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Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer’s Disease
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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The Natural Product Berberine is a Human Prolyl Oligopeptidase Inhibitor
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Synthesis of (+)‐O‐Methylthalibrine by Employing a Stereocontrolled Bischler–Napieralski Reaction and an Electrochemically Generated Diaryl Ether
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UCSF Chimera—A visualization system for exploratory research and analysis
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AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
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AutoDock Vina: Improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading
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Berberine: a plant alkaloid with therapeutic potential for central nervous system disorders
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Evaluation of a new lead for acetylcholinesterase inhibition
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A new and rapid colorimetric determination of acetylcholinesterase activity
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[16] Preparation of impermeable ghosts and inside-out vesicles from human erythrocyte membranes
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Recent advances in the neurobiology and neuropharmacology of Alzheimer’s disease
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8,8-Dimethyldihydroberberine with improved bioavailability and oral efficacy on obese and diabetic mouse models
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Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease
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Design, synthesis and biological evaluation of new phthalimide and saccharin derivatives with alicyclic amines targeting cholinesterases, beta-secretase and amyloid beta aggregation
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The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease
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A pharmacological study on Berberis vulgaris fruit extract
inferredcites →https://doi.org/10.1016/j.phrs.2003.11.017openalex-snapshot
Cholinesterase inhibitors: new roles and therapeutic alternatives
inferredcites →https://doi.org/10.1016/j.saa.2003.09.022openalex-snapshot
Total assignment and structure in solution of tetrandrine by NMR spectroscopy and molecular modelling
inferredcites →https://doi.org/10.1016/s0031-9422(98)00121-6openalex-snapshot
Isoquinoline alkaloids from Berberis Vulgaris subsp. Australis
inferredcites →https://doi.org/10.1016/s0223-5234(03)00012-6openalex-snapshot
High throughput artificial membrane permeability assay for blood–brain barrier
inferredcites →https://doi.org/10.1016/s0896-6273(00)80108-7openalex-snapshot
Acetylcholinesterase Accelerates Assembly of Amyloid-β-Peptides into Alzheimer's Fibrils: Possible Role of the Peripheral Site of the Enzyme
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Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors
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5-Aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
inferredcites →https://doi.org/10.1021/bi00096a018openalex-snapshot
Three distinct domains in the cholinesterase molecule confer selectivity for acetyl- and butyrylcholinesterase inhibitors
inferredcites →https://doi.org/10.1021/jm300871xopenalex-snapshot
Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands
inferredcites →https://doi.org/10.1021/jm990968+openalex-snapshot
Predicting Blood−Brain Barrier Permeation from Three-Dimensional Molecular Structure
inferredcites →https://doi.org/10.1021/jo00143a040openalex-snapshot
Carbon-13 NMR spectroscopy and conformational analysis of the daphnoline-repandine class of bis(benzylisoquinoline) alkaloids
inferredcites →https://doi.org/10.1021/jo00938a030openalex-snapshot
Phlebicine, a new biphenylbisbenzylisoquinoline alkaloid from Cremastosperma polyphlebum
inferredcites →https://doi.org/10.1021/np060092ropenalex-snapshot
Glycogen Synthase Kinase-3 (GSK-3) Inhibitory Activity and Structure–Activity Relationship (SAR) Studies of the Manzamine Alkaloids. Potential for Alzheimer’s Disease
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Bisbenzylisoquinoline Alkaloids--A Review
inferredcites →https://doi.org/10.1021/np50061a010openalex-snapshot
Alkaloidal Content of Four Berberis Species. Structure of Berberilaurine, a New Bisbenzyltetrahydroisoquinoline
inferredcites →https://doi.org/10.1021/np50062a016openalex-snapshot
Berbidine: A Simple Isoquinoline-Isoquinolone Dimer
inferredcites →https://doi.org/10.1042/bj20130013openalex-snapshot
Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase
inferredcites →https://doi.org/10.1046/j.1432-1033.2002.03297.xopenalex-snapshot
Modulation of inositol 1,4,5‐triphosphate concentration by prolyl endopeptidase inhibition
inferredcites →https://doi.org/10.1055/s-0028-1099794openalex-snapshot
NEUE METHODEN ZUR EXTRAHIERUNG DER ALKALOIDE AUSBERBERIS VULGARIS
inferredcites →https://doi.org/10.1074/jbc.271.39.23646openalex-snapshot
Highly Potent, Selective, and Low Cost Bis-tetrahydroaminacrine Inhibitors of Acetylcholinesterase
inferredcites →https://doi.org/10.1074/jbc.m603469200openalex-snapshot
The Roles of Cyclin-dependent Kinase 5 and Glycogen Synthase Kinase 3 in Tau Hyperphosphorylation
inferredcites →https://doi.org/10.1126/science.7046051openalex-snapshot
The Cholinergic Hypothesis of Geriatric Memory Dysfunction
inferredcites →https://doi.org/10.1135/cccc19870242openalex-snapshot
A new bisbenzylisoquinoline alkaloid from Mahonia aquifolium (PURSH) NUTT.
inferredcites →https://doi.org/10.1146/annurev.pa.34.040194.001433openalex-snapshot
The Cholinesterases: From Genes to Proteins
inferredcites →https://doi.org/10.1177/1934578x1300800407openalex-snapshot
Berbanine: A New Isoquinoline-Isoquinolone Alkaloid from Berberis Vulgaris (Berberidaceae)
inferredcites →https://doi.org/10.1177/1934578x1501001015openalex-snapshot
(+)-Chenabinol (Revised NMR Data) and Two New Alkaloids from Berberis vulgaris and their Biological Activity
inferredcites →https://doi.org/10.1185/03007990152673800openalex-snapshot
A New Therapeutic Target in Alzheimer's Disease Treatment: Attention to Butyrylcholinesterase
inferredcites →https://doi.org/10.1186/1758-2946-3-33openalex-snapshot
Open Babel: An open chemical toolbox
inferredcites →https://doi.org/10.1515/revneuro-2017-0049openalex-snapshot
Recent studies on cellular and molecular mechanisms in Alzheimer’s disease: focus on epigenetic factors and histone deacetylase
inferredcites →https://doi.org/10.1517/14712598.2012.704014openalex-snapshot
Berberine on metabolic and cardiovascular risk factors: an analysis from preclinical evidences to clinical trials
inferredcites →https://doi.org/10.2165/00002512-200118120-00001openalex-snapshot
Selective Inhibitors of Butyrylcholinesterase
inferredcites →https://doi.org/10.2174/092986712800229032openalex-snapshot
Current Concepts on Selected Plant Secondary Metabolites With Promising Inhibitory Effects Against Enzymes Linked to Alzheimer's Disease
inferredcites →https://doi.org/10.2174/0929867311320250006openalex-snapshot
Parasite Prolyl Oligopeptidases and the Challenge of Designing Chemotherapeuticals for Chagas Disease, Leishmaniasis and African Trypanosomiasis
inferredcites →https://doi.org/10.2174/0929867323666160525114026openalex-snapshot
Adamantane – A Lead Structure for Drugs in Clinical Practice
inferredcites →https://doi.org/10.3109/14756369509036557openalex-snapshot
Protein Ligand Interactions. Part 5: Isoquinoline Alkaloids as Inhibitors of Acetylcholinesterase fromElectrophorus Electricus
inferredcites →https://doi.org/10.3233/jad-160484openalex-snapshot
Alzheimer’s and Parkinson’s Diseases: Expected Economic Impact on Europe—A Call for a Uniform European Strategy
inferredcites →https://doi.org/10.3724/sp.j.1009.2013.00406openalex-snapshot
A new Amaryllidaceae alkaloid from the bulbs of Lycoris radiata
inferredcites →https://doi.org/10.4088/pcc.12r01412openalex-snapshot
A Review of Butyrylcholinesterase as a Therapeutic Target in the Treatment of Alzheimer’s Disease
inferredcites →https://doi.org/10.4155/fmc-2017-0030openalex-snapshot
Prolyl Oligopeptidase and Its Role in the Organism: Attention to the Most Promising and Clinically Relevant Inhibitors
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NMR Studies on Antitumor Drug Candidates, Berberine and Berberrubine
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Conceptual search for MTDs of plant natural compounds for multifactorial Alzheimer's disease therapy
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(+)/(−)-Yanhusamides A−C, three pairs of unprecedented benzylisoquinoline-pyrrole hetero-dimeric alkaloid enantiomers from Corydalis yanhusuo
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Isoquinoline alkaloids from the roots of Zanthoxylum rigidum as multi-target inhibitors of cholinesterase, monoamine oxidase A and Aβ1-42 aggregation
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Functionalized aromatic esters of the Amaryllidaceae alkaloid haemanthamine and their in vitro and in silico biological activity connected to Alzheimer’s disease
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Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity
inferred← citeshttps://doi.org/10.1016/j.bioorg.2024.107252openalex-snapshot
Biologically active isoquinoline alkaloids covering 2019–2022
inferred← citeshttps://doi.org/10.1016/j.biopha.2022.114111openalex-snapshot
Proteomic alterations in the cerebellum and hippocampus in an Alzheimer’s disease mouse model: Alleviating effect of palmatine
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New trends in the practical use of isoquinoline alkaloids as potential drugs applicated in infectious and non-infectious diseases
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Dual regulatory effects of neferine on amyloid-β and tau aggregation studied by in silico, in vitro, and lab-on-a-chip technology
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Innovative bioinspired hydrogel scaffolds enabling in-situ hybrid nanoflower integration for dual-mode acetylcholinesterase inhibitor profiling
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Chemical constituents from the roots of Berberis aetnensis C. Presl. and their chemotaxonomic significance
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Synthesis, biological evaluation and toxicity of novel tetrandrine analogues
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An updated review of isoquinoline alkaloids: Biological activity and mode of action, structural modifications, and agricultural applications
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Sex-dependent neuro-deconvolution analysis of Alzheimer's disease brain transcriptomes according to CHI3L1 expression levels
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Natural isoquinoline alkaloids: Pharmacological features and multi-target potential for complex diseases
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Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease
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Natural products as a source of cholinesterase inhibitors
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Cholinesterase inhibitors for the treatment of Alzheimer’s disorder: Synthesis, biological analysis and molecular modelling studies of iso-quinoline derivatives
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Amaryllidaceae alkaloids from Hippeastrum X Hybridum CV. Ferrari, and preparation of vittatine derivatives as potential ligands for Alzheimer´s disease
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Exploring the role of Berberis vulgaris in urolithiasis: Mechanisms, pathophysiology and therapeutic potential
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(±)-Bicoryanhunine A, dimeric benzylisoquinoline alkaloid atropo-enantiomers from Corydalis yanhusuo
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Papaverine-Derived Dual-Active Modulator Ameliorates Alzheimer’s Disease Pathology in Aged APP/PSEN1 Transgenic Mice
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Structural Similarity in Natural Products Leading to Sample Misidentification: A Case Study of the Bisbenzylisoquinoline Alkaloids Oxyacanthine and Berbamine
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Asymmetric Total Synthesis and Anti-Inflammatory Activity of Berbamine, Oxyacanthine, and Related Intermediates
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Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase
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Copper(I)-Catalyzed Radical Carbamylation/Cyclization of 2-Aryl-N-methacryloylindoles with Substituted Formamides to Assemble Amidated Indolo[2,1-a]isoquinolin-6(5H)-ones
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Colorimetric Sensors for Alkaloids Based on the Etching of Au@MnO 2 Nanoparticles and MnO 2 Nanostars
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A membrane permeability database for nonpeptidic macrocycles
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Isolation, biological activity, and synthesis of isoquinoline alkaloids
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Semisynthesis of bersavine and berbamine derivatives that target the CaMKIIγ:cMyc axis for lymphoma therapy
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Easy Route to New Fused Dihydroisoquinoline-Naphthyridinone Frameworks
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Berberis microphylla G. Forst: a Chilean renewable source of cholinesterases and prolyl oligopeptidase inhibitors
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Trévo abrogates Lead Acetate Neurotoxicity in Male Wistar Rats viz Antiamyloidogenesis, Antiglutaminergic, and Anticholinesterase Activities
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Anti-Hyperuricemic and Uricosuric Potential of Berberis vulgaris in Oxonate-Induced Hyperuricemic Rats
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A comparative study of alkaloid and phenolic compounds in different organs and tissues of Berberis integerrima
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Berberis vulgarisL. (Berberidaceae) Épine-vinette
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Secoyanhusamine A, an Oxidatively Ring-Opened Isoquinoline Inner Salt From Corydalis yanhusuo
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Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase
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Alkaloids of Dicranostigma franchetianum (Papaveraceae) and Berberine Derivatives as a New Class of Antimycobacterial Agents
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Robust Sampling of Defective Pathways in Alzheimer’s Disease. Implications in Drug Repositioning
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The Anticancer Effect of Natural Plant Alkaloid Isoquinolines
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Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies
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Natural Alkaloids as Multi-Target Compounds towards Factors Implicated in Alzheimer’s Disease
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Berberis vulgaris L. Root Extract as a Multi-Target Chemopreventive Agent against Colon Cancer Causing Apoptosis in Human Colon Adenocarcinoma Cell Lines
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Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer’s Disease
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Bersavine: A Novel Bisbenzylisoquinoline Alkaloid with Cytotoxic, Antiproliferative and Apoptosis-Inducing Effects on Human Leukemic Cells
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Application of HPLC-DAD for In Vitro Investigation of Acetylcholinesterase Inhibition Activity of Selected Isoquinoline Alkaloids from Sanguinaria canadensis Extracts
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Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids
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Recent Progress on Biological Activity of Amaryllidaceae and Further Isoquinoline Alkaloids in Connection with Alzheimer’s Disease
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In Vitro and In Silico of Cholinesterases Inhibition and In Vitro and In Vivo Anti-Melanoma Activity Investigations of Extracts Obtained from Selected Berberis Species
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Synthesis, Characterization, and Biological Evaluation of N-Methyl Derivatives of Norbelladine
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Phytochemical Profiling of Mulberry Diels-Alder Adducts as Selective Butyrylcholinesterase Inhibitors: In Vitro Activity, Molecular Docking, and Molecular Dynamics Simulation
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Neuroprotective Herbs Associated with Parkinson’s and Alzheimer’s Disease
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Optimized Centrifugal Partition Chromatography (CPC) Protocol for Isolation of Urease Inhibitors: Magnoflorine and Berberine from Berberis vulgaris Extracts
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Plant extracts and phytochemicals targeting Alzheimer’s through acetylcholinesterase inhibition
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Screening for acetylcholinesterase inhibition, lipid peroxidation inhibition and antioxidant activity of medicinal plants from Morocco
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Bibliometric study of chemical compounds based on medicinal plants anti-Alzheimer
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Alkaloids as New Leads for Neurodegenerative Diseases
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Copper(I)-Catalyzed Acylation/Cyclization of 2-Aryl-N-acryloyl Indole toward Indolo[2,1-α]isoquinoline Derivatives
Editorial review for independent work. ICSAC — the Institute for Complexity
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