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Glycogen Synthase Kinase-3 (GSK-3) Inhibitory Activity and Structure–Activity Relationship (SAR) Studies of the Manzamine Alkaloids. Potential for Alzheimer’s Disease
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Phosphorylation of human tau protein by microtubule-associated kinases: GSK3? and cdk5 are key participants
inferredcites →https://doi.org/10.1002/med.10011openalex-snapshot
Glycogen synthase kinase 3 (GSK‐3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
inferredcites →https://doi.org/10.1016/0040-4020(95)95723-9openalex-snapshot
Four new β-carboline alkaloids isolated from two Okinawan marine sponges of Xestospongia sp. and Haliclona sp.)
inferredcites →https://doi.org/10.1016/0040-4039(88)85091-3openalex-snapshot
New manzamine alkaloids from a sponge of the genus xestospongia
inferredcites →https://doi.org/10.1016/0167-4838(84)90047-5openalex-snapshot
Multisite phosphorylation of glycogen synthase
inferredcites →https://doi.org/10.1016/j.bmcl.2004.01.050openalex-snapshot
Meridianins, a new family of protein kinase inhibitors isolated from the Ascidian Aplidium meridianum
inferredcites →https://doi.org/10.1016/j.chembiol.2003.11.010openalex-snapshot
GSK-3-Selective Inhibitors Derived from Tyrian Purple Indirubins
inferredcites →https://doi.org/10.1016/j.chembiol.2003.12.009openalex-snapshot
CDK versus GSK-3 Inhibition
inferredcites →https://doi.org/10.1016/j.tips.2004.07.006openalex-snapshot
Pharmacological inhibitors of glycogen synthase kinase 3
inferredcites →https://doi.org/10.1016/s0099-9598(03)60004-0openalex-snapshot
THE MANZAMINE ALKALOIDS
inferredcites →https://doi.org/10.1016/s0304-3940(01)01864-xopenalex-snapshot
Involvement of cyclin dependent kinase5 activator p25 on tau phosphorylation in mouse brain
inferredcites →https://doi.org/10.1016/s0960-894x(02)00169-5openalex-snapshot
Scaffold hopping and optimization towards libraries of glycogen synthase kinase-3 inhibitors
inferredcites →https://doi.org/10.1016/s0960-894x(03)00134-3openalex-snapshot
5-Aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3)
inferredcites →https://doi.org/10.1016/s0960-9822(00)00246-3openalex-snapshot
Alzheimer's disease-like phosphorylation of the microtubule-associated protein tau by glycogen synthase kinase-3 in transfected mammalian cells
inferredcites →https://doi.org/10.1016/s1074-5521(00)00025-9openalex-snapshot
Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
inferredcites →https://doi.org/10.1016/s1074-5521(00)00063-6openalex-snapshot
Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent
inferredcites →https://doi.org/10.1021/ja00280a055openalex-snapshot
Manzamine A, a novel antitumor alkaloid from a sponge
inferredcites →https://doi.org/10.1021/ja030087zopenalex-snapshot
Manadomanzamines A and B: A Novel Alkaloid Ring System with Potent Activity against Mycobacteria and HIV-1
inferredcites →https://doi.org/10.1021/jm011020uopenalex-snapshot
First Non-ATP Competitive Glycogen Synthase Kinase 3 β (GSK-3β) Inhibitors: Thiadiazolidinones (TDZD) as Potential Drugs for the Treatment of Alzheimer's Disease
inferredcites →https://doi.org/10.1021/jm030475bopenalex-snapshot
New Manzamine Alkaloids from an Indo-Pacific Sponge. Pharmacokinetics, Oral Availability, and the Significant Activity of Several Manzamines against HIV-I, AIDS Opportunistic Infections, and Inflammatory Diseases
inferredcites →https://doi.org/10.1021/np020592uopenalex-snapshot
New Manzamine Alkaloids with Activity against Infectious and Tropical Parasitic Diseases from an Indonesian Sponge
inferredcites →https://doi.org/10.1021/np0400095openalex-snapshot
Three New Manzamine Alkaloids from a Common Indonesian Sponge and Their Activity against Infectious and Tropical Parasitic Diseases
inferredcites →https://doi.org/10.1021/np0601399openalex-snapshot
Manzamine B and E and Ircinal A Related Alkaloids from an Indonesian Acanthostrongylophora Sponge and Their Activity against Infectious, Tropical Parasitic, and Alzheimer's Diseases
inferredcites →https://doi.org/10.1021/np50103a027openalex-snapshot
8-Hydroxymanzamine A, a β-Carboline Alkaloid from a Sponge, Pachypellina sp.
inferredcites →https://doi.org/10.1021/np9604083openalex-snapshot
Four New Bioactive Manzamine-Type Alkaloids from the Philippine Marine Sponge Xestospongia ashmorica
inferredcites →https://doi.org/10.1517/13543776.12.10.1527openalex-snapshot
Inhibitors of glycogen synthase kinase-3: future therapy for unmet medical needs?
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Marine natural products as therapeutic agents: Part 2
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Marine compounds for the therapeutic treatment of neurological disorders
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GSK-3 Inhibitors: Discoveries and Developments
inferredcites →https://doi.org/10.2337/diabetes.49.2.263openalex-snapshot
Potential role of glycogen synthase kinase-3 in skeletal muscle insulin resistance of type 2 diabetes.
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inferred← citeshttps://doi.org/10.3390/cells10113255openalex-snapshot
Revisiting the Role of GSK3, A Modulator of Innate Immunity, in Idiopathic Inclusion Body Myositis
inferred← citeshttps://doi.org/10.3390/ijms21176394openalex-snapshot
Drug Repurposing in Dentistry: Towards Application of Small Molecules in Dentin Repair
inferred← citeshttps://doi.org/10.3390/ijms22169098openalex-snapshot
GSK-3β, FYN, and DYRK1A: Master Regulators in Neurodegenerative Pathways
inferred← citeshttps://doi.org/10.3390/ijms24087541openalex-snapshot
GSK-3β Allosteric Inhibition: A Dead End or a New Pharmacological Frontier?
inferred← citeshttps://doi.org/10.3390/md12052539openalex-snapshot
Bioactive Marine Drugs and Marine Biomaterials for Brain Diseases
inferred← citeshttps://doi.org/10.3390/md14030058openalex-snapshot
Marine Natural Products from New Caledonia—A Review
inferred← citeshttps://doi.org/10.3390/md15060173openalex-snapshot
Marine Sponges and Bacteria as Challenging Sources of Enzyme Inhibitors for Pharmacological Applications
inferred← citeshttps://doi.org/10.3390/md16050175openalex-snapshot
Molecular Targets of Active Anticancer Compounds Derived from Marine Sources
inferred← citeshttps://doi.org/10.3390/md18070368openalex-snapshot
Marine-Derived Macrocyclic Alkaloids (MDMAs): Chemical and Biological Diversity
inferred← citeshttps://doi.org/10.3390/md19070373openalex-snapshot
Exploitation of Marine Molecules to Manage Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3390/md19080410openalex-snapshot
Marine-Derived Compounds with Anti-Alzheimer’s Disease Activities
inferred← citeshttps://doi.org/10.3390/md19090506openalex-snapshot
RSK1 vs. RSK2 Inhibitory Activity of the Marine β-Carboline Alkaloid Manzamine A: A Biochemical, Cervical Cancer Protein Expression, and Computational Study
inferred← citeshttps://doi.org/10.3390/md20100647openalex-snapshot
Manzamine-A Alters In Vitro Calvarial Osteoblast Function
inferred← citeshttps://doi.org/10.3390/md22030126openalex-snapshot
Current Status of Indole-Derived Marine Natural Products: Synthetic Approaches and Therapeutic Applications
inferred← citeshttps://doi.org/10.3390/md24060190openalex-snapshot
Manzamine-A: Unraveling the Chemical and Biological Tapestry of a Marine-Derived Drug Lead
inferred← citeshttps://doi.org/10.3390/md24090313openalex-snapshot
Proposed Biosynthesis and Molecular Targets of Manzamine Alkaloids from Acanthostrongylophora ingens (Phylum Porifera: Class Demospongiae)
inferred← citeshttps://doi.org/10.3390/md24100356openalex-snapshot
Therapeutic Potential of Marine Natural Products Against Alzheimer’s Disease: Molecular Mechanisms, Druggability Evaluation and Clinical Translation Barriers
inferred← citeshttps://doi.org/10.3390/md9102131openalex-snapshot
Kinase Inhibitors from Marine Sponges
inferred← citeshttps://doi.org/10.3390/molecules16075629openalex-snapshot
A Survey of Marine Natural Compounds and Their Derivatives with Anti-Cancer Activity Reported in 2010
inferred← citeshttps://doi.org/10.3390/molecules23040719openalex-snapshot
Amaryllidaceae Alkaloids as Potential Glycogen Synthase Kinase-3β Inhibitors
inferred← citeshttps://doi.org/10.3390/molecules28010202openalex-snapshot
Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study
inferred← citeshttps://doi.org/10.3390/pharmaceutics15092321openalex-snapshot
Natural Bioactive Compounds from Marine Invertebrates That Modulate Key Targets Implicated in the Onset of Type 2 Diabetes Mellitus (T2DM) and Its Complications
inferred← citeshttps://doi.org/10.34172/apb.2023.071openalex-snapshot
Role of GSK-3β Inhibitors: New Promises and Opportunities for Alzheimer’s Disease
inferred← citeshttps://doi.org/10.3923/jbs.2017.47.51openalex-snapshot
Assessment of the Inhibitory Mechanism of Action for a Yeast Cell-based Screening System Targeting Glycogen Synthase Kinase-3β (GSK-3β)
inferred← citeshttps://doi.org/10.4018/978-1-6684-6737-4.ch013openalex-snapshot
Marine Bioactive Products as Potential Antileishmanial Therapeutics
inferred← citeshttps://doi.org/10.4061/2011/280502openalex-snapshot
Glycogen Synthase Kinase 3 Inhibitors in the Next Horizon for Alzheimer′s Disease Treatment
inferred← citeshttps://doi.org/10.4103/1735-5362.323919openalex-snapshot
Quinazoline analogues as cytotoxic agents; QSAR, docking, and in silico studies
inferred← citeshttps://doi.org/10.4155/fmc.12.124openalex-snapshot
Natural Products As A Rich Source Of Tau-Targeting Drugs For Alzheimer’s Disease
inferred← citeshttps://doi.org/10.5812/ijpr-172672openalex-snapshot
Design, Synthesis, Molecular Dynamics Analysis, and Biological Evaluation of New Urea Derivatives in an Animal Model of Alzheimer Disease
inferred← citeshttps://doi.org/10.70675/3f96af6cz0962z4548zb02cza3069377cd95openalex-snapshot
Approche biomimétique des manadomanzamines et préparation d’analogues de la pelletiérine pour la synthèse biomimétique d’alcaloïdes de lycopodes
inferred← citeshttps://doi.org/10.70675/76b1d104zaa6az4253z864ez51e50bc9290fopenalex-snapshot
Valorisation de substances naturelles marines de Nouvelle-Calédonie d'intérêt en traitement anticancéreux
inferred← citeshttps://doi.org/10.70675/7b77d45bz138fz4454zb171z24a975c5d409openalex-snapshot
Développement synthétique d'une nouvelle librairie de 5-arylidène rhodanines sous irradiation micro-onde et d'analogues du SKF-96365 comportant des plateformes pyrazole, rhodanine et leurs évaluations biologiques
inferred← citeshttps://doi.org/10.70675/f380d140z8393z4d57z8635z025b566d8157openalex-snapshot
Valorisation chimique et biotechnologique de la biodiversité marine de l’Archipel des Comores : recherche de molécules naturelles anti-âge
inferred← citeshttps://doi.org/10.7150/thno.14334openalex-snapshot
Glycogen Synthase Kinase-3 (GSK-3)-Targeted Therapy and Imaging
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