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Identification of New N-methyl-piperazine Chalcones as Dual MAO-B/AChE Inhibitors

https://doi.org/10.3390/ph16010083
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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/ardp.201300242openalex-snapshot
Design, Synthesis, Biological Evaluation, and Molecular Modeling of Coumarin– P iperazine Derivatives as Acetylcholinesterase Inhibitors
inferredcites →https://doi.org/10.1002/cmdc.201600497openalex-snapshot
Monoamine Oxidase Inhibitory Activity: Methyl‐ versus Chlorochalcone Derivatives
inferredcites →https://doi.org/10.1002/cmdc.202000491openalex-snapshot
Selected 1,3‐Benzodioxine‐Containing Chalcones as Multipotent Oxidase and Acetylcholinesterase Inhibitors
inferredcites →https://doi.org/10.1002/ejoc.201201122openalex-snapshot
How are Biogenic Amines Metabolized by Monoamine Oxidases?
inferredcites →https://doi.org/10.1002/jcc.21287openalex-snapshot
CHARMM: The biomolecular simulation program
inferredcites →https://doi.org/10.1002/jcc.21334openalex-snapshot
AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
inferredcites →https://doi.org/10.1002/jhet.4156openalex-snapshot
Phenothiazine‐based chalcones as potential dual‐target inhibitors toward cholinesterases (AChE, BuChE) and monoamine oxidases (MAO‐A, MAO‐B)
inferredcites →https://doi.org/10.1002/slct.201901093openalex-snapshot
Ethoxylated Head of Chalcones as a New Class of Multi‐Targeted MAO Inhibitors
inferredcites →https://doi.org/10.1007/s11356-021-13320-yopenalex-snapshot
Piperazine-substituted chalcones: a new class of MAO-B, AChE, and BACE-1 inhibitors for the treatment of neurological disorders
inferredcites →https://doi.org/10.1016/0006-2952(61)90145-9openalex-snapshot
A new and rapid colorimetric determination of acetylcholinesterase activity
inferredcites →https://doi.org/10.1016/j.bioorg.2018.01.020openalex-snapshot
Synthesis, biological evaluation and molecular modeling studies of phenyl-/benzhydrylpiperazine derivatives as potential MAO inhibitors
inferredcites →https://doi.org/10.1016/j.bioorg.2019.103335openalex-snapshot
Design, synthesis and biological evaluation of oxygenated chalcones as potent and selective MAO-B inhibitors
inferredcites →https://doi.org/10.1016/j.bioorg.2019.103477openalex-snapshot
Flurbiprofen-chalcone hybrid Mannich base derivatives as balanced multifunctional agents against Alzheimer’s disease: Design, synthesis and biological evaluation
inferredcites →https://doi.org/10.1016/j.bioorg.2022.106007openalex-snapshot
Novel donepezil-chalcone-rivastigmine hybrids as potential multifunctional anti-Alzheimer's agents: Design, synthesis, in vitro biological evaluation, in vivo and in silico studies
inferredcites →https://doi.org/10.1016/j.bmc.2016.12.013openalex-snapshot
Design, synthesis and biological evaluation of 4′-aminochalcone-rivastigmine hybrids as multifunctional agents for the treatment of Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.bmcl.2016.08.044openalex-snapshot
Potent selective monoamine oxidase B inhibition by maackiain, a pterocarpan from the roots of Sophora flavescens
inferredcites →https://doi.org/10.1016/j.ddtec.2004.11.007openalex-snapshot
Lead- and drug-like compounds: the rule-of-five revolution
inferredcites →https://doi.org/10.1016/j.ejmech.2011.02.071openalex-snapshot
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.ejmech.2016.02.038openalex-snapshot
Design and synthesis of novel chalcones as potent selective monoamine oxidase-B inhibitors
inferredcites →https://doi.org/10.1016/j.ejmech.2018.07.056openalex-snapshot
Multi-target-directed ligands for Alzheimer's disease: Discovery of chromone-based monoamine oxidase/cholinesterase inhibitors
inferredcites →https://doi.org/10.1016/j.ejmech.2019.05.020openalex-snapshot
Multi-target design strategies for the improved treatment of Alzheimer's disease
inferredcites →https://doi.org/10.1016/j.ejmech.2019.07.040openalex-snapshot
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands
inferredcites →https://doi.org/10.1016/j.ejmech.2020.112650openalex-snapshot
Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors
inferredcites →https://doi.org/10.1016/j.ejmech.2021.113310openalex-snapshot
Design, synthesis and evaluation of novel dimethylamino chalcone-O-alkylamines derivatives as potential multifunctional agents against Alzheimer’s disease
inferredcites →https://doi.org/10.1016/j.ijbiomac.2020.02.144openalex-snapshot
Calycosin and 8-O-methylretusin isolated from Maackia amurensis as potent and selective reversible inhibitors of human monoamine oxidase-B
inferredcites →https://doi.org/10.1016/s1474-4422(18)30295-3openalex-snapshot
Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
inferredcites →https://doi.org/10.1021/acs.chemrev.7b00020openalex-snapshot
Chalcone: A Privileged Structure in Medicinal Chemistry
inferredcites →https://doi.org/10.1021/acs.jmedchem.0c01775openalex-snapshot
Discovery of a Potent Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase with Antioxidant Activity that Alleviates Alzheimer-like Pathology in Old APP/PS1 Mice
inferredcites →https://doi.org/10.1021/acs.jmedchem.1c00963openalex-snapshot
Small Molecule Kinase Inhibitor Drugs (1995–2021): Medical Indication, Pharmacology, and Synthesis
inferredcites →https://doi.org/10.1021/acs.jmedchem.1c01784openalex-snapshot
Probing Fluorinated Motifs onto Dual AChE-MAO B Inhibitors: Rational Design, Synthesis, Biological Evaluation, and Early-ADME Studies
inferredcites →https://doi.org/10.1021/jm300978hopenalex-snapshot
Multitarget-Directed Benzylideneindanone Derivatives: Anti-β-Amyloid (Aβ) Aggregation, Antioxidant, Metal Chelation, and Monoamine Oxidase B (MAO-B) Inhibition Properties against Alzheimer’s Disease
inferredcites →https://doi.org/10.1021/jm801590uopenalex-snapshot
Chalcones: A Valid Scaffold for Monoamine Oxidases Inhibitors
inferredcites →https://doi.org/10.1038/nprot.2016.051openalex-snapshot
Computational protein–ligand docking and virtual drug screening with the AutoDock suite
inferredcites →https://doi.org/10.1038/srep42717openalex-snapshot
SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules
inferredcites →https://doi.org/10.1073/pnas.0710626105openalex-snapshot
Structure of human monoamine oxidase A at 2.2-Å resolution: The control of opening the entry for substrates/inhibitors
inferredcites →https://doi.org/10.1073/pnas.102179699openalex-snapshot
Evaluating conformational free energies: The colony energy and its application to the problem of loop prediction
inferredcites →https://doi.org/10.1080/13543776.2016.1189902openalex-snapshot
Piperazine derivatives for therapeutic use: a patent review (2010-present)
inferredcites →https://doi.org/10.1080/14756366.2020.1842390openalex-snapshot
Morpholine-based chalcones as dual-acting monoamine oxidase-B and acetylcholinesterase inhibitors: synthesis and biochemical investigations
inferredcites →https://doi.org/10.1111/fcp.12408openalex-snapshot
Piperazine derivatives with central pharmacological activity used as therapeutic tools
inferredcites →https://doi.org/10.1126/sciadv.aav0316openalex-snapshot
Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease
inferredcites →https://doi.org/10.1212/wnl.47.6_suppl_3.161sopenalex-snapshot
Oxidative stress and the pathogenesis of Parkinson's disease
inferredcites →https://doi.org/10.1517/13543776.2012.698613openalex-snapshot
Patent-related survey on new monoamine oxidase inhibitors and their therapeutic potential
inferredcites →https://doi.org/10.2147/ppa.s11182openalex-snapshot
Efficacy, safety, and patient preference of monoamine oxidase B inhibitors in the treatment of Parkinson's disease
inferredcites →https://doi.org/10.2174/0929867325666180111101843openalex-snapshot
Multi-Target Directed Drugs as a Modern Approach for Drug Design Towards Alzheimer’s Disease: An Update
inferredcites →https://doi.org/10.2174/1386207323666200428091306openalex-snapshot
A Comprehensive Review of Monoamine Oxidase-A Inhibitors in their Syntheses and Potencies
inferredcites →https://doi.org/10.2174/1568026621999210902123132openalex-snapshot
Recent Updates on Pyrazoline Derivatives as Promising Candidates for Neuropsychiatric and Neurodegenerative Disorders
inferredcites →https://doi.org/10.3390/ijms20030719openalex-snapshot
Novel Approaches for the Treatment of Alzheimer’s and Parkinson’s Disease
inferredcites →https://doi.org/10.3390/molecules25214941openalex-snapshot
Newly Synthesized Fluorinated Cinnamylpiperazines Possessing Low In Vitro MAO-B Binding

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.3897/pharmacia.72.e164727zenodo-depositor-declared
Multi-target monoamine oxidase-B (MAO-B) inhibitors in the treatment of Parkinson’s disease
inferred← citeshttps://doi.org/10.1002/ardp.70046openalex-snapshot
Click Chemistry‐Aided Synthesis of Triazole‐Tethered Benzothiazoles as Novel Multifunctional Agents Against Alzheimer's Disease
inferred← citeshttps://doi.org/10.1002/ddr.70349openalex-snapshot
Discovery of a Potent and Selective MAO‐B Inhibitor From a Donepezil‐Linked Chalcone Library With Promising Antiparkinsonian Activity
inferred← citeshttps://doi.org/10.1002/slct.202400465openalex-snapshot
Chalcones with N‐Methylpiperazine Moiety: Synthesis, Monoamine Oxidase Inhibition, Neuroprotective Effect and Computer Simulation Study
inferred← citeshttps://doi.org/10.1002/slct.202404717openalex-snapshot
Inhibitory Activity of Chalcones as MAO‐B Inhibitors: An Insight from Molecular Docking, ADME Analysis, MD Simulation, and MM‐PBSA Calculations
inferred← citeshttps://doi.org/10.1007/s00894-024-05889-1openalex-snapshot
Probing the inhibition of MAO-B by chalcones: an integrated approach combining molecular docking, ADME analysis, MD simulation, and MM-PBSA calculations
inferred← citeshttps://doi.org/10.1007/s11030-024-10841-9openalex-snapshot
Rational design, synthesis, biological evaluation, and molecular modeling of novel naphthamide derivatives possessing potent, reversible, and competitive inhibitory mode of action over human monoamine oxidase
inferred← citeshttps://doi.org/10.1007/s11030-024-10959-wopenalex-snapshot
Inhibition of monoamine oxidases and neuroprotective effects: chalcones vs. chromones
inferred← citeshttps://doi.org/10.1007/s11030-026-11733-wopenalex-snapshot
Discovery of potent and selective MAO-B inhibitors from a morpholine-substituted chalcone library for neurodegenerative disorders
inferred← citeshttps://doi.org/10.1007/s11696-026-04818-1openalex-snapshot
Piperazine as a privileged scaffold in medicinal chemistry: biological activities, synthetic strategies, and multitarget drug design
inferred← citeshttps://doi.org/10.1016/b978-0-443-43812-7.00001-0openalex-snapshot
Chalcones as neuroprotective and anti-Alzheimer’s disease agents
inferred← citeshttps://doi.org/10.1016/b978-0-443-43812-7.00011-3openalex-snapshot
Pharmacokinetic properties, pharmacomicrobiomics, and bioavailability of natural and synthetic chalcones
inferred← citeshttps://doi.org/10.1016/j.bioorg.2023.106939openalex-snapshot
Novel coumarin benzamides as potent and reversible monoamine oxidase-B inhibitors: Design, synthesis, and neuroprotective effects
inferred← citeshttps://doi.org/10.1016/j.bioorg.2026.110013openalex-snapshot
Identification of a nanomolar, selective MAO-B inhibitor from piperidine-based chalcones with anti-Parkinson potential
inferred← citeshttps://doi.org/10.1016/j.bmcl.2026.130716openalex-snapshot
Rational design, synthesis, and biological evaluation of chalcone hybrids including benzoylpiperazin (phenylacetylpiperazin)-thiophene as anti- Alzheimer's agents
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116810openalex-snapshot
Dual-target inhibitors based on acetylcholinesterase: Novel agents for Alzheimer's disease
inferred← citeshttps://doi.org/10.1016/j.lfs.2023.121568openalex-snapshot
An ongoing journey of chalcone analogues as single and multi-target ligands in the field of Alzheimer's disease: A review with structural aspects
inferred← citeshttps://doi.org/10.1016/j.molstruc.2024.140503openalex-snapshot
Isatin derived morpholine and piperazine derivatives as acetylcholinesterase inhibitors
inferred← citeshttps://doi.org/10.1016/j.molstruc.2026.147033openalex-snapshot
Synthesis, spectroscopic characterizations and structural analysis of (E)-1-(4-(4-(2-hydroxyethyl)piperazin-1-yl)phenyl)-3-phenylprop-2-en-1-one
inferred← citeshttps://doi.org/10.1016/j.tet.2025.134978openalex-snapshot
Novel piperazine derivatives as MAO-B inhibitors: Design, synthesis and computational exploration through molecular docking, MD simulations, MM-PBSA and DFT studies
inferred← citeshttps://doi.org/10.1021/acsinfecdis.5c00564openalex-snapshot
Synthesis of Innovative Photosensitizers for Enhanced Photodynamic Therapy of Drug-Resistant Pathogens and Biofilms
inferred← citeshttps://doi.org/10.1039/d5ra06971hopenalex-snapshot
Inhibition of monoamine oxidase by fluorobenzyloxy chalcone derivatives
inferred← citeshttps://doi.org/10.1039/d6ra05787jopenalex-snapshot
Discovery of tricyclic benzo[4,5]imidazo[2,1- b ]thiazole-3-hydroxyindolin-2-one hybrids as selective MAO-B and cholinesterase inhibitors
inferred← citeshttps://doi.org/10.1080/10286020.2026.2693149openalex-snapshot
Study on structural modification and hepatoprotective activities of shikonofuran derivatives
inferred← citeshttps://doi.org/10.2174/0115701786403432260129211331openalex-snapshot
Advances in Synthesis of Piperazine Analogues and Molecular Targets: Unlocking Their Potential in CNS Disorder Therapy
inferred← citeshttps://doi.org/10.3390/ijms24098164openalex-snapshot
β-Secretase-1: In Silico Drug Reposition for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/ijms24119482openalex-snapshot
Towards Novel Potential Molecular Targets for Antidepressant and Antipsychotic Pharmacotherapies
inferred← citeshttps://doi.org/10.52711/0974-360x.2025.00589openalex-snapshot
Unveiling Pyridocarbazole Fused with Carbamate as MAO-B Inhibitors using In silico and In vitro approaches
inferred← citeshttps://doi.org/10.55971/ejls.1497639openalex-snapshot
Investigation of dual AChE/MAO inhibitory activities of new morpholine and piperazine structured compounds
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