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Discovery of a new series of jatrophane and lathyrane diterpenes as potent and specific P-glycoprotein modulators
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/0470846356.ch7openalex-snapshot
Reversal of Multidrug Resistance: Lessons from Clinical Oncology
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Practical Methods of Optimization
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MOPAC: A semiempirical molecular orbital program
inferredcites →https://doi.org/10.1016/0005-2736(76)90160-7openalex-snapshot
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
inferredcites →https://doi.org/10.1016/0031-9422(89)80360-7openalex-snapshot
Diterpenes from Euphorbia helioscopia
inferredcites →https://doi.org/10.1016/0092-8674(86)90594-5openalex-snapshot
Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins
inferredcites →https://doi.org/10.1016/0959-8049(96)00091-3openalex-snapshot
Clinical trials of p-glycoprotein reversal in solid tumours
inferredcites →https://doi.org/10.1016/j.addr.2012.09.027openalex-snapshot
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
inferredcites →https://doi.org/10.1016/j.bmc.2003.08.013openalex-snapshot
Modified jatrophane diterpenes as modulators of multidrug resistance from Euphorbia dendroides L.
inferredcites →https://doi.org/10.1016/s0031-9422(00)98551-0openalex-snapshot
A diterpene from Euphorbia maddeni
inferredcites →https://doi.org/10.1016/s0040-4039(00)81986-3openalex-snapshot
Structural and conformational studies on euphohelioscopins A and B and related diterpenes
inferredcites →https://doi.org/10.1016/s0040-4039(01)91548-5openalex-snapshot
Structural and conformational studies on euphornin and related diterpenes
inferredcites →https://doi.org/10.1016/s0040-4039(01)92490-6openalex-snapshot
The isolation and structures of euphoscopins a and b
inferredcites →https://doi.org/10.1016/s0169-409x(02)00169-2openalex-snapshot
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: an overview
inferredcites →https://doi.org/10.1021/jm030787eopenalex-snapshot
Jatrophane Diterpenes as P-Glycoprotein Inhibitors. First Insights of Structure−Activity Relationships and Discovery of a New, Powerful Lead
inferredcites →https://doi.org/10.1021/jm030951yopenalex-snapshot
Jatrophane Diterpenes as Modulators of Multidrug Resistance. Advances of Structure−Activity Relationships and Discovery of the Potent Lead Pepluanin A
inferredcites →https://doi.org/10.1038/324485a0openalex-snapshot
Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance
inferredcites →https://doi.org/10.1038/nrd1984openalex-snapshot
Targeting multidrug resistance in cancer
inferredcites →https://doi.org/10.1038/sj.onc.1206938openalex-snapshot
Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2)
inferredcites →https://doi.org/10.1042/bj20020957openalex-snapshot
Structure and function of efflux pumps that confer resistance to drugs
inferredcites →https://doi.org/10.1053/beha.2000.0124openalex-snapshot
Chemotherapy resistance in acute myeloid leukaemia
inferredcites →https://doi.org/10.1055/s-2004-827191openalex-snapshot
Structure-Activity Relationships for Euphocharacins A - L, a New Series of Jatrophane Diterpenes, as Inhibitors of Cancer Cell P-Glycoprotein
inferredcites →https://doi.org/10.1073/pnas.85.15.5350openalex-snapshot
Derivation of force fields for molecular mechanics and dynamics from ab initio energy surfaces
inferredcites →https://doi.org/10.1080/03009740310004333openalex-snapshot
Multidrug resistance proteins in rheumatoid arthritis, role in disease‐modifying antirheumatic drug efficacy and inflammatory processes: an overview
inferredcites →https://doi.org/10.1093/jnci/92.16.1295openalex-snapshot
A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins
inferredcites →https://doi.org/10.1097/00001813-200603000-00001openalex-snapshot
Inhibitors of cancer cell multidrug resistance mediated by breast cancer resistance protein (BCRP/ABCG2)
inferredcites →https://doi.org/10.1097/00019052-200304000-00013openalex-snapshot
Mechanisms of antiepileptic drug resistance
inferredcites →https://doi.org/10.1158/0008-5472.can-04-1817openalex-snapshot
Flavonoid Structure-Activity Studies Identify 6-Prenylchrysin and Tectochrysin as Potent and Specific Inhibitors of Breast Cancer Resistance Protein ABCG2
inferredcites →https://doi.org/10.1177/107327480301000207openalex-snapshot
Overcoming Multidrug Resistance in Cancer: An Update on the Clinical Strategy of Inhibiting P-Glycoprotein
inferredcites →https://doi.org/10.1200/jco.1992.10.11.1730openalex-snapshot
Feasibility of using quinine, a potential multidrug resistance-reversing agent, in combination with mitoxantrone and cytarabine for the treatment of acute leukemia.
inferredcites →https://doi.org/10.5414/cpp38111openalex-snapshot
Substrate recognition by P-glycoprotein and the multidrug resistance-associated protein MRP1: a comparison
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
inferred← citeshttps://doi.org/10.1016/j.phytochem.2020.112649zenodo-depositor-declared
Euphorbia helioscopia L.: A phytochemical and pharmacological overview
inferred← citeshttps://doi.org/10.1002/ar.21517openalex-snapshot
Anticancer Potential of Euphorbia helioscopia L Extracts Against Human Cancer Cells
inferred← citeshttps://doi.org/10.1002/asia.201600736openalex-snapshot
Synthesis of an Orthogonally Protected Polyhydroxylated Cyclopentene from l ‐Sorbose
inferred← citeshttps://doi.org/10.1002/cbdv.202500736openalex-snapshot
Eupholine A and B, A Pair of Lathyrane Epimers with Inhibitory Activity of Fibrinogen from Euphorbia helioscopia L.
inferred← citeshttps://doi.org/10.1002/med.21428openalex-snapshot
ABCG2/BCRP: Specific and Nonspecific Modulators
inferred← citeshttps://doi.org/10.1002/pca.2841openalex-snapshot
Effective MDR reversers through phytochemical study of Euphorbia boetica
inferred← citeshttps://doi.org/10.1007/978-3-319-20397-3_3openalex-snapshot
Jatropha Natural Products as Potential Therapeutic Leads
inferred← citeshttps://doi.org/10.1007/978-3-642-22144-6_192openalex-snapshot
Diterpenes for Therapeutic Use
inferred← citeshttps://doi.org/10.1007/s11101-009-9126-8openalex-snapshot
Jatrophane diterpenes from Euphorbia spp. as modulators of multidrug resistance in cancer therapy
inferred← citeshttps://doi.org/10.1007/s11101-014-9337-5openalex-snapshot
Oleanane triterpenoids in the prevention and therapy of breast cancer: current evidence and future perspectives
inferred← citeshttps://doi.org/10.1007/s11101-014-9341-9openalex-snapshot
Cancer chemopreventive pharmacology of phytochemicals derived from plants of dietary and non-dietary origin: implication for alternative and complementary approaches
inferred← citeshttps://doi.org/10.1007/s11101-014-9342-8openalex-snapshot
Euphorbia and Momordica metabolites for overcoming multidrug resistance
inferred← citeshttps://doi.org/10.1007/s11101-020-09667-8openalex-snapshot
Jatrophane and rearranged jatrophane-type diterpenes: biogenesis, structure, isolation, biological activity and SARs (1984–2019)
inferred← citeshttps://doi.org/10.1016/b978-0-12-817905-5.00009-3openalex-snapshot
Jatrophane diterpenes from Euphorbiaceae family
inferred← citeshttps://doi.org/10.1016/j.apsb.2018.03.011openalex-snapshot
Helioscopianoids A–Q, bioactive jatrophane diterpenoid esters from Euphorbia helioscopia
inferred← citeshttps://doi.org/10.1016/j.bioorg.2021.105534openalex-snapshot
Diterpenoids from Euphorbia helioscopia and their enhancement of NK cell-mediated killing of NSCLC cells
inferred← citeshttps://doi.org/10.1016/j.bmc.2008.08.071openalex-snapshot
Synergistic interaction between p-glycoprotein modulators and epirubicine on resistant cancer cells
inferred← citeshttps://doi.org/10.1016/j.bmc.2009.04.041openalex-snapshot
Lathyrane diterpenes from Euphorbia lathyris as modulators of multidrug resistance and their crystal structures
inferred← citeshttps://doi.org/10.1016/j.cclet.2009.09.013openalex-snapshot
A new diterpenoid from Euphorbia helioscopia
inferred← citeshttps://doi.org/10.1016/j.chembiol.2012.06.010openalex-snapshot
Euphohelioscopin A Is a PKC Activator Capable of Inducing Macrophage Differentiation
inferred← citeshttps://doi.org/10.1016/j.fitote.2015.05.012openalex-snapshot
Cyparissins A and B, jatrophane diterpenes from Euphorbia cyparissias as Pgp inhibitors and cytotoxic agents against ovarian cancer cell lines
inferred← citeshttps://doi.org/10.1016/j.fitote.2015.11.008openalex-snapshot
6(17)-Epoxylathyrane diterpenes from Euphorbia sogdiana Popov with cytotoxic activity
inferred← citeshttps://doi.org/10.1016/j.fitote.2025.106830openalex-snapshot
Lathyrane and jatrophane diterpenoids: Potential lipid-lowering agents from Euphorbia helioscopia L
inferred← citeshttps://doi.org/10.1016/j.phytochem.2017.10.012openalex-snapshot
Highly oxygenated and structurally diverse diterpenoids from Euphorbia helioscopia
inferred← citeshttps://doi.org/10.1016/j.tet.2012.07.101openalex-snapshot
Jatrophane diterpenoids with multidrug resistance-modulating activity from Euphorbia mongolica Prokh.
inferred← citeshttps://doi.org/10.1016/j.tet.2020.130981openalex-snapshot
Synthesis of the cyclopentane core of pepluanin A
inferred← citeshttps://doi.org/10.1016/s1875-5364(15)30069-8openalex-snapshot
Structure and antibacterial property of a new diterpenoid from Euphorbia helioscopia
inferred← citeshttps://doi.org/10.1016/s2222-1808(14)60791-xopenalex-snapshot
Anti-nociceptive, anti-inflammatory and anti-pyretic activities of latex and leaves methanol extract of Euphorbia helioscopia
inferred← citeshttps://doi.org/10.1016/s2222-1808(15)60877-5openalex-snapshot
Estimation of genotoxic and mutagenic potential of latex and methanolic leaves extract of Euphorbia helioscopia by comet assay and Ames test
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.0c00986openalex-snapshot
Jatrophane Diterpenoids from Euphorbia peplus as Multidrug Resistance Modulators with Inhibitory Effects on the ATR-Chk-1 Pathway
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.6b00627openalex-snapshot
Drug Affinity Responsive Target Stability (DARTS) Identifies Laurifolioside as a New Clathrin Heavy Chain Modulator
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.7b00981openalex-snapshot
Identification of Ingol and Rhamnofolane Diterpenoids from Euphorbia resinifera and Their Abilities to Induce Lysosomal Biosynthesis
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.8b00500openalex-snapshot
Diterpenoids from Euphorbia dulcis with Potassium Ion Channel Inhibitory Activity with Selective G Protein-Activated Inwardly Rectifying Ion Channel (GIRK) Blocking Effect
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.9b00519openalex-snapshot
Macrocyclic Diterpenoids from Euphorbia helioscopia and Their Potential Anti-inflammatory Activity
inferred← citeshttps://doi.org/10.1021/acs.joc.7b02012openalex-snapshot
Synthesis of Homoverrucosanoid-Derived Esters and Evaluation as MDR Modulators
inferred← citeshttps://doi.org/10.1021/acs.joc.7b02558openalex-snapshot
Secoheliosphanes A and B and Secoheliospholane A, Three Diterpenoids with Unusual seco-Jatrophane and seco-Jatropholane Skeletons from Euphorbia helioscopia
inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.5b00465openalex-snapshot
Development of in Silico Models for Predicting P-Glycoprotein Inhibitors Based on a Two-Step Approach for Feature Selection and Its Application to Chinese Herbal Medicine Screening
inferred← citeshttps://doi.org/10.1021/jm401879zopenalex-snapshot
Symmetric Bis-chalcones as a New Type of Breast Cancer Resistance Protein Inhibitors with a Mechanism Different from That of Chromones
inferred← citeshttps://doi.org/10.1021/jo1019738openalex-snapshot
Total Synthesis of Natural and Non-Natural Δ5,6Δ12,13-Jatrophane Diterpenes and Their Evaluation as MDR Modulators
inferred← citeshttps://doi.org/10.1021/jo802581gopenalex-snapshot
Synthetic Studies toward Jatrophane Diterpenes from Euphorbia characias. Enantioselective Synthesis of (−)-15-O-Acetyl-3-O-propionyl-17-norcharaciol
inferred← citeshttps://doi.org/10.1021/np3004003openalex-snapshot
Jatrophane Diterpenes fromEuphorbia melliferaand Their Activity as P-Glycoprotein Modulators on Multidrug-Resistant Mouse Lymphoma and Human Colon Adenocarcinoma Cells
inferred← citeshttps://doi.org/10.1021/np500756zopenalex-snapshot
Jatrophanes from Euphorbia squamosa as Potent Inhibitors of Candida albicans Multidrug Transporters
inferred← citeshttps://doi.org/10.1038/s41598-017-04399-wopenalex-snapshot
Heliosterpenoids A and B, two Novel Jatrophane-Derived Diterpenoids with a 5/6/4/6 Ring System from Euphorbia helioscopia
inferred← citeshttps://doi.org/10.1039/c3ra22417aopenalex-snapshot
Bioactive constituents from toxic seed plants in China
inferred← citeshttps://doi.org/10.1039/d2np00047dopenalex-snapshot
Euphorbia diterpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021)
inferred← citeshttps://doi.org/10.1080/14786419.2011.622275openalex-snapshot
Analysis of euphornin inEuphorbia helioscopiaL. and its cytotoxicity to mice lung adenocarcinoma cells (LA795)
inferred← citeshttps://doi.org/10.1080/14786419.2022.2095379openalex-snapshot
Microbial and chemical transformations of euphorbia factor L1 and the P-glycoprotein inhibitory activity in zebrafishes
inferred← citeshttps://doi.org/10.1139/bcb-2017-0034openalex-snapshot
Jatropha-6(17),11E-diene class derivatives induce apoptosis effects in OVCAR-3 and Caov-4 ovarian cancer cell lines via a mitochondrial pathway
inferred← citeshttps://doi.org/10.1155/2015/601015openalex-snapshot
Hepatocellular Carcinoma Growth Is Inhibited byEuphorbia helioscopiaL. Extract in Nude Mice Xenografts
inferred← citeshttps://doi.org/10.3390/pharmaceutics10030127openalex-snapshot
The Effects of Synthetically Modified Natural Compounds on ABC Transporters
inferred← citeshttps://doi.org/10.3892/etm.2021.10817openalex-snapshot
Euphornin L promotes lipid clearance by dual regulation of LDLR and PCSK9
inferred← citeshttps://doi.org/10.4028/www.scientific.net/amr.396-398.1337openalex-snapshot
Chemical Constituents from Euphorbia helioscopia
inferred← citeshttps://doi.org/10.5012/bkcs.2011.32.12.4444openalex-snapshot
Synthesis and Bioactivity of Novel Adamantyl Derivatives as Potent MDR Reversal Agents
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