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Potent Cytotoxic Lignans from Justicia procumbens and Their Effects on Nitric Oxide and Tumor Necrosis Factor-α Production in Mouse Macrophages
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
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Inducible nitric oxide synthase expression in activated rat microglial cultures is downregulated by exogenous prostaglandin E2 and by cyclooxygenase inhibitors
inferredcites →https://doi.org/10.1021/np50088a013openalex-snapshot
Saponins from Collinsonia canadensis
inferredcites →https://doi.org/10.1038/374647a0openalex-snapshot
Activation of microglial cells by β-amyloid protein and interferon-γ
inferredcites →https://doi.org/10.1038/374650a0openalex-snapshot
Impairment of muscle function caused by mutations of phosphorylation sites in myosin regulatory light chain
inferredcites →https://doi.org/10.1038/bjc.1988.125openalex-snapshot
Chemosensitivity testing of human lung cancer cell lines using the MTT assay
inferredcites →https://doi.org/10.1248/cpb.18.862openalex-snapshot
The Isolation of Neojusticin from Justicia procumbens LINN.
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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Arylnaphthalene lignans with a focus Linum species: a review on phytochemical, biotechnological and pharmacological potential
inferred← citeshttps://doi.org/10.1002/9781118682784.ch11openalex-snapshot
Biological Properties of Lignans
inferred← citeshttps://doi.org/10.1002/ajoc.202200267openalex-snapshot
Axial Chirality and Antiviral Activity Evaluation of Arylnaphthalene Lignan Glycosides from Justicia procumbens
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Two New Arylnaphthalide Lignans and Antiplatelet Constituents from Justicia procumbens
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Synthesis and Bioevaluation of Diphyllin Glycosides as Novel Anticancer Agents
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Quantification and pharmacokinetics of Taiwanin E methyl ether in rats by liquid chromatography–tandem mass spectrometry
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A Combined Transition‐Metal‐Catalyzed and Photopromoted Process: Synthesis of 2,3‐Fused 4‐Phenylnaphthalen‐1‐yl Carboxylates from 1,7‐Diaryl‐1,6‐diynes
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Production of (R)‐1‐(1,3‐benzodioxol‐5‐yl)ethanol in high enantiomeric purity by Lactobacillus paracasei BD 101
inferred← citeshttps://doi.org/10.1002/cjoc.200790127openalex-snapshot
First Synthesis of Bioactive Diphyllin Glycosides Isolated from Justicia patentiflor Hemsl
inferred← citeshttps://doi.org/10.1002/ejoc.201700556openalex-snapshot
First Total Synthesis of the Bioactive Arylnaphthyl Lignan 4‐O‐Glycosides Phyllanthusmin D and 4′′‐O‐Acetylmananthoside B
inferred← citeshttps://doi.org/10.1002/hlca.200690033openalex-snapshot
A New Lignan and Four New Lignan Glycosides from Mananthes patentiflora
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Justicidin A‐Induced Autophagy Flux Enhances Apoptosis of Human Colorectal Cancer Cells via Class III PI3K and Atg5 Pathway
inferred← citeshttps://doi.org/10.1002/jssc.201000781openalex-snapshot
Chromatographic fingerprint analysis and simultaneous determination of eight lignans in Justicia procumbens and its compound preparation by HPLC‐DAD
inferred← citeshttps://doi.org/10.1002/jssc.201200851openalex-snapshot
Simultaneous determination of seven lignans in J usticia procumbens by high performance liquid chromatography–photodiode array detection using relative response factors
inferred← citeshttps://doi.org/10.1002/jssc.201600961openalex-snapshot
Ultra high performance liquid chromatography–electrospray ionization‐tandem mass spectrometry and pharmacokinetic analysis of justicidin B and 6′‐hydroxy justicidin C in rats
inferred← citeshttps://doi.org/10.1002/med.22037openalex-snapshot
Bioactive atropisomers: Unraveling design strategies and synthetic routes for drug discovery
inferred← citeshttps://doi.org/10.1002/mrc.1830openalex-snapshot
Complete assignments of 1H and 13C NMR data for seven arylnaphthalide lignans from Justicia procumbens
inferred← citeshttps://doi.org/10.1002/mrc.2175openalex-snapshot
Complete assignments of 1H and 13C NMR data for three new arylnaphthalene lignan from Justicia procumbens
inferred← citeshttps://doi.org/10.1002/rcm.6189openalex-snapshot
Fragmentation investigation of seven arylnaphthalide lignans using liquid chromatography/tandem quadrupole time‐of‐flight mass spectrometry
inferred← citeshttps://doi.org/10.1007/s00044-009-9172-1openalex-snapshot
Synthesis and bioevaluation of novel analogues of justicidin A
inferred← citeshttps://doi.org/10.1007/s00044-011-9937-1openalex-snapshot
Synthesis and in vitro anticancer activities of novel aryl-naphthalene lignans
inferred← citeshttps://doi.org/10.1007/s00044-012-0245-1openalex-snapshot
Synthesis and bioevaluation of novel arylnaphthalene lignans as anticancer agents
inferred← citeshttps://doi.org/10.1007/s11101-020-09735-zopenalex-snapshot
Arylnaphthalene lactones: structures and pharmacological potentials
inferred← citeshttps://doi.org/10.1007/s13353-023-00812-5openalex-snapshot
Chloroplast genome of Justicia procumbens: genomic features, comparative analysis, and phylogenetic relationships among Justicieae species
inferred← citeshttps://doi.org/10.1016/b978-0-12-405927-6.00012-6openalex-snapshot
Lignans and Stilbenes from African Medicinal Plants
inferred← citeshttps://doi.org/10.1016/bs.abr.2024.02.008openalex-snapshot
Cytotoxic lignans, neolignans, and stilbenes from African medicinal plants
inferred← citeshttps://doi.org/10.1016/j.biocel.2012.05.014openalex-snapshot
V-ATPases in osteoclasts: Structure, function and potential inhibitors of bone resorption
inferred← citeshttps://doi.org/10.1016/j.bmc.2018.03.033openalex-snapshot
Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones
inferred← citeshttps://doi.org/10.1016/j.bmc.2025.118197openalex-snapshot
Antitumor and immunomodulatory activities of diphyllin and its derivatives
inferred← citeshttps://doi.org/10.1016/j.bse.2024.104901openalex-snapshot
Cytotoxicity of endemic Haplophyllum megalanthum Bornm. and its newly isolated alkaloids and lignans
inferred← citeshttps://doi.org/10.1016/j.cbi.2025.111723openalex-snapshot
Natural lignan justicidin A-induced mitophagy as a targetable niche in bladder cancer
inferred← citeshttps://doi.org/10.1016/j.ejmech.2011.11.011openalex-snapshot
Design, synthesis and biological evaluation of novel glycosylated diphyllin derivatives as topoisomerase II inhibitors
inferred← citeshttps://doi.org/10.1016/j.ejmech.2013.11.008openalex-snapshot
Synthesis, characterization and anticancer screening of some novel piperonyl–tetrazole derivatives
inferred← citeshttps://doi.org/10.1016/j.febslet.2006.04.085openalex-snapshot
Caspase‐8 acts as a key upstream executor of mitochondria during justicidin A‐induced apoptosis in human hepatoma cells
inferred← citeshttps://doi.org/10.1016/j.fitote.2014.01.025openalex-snapshot
Cytotoxic activity of lignans from Justicia procumbens
inferred← citeshttps://doi.org/10.1016/j.hermed.2017.12.001openalex-snapshot
In-vitro assessment of cytotoxicity, antioxidant and anti-inflammatory activities of Ficus palmata
inferred← citeshttps://doi.org/10.1016/j.jchromb.2012.06.045openalex-snapshot
Application of a sensitive and specific LC–MS/MS method for determination of chinensinaphthol methyl ether in rat plasma for a bioavailability study
inferred← citeshttps://doi.org/10.1016/j.jchromb.2016.08.041openalex-snapshot
Determination and pharmacokinetics of chinensinaphthol methyl ether in rat urine by a sensitive and specific UFLC-ESI-MS/MS method
inferred← citeshttps://doi.org/10.1016/j.jep.2005.07.021openalex-snapshot
Anti-inflammatory activities of constituents isolated from Phyllanthus polyphyllus
inferred← citeshttps://doi.org/10.1016/j.jep.2012.09.010openalex-snapshot
JR6, a new compound isolated from Justicia procumbens, induces apoptosis in human bladder cancer EJ cells through caspase-dependent pathway
inferred← citeshttps://doi.org/10.1016/j.jep.2023.116819openalex-snapshot
Ethnomedicinal uses, phytochemistry, and pharmacological relevance of Justicia procumbens (Oriental Water Willow) - A promising traditional plant
inferred← citeshttps://doi.org/10.1016/j.jff.2015.04.025openalex-snapshot
Discovery of molecular mechanisms of lignan justicidin A using L1000 gene expression profiles and the Library of Integrated Network-based Cellular Signatures database
inferred← citeshttps://doi.org/10.1016/j.jff.2017.04.017openalex-snapshot
Using connectivity map to identify natural lignan justicidin A as a NF-κB suppressor
inferred← citeshttps://doi.org/10.1016/j.jfutfo.2022.03.019openalex-snapshot
Identification of targets and mechanisms for Eleutheroside E in the treatment of cancer
inferred← citeshttps://doi.org/10.1016/j.jpba.2005.12.014openalex-snapshot
A new lignan from the Jian-er syrup and its content determination by RP-HPLC
inferred← citeshttps://doi.org/10.1016/j.jpba.2012.05.002openalex-snapshot
LC–ESI-MS/MS analysis and pharmacokinetics of 6′-hydroxy justicidin A, a potential antitumor active component isolated from Justicia procumbens, in rats
inferred← citeshttps://doi.org/10.1016/j.phymed.2023.155197openalex-snapshot
Exploring the antiviral potential of justicidin B and four glycosylated lignans from Phyllanthus brasiliensis against Zika virus: A promising pharmacological approach
inferred← citeshttps://doi.org/10.1016/j.phytochem.2007.06.026openalex-snapshot
DNA strand-scission by phloroglucinols and lignans from heartwood of Garcinia subelliptica Merr. and Justicia plants
inferred← citeshttps://doi.org/10.1016/j.phytochem.2009.05.016openalex-snapshot
Glycosides of arylnaphthalene lignans from Acanthus mollis having axial chirality
inferred← citeshttps://doi.org/10.1016/j.tet.2021.132214openalex-snapshot
Triflic acid catalysed regioselective synthesis of substituted naphthalenes by benzannulation of carbonyls with alkynes
inferred← citeshttps://doi.org/10.1016/j.tetlet.2026.156149openalex-snapshot
Indium chloride catalysed annulation of arylmethyl carbonyls & arylalkynes for the synthesis of naphthalene derivatives
inferred← citeshttps://doi.org/10.1016/s1875-5364(19)30117-7openalex-snapshot
Anti-HIV lignans from Justicia procumbens
inferred← citeshttps://doi.org/10.1021/acs.joc.1c00068openalex-snapshot
Stable Axially Chiral Isomers of Arylnaphthalene Lignan Glycosides with Antiviral Potential Discovered from Justicia procumbens
inferred← citeshttps://doi.org/10.1021/acsomega.6c00627openalex-snapshot
Antiviral Mechanisms of Justicidin B and Tuberculatin from Phyllanthus brasiliensis against Oropouche Virus Infection
inferred← citeshttps://doi.org/10.1021/np5002785openalex-snapshot
Potent Cytotoxic Arylnaphthalene Lignan Lactones from Phyllanthus poilanei
inferred← citeshttps://doi.org/10.1023/b:phyt.0000046174.97809.b6openalex-snapshot
Flax seed lignan in disease prevention and health promotion
inferred← citeshttps://doi.org/10.1039/b514045popenalex-snapshot
An update on bioactive plant lignans
inferred← citeshttps://doi.org/10.1055/s-2007-993754openalex-snapshot
Reversal of P-Glycoprotein-Mediated Drug Efflux by Eudesmin from Haplophyllum perforatum and Cytotoxicity Pattern versus Diphyllin, Podophyllotoxin and Etoposide
inferred← citeshttps://doi.org/10.1080/07328300802030860openalex-snapshot
Synthesis of Per‐acetyl d ‐fucopyranosyl Bromide and Its Use in Preparation of Diphyllin d ‐fucopyranosyl Glycoside
inferred← citeshttps://doi.org/10.1080/10286020.2013.805208openalex-snapshot
The synthesis of justicidinoside B and its atropisomer
inferred← citeshttps://doi.org/10.1080/10286020.2016.1241771openalex-snapshot
New lignan glycosides from Justicia procumbens
inferred← citeshttps://doi.org/10.1080/10826068.2021.1925913openalex-snapshot
Optimization of asymmetric reduction conditions of 1-(benzo [d] [1,3] dioxol-5-yl) ethanone by Lactobacillus fermentum P1 using D-optimal experimental design-based model
inferred← citeshttps://doi.org/10.1080/14786419.2020.1758090openalex-snapshot
New cyclopeptide alkaloids from the whole plant of Justicia procumbens L
inferred← citeshttps://doi.org/10.1093/carcin/bgi133openalex-snapshot
Justicidin A decreases the level of cytosolic Ku70 leading to apoptosis in human colorectal cancer cells
inferred← citeshttps://doi.org/10.1097/cad.0000000000000203openalex-snapshot
Antiangiogenesis as the novel mechanism for justicidin A in the anticancer effect on human bladder cancer
inferred← citeshttps://doi.org/10.1124/mol.65.5.1063openalex-snapshot
Justicidin A Inhibits the Transport of Tumor Necrosis Factor-α to Cell Surface in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages
inferred← citeshttps://doi.org/10.1134/s1068162020060345openalex-snapshot
Synthesis and Anti-Proliferative Activity of New Acridinyl and Benzothiazolyl-Based Triazole Glycosides via Click Cycloaddition and Their Tetrazolyl Analogs
inferred← citeshttps://doi.org/10.1142/9789812709301_0014openalex-snapshot
New Approach for Evaluating the Anti-Breast Cancer Activity of Traditional Chinese Medicine
inferred← citeshttps://doi.org/10.1186/s12906-023-04079-5openalex-snapshot
Mechanisms of Rostellularia procumbens (L.) Nees on treating chronic glomerulonephritis explored by network pharmacology, RNA-seq, and in vitro experiments
inferred← citeshttps://doi.org/10.1248/cpb.58.1324openalex-snapshot
Synthesis, Cytotoxicity and Pro-apoptosis of Novel Benzoisoindolin Hydrazones as Anticancer Agents
inferred← citeshttps://doi.org/10.1254/jphs.13211fpopenalex-snapshot
HJC, a New Arylnaphthalene Lignan Isolated From Justicia procumbens, Causes Apoptosis and Caspase Activation in K562 Leukemia Cells
inferred← citeshttps://doi.org/10.1359/jbmr.070613openalex-snapshot
Diphyllin, a Novel and Naturally Potent V-ATPase Inhibitor, Abrogates Acidification of the Osteoclastic Resorption Lacunae and Bone Resorption
inferred← citeshttps://doi.org/10.1371/journal.pone.0093516openalex-snapshot
Evaluation and Structure-Activity Relationship Analysis of a New Series of Arylnaphthalene lignans as Potential Anti-Tumor Agents
inferred← citeshttps://doi.org/10.1590/s0102-695x2011005000196openalex-snapshot
Chemical constituents and biological activities of species of Justicia: a review
inferred← citeshttps://doi.org/10.18632/oncotarget.21625openalex-snapshot
Differential modulation of Bax/Bcl-2 ratio and onset of caspase-3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375
inferred← citeshttps://doi.org/10.2174/0113862073316439240515072946openalex-snapshot
Lignans: Advances in Biosynthesis, Bioavailability, and Pharmacological Activity
inferred← citeshttps://doi.org/10.2174/1389557519666181231121217openalex-snapshot
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inferred← citeshttps://doi.org/10.22159/ijpps.2023v15i5.47280openalex-snapshot
GENUS LEPIDAGATHIS (ACANTHACEAE): REVIEW OF ITS ETHANOBOTANY, PHYTOCHEMISTRY AND PHARMACOLOGICAL POTENTIAL
inferred← citeshttps://doi.org/10.3389/fchem.2020.00628openalex-snapshot
Transition Metal-Mediated Annulation Approaches for Synthesis of Arylnaphthalene Lignan Lactones
inferred← citeshttps://doi.org/10.3389/fchem.2022.1103554openalex-snapshot
Total synthesis of justicidin B, justicidin E, and taiwanin C: A general and flexible approach toward the synthesis of natural arylnaphthalene lactone lignans
inferred← citeshttps://doi.org/10.3389/fmicb.2020.00350openalex-snapshot
Evidence of Biocontrol Activity of Bioinoculants Against a Human Pathogen, Listeria monocytogenes
inferred← citeshttps://doi.org/10.3389/fphar.2021.681190openalex-snapshot
An Ethnobotanical Study of Medicinal Plants in Kinmen
inferred← citeshttps://doi.org/10.3390/antiox11020298openalex-snapshot
Vulnerability of Triple-Negative Breast Cancer to Saponin Formosanin C-Induced Ferroptosis
inferred← citeshttps://doi.org/10.3390/antiox11081526openalex-snapshot
Linum lewisii Adventitious and Hairy-Roots Cultures as Lignan Plant Factories
inferred← citeshttps://doi.org/10.3390/antiox14081027openalex-snapshot
Using Integrated Bioinformatics Analysis to Identify Saponin Formosanin C as a Ferroptosis Inducer in Colorectal Cancer with p53 and Oncogenic KRAS
inferred← citeshttps://doi.org/10.3390/antiox9080682openalex-snapshot
Saponin Formosanin C-Induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells
inferred← citeshttps://doi.org/10.3390/i8080830openalex-snapshot
Antiplatelet Effect and Selective Binding to Cyclooxygenase (COX) by Molecular Docking Analysis of Flavonoids and Lignans
inferred← citeshttps://doi.org/10.3390/molecules20047048openalex-snapshot
Preparative Isolation and Purification of Lignans from Justicia procumbens Using High-Speed Counter-Current Chromatography in Stepwise Elution Mode
inferred← citeshttps://doi.org/10.3390/molecules22122024openalex-snapshot
A Strategy for Preparative Separation of 10 Lignans from Justicia procumbens L. by High-Speed Counter-Current Chromatography
inferred← citeshttps://doi.org/10.3390/molecules28010302openalex-snapshot
Chemistry and Biological Activities of Naturally Occurring and Structurally Modified Podophyllotoxins
inferred← citeshttps://doi.org/10.3390/molecules28237874openalex-snapshot
Bioactivities and Mechanisms of Action of Diphyllin and Its Derivatives: A Comprehensive Systematic Review
inferred← citeshttps://doi.org/10.3390/plants9070860openalex-snapshot
Comparative Metabolite Profiling of Wild and Cultivated Justicia procumbens L. Based on 1H-NMR Spectroscopy and HPLC-DAD Analysis
inferred← citeshttps://doi.org/10.3390/v14020354openalex-snapshot
Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses
inferred← citeshttps://doi.org/10.6084/m9.figshare.23740724openalex-snapshot
Additional file 1 of Mechanisms of Rostellularia procumbens (L.) Nees on treating chronic glomerulonephritis explored by network pharmacology, RNA-seq, and in vitro experiments
inferred← citeshttps://doi.org/10.70675/48cfd5e7z542dz4aebz8922z3b14d21430d3openalex-snapshot
Synthèse et évaluation pharmacologique de composés originaux de la famille des méthoxynaphtalènes et lignanes arylnaphtalènes à visée antitumorale
inferred← citeshttps://doi.org/10.9734/ijbcrr/2020/v29i630194openalex-snapshot
Inhibitory Potential and Antidiabetic Activity of Leaf Extracts of Justicia carnea
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