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Stable Axially Chiral Isomers of Arylnaphthalene Lignan Glycosides with Antiviral Potential Discovered from Justicia procumbens

https://doi.org/10.1021/acs.joc.1c00068

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What this work says

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Two New Arylnaphthalide Lignans and Antiplatelet Constituents from Justicia procumbens

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Atropisomerism, Biphenyls, and Fluorine: A Comparison of Rotational Barriers and Twist Angles

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Good Computational Practice in the Assignment of Absolute Configurations by TDDFT Calculations of ECD Spectra

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Revealing Atropisomer Axial Chirality in Drug Discovery

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Stereochemistry and Recent Applications of Axially Chiral Organic Molecules

inferredcites →https://doi.org/10.1002/mrc.1830openalex-snapshot

Complete assignments of 1H and 13C NMR data for seven arylnaphthalide lignans from Justicia procumbens

inferredcites →https://doi.org/10.1016/0031-9422(84)83096-4openalex-snapshot

Lignans of haplophyllum tuberculatum

inferredcites →https://doi.org/10.1016/0031-9422(96)00024-6openalex-snapshot

Antiviral activity of lignans and their glycosides from Justicia procumbens

inferredcites →https://doi.org/10.1016/0031-9422(96)00061-1openalex-snapshot

Minor lignans from haplophyllum cappadocicum

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Studies in the Synthesis of Biaryl Natural Products

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Glycosylated diphyllin as a broad-spectrum antiviral agent against Zika virus

inferredcites →https://doi.org/10.1016/j.phytochem.2009.05.016openalex-snapshot

Glycosides of arylnaphthalene lignans from Acanthus mollis having axial chirality

inferredcites →https://doi.org/10.1016/j.phytochem.2017.01.005openalex-snapshot

Anti-HIV diphyllin glycosides from Justicia gendarussa

inferredcites →https://doi.org/10.1016/j.tetasy.2017.09.006openalex-snapshot

Thermal racemization of biaryl atropisomers

inferredcites →https://doi.org/10.1021/acs.jnatprod.7b00004openalex-snapshot

Potent Inhibitor of Drug-Resistant HIV-1 Strains Identified from the Medicinal Plant Justicia gendarussa

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Assessing Atropisomer Axial Chirality in Drug Discovery and Development

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Hindered Rotation in Arylnaphthalene Lignans

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Determination of the Enantiomerization Barrier of Arylnaphthalene Lignans by Cryogenic Subcritical Fluid Chromatography and Computer Simulation

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New Lignan Glycosides with Potent Antiinflammatory Effect, Isolated from Justicia ciliata

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Potent Cytotoxic Lignans from Justicia procumbens and Their Effects on Nitric Oxide and Tumor Necrosis Factor-α Production in Mouse Macrophages

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A twist of nature – the significance of atropisomers in biological systems

inferredcites →https://doi.org/10.1039/c6np00021eopenalex-snapshot

Recent advances in research on lignans and neolignans

inferredcites →https://doi.org/10.1039/c7ra13754kopenalex-snapshot

Arylnaphthalene lactone analogues: synthesis and development as excellent biological candidates for future drug discovery

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Determination of the absolute configuration of conformationally flexible molecules by simulation of chiro-optical spectra: a case study

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Comparative assessment of a new nonempirical density functional: Molecules and hydrogen-bonded complexes

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Toward reliable density functional methods without adjustable parameters: The PBE0 model

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Total synthesis of 6′-hydroxyjusticidin A

inferredcites →https://doi.org/10.1080/10286020.2013.805208openalex-snapshot

The synthesis of justicidinoside B and its atropisomer

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Generalized Gradient Approximation Made Simple

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Absolute Configuration Determination by Quantum Mechanical Calculation of Chiroptical Spectra: Basics and Applications to Fungal Metabolites

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Development of an Antiviral Screening Protocol: One-Stone-Two-birds

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Axial Chirality and Antiviral Activity Evaluation of Arylnaphthalene Lignan Glycosides from Justicia procumbens

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Bioactive atropisomers: Unraveling design strategies and synthetic routes for drug discovery

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Survey of natural products reported by Asian research groups in 2021

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The efficient synthesis and biological evaluation of justicidin B

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Mechanisms of Rostellularia procumbens (L.) Nees on treating chronic glomerulonephritis explored by network pharmacology, RNA-seq, and in vitro experiments

inferred← citeshttps://doi.org/10.3390/molecules28010302openalex-snapshot

Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins

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In-Depth Exploration of Chemical Constituents from Justicia procumbens L. Through UHPLC-Q-Exactive Orbitrap Mass Spectrometry

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Additional file 1 of Mechanisms of Rostellularia procumbens (L.) Nees on treating chronic glomerulonephritis explored by network pharmacology, RNA-seq, and in vitro experiments

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