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Studies of Jatrogossone A as a Reactive Oxygen Species Inducer in Cancer Cellular Models

https://doi.org/10.1021/acs.jnatprod.8b01087

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Molluscicidal activity of the diterpenoids jatrophone and jatropholones A and B isolated fromJatropha elliptica (Pohl) Muell. Arg.

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Jatropha Natural Products as Potential Therapeutic Leads

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Natural and semisynthetic diterpenoids with antiviral and immunomodulatory activities block the ERK signaling pathway

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Jatrophone and 12-O-tetradecanoyl phorbol-13-acetate antagonism of stimulation of natural killer activity and lymphocyte proliferation

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Synthesis and structure–activity relationship of disubstituted benzamides as a novel class of antimalarial agents

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Evaluation of Jatropha isabelli natural products and their synthetic analogs as potential antimalarial therapeutic agents

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Novel vitexin-inspired scaffold against leukemia

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Apoptosis-like yeast cell death in response to DNA damage and replication defects

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Jatrophane diterpenes and cancer multidrug resistance – ABCB1 efflux modulation and selective cell death induction

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Diterpenes from Euphorbia peplus

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Recognizing molecules with drug-like properties

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12,17-Cyclojatrophane and Jatrophane Constituents of Euphorbia welwitschii

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Antitumor Activity of Diterpenoids from Jatropha gossypiifolia: Cell Cycle Arrest and Apoptosis-Inducing Activity in RKO Colon Cancer Cells

inferredcites →https://doi.org/10.1021/acs.orglett.5b03473openalex-snapshot

One-Step Semisynthesis of a Segetane Diterpenoid from a Jatrophane Precursor via a Diels–Alder Reaction

inferredcites →https://doi.org/10.1021/ci300293fopenalex-snapshot

Plane of Best Fit: A Novel Method to Characterize the Three-Dimensionality of Molecules

inferredcites →https://doi.org/10.1021/cr078350sopenalex-snapshot

Chemical and Pharmacological Research of the Plants in Genus Euphorbia

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The Properties of Known Drugs. 1. Molecular Frameworks

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Jatrophane Diterpenes as Inhibitors of Chikungunya Virus Replication: Structure–Activity Relationship and Discovery of a Potent Lead

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The MLL recombinome of acute leukemias in 2013

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The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias

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The re-emergence of natural products for drug discovery in the genomics era

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Building and decoding ubiquitin chains for mitophagy

inferredcites →https://doi.org/10.1038/s41418-017-0012-4openalex-snapshot

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

inferredcites →https://doi.org/10.1113/jphysiol.2012.228387openalex-snapshot

Quantitative measurement of mitochondrial membrane potential in cultured cells: calcium‐induced de‐ and hyperpolarization of neuronal mitochondria

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Genomic Analysis of the Clonal Origins of Relapsed Acute Lymphoblastic Leukemia

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Biological Activities of Aerial Parts Extracts ofEuphorbia characias

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Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix

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A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

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Natural resistance to ascorbic acid induced oxidative stress is mainly mediated by catalase activity in human cancer cells and catalase-silencing sensitizes to oxidative stress

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Mitochondrial reactive oxygen species and cancer

inferredcites →https://doi.org/10.1371/journal.pone.0189864openalex-snapshot

The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer

inferredcites →https://doi.org/10.18632/oncotarget.7204openalex-snapshot

Defining specificity and on-target activity of BH3-mimetics using engineered B-ALL cell lines

inferredcites →https://doi.org/10.20455/ros.2016.805openalex-snapshot

ROS-Inducing Agents for Cancer Chemotherapy

inferredcites →https://doi.org/10.3109/01480545.2010.536767openalex-snapshot

Antioxidant and drug detoxification potentials ofHibiscus sabdariffaanthocyanin extract

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Xanthatin Induces Cell Cycle Arrest at G2/M Checkpoint and Apoptosis via Disrupting NF-κB Pathway in A549 Non-Small-Cell Lung Cancer Cells

inferredcites →https://doi.org/10.4155/fmc-2016-0095openalex-snapshot

On the Origins of Three-Dimensionality in Drug-Like Molecules

inferredcites →https://doi.org/10.4161/auto.28615openalex-snapshot

BECN1 is involved in the initiation of mitophagy

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Why do Euphorbiaceae tick as medicinal plants? A review of Euphorbiaceae family and its medicinal features

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2020.112519zenodo-depositor-declared

Bond reactivity indices approach analysis of the [2+2] cycloaddition of jatrophane skeleton diterpenoids from Euphorbia gaditana Coss to tetracyclic gaditanone

inferred← citeshttps://doi.org/10.1016/j.phymed.2024.155634openalex-snapshot

Anticancer diterpenes of African natural products: Mechanistic pathways and preclinical developments

inferred← citeshttps://doi.org/10.1021/acs.orglett.1c04145openalex-snapshot

Diterpenoids with Rearranged 9(10→11)-abeo-10,12-Cyclojatrophane Skeleton and the First (15S)-Jatrophane from Euphorbia helioscopia: Structural Elucidation, Biomimetic Conversion, and Their Immunosuppressive Effects

inferred← citeshttps://doi.org/10.1080/14786419.2019.1660656openalex-snapshot

Jatrophacine, a 4,5-seco-rhamnofolane diterpenoid with potent anti-inflammatory activity from Jatropha curcas

inferred← citeshttps://doi.org/10.21007/etd.cghs.2020.0512openalex-snapshot

Investigation of a Novel Mitophagy Regulatory Pathway and Chemical Inducer

inferred← citeshttps://doi.org/10.3390/antiox13020207openalex-snapshot

Molecular Mechanism of Natural Food Antioxidants to Regulate ROS in Treating Cancer: A Review

inferred← citeshttps://doi.org/10.3390/ijms26104588openalex-snapshot

Ergosterol Peroxide Disrupts Triple-Negative Breast Cancer Mitochondrial Function and Inhibits Tumor Growth and Metastasis

inferred← citeshttps://doi.org/10.3390/molecules26010092openalex-snapshot

Natural Products Targeting the Mitochondria in Cancers

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In Vitro Effect of Ferruginol, Tanshinone, and Carnosol Analogues on the Proliferation of Three Breast Cancer Cell Lines

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