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Isolation, Structures, and Structure−Cytotoxic Activity Relationships of Withanolides and Physalins from Physalis angulata

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1007/bf00579480openalex-snapshot

Withasteroids ofPhysalis. IV. 28-Hydrowithaphysanolide.13C NMR spectrum of 14-?-hydroxywithasteroids

inferredcites →https://doi.org/10.1007/bf00579481openalex-snapshot

Triterpene saponins fromThalictrum minus. III. The structure of thalicogenin

inferredcites →https://doi.org/10.1016/s0031-9422(00)81775-6openalex-snapshot

Homoheveadride, a cyclononadiene bis-anhydride from Cladonia polycarpoides

inferredcites →https://doi.org/10.1016/s0031-9422(00)89029-9openalex-snapshot

4β-Hydroxywithanolide E, a new natural steroid with a 17α-oriented side-chain

inferredcites →https://doi.org/10.1016/s0031-9422(00)89030-5openalex-snapshot

Isolation of 2-(4-hydroxybenzyl)malic acid from Lycoris radiata

inferredcites →https://doi.org/10.1016/s0031-9422(03)00183-3openalex-snapshot

Chemical and cytotoxic constituents from Peperomia sui

inferredcites →https://doi.org/10.1021/jf970246wopenalex-snapshot

Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos)

inferredcites →https://doi.org/10.1021/np0106337openalex-snapshot

Induction of Quinone Reductase by Withanolides

inferredcites →https://doi.org/10.1021/np50098a021openalex-snapshot

Insect Inhibitory Steroidal Saccharide Esters from Physalis peruviana

inferredcites →https://doi.org/10.1021/np50125a004openalex-snapshot

Structural Revision of Physalin H Isolated from Physalis angulata

inferredcites →https://doi.org/10.1039/np9910800415openalex-snapshot

Withanolides and related ergostane-type steroids

inferredcites →https://doi.org/10.1080/10286020108041391openalex-snapshot

The Structure of Physalin T fromPhysalis alkekengivar.francheti

inferredcites →https://doi.org/10.1248/cpb.41.1873openalex-snapshot

Part XXVII. Studies on the constituents of solanaceous plants. Physapruins A and B, Two New Withanolides from Physalis pruinosa BAILEY.

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Naturally occurring physalins from the genus Physalis: A review

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Domino Reactions in the Total Synthesis of Natural Products

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Synthesis of the DFGH ring system of Type B Physalins: Highly Oxygenated, Cage‐Shaped Molecules

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Synthesis of the DFGH ring system of Type B Physalins: Highly Oxygenated, Cage‐Shaped Molecules

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Chemical Constituents and Biological Activities of Plants from the Genus Physalis

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Phytochemical Study of the Genus Salpichroa (Solanaceae), Chemotaxonomic Considerations, and Biological Evaluation in Prostate and Breast Cancer Cells

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Naturally Occurring Small‐Molecule Inhibitors of Hedgehog/GLI‐Mediated Transcription

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Withanolides from Aureliana fasciculata var. fasciculata

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Synthesis of the Right‐Side Structure of Type B Physalins

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Identification and quantitative analysis of physalin D and its metabolites in rat urine and feces by liquid chromatography with triple quadrupole time‐of‐flight mass spectrometry

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Induction of cell cycle arrest and apoptosis with downregulation of Hsp90 client proteins and histone modification by 4β‐hydroxywithanolide E isolated fromPhysalis peruviana

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Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

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Withanolides: Promising candidates for cancer therapy

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Withanolides from the whole plant of Physalis angulata and their anti‐inflammatory activities

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Small-Molecule Inhibitors of the Hedgehog Pathway

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Natural Withanolides in the Treatment of Chronic Diseases

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Withanolides: Chemistry and Antitumor Activity

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Withanolides and Related Steroids

inferred← citeshttps://doi.org/10.1007/978-94-007-5628-1_34openalex-snapshot

Physalis angulata

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Physalis minima L.: A comprehensive review on phytochemistry, pharmacology, and food applications

inferred← citeshttps://doi.org/10.1007/s11101-015-9420-6openalex-snapshot

Phytochemistry and biosynthesis of δ-lactone withanolides

inferred← citeshttps://doi.org/10.1007/s11101-026-10240-yopenalex-snapshot

Withanolides as molecular inhibitors in oral squamous cell carcinoma: unveiling anticancer mechanisms and therapeutic targets

inferred← citeshttps://doi.org/10.1007/s11130-020-00821-3openalex-snapshot

A review of nutritional properties and health benefits of Physalis species

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The interplay of Ashwagandha with hormonal dynamics and gut microbiota in women with breast cancer: a tri-axial perspective

inferred← citeshttps://doi.org/10.1007/s42161-025-02103-wopenalex-snapshot

First report of cucumber mosaic virus infecting Physalis angulata L. in China

inferred← citeshttps://doi.org/10.1007/s42535-025-01581-8openalex-snapshot

Micromorphology and histochemical secretion profiling of glandular trichomes in the leaf and stem epidermis of Physalis angulata L. (Solanaceae)

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Cancer Chemopreventive and Cytotoxic Activities of Isowithametelin from Datura innoxia

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Eight-Membered Rings With One Oxygen Atom

inferred← citeshttps://doi.org/10.1016/b978-0-443-21842-2.00003-6openalex-snapshot

Withanolides as anti-prostate cancer agents of promise

inferred← citeshttps://doi.org/10.1016/b978-008044992-0.01219-0openalex-snapshot

Eight-membered Rings with One Oxygen Atom

inferred← citeshttps://doi.org/10.1016/j.bcp.2009.09.017openalex-snapshot

Withaferin A targets heat shock protein 90 in pancreatic cancer cells

inferred← citeshttps://doi.org/10.1016/j.bcp.2010.04.016openalex-snapshot

Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations

inferred← citeshttps://doi.org/10.1016/j.bioorg.2019.103541openalex-snapshot

New withanolides with anti-inflammatory activity from the leaves of Datura metel L.

inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.108082openalex-snapshot

Physalins and neophysalins from the calyx of Physalis alkekengi: Structures and anti-inflammatory efficacy

inferred← citeshttps://doi.org/10.1016/j.bmc.2018.05.009openalex-snapshot

Design and synthesis of new antitumor agents with the 1,7-epoxycyclononane framework. Study of their anticancer action mechanism by a model compound

inferred← citeshttps://doi.org/10.1016/j.chroma.2017.09.070openalex-snapshot

High performance thin-layer chromatography–mass spectrometry enables reliable analysis of physalins in different plant parts of Physalis alkekengi L.

inferred← citeshttps://doi.org/10.1016/j.ejmech.2012.05.032openalex-snapshot

Withaferin A-related steroids from Withania aristata exhibit potent antiproliferative activity by inducing apoptosis in human tumor cells

inferred← citeshttps://doi.org/10.1016/j.ejphar.2012.04.012openalex-snapshot

Stephanthraniline A inhibits the proliferation and activation of T cells in vitro and in vivo

inferred← citeshttps://doi.org/10.1016/j.etap.2013.10.013openalex-snapshot

Genotoxicity and antileishmanial activity evaluation of Physalis angulata concentrated ethanolic extract

inferred← citeshttps://doi.org/10.1016/j.fitote.2024.105950openalex-snapshot

In vitro inhibition of 5-α reductase and in vivo suppression of benign prostatic hyperplasia by Physalis angulata ethyl acetate extract

inferred← citeshttps://doi.org/10.1016/j.fitote.2024.106124openalex-snapshot

Anti-tumor withanolides as signal transducers and activators of transcription 3 (STAT3)-inhibition from Withania obtusifolia

inferred← citeshttps://doi.org/10.1016/j.jchromb.2010.12.032openalex-snapshot

Plasma pharmacokinetics and tissue distribution study of physalin D in rats by ultra-pressure liquid chromatography with tandem mass spectrometry

inferred← citeshttps://doi.org/10.1016/j.jchromb.2018.02.022openalex-snapshot

Comparisons of the pharmacokinetic and tissue distribution profiles of withanolide B after intragastric administration of the effective part of Datura metel L. in normal and psoriasis guinea pigs

inferred← citeshttps://doi.org/10.1016/j.jep.2008.03.004openalex-snapshot

Diuretic activity of some Withania aristata Ait. fractions

inferred← citeshttps://doi.org/10.1016/j.jep.2010.04.007openalex-snapshot

In vitro and in vivo antimalarial and cytotoxic activity of five plants used in congolese traditional medicine

inferred← citeshttps://doi.org/10.1016/j.jep.2024.117736openalex-snapshot

Genus Physalis L.: A review of resources and cultivation, chemical composition, pharmacological effects and applications

inferred← citeshttps://doi.org/10.1016/j.jinsphys.2007.12.004openalex-snapshot

Immune depression in Rhodnius prolixus by seco-steroids, physalins

inferred← citeshttps://doi.org/10.1016/j.jpba.2011.09.012openalex-snapshot

An ultra-pressure liquid chromatography–tandem mass spectrometry method for the simultaneous determination of three physalins in rat plasma and its application to pharmacokinetic study of Physalis alkekengi var. franchetii (Chinese lantern) in rats

inferred← citeshttps://doi.org/10.1016/j.phymed.2010.01.006openalex-snapshot

Topical anti-inflammatory potential of Physalin E from Physalis angulata on experimental dermatitis in mice

inferred← citeshttps://doi.org/10.1016/j.phytol.2018.07.029openalex-snapshot

Phytochemical constituents and cytotoxic activity of Physalis angulata L. growing in Vietnam

inferred← citeshttps://doi.org/10.1016/j.steroids.2010.01.014openalex-snapshot

Virginols A–C, three new withanolides from Physalis virginiana

inferred← citeshttps://doi.org/10.1016/j.steroids.2010.06.001openalex-snapshot

Withanolides from Withania aristata and their cytotoxic activity

inferred← citeshttps://doi.org/10.1016/j.steroids.2011.03.018openalex-snapshot

Philadelphicalactones C and D and other cytotoxic compounds from Physalis philadelphica

inferred← citeshttps://doi.org/10.1016/j.steroids.2013.05.008openalex-snapshot

Induction of quinone reductase (QR) by withanolides isolated from Physalis pubescens L. (Solanaceae)

inferred← citeshttps://doi.org/10.1016/j.steroids.2014.06.016openalex-snapshot

Unprecedent aminophysalin from Physalis angulata

inferred← citeshttps://doi.org/10.1016/j.steroids.2015.08.015openalex-snapshot

Cytotoxic 20,24-epoxywithanolides from Physalis angulata

inferred← citeshttps://doi.org/10.1016/j.steroids.2016.09.002openalex-snapshot

Withanolides from the stems and leaves of Physalis pubescens and their cytotoxic activity

inferred← citeshttps://doi.org/10.1016/j.steroids.2020.108776openalex-snapshot

The synthesis and cytotoxic activity of derivatives of 4β-hydroxywithanolide E

inferred← citeshttps://doi.org/10.1017/s0031182013001297openalex-snapshot

Physalins B and F,seco-steroids isolated fromPhysalis angulataL., strongly inhibit proliferation, ultrastructure and infectivity ofTrypanosoma cruzi

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5b00867openalex-snapshot

Discovery of Potent 17β-Hydroxywithanolides for Castration-Resistant Prostate Cancer by High-Throughput Screening of a Natural Products Library for Androgen-Induced Gene Expression Inhibitors

inferred← citeshttps://doi.org/10.1021/acs.jmedchem.7b00069openalex-snapshot

17β-Hydroxywithanolides as Sensitizers of Renal Carcinoma Cells to Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) Mediated Apoptosis: Structure–Activity Relationships

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00380openalex-snapshot

Cytotoxic Physalins from Aeroponically Grown Physalis acutifolia

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.5b00911openalex-snapshot

17β-Hydroxy-18-acetoxywithanolides from Aeroponically Grown Physalis crassifolia and Their Potent and Selective Cytotoxicity for Prostate Cancer Cells

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b00310openalex-snapshot

Biotransformation of Salpichrolides A, C, and G by Three Filamentous Fungi

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b01129openalex-snapshot

Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.8b00861openalex-snapshot

Physalactone and 4β-Hydroxywithanolide E Isolated from Physalis peruviana Inhibit LPS-Induced Expression of COX-2 and iNOS Accompanied by Abatement of Akt and STAT1

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.9b00233openalex-snapshot

Labdanes, Withanolides, and Other Constituents from Physalis nicandroides

inferred← citeshttps://doi.org/10.1021/acs.orglett.0c03255openalex-snapshot

Synthesis of DFGH-Ring Derivatives of Physalins via One-Pot Construction of GH-Ring and Evaluation of Their NF-κB-Inhibitory Activity

inferred← citeshttps://doi.org/10.1021/je100227kopenalex-snapshot

Solubility of Physalin D in Ethanol, Methanol, Propanone, Trichloromethane, Ethyl Ethanoate, and Water at Temperatures from (283.2 to 313.2) K

inferred← citeshttps://doi.org/10.1021/jf2006535openalex-snapshot

Withanolides from the Rhizomes of Dioscorea japonica and Their Cytotoxicity

inferred← citeshttps://doi.org/10.1021/jm401279nopenalex-snapshot

Structure–Activity Relationships for Withanolides as Inducers of the Cellular Heat-Shock Response

inferred← citeshttps://doi.org/10.1021/ml400144eopenalex-snapshot

Contribution of Cage-Shaped Structure of Physalins to Their Mode of Action in Inhibition of NF-κB Activation

inferred← citeshttps://doi.org/10.1021/np100127kopenalex-snapshot

Labdanes and Sucrose Esters from Physalis sordida

inferred← citeshttps://doi.org/10.1021/np400017kopenalex-snapshot

Physalin A Induces Apoptotic Cell Death and Protective Autophagy in HT1080 Human Fibrosarcoma Cells

inferred← citeshttps://doi.org/10.1021/np400296sopenalex-snapshot

Withanolide Artifacts Formed in Methanol

inferred← citeshttps://doi.org/10.1021/ol203498aopenalex-snapshot

Physangulidines A, B, and C: Three New Antiproliferative Withanolides from Physalis angulata L.

inferred← citeshttps://doi.org/10.1021/ol301394bopenalex-snapshot

Kinetically Controlled One-Pot Formation of DEFGH-Rings of Type B Physalins through Domino-Type Transformations

inferred← citeshttps://doi.org/10.1038/cddis.2015.38openalex-snapshot

Withanolide E sensitizes renal carcinoma cells to TRAIL-induced apoptosis by increasing cFLIP degradation

inferred← citeshttps://doi.org/10.1038/s41438-021-00705-wopenalex-snapshot

The Physalis floridana genome provides insights into the biochemical and morphological evolution of Physalis fruits

inferred← citeshttps://doi.org/10.1038/s41598-017-03849-9openalex-snapshot

Physalins V-IX, 16,24-cyclo-13,14-seco withanolides from Physalis angulata and their antiproliferative and anti-inflammatory activities

inferred← citeshttps://doi.org/10.1039/c0np00045kopenalex-snapshot

Natural withanolides: an overview

inferred← citeshttps://doi.org/10.1039/c6ob02656gopenalex-snapshot

A novel withanolide with an unprecedented carbon skeleton from Physalis angulata

inferred← citeshttps://doi.org/10.1039/c6ra07031kopenalex-snapshot

New withanolides with TRAIL-sensitizing effect from Physalis pubescens L.

inferred← citeshttps://doi.org/10.1039/c7ob02205kopenalex-snapshot

Unprecedented 22,26-seco physalins from Physalis angulata and their anti-inflammatory potential

inferred← citeshttps://doi.org/10.1039/c8ob00194dopenalex-snapshot

Synthesis of the 10-oxabicyclo[5.2.1]decane framework present in bioactive natural products

inferred← citeshttps://doi.org/10.1039/c9cc03653aopenalex-snapshot

Cellular target identification of Withangulatin A using fluorescent analogues and subsequent chemical proteomics

inferred← citeshttps://doi.org/10.1079/cabicompendium.40711openalex-snapshot

Physalis angulata (cutleaf groundcherry)

inferred← citeshttps://doi.org/10.1080/08923973.2017.1282514openalex-snapshot

Anti-inflammatory effects of physalin E from Physalis angulata on lipopolysaccharide-stimulated RAW 264.7 cells through inhibition of NF-κB pathway

inferred← citeshttps://doi.org/10.1080/14786419.2015.1030340openalex-snapshot

Trichosides A and B, new withanolide glucosides from Tricholepis eburnea

inferred← citeshttps://doi.org/10.1080/14786419.2018.1550766openalex-snapshot

A new 22,26-seco physalin steroid from Physalis angulata

inferred← citeshttps://doi.org/10.1080/15592324.2019.1629267openalex-snapshot

Transcriptome-wide identification of microRNAs and functional insights inferred from microRNA—target pairs in Physalis angulata L

inferred← citeshttps://doi.org/10.1177/1934578x0800300302openalex-snapshot

Structure – Activity Relationships of Modified Eremophilanes and Anti-inflammatory Activity Using the TPA Mouse Edema Ear Test

inferred← citeshttps://doi.org/10.1177/1934578x0800300420openalex-snapshot

Toxic Chemical Compounds of the Solanaceae

inferred← citeshttps://doi.org/10.1177/1934578x1701201016openalex-snapshot

A Novel Cytotoxic Physalin from Physalis angulata

inferred← citeshttps://doi.org/10.1248/cpb.56.234openalex-snapshot

Withangulatin I, a New Cytotoxic Withanolide from Physalis angulata

inferred← citeshttps://doi.org/10.1351/pac-con-11-10-08openalex-snapshot

Antiproliferative withanolides from the Solanaceae: A structure–activity study

inferred← citeshttps://doi.org/10.1371/journal.pone.0040727openalex-snapshot

Physalin F Induces Cell Apoptosis in Human Renal Carcinoma Cells by Targeting NF-kappaB and Generating Reactive Oxygen Species

inferred← citeshttps://doi.org/10.1556/018.68.2017.3.7openalex-snapshot

Isolation and quantitative analysis of physalin D in the fruit and calyx of Physalis alkekengi L.

inferred← citeshttps://doi.org/10.1556/1006.2017.30.5.14openalex-snapshot

High selectivity of thin-layer chromatography enables characterization of physalin L standard and its impurity

inferred← citeshttps://doi.org/10.1590/0001-3765201620150043openalex-snapshot

Effect of osmopriming on germination and initial growth of Physalis angulata L. under salt stress and on expression of associated genes

inferred← citeshttps://doi.org/10.1590/s0102-695x2011005000106openalex-snapshot

Plants from Solanaceae family with possible anxiolytic effect reported on 19th century's Brazilian medical journal

inferred← citeshttps://doi.org/10.18240/ijo.2019.09.05openalex-snapshot

Pro-apoptotic and anti-proliferative effects of Physalis angulata leaf extract on retinoblastoma cells

inferred← citeshttps://doi.org/10.18502/jabs.v11i1.8753openalex-snapshot

Anti-Angiogenic and Anti-Proliferative Effects of Physalis Alkekengi Hydroalcholic Extract on Breast Cancer in Mice

inferred← citeshttps://doi.org/10.18632/oncotarget.19593openalex-snapshot

Physapubescin B inhibits tumorgenesis and circumvents taxol resistance of ovarian cancer cells through STAT3 signaling

inferred← citeshttps://doi.org/10.29356/jmcs.v63i4.944openalex-snapshot

Chemical Constituents of Egyptian Withania Somnifera Leaves and Fruits and their Anticholinesterase Activity

inferred← citeshttps://doi.org/10.3109/13880200903062606openalex-snapshot

Antimicrobial activity of the extracts and physalin D fromPhysalis alkekengiand evaluation of antioxidant potential of physalin D

inferred← citeshttps://doi.org/10.3389/fphar.2022.864714openalex-snapshot

Therapeutic Applications of Physalins: Powerful Natural Weapons

inferred← citeshttps://doi.org/10.3389/fphar.2024.1365815openalex-snapshot

Physalin H, physalin B, and isophysalin B suppress the quorum-sensing function of Staphylococcus aureus by binding to AgrA

inferred← citeshttps://doi.org/10.3389/fpls.2022.850711openalex-snapshot

RNAi of Sterol Δ24-Isomerase Implicated Its Involvement in Physalin Biosynthesis in Physalis angulata L.

inferred← citeshttps://doi.org/10.3390/biom11111710openalex-snapshot

Engineering of Saccharomyces cerevisiae for 24-Methylene-Cholesterol Production

inferred← citeshttps://doi.org/10.3390/molecules24081608openalex-snapshot

Cytotoxic Withanolides from the Whole Herb of Physalis angulata L.

inferred← citeshttps://doi.org/10.3390/molecules26092756openalex-snapshot

Effect of Salt Stress on Growth and Metabolite Profiles of Cape Gooseberry (Physalis peruviana L.) along Three Growth Stages

inferred← citeshttps://doi.org/10.3390/molecules27030886openalex-snapshot

Recent Advances in the Chemistry and Therapeutic Evaluation of Naturally Occurring and Synthetic Withanolides

inferred← citeshttps://doi.org/10.3390/pharmaceutics18091158openalex-snapshot

Developing a Fluorescence-Based High-Throughput Screening Method for Natural Product Fractions to Identify Inhibitors of AR-V7 for Castration-Resistant Prostate Cancer

inferred← citeshttps://doi.org/10.3892/etm.2015.2480openalex-snapshot

Antiproliferation potential of withaferin A on human osteosarcoma cells via the inhibition of G2/M checkpoint proteins

inferred← citeshttps://doi.org/10.3923/ijcr.2009.69.82openalex-snapshot

A Review: Cancer Research of Natural Products in Asia

inferred← citeshttps://doi.org/10.4025/actascibiolsci.v36i1.18074openalex-snapshot

Establishment and content of sugars and phenols in Physalis callus obtained from different explants and concentrations of bap and naa - doi: 10.4025/actascibiolsci.v36i1.18074

inferred← citeshttps://doi.org/10.4103/0973-1296.93307openalex-snapshot

Isolation and characterization of a bactericidal withanolide from Physalis virginiana

inferred← citeshttps://doi.org/10.7476/9788523212179.0021openalex-snapshot

Physalis angulata L.

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