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Diterpenoids from Euphorbia dulcis with Potassium Ion Channel Inhibitory Activity with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effect

https://doi.org/10.1021/acs.jnatprod.8b00500

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Diterpenes and Their Derivatives as Potential Anticancer Agents

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Diterpenes from Euphorbia helioscopia

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Effects of Chelidonium majus extracts and major alkaloids on hERG potassium channels and on dog cardiac action potential — A safety approach

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The State of the Art

inferredcites →https://doi.org/10.1016/j.phrs.2006.03.021openalex-snapshot

Tertiapin, a selective IKACh blocker, terminates atrial fibrillation with selective atrial effective refractory period prolongation

inferredcites →https://doi.org/10.1016/j.tet.2012.07.101openalex-snapshot

Jatrophane diterpenoids with multidrug resistance-modulating activity from Euphorbia mongolica Prokh.

inferredcites →https://doi.org/10.1016/j.tet.2016.08.007openalex-snapshot

Jatrophane diterpenes from Euphorbia guyoniana are new potent inhibitors of atrial GIRK channels

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Jatrophane derivatives and a rearranged jatrophane from Euphorbia terracina

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Keynote review: In vitro safety pharmacology profiling: an essential tool for successful drug development

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hERG Channel Inhibitory Daphnane Diterpenoid Orthoesters and Polycephalones A and B with Unprecedented Skeletons from Gnidia polycephala

inferredcites →https://doi.org/10.1021/acs.jnatprod.5b00511openalex-snapshot

Advanced Structural Determination of Diterpene Esters Using Molecular Modeling and NMR Spectroscopy

inferredcites →https://doi.org/10.1021/acs.jnatprod.6b00260openalex-snapshot

Myrsinane, Premyrsinane, and Cyclomyrsinane Diterpenes from Euphorbia falcata as Potassium Ion Channel Inhibitors with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effects

inferredcites →https://doi.org/10.1021/acs.jnatprod.6b00644openalex-snapshot

Euphorbia dendroides Latex as a Source of Jatrophane Esters: Isolation, Structural Analysis, Conformational Study, and Anti-CHIKV Activity

inferredcites →https://doi.org/10.1021/np3004003openalex-snapshot

Jatrophane Diterpenes fromEuphorbia melliferaand Their Activity as P-Glycoprotein Modulators on Multidrug-Resistant Mouse Lymphoma and Human Colon Adenocarcinoma Cells

inferredcites →https://doi.org/10.1021/np500271uopenalex-snapshot

Jatrophane Diterpenes as Inhibitors of Chikungunya Virus Replication: Structure–Activity Relationship and Discovery of a Potent Lead

inferredcites →https://doi.org/10.1038/nature04710openalex-snapshot

hERG potassium channels and cardiac arrhythmia

inferredcites →https://doi.org/10.1039/b800485dopenalex-snapshot

Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators

inferredcites →https://doi.org/10.1055/a-0589-0525openalex-snapshot

Bioactive Segetane, Ingenane, and Jatrophane Diterpenes from Euphorbia taurinensis

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DIE FLAVONOLGLYCOSIDE VONEUPHORBIA HELIOSCOPIA, E. STRICTA, E. VERRUCOSAundE. DULCIS

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Anti-HERG activity and the risk of drug-induced arrhythmias and sudden death

inferredcites →https://doi.org/10.1093/europace/eur194openalex-snapshot

The cost of illness of atrial fibrillation: a systematic review of the recent literature

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A short history of SHELX

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On enantiomorph-polarity estimation

inferredcites →https://doi.org/10.1152/physrev.00036.2011openalex-snapshot

hERG K + Channels: Structure, Function, and Clinical Significance

inferredcites →https://doi.org/10.1161/cir.0000000000000040openalex-snapshot

2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation: Executive Summary

inferredcites →https://doi.org/10.1161/circresaha.114.302362openalex-snapshot

Atrial Fibrillation Therapy Now and in the Future

inferredcites →https://doi.org/10.1161/circresaha.114.303772openalex-snapshot

Role of the Autonomic Nervous System in Atrial Fibrillation

inferredcites →https://doi.org/10.3389/fphar.2011.00064openalex-snapshot

Targeting GIRK Channels for the Development of New Therapeutic Agents

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Diterpenoids from the genus Euphorbia: Structure and biological activity (2013–2019)

inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113106zenodo-depositor-declared

Diverse diterpenoids with α-glucosidase and β-glucuronidase inhibitory activities from Euphorbia milii

inferred← citeshttps://doi.org/10.1007/s10600-025-04841-wopenalex-snapshot

Design, Synthesis, and Anticancer Activity Evaluation of N′-Arylidenehydrazides of Isopimaric Acid

inferred← citeshttps://doi.org/10.1007/s11101-020-09667-8openalex-snapshot

Jatrophane and rearranged jatrophane-type diterpenes: biogenesis, structure, isolation, biological activity and SARs (1984–2019)

inferred← citeshttps://doi.org/10.1007/s40199-025-00586-7openalex-snapshot

Plant-derived compounds as potential candidates for atrial fibrillation drug discovery: A review on phytochemicals with atrial-selective activity

inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.105442openalex-snapshot

Diterpenoids from Euphorbia glomerulans with potential reversal activities against P-glycoprotein-mediated multidrug resistance

inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.105534openalex-snapshot

Diterpenoids from Euphorbia helioscopia and their enhancement of NK cell-mediated killing of NSCLC cells

inferred← citeshttps://doi.org/10.1016/j.fitote.2019.104272openalex-snapshot

GIRK channel activity of Hungarian mushrooms: From screening to biologically active metabolites

inferred← citeshttps://doi.org/10.1016/j.jep.2022.115574openalex-snapshot

Phytochemical and pharmacological review of diterpenoids from the genus Euphorbia Linn (2012–2021)

inferred← citeshttps://doi.org/10.1016/j.phytochem.2022.113444openalex-snapshot

Jatrophane diterpenoids from Euphorbia microcarpa (prokh.) krylov with multidrug resistance modulating activity

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.3c00580openalex-snapshot

Diterpenoids from Euphorbia fischeriana with Kv1.3 Inhibitory Activity

inferred← citeshttps://doi.org/10.1021/acs.jnatprod.9b00519openalex-snapshot

Macrocyclic Diterpenoids from Euphorbia helioscopia and Their Potential Anti-inflammatory Activity

inferred← citeshttps://doi.org/10.1038/s41598-024-73576-5openalex-snapshot

Effects of SZV-2649, a new multiple ion channel inhibitor mexiletine analogue

inferred← citeshttps://doi.org/10.1039/d2np00047dopenalex-snapshot

Euphorbia diterpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)

inferred← citeshttps://doi.org/10.1080/14786419.2025.2478303openalex-snapshot

Euphthymifolols A-E, anti-inflammatory jatrophane-type macrocyclic diterpenoids from Euphorbia thymifolia L

inferred← citeshttps://doi.org/10.1080/14786419.2025.2528150openalex-snapshot

Euphothymifols a and B, novel bioactive bicyclic jatrophane-type diterpenoids from euphorbia thymifolia L

inferred← citeshttps://doi.org/10.1152/ajpcell.00102.2022openalex-snapshot

Neuronal G protein-gated K+ channels

inferred← citeshttps://doi.org/10.1177/2472555220905558openalex-snapshot

Screening Technologies for Inward Rectifier Potassium Channels: Discovery of New Blockers and Activators

inferred← citeshttps://doi.org/10.14232/phd.10916openalex-snapshot

Triterpenes from Hypholoma lateritium

inferred← citeshttps://doi.org/10.3390/molecules29174104openalex-snapshot

Diterpenoids with Potent Anti-Psoriasis Activity from Euphorbia helioscopia L.

inferred← citeshttps://doi.org/10.3390/molecules31173024openalex-snapshot

Jatrophane Diterpenoids from Euphorbia peplus with LysoTracker-Associated Cellular Activity

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Bioactive Compounds from Euphorbia usambarica Pax. with HIV-1 Latency Reversal Activity

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Phorbol Esters in the Euphorbiaceae Family (Croton, Euphorbia, and Sapium)

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