089/ars.2011.4406openalex-snapshot

4-Hydroxy-2-Nonenal, a Reactive Product of Lipid Peroxidation, and Neurodegenerative Diseases: A Toxic Combination Illuminated by Redox Proteomics Studies

inferredcites →https://doi.org/10.1097/00005072-199801000-00008openalex-snapshot

Relationship Between Plaques, Tangles, and Loss of Cortical Cholinergic Fibers in Alzheimer Disease

inferredcites →https://doi.org/10.1097/nen.0b013e31823cc7a6openalex-snapshot

Butyrylcholinesterase Is Associated With β-Amyloid Plaques in the Transgenic APP SWE /PSEN1dE9 Mouse Model of Alzheimer Disease

inferredcites →https://doi.org/10.1111/acel.13113openalex-snapshot

TRPV1 activation alleviates cognitive and synaptic plasticity impairments through inhibiting AMPAR endocytosis in APP23/PS45 mouse model of Alzheimer’s disease

inferredcites →https://doi.org/10.1111/j.1742-4658.2012.08672.xopenalex-snapshot

Human butyrylcholinesterase produced in insect cells: huprine‐based affinity purification and crystal structure

inferredcites →https://doi.org/10.1126/science.1074069openalex-snapshot

Alzheimer's Disease Is a Synaptic Failure

inferredcites →https://doi.org/10.1186/1750-1326-9-61openalex-snapshot

Andrographolide reduces cognitive impairment in young and mature AβPPswe/PS-1 mice

inferredcites →https://doi.org/10.1186/s12906-018-2237-2openalex-snapshot

Huatuo Zaizao pill ameliorates cognitive impairment of APP/PS1 transgenic mice by improving synaptic plasticity and reducing Aβ deposition

inferredcites →https://doi.org/10.1371/journal.pone.0177683openalex-snapshot

Unveiling a novel transient druggable pocket in BACE-1 through molecular simulations: Conformational analysis and binding mode of multisite inhibitors

inferredcites →https://doi.org/10.1385/jmn:20:3:369openalex-snapshot

Acetylcholinesterase: A Multifaceted Target for Structure-Based Drug Design of Anticholinesterase Agents for the Treatment of Alzheimer's Disease

inferredcites →https://doi.org/10.1517/17460441.3.1.65openalex-snapshot

Huprines for Alzheimer's disease drug development

inferredcites →https://doi.org/10.1523/jneurosci.0862-13.2014openalex-snapshot

In vivoActivation ofWntSignaling Pathway Enhances Cognitive Function of Adult Mice and Reverses Cognitive Deficits in an Alzheimer's Disease Model

inferredcites →https://doi.org/10.1523/jneurosci.18-09-03213.1998openalex-snapshot

Stable Complexes Involving Acetylcholinesterase and Amyloid-β Peptide Change the Biochemical Properties of the Enzyme and Increase the Neurotoxicity of Alzheimer’s Fibrils

inferredcites →https://doi.org/10.2174/1385272823666191021124443openalex-snapshot

Molecular Hybridization as a Tool in the Design of Multi-target Directed Drug Candidates for Neurodegenerative Diseases

inferredcites →https://doi.org/10.3233/jad-121837openalex-snapshot

Capsaicin Ameliorates Stress-Induced Alzheimer's Disease-Like Pathological and Cognitive Impairments in Rats

inferredcites →https://doi.org/10.3233/jad-151079openalex-snapshot

The Associations between a Capsaicin-Rich Diet and Blood Amyloid-β Levels and Cognitive Function

inferredcites →https://doi.org/10.3233/jad-170337openalex-snapshot

Capsaicin Attenuates Amyloid-β-Induced Synapse Loss and Cognitive Impairments in Mice

inferredcites →https://doi.org/10.3389/fncel.2019.00295openalex-snapshot

Presymptomatic Treatment With Andrographolide Improves Brain Metabolic Markers and Cognitive Behavior in a Model of Early-Onset Alzheimer’s Disease

inferredcites →https://doi.org/10.3389/fphar.2019.00778openalex-snapshot

Targeting Synaptic Plasticity in Experimental Models of Alzheimer’s Disease

inferredcites →https://doi.org/10.3390/molecules22122098openalex-snapshot

Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study

inferredcites →https://doi.org/10.3390/nu10101554openalex-snapshot

Bioactive Compounds in Kimchi Improve the Cognitive and Memory Functions Impaired by Amyloid Beta

inferredcites →https://doi.org/10.4088/pcc.12r01412openalex-snapshot

A Review of Butyrylcholinesterase as a Therapeutic Target in the Treatment of Alzheimer’s Disease

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.2139/ssrn.4633265openalex-extracted

Carltonine-Derived Compounds for Targeted Butyrylcholinesterase Inhibition

inferred← citeshttps://doi.org/10.1002/ardp.70124openalex-snapshot

Structure‐Based Design of Chiral Thioureas as Anticholinesterase Inhibitors Using Enantiopure α‐Methylbenzylamines: Synthesis, Enzyme Inhibition, and In Silico Studies

inferred← citeshttps://doi.org/10.1002/cbdv.202501270openalex-snapshot

LC–HRESIMS‐Guided Phytochemical Characterization and Bioactivity Evaluation of Filipendula hexapetala Gilib. From Algeria: Antioxidant and Anticholinesterase Potential Supported by In Silico Analysis

inferred← citeshttps://doi.org/10.1002/jhet.4452openalex-snapshot

Design, synthesis, in vitro evaluation of a new pyrrolo[1,2‐a]thiazolo[5,4‐d]pyrimidinone derivatives as cholinesterase inhibitors against Alzheimer's disease

inferred← citeshttps://doi.org/10.1002/jhet.4863openalex-snapshot

Design, synthesis, biological evaluation of a new tricyclicthiazolopy‐rimidinone derivatives as acetylcholinesterase inhibitors

inferred← citeshttps://doi.org/10.1002/med.70047openalex-snapshot

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

inferred← citeshttps://doi.org/10.1007/978-3-031-33871-7_3openalex-snapshot

Role of Computational Modeling in Drug Discovery for Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1007/s00044-025-03387-4openalex-snapshot

Design, synthesis, biological evaluation, and in silico studies of imidazo[2,1-b][1,3,4]thiadiazole derivatives as cholinesterase inhibitors

inferred← citeshttps://doi.org/10.1007/s00044-025-03468-4openalex-snapshot

Design, synthesis, biological evaluation, and in silico studies of cholinesterase inhibitors based on the 2-aminothiazole scaffold

inferred← citeshttps://doi.org/10.1007/s00044-025-03484-4openalex-snapshot

Novel diazepine-carbamate derivatives as dual-acting butyrylcholinesterase inhibitors and antioxidants for Alzheimer’s disease

inferred← citeshttps://doi.org/10.1007/s00044-026-03587-6openalex-snapshot

Design, synthesis, biological evaluation, and computational studies of N-benzoylethylenediamine derivatives as cholinesterase inhibitors

inferred← citeshttps://doi.org/10.1007/s00044-026-03611-9openalex-snapshot

Design, synthesis, biological activity and computational simulation evaluation of pyrimidine-2-aminoacetamide derivatives as cholinesterase inhibitors

inferred← citeshttps://doi.org/10.1007/s00114-026-02112-4openalex-snapshot

Solvent-free synthesis of quinazolinone–chalcone hybrids and their evaluation as dual inhibitors of AChE and BuChE for alzheimer’s disease

inferred← citeshttps://doi.org/10.1007/s10822-025-00746-6openalex-snapshot

Ligand and structure-based toxicological assessment of (thio)semicarbazones on cholinesterases

inferred← citeshttps://doi.org/10.1007/s11030-026-11733-wopenalex-snapshot

Discovery of potent and selective MAO-B inhibitors from a morpholine-substituted chalcone library for neurodegenerative disorders

inferred← citeshttps://doi.org/10.1007/s12035-024-04337-8openalex-snapshot

Specific Mode Electroacupuncture Stimulation Mediates the Delivery of NGF Across the Hippocampus Blood–Brain Barrier Through p65-VEGFA-TJs to Improve the Cognitive Function of MCAO/R Convalescent Rats

inferred← citeshttps://doi.org/10.1007/s13205-023-03725-6openalex-snapshot

In vitro and in silico cholinesterase inhibitory potential of metabolites from Laurencia snackeyi (Weber-van Bosse) M. Masuda

inferred← citeshttps://doi.org/10.1007/s40203-025-00544-wopenalex-snapshot

Targeting Alzheimer’s diseases via nitro-substituted Schiff base derivatives: synthesis, DFT, and molecular dynamics studies

inferred← citeshttps://doi.org/10.1007/s41061-025-00502-2openalex-snapshot

Applications of Bridgehead Heterocycles in Drug Design and Medicinal Chemistry

inferred← citeshttps://doi.org/10.1007/s42250-023-00783-4openalex-snapshot

Conception, Synthesis and In silico Assessment of New Morpholine-Containing Compounds Against Human Legumain and Cholinesterase Enzymes

inferred← citeshttps://doi.org/10.1016/j.aquatox.2024.106868openalex-snapshot

Neurotoxicant effects of bisphenol A, nonylphenol, and tert‑butyl phenol in the Nile tilapia (Oreochromis niloticus)

inferred← citeshttps://doi.org/10.1016/j.arr.2025.102707openalex-snapshot

Antioxidants in anti‐Alzheimer's disease drug discovery

inferred← citeshttps://doi.org/10.1016/j.bioorg.2022.105724openalex-snapshot

HDAC1/MAO-B dual inhibitors against Alzheimer’s disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids

inferred← citeshttps://doi.org/10.1016/j.bioorg.2023.106939openalex-snapshot

Novel coumarin benzamides as potent and reversible monoamine oxidase-B inhibitors: Design, synthesis, and neuroprotective effects

inferred← citeshttps://doi.org/10.1016/j.bioorg.2023.107026openalex-snapshot

Design, synthesis, and biological evaluation of novel capsaicin-tacrine hybrids as multi-target agents for the treatment of Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107954openalex-snapshot

Discovery of new 4-aminoquinoline derivatives containing an amine or hydroxamic acid terminal as multifunctional agents for the treatment of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.108012openalex-snapshot

Advances in the structural modification of Alzheimer’s disease drug – Huperzine A

inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108478openalex-snapshot

Design, synthesis and evaluation of novel L-tryptophan derivatives as multifunctional agents with cholinesterase inhibition, anti-β-amyloid aggregation, anti-inflammatory, antioxidant and neuroprotection properties against Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.108747openalex-snapshot

Fragment-informed SAR: rational construction of quinoline derivatives as dual AChE/BChE inhibitors

inferred← citeshttps://doi.org/10.1016/j.bioorg.2025.109372openalex-snapshot

Novel bis-Thiazolidinone -based chalcones with pyridine linker: Eco-friendly synthesis, cholinesterase and beta-amyloid inhibition potency, and molecular docking studies

inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110019openalex-snapshot

β-Maltose-conjugated acetophenone thiosemicarbazones as multitarget inhibitors of diabetes- and Alzheimer's disease-related enzymes: Design, synthesis, and mechanistic evaluation

inferred← citeshttps://doi.org/10.1016/j.bmcl.2021.128100openalex-snapshot

Huprine Y – Tryptophan heterodimers with potential implication to Alzheimer’s disease treatment

inferred← citeshttps://doi.org/10.1016/j.bmcl.2026.130650openalex-snapshot

Novel 2-aminopyrimidine carboxamide derivatives as potential anti-Alzheimer's disease agents: Design, synthesis, biological activity and computational simulation evaluation

inferred← citeshttps://doi.org/10.1016/j.cbi.2023.110623openalex-snapshot

Review of triazole scaffolds for treatment and diagnosis of Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.cbi.2026.112224openalex-snapshot

Interactions-guided blueprint of acetylcholinesterase binding: A review on structural and molecular determinants

inferred← citeshttps://doi.org/10.1016/j.cpan.2025.03.005openalex-snapshot

In silico exploration of Aloe vera leaf compounds as dual AChE and BChE inhibitors for Alzheimer’s disease therapy

inferred← citeshttps://doi.org/10.1016/j.cpb.2024.100414openalex-snapshot

Unlocking the biochemical and computational parameters of Ceropegia foetida: A scientific approach for functional bioactive compounds from a medicinal food plant

inferred← citeshttps://doi.org/10.1016/j.csbj.2021.07.041openalex-snapshot

Neuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase – Design, synthesis and biological evaluation

inferred← citeshttps://doi.org/10.1016/j.ejbt.2023.11.004openalex-snapshot

In silico and in vitro assessment of the anti-β-amyloid aggregation and anti-cholinesterase activities of Ptaeroxylon obliquum and Bauhinia bowkeri extracts

inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.113779openalex-snapshot

From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects

inferred← citeshttps://doi.org/10.1016/j.ejmech.2021.114098openalex-snapshot

Development of novel 2-aminoalkyl-6-(2-hydroxyphenyl)pyridazin-3(2H)-one derivatives as balanced multifunctional agents against Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.ejmech.2022.114825openalex-snapshot

In vitro and in vivo biological evaluation of newly synthesized multi-target 20(R)-panaxadiol derivatives for treating Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.115346openalex-snapshot

Discovery of quinazolin-4(3H)-one derivatives as novel AChE inhibitors with anti-inflammatory activities

inferred← citeshttps://doi.org/10.1016/j.ejmech.2023.116037openalex-snapshot

Click chemistry-aided drug discovery: A retrospective and prospective outlook

inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.117003openalex-snapshot

Natural phenol carbamates: Selective BuChE/FAAH dual inhibitors show neuroprotection in an Alzheimer's disease mouse model

inferred← citeshttps://doi.org/10.1016/j.ejmech.2025.117277openalex-snapshot

Analysis of skeletal diversity of multi-target directed ligands (MTDLs) targeting Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.ejmech.2026.118701openalex-snapshot

Multi-target-directed chromone–carboxamide hybrids: Potent AChE/MAO-B inhibitors with anti-Aβ/Tau and neuroprotective activities

inferred← citeshttps://doi.org/10.1016/j.fct.2024.115028openalex-snapshot

Deciphering the toxicological and computational assessment of Verbascum yemenese.: Integrating phytochemistry and bioinformatics tools

inferred← citeshttps://doi.org/10.1016/j.indcrop.2024.119316openalex-snapshot

Essential oils of Plumeria alba L. and Plumeria rubra L. growing in Egypt: GC/MS analysis, molecular dynamics and in-vitro anti-cholinesterase activity

inferred← citeshttps://doi.org/10.1016/j.inoche.2022.110028openalex-snapshot

Antioxidant activity, enzyme inhibition, electrochemical and theoretical evaluation of novel PEPPSI type N-heterocyclic carbene complexes

inferred← citeshttps://doi.org/10.1016/j.jep.2026.121997openalex-snapshot

Multidimensional pharmacological evaluation of Umbilicus horizontalis (Guss.) DC. leaves and stems: Antioxidant, anti-inflammatory, analgesic, and cholinesterase inhibitory activities

inferred← citeshttps://doi.org/10.1016/j.jsbmb.2026.106950openalex-snapshot

Targeting cholinesterases with steroid hormone derivatives: Insights from In Vitro assays and molecular modeling

inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.142587openalex-snapshot

Exploring 2-mercaptobenzimidazole-derived N-acylhydrazide-hydrazones for anticholinesterase activity: Synthesis, docking, and DFT investigations

inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.143176openalex-snapshot

Novel triazole-based N-Acetyl schiff bases: Synthesis, computational analysis, and acetylcholinesterase and butyrylcholinesterase inhibitory potential for Alzheimer's disease

inferred← citeshttps://doi.org/10.1016/j.molstruc.2025.143407openalex-snapshot

Design and synthesis of benzimidazole analogs as a potent inhibitor of acetylcholinesterase and butyrylcholinesterase and their docking and MD simulation analysis

inferred← citeshttps://doi.org/10.1016/j.prenap.2024.100099openalex-snapshot

Natural products as a source of cholinesterase inhibitors

inferred← citeshttps://doi.org/10.1016/j.steroids.2025.109705openalex-snapshot

Selectivity, stability, and pharmacokinetic profiling of Spongia-derived steroids targeting AChE and BuChE for Alzheimer’s therapy

inferred← citeshttps://doi.org/10.1016/j.tetlet.2021.153176openalex-snapshot

Development of a novel antioxidant based on a dimeric dihydroisocoumarin derivative

inferred← citeshttps://doi.org/10.1021/acs.accounts.3c00617openalex-snapshot

Acetylcholinesterase: A Versatile Template to Coin Potent Modulators of Multiple Therapeutic Targets

inferred← citeshttps://doi.org/10.1021/acs.jafc.5c11580openalex-snapshot

Recent Progress on Capsaicin- and Nonivamide-Type Compounds as Agrochemicals and Drugs

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00048openalex-snapshot

Sustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c01748openalex-snapshot

A New Class of Bi- and Trifunctional Sugar Oximes as Antidotes against Organophosphorus Poisoning

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c02150openalex-snapshot

Discovery and In Vivo Proof of Concept of a Highly Potent Dual Inhibitor of Soluble Epoxide Hydrolase and Acetylcholinesterase for the Treatment of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.3c00541openalex-snapshot

Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer’s Disease Mouse Model

inferred← citeshttps://doi.org/10.1021/acschemneuro.1c00443openalex-snapshot

Exploration of Neuroprotective Properties of a Naturally Inspired Multifunctional Molecule (F24) against Oxidative Stress and Amyloid β Induced Neurotoxicity in Alzheimer’s Disease Models

inferred← citeshttps://doi.org/10.1021/acschemneuro.4c00055openalex-snapshot

Practical Three-Component Regioselective Synthesis of Drug-Like 3-Aryl(or heteroaryl)-5,6-dihydrobenzo[h]cinnolines as Potential Non-Covalent Multi-Targeting Inhibitors To Combat Neurodegenerative Diseases

inferred← citeshttps://doi.org/10.1021/acsomega.4c02980openalex-snapshot

Exploring the Therapeutic Potential of Camellia longii Orel & Luu Leaf Extracts for Memory Loss in Alzheimer’s Disease: Novel Findings and Functional Food Applications

inferred← citeshttps://doi.org/10.1038/s41392-024-01911-3openalex-snapshot

Recent advances in Alzheimer’s disease: mechanisms, clinical trials and new drug development strategies

inferred← citeshttps://doi.org/10.1039/d1md00046bopenalex-snapshot

Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties

inferred← citeshttps://doi.org/10.1039/d2ob00553kopenalex-snapshot

Synthesis and cholinesterase inhibitory activity study of Amaryllidaceae alkaloid analogues with N -methyl substitution

inferred← citeshttps://doi.org/10.1039/d3np00029jopenalex-snapshot

Huperzine alkaloids: forty years of total syntheses

inferred← citeshttps://doi.org/10.1039/d3ra05107bopenalex-snapshot

Synthesis and biological evaluation of capsaicin analogues as antioxidant and neuroprotective agents

inferred← citeshttps://doi.org/10.1039/d4md00060aopenalex-snapshot

Carltonine-derived compounds for targeted butyrylcholinesterase inhibition

inferred← citeshttps://doi.org/10.1080/07391102.2021.1957716openalex-snapshot

Accuracy and precision of binding free energy prediction for a tacrine related lead inhibitor of acetylcholinesterase with an arsenal of supercomputerized molecular modelling methods: a comparative study

inferred← citeshttps://doi.org/10.1080/14756366.2022.2103553openalex-snapshot

Fluorosulfate-containing pyrazole heterocycles as selective BuChE inhibitors: structure-activity relationship and biological evaluation for the treatment of Alzheimer’s disease

inferred← citeshttps://doi.org/10.1080/14756366.2023.2166040openalex-snapshot

Dual-target ligand discovery for Alzheimer’s disease: triphenylphosphoranylidene derivatives as inhibitors of acetylcholinesterase and β-amyloid aggregation

inferred← citeshttps://doi.org/10.1111/cbdd.14462openalex-snapshot

Capsaicin derivatives: Synthesis and biological activity

inferred← citeshttps://doi.org/10.1111/cbdd.14478openalex-snapshot

A recent update on huprine and its hybrids as a potential multifunctional agent for the treatment of Alzheimer's disease

inferred← citeshttps://doi.org/10.1111/fcp.12861openalex-snapshot

Molecular mechanisms of Alzheimer's disease: From therapeutic targets to promising drugs

inferred← citeshttps://doi.org/10.1155/bri/4503245openalex-snapshot

Machine Learning–Driven Bioprospecting of Cholinergic Medicinal Plants for Putative Leads Against Butyrylcholinesterase Towards Alzheimer’s Care

inferred← citeshttps://doi.org/10.1186/s13578-023-01000-yopenalex-snapshot

A novel rhein-huprine hybrid ameliorates disease-modifying properties in preclinical mice model of Alzheimer’s disease exacerbated with high fat diet

inferred← citeshttps://doi.org/10.1371/journal.pone.0326219openalex-snapshot

Novel fungal metabolites as dual cholinesterase inhibitors: A computational approach for Alzheimer’s disease therapy

inferred← citeshttps://doi.org/10.1371/journal.pone.0328457openalex-snapshot

Integrated in silico identification of cholinesterase inhibitors from Nyctanthes arbor-tristis

inferred← citeshttps://doi.org/10.33263/lianbs134.199openalex-snapshot

Polypharmacological and Computational Approaches to Establish HDAC Inhibitors in the Treatment of Alzheimer

inferred← citeshttps://doi.org/10.3389/fnagi.2022.922650openalex-snapshot

A Novel Multifunctional 5,6-Dimethoxy-Indanone-Chalcone-Carbamate Hybrids Alleviates Cognitive Decline in Alzheimer’s Disease by Dual Inhibition of Acetylcholinesterase and Inflammation

inferred← citeshttps://doi.org/10.3389/fnint.2022.799147openalex-snapshot

Differential Role of Sex and Age in the Synaptic Transmission of Degus (Octodon degus)

inferred← citeshttps://doi.org/10.3390/antiox14020162openalex-snapshot

Causal Impacts of Psychiatric Disorders on Cognition and the Mediating Effect of Oxidative Stress: A Mendelian Randomization Study

inferred← citeshttps://doi.org/10.3390/antiox14080921openalex-snapshot

Rivastigmine Templates with Antioxidant Motifs—A Medicinal Chemist’s Toolbox Towards New Multipotent AD Drugs

inferred← citeshttps://doi.org/10.3390/antiox14080985openalex-snapshot

Past and Present of the Antioxidant Studies in Chile: A Bibliometric Study from 2000 to 2024

inferred← citeshttps://doi.org/10.3390/cimb48040407openalex-snapshot

Exploring the Biological Potency of Carotenoids Against Alzheimer’s Disease: An Integrated Approach of Molecular Docking and Molecular Dynamics

inferred← citeshttps://doi.org/10.3390/ijms24021717openalex-snapshot

Tacrine-Based Hybrids: Past, Present, and Future

inferred← citeshttps://doi.org/10.3390/ijms25126310openalex-snapshot

Evaluation of Anticholinesterase Activity of the Fungicides Mefentrifluconazole and Pyraclostrobin

inferred← citeshttps://doi.org/10.3390/molecules30142975openalex-snapshot

Dual Inhibitors of Acetylcholinesterase and Monoamine Oxidase-B for the Treatment of Alzheimer’s Disease

inferred← citeshttps://doi.org/10.3390/nu15061537openalex-snapshot

Capsaicin: A Potential Treatment to Improve Cerebrovascular Function and Cognition in Obesity and Ageing

inferred← citeshttps://doi.org/10.3390/ph15050545openalex-snapshot

Unveiling the Multitarget Anti-Alzheimer Drug Discovery Landscape: A Bibliometric Analysis

inferred← citeshttps://doi.org/10.3390/ph16010083openalex-snapshot

Identification of New N-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors

inferred← citeshttps://doi.org/10.3390/ph19081216openalex-snapshot

Design, Synthesis, In Vitro and In Vivo Evaluation of Novel Anti-Alzheimer’s (1E,4E)-1,5-Bis[(het)aryl]penta-1,4-dien-3-one Derivatives

inferred← citeshttps://doi.org/10.3390/plants12183296openalex-snapshot

Comparative In Vitro and In Silico Enzyme Inhibitory Screening of Rosa x damascena and Pelargonium graveolens Essential Oils and Geraniol

inferred← citeshttps://doi.org/10.4155/fmc-2021-0119openalex-snapshot

Multitarget Therapeutic Approaches for Alzheimer's and Parkinson's Diseases: An Opportunity or an illusion?

Editorial review for independent work. ICSAC — the Institute for Complexity Science and Advanced Computing — runs a structured editorial panel for researchers publishing outside journals, and publishes on CiteStamp rails. Submission is free and goes through ORCID: icsacinstitute.org/submit.