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Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cbdv.201400435openalex-snapshot
Chemical Constituents and Biological Activities of Plants from the Genus Physalis
inferredcites →https://doi.org/10.1002/hlca.200900005openalex-snapshot
Two New Withanolides from Physalis peruviana
inferredcites →https://doi.org/10.1002/mnfr.201500977openalex-snapshot
Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4β‐hydroxywithanolide E isolated fromPhysalis peruviana
inferredcites →https://doi.org/10.1007/s10637-012-9796-8openalex-snapshot
Antiangiogenic therapy for advanced renal cell carcinoma: Management of treatment-related toxicities
inferredcites →https://doi.org/10.1007/s12325-010-0038-1openalex-snapshot
Castration-refractory prostate cancer: New drugs in the pipeline
inferredcites →https://doi.org/10.1007/s40265-013-0129-9openalex-snapshot
Enzalutamide: A Review of Its Use in Metastatic, Castration-Resistant Prostate Cancer
inferredcites →https://doi.org/10.1016/0031-9422(93)85510-xopenalex-snapshot
Chemical defence by withanolides during fruit development in Physalis peruviana
inferredcites →https://doi.org/10.1016/j.bmcl.2016.04.077openalex-snapshot
Withanolides derived from Physalis peruviana (Poha) with potential anti-inflammatory activity
inferredcites →https://doi.org/10.1016/j.fct.2013.12.026openalex-snapshot
Non-homologous end joining pathway is the major route of protection against 4β-hydroxywithanolide E-induced DNA damage in MCF-7 cells
inferredcites →https://doi.org/10.1016/j.foodchem.2009.02.061openalex-snapshot
New cytotoxic withanolides from Physalis peruviana
inferredcites →https://doi.org/10.1016/j.phytochem.2010.12.020openalex-snapshot
Unusual withanolides from aeroponically grown Withania somnifera
inferredcites →https://doi.org/10.1016/j.steroids.2011.09.011openalex-snapshot
Ten new withanolides from Physalis peruviana
inferredcites →https://doi.org/10.1016/s0031-9422(00)80156-9openalex-snapshot
Potential biogenetic precursors of withanolides from withania coagulans
inferredcites →https://doi.org/10.1016/s0031-9422(96)00553-5openalex-snapshot
28-Hydroxywithanolide E from Physalis peruviana
inferredcites →https://doi.org/10.1016/s0040-4020(02)00277-6openalex-snapshot
Isolation and characterization of bioactive principles of the leaves and stems of Physalis philadelphica
inferredcites →https://doi.org/10.1021/acs.jmedchem.5b00867openalex-snapshot
Discovery of Potent 17β-Hydroxywithanolides for Castration-Resistant Prostate Cancer by High-Throughput Screening of a Natural Products Library for Androgen-Induced Gene Expression Inhibitors
inferredcites →https://doi.org/10.1021/acs.jnatprod.5b00911openalex-snapshot
17β-Hydroxy-18-acetoxywithanolides from Aeroponically Grown Physalis crassifolia and Their Potent and Selective Cytotoxicity for Prostate Cancer Cells
inferredcites →https://doi.org/10.1021/ml400144eopenalex-snapshot
Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation
inferredcites →https://doi.org/10.1021/np0701374openalex-snapshot
Isolation, Structures, and Structure−Cytotoxic Activity Relationships of Withanolides and Physalins from Physalis angulata
inferredcites →https://doi.org/10.1038/aps.2014.18openalex-snapshot
Androgen receptor: structure, role in prostate cancer and drug discovery
inferredcites →https://doi.org/10.1038/cddis.2015.38openalex-snapshot
Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation
inferredcites →https://doi.org/10.1038/nature13229openalex-snapshot
Therapeutic targeting of BET bromodomain proteins in castration-resistant prostate cancer
inferredcites →https://doi.org/10.1038/nm972openalex-snapshot
Molecular determinants of resistance to antiandrogen therapy
inferredcites →https://doi.org/10.1039/c0np00045kopenalex-snapshot
Natural withanolides: an overview
inferredcites →https://doi.org/10.1039/p19770000341openalex-snapshot
Naturally occurring steroidal lactones with a 17α-oriented side chain. Structure of withanolide E and related compounds
inferredcites →https://doi.org/10.1039/p19810001029openalex-snapshot
Withaperuvin and 4-deoxyphysalolactone, two new ergostane-type steroids from Physalis peruviana(Solanaceae)
inferredcites →https://doi.org/10.1039/p19860000229openalex-snapshot
Selective cleavage of ditertiary glycols under mild conditions, with bisacetylacetonato-oxovanadium
inferredcites →https://doi.org/10.1053/j.seminoncol.2006.06.004openalex-snapshot
Interleukin-2 Therapy of Metastatic Renal Cell Carcinoma—Predictors of Response
inferredcites →https://doi.org/10.1055/s-2006-957884openalex-snapshot
Withanolide Composition andin vitroCulture of ItalianWithania somnifera
inferredcites →https://doi.org/10.1080/10286020.2010.482523openalex-snapshot
A novel 1,10-seco withanolide from Physalis peruviana
inferredcites →https://doi.org/10.1158/1078-0432.ccr-10-0567openalex-snapshot
New Strategies in Metastatic Prostate Cancer: Targeting the Androgen Receptor Signaling Pathway
inferredcites →https://doi.org/10.1158/1541-7786.mcr-10-0022openalex-snapshot
Bortezomib Sensitizes Human Renal Cell Carcinomas to TRAIL Apoptosis through Increased Activation of Caspase-8 in the Death-Inducing Signaling Complex
inferredcites →https://doi.org/10.1186/1471-2407-10-46openalex-snapshot
4β-Hydroxywithanolide E from Physalis peruviana (golden berry) inhibits growth of human lung cancer cells through DNA damage, apoptosis and G2/M arrest
inferredcites →https://doi.org/10.1248/cpb.41.1873openalex-snapshot
Part XXVII. Studies on the constituents of solanaceous plants. Physapruins A and B, Two New Withanolides from Physalis pruinosa BAILEY.
inferredcites →https://doi.org/10.1248/cpb.47.477openalex-snapshot
New Withanolide Glycosides from Physalis peruviana L.
inferredcites →https://doi.org/10.1371/journal.pone.0037764openalex-snapshot
Withanolides-Induced Breast Cancer Cell Death Is Correlated with Their Ability to Inhibit Heat Protein 90
inferredcites →https://doi.org/10.1371/journal.pone.0064739openalex-snapshot
Golden Berry-Derived 4β-hydroxywithanolide E for Selectively Killing Oral Cancer Cells by Generating ROS, DNA Damage, and Apoptotic Pathways
inferredcites →https://doi.org/10.3322/caac.20107openalex-snapshot
Global cancer statistics

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113301zenodo-depositor-declared
Anti-inflammatory withanolides from the aerial parts of Physalis minima
inferred← citeshttps://doi.org/10.1002/jsfa.10386openalex-snapshot
Composition and biological effects of goldenberry byproducts: an overview
inferred← citeshttps://doi.org/10.1002/vjch.2019000133openalex-snapshot
The anti‐microbial activities of secosteroids isolated from Physalis angulata
inferred← citeshttps://doi.org/10.1007/978-3-030-31885-7_34openalex-snapshot
Physalis peruviana Linnaeus, an Update on its Functional Properties and Beneficial Effects in Human Health
inferred← citeshttps://doi.org/10.1007/s11130-020-00821-3openalex-snapshot
A review of nutritional properties and health benefits of Physalis species
inferred← citeshttps://doi.org/10.1007/s13668-025-00659-8openalex-snapshot
The Emerging Superfruit: Physalis peruviana's Role in Revolutionizing the Nutraceutical and Food Industries
inferred← citeshttps://doi.org/10.1016/b978-0-443-15433-1.00013-3openalex-snapshot
Physicochemical, nutritional, and bioactive characteristics of Physalis peruviana L. fruit
inferred← citeshttps://doi.org/10.1016/b978-0-443-15433-1.00021-2openalex-snapshot
Withanolides from Physalis peruviana
inferred← citeshttps://doi.org/10.1016/b978-0-443-15433-1.00030-3openalex-snapshot
Physalis peruviana intake against noncommunicable chronic diseases: a biomedical approach
inferred← citeshttps://doi.org/10.1016/bs.afnr.2022.03.004openalex-snapshot
The powerful Solanaceae: Food and nutraceutical applications in a sustainable world
inferred← citeshttps://doi.org/10.1016/j.bioorg.2018.08.034openalex-snapshot
Cytotoxic withanolides from the aerial parts of Tubocapsicum anomalum
inferred← citeshttps://doi.org/10.1016/j.bioorg.2019.03.051openalex-snapshot
Withanolides from Physalis peruviana showing nitric oxide inhibitory effects and affinities with iNOS
inferred← citeshttps://doi.org/10.1016/j.foodchem.2023.138136openalex-snapshot
Cytotoxic withanolides from the stems and leaves of Physalis ixocarpa
inferred← citeshttps://doi.org/10.1016/j.heliyon.2021.e06173openalex-snapshot
Chemical constituents and their biological activities from Taunggyi (Shan state) medicinal plants
inferred← citeshttps://doi.org/10.1016/j.nutos.2022.06.005openalex-snapshot
Efficacy of physalis peruviana on restoring histopathological alternations against lead induced toxicity in albino rats
inferred← citeshttps://doi.org/10.1016/j.phytochem.2018.04.018openalex-snapshot
Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica
inferred← citeshttps://doi.org/10.1016/j.sajb.2026.01.037openalex-snapshot
Goldenberry (Physalis peruviana) as source of anti-skin aging compounds: UPLC-ESI/MS-MS metabolic profiling, In vitro and In-Silico molecular approaches
inferred← citeshttps://doi.org/10.1016/j.scienta.2020.109307openalex-snapshot
Reproductive biology of Physalis angulata L. (Solanaceae)
inferred← citeshttps://doi.org/10.1016/j.steroids.2020.108776openalex-snapshot
The synthesis and cytotoxic activity of derivatives of 4β-hydroxywithanolide E
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01770openalex-snapshot
Physachenolide C is a Potent, Selective BET Inhibitor
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c00446openalex-snapshot
Structure–Activity Relationships of Withanolides as Antiproliferative Agents for Multiple Myeloma: Comparison of Activity in 2D Models and a 3D Coculture Model
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.1c00724openalex-snapshot
Ring A/B-Modified 17β-Hydroxywithanolide Analogues as Antiproliferative Agents for Prostate Cancer and Potentiators of Immunotherapy for Renal Carcinoma and Melanoma
inferred← citeshttps://doi.org/10.1038/s41598-021-84207-8openalex-snapshot
Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells
inferred← citeshttps://doi.org/10.1039/d1np00055aopenalex-snapshot
Natural withanolides, an update
inferred← citeshttps://doi.org/10.1042/bsr20192826openalex-snapshot
Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway
inferred← citeshttps://doi.org/10.1080/10286020.2022.2095263openalex-snapshot
Two new withanolides from the whole plants of Physalis peruviana
inferred← citeshttps://doi.org/10.1080/13880209.2025.2488136openalex-snapshot
Biologically active withanolides from Physalis peruviana
inferred← citeshttps://doi.org/10.1080/14786419.2024.2323539openalex-snapshot
Withaperuvin O, a new withanolide from Physalis peruviana L
inferred← citeshttps://doi.org/10.1080/14786419.2024.2354858openalex-snapshot
Two new withanolides from Physalis minima L
inferred← citeshttps://doi.org/10.1080/21655979.2020.1868733openalex-snapshot
Puerarin induces apoptosis in prostate cancer cells via inactivation of the Keap1/Nrf2/ARE signaling pathway
inferred← citeshttps://doi.org/10.1111/1750-3841.14916openalex-snapshot
Metabolomic Profiling of Carotenoid Constituents in Physalis peruviana During Different Growth Stages by LC‐MS/MS Technology
inferred← citeshttps://doi.org/10.1111/jphp.13209openalex-snapshot
Withanolides from the genus Physalis: a review on their phytochemical and pharmacological aspects
inferred← citeshttps://doi.org/10.1515/chem-2024-0040openalex-snapshot
Optimization of polyphenol extraction, phenolic profile by LC-ESI-MS/MS, antioxidant, anti-enzymatic, and cytotoxic activities of Physalis acutifolia
inferred← citeshttps://doi.org/10.24820/ark.5550190.p010.610openalex-snapshot
Newly discovered naturally occurring organohalogens
inferred← citeshttps://doi.org/10.31083/j.fbl2703098openalex-snapshot
Peruranolides A–D, four new withanolides with potential antibacterial and cytotoxic activity from Physalis peruviana L.
inferred← citeshttps://doi.org/10.32870/e-cucba.v0i13.144openalex-snapshot
LA SALINIDAD INCREMENTA EL CONTENIDO DE FLAVONOIDES, DE ANTOCIANINAS Y EL POTENCIAL HIPOGLUCEMIANTE DE TOMATILLO (Physalis ixocarpa)
inferred← citeshttps://doi.org/10.33448/rsd-v10i10.18700openalex-snapshot
Physalis peruviana L.: perspectiva de aplicabilidade no tratamento de câncer
inferred← citeshttps://doi.org/10.3389/fchem.2018.00276openalex-snapshot
Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone
inferred← citeshttps://doi.org/10.3389/fphar.2020.00397openalex-snapshot
Unraveling Plant Natural Chemical Diversity for Drug Discovery Purposes
inferred← citeshttps://doi.org/10.3390/antiox10030393openalex-snapshot
Physalis peruviana-Derived Physapruin A (PHA) Inhibits Breast Cancer Cell Proliferation and Induces Oxidative-Stress-Mediated Apoptosis and DNA Damage
inferred← citeshttps://doi.org/10.3390/antiox11071352openalex-snapshot
Physapruin A Induces Reactive Oxygen Species to Trigger Cytoprotective Autophagy of Breast Cancer Cells
inferred← citeshttps://doi.org/10.3390/antiox11112227openalex-snapshot
Combined Treatment (Ultraviolet-C/Physapruin A) Enhances Antiproliferation and Oxidative-Stress-Associated Mechanism in Oral Cancer Cells
inferred← citeshttps://doi.org/10.3390/cancers14061455openalex-snapshot
Hidden in Plants—A Review of the Anticancer Potential of the Solanaceae Family in In Vitro and In Vivo Studies
inferred← citeshttps://doi.org/10.3390/fermentation8030128openalex-snapshot
Health Benefits of Postbiotics Produced by E. coli Nissle 1917 in Functional Yogurt Enriched with Cape Gooseberry (Physalis peruviana L.)
inferred← citeshttps://doi.org/10.3390/foods10112699openalex-snapshot
Chemical Characterization, Nutritional and Bioactive Properties of Physalis peruviana Fruit from High Areas of the Atacama Desert
inferred← citeshttps://doi.org/10.3390/ijms23168839openalex-snapshot
Physapruin A Enhances DNA Damage and Inhibits DNA Repair to Suppress Oral Cancer Cell Proliferation
inferred← citeshttps://doi.org/10.3390/ijms24108853openalex-snapshot
Physapruin A Exerts Endoplasmic Reticulum Stress to Trigger Breast Cancer Cell Apoptosis via Oxidative Stress
inferred← citeshttps://doi.org/10.3390/molecules27030886openalex-snapshot
Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides
inferred← citeshttps://doi.org/10.3390/molecules27030909openalex-snapshot
Production and Structural Diversification of Withanolides by Aeroponic Cultivation of Plants of Solanaceae: Cytotoxic and Other Withanolides from Aeroponically Grown Physalis coztomatl
inferred← citeshttps://doi.org/10.3390/ph17060750openalex-snapshot
A Machine Learning Approach for Predicting Caco-2 Cell Permeability in Natural Products from the Biodiversity in Peru
inferred← citeshttps://doi.org/10.34172/jhp.2022.04openalex-snapshot
Chemical constituents and evidence-based pharmacological properties of Physalis peruviana L.: An overview
inferred← citeshttps://doi.org/10.3762/bjoc.15.196openalex-snapshot
Isolation and characterisation of irinans, androstane-type withanolides from Physalis peruviana L.
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