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Catalytic Asymmetric Mukaiyama–Mannich Reaction of Cyclic C-Acylimines with Difluoroenoxysilanes: Access to Difluoroalkylated Indolin-3-ones

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Organofluorine Chemistry
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Chiral Brønsted Acid‐Mediated Enantioselective Organocatalytic Three‐Component Reaction for the Construction of Trifluoromethyl‐Containing Molecules
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Catalytic Asymmetric Synthesis of Oxindoles Bearing a Tetrasubstituted Stereocenter at the C‐3 Position
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Chiral Brønsted Acid‐Catalyzed Enantioselective Friedel–Crafts Reaction of 4,7‐Dihydroindoles with Trifluoromethyl Ketones
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Asymmetric Brønsted Acid‐Catalyzed Friedel–Crafts Reactions of Indoles with Cyclic Imines ‐ Efficient Generation of Nitrogen‐Substituted Quaternary Carbon Centers
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Chiral Phosphoric Acid‐Catalyzed Asymmetric Aza‐Friedel–Crafts Reaction of Indoles with Cyclic N‐Acylketimines: Enantioselective Synthesis of Trifluoromethyldihydroquinazolines
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Recent Catalytic Asymmetric Syntheses of 3,3‐Disubstituted Indolin‐2‐ones and 2,2‐Disubstituted Indolin‐3‐ones
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Gelsemine: A Thought‐Provoking Target for Total Synthesis
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Total Synthesis of Complex Cyclotryptamine Alkaloids: Stereocontrolled Construction of Quaternary Carbon Stereocenters
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Pyrrolidinyl‐Spirooxindole Natural Products as Inspirations for the Development of Potential Therapeutic Agents
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Cinchona Alkaloid Catalyzed Enantioselective Fluorination of Allyl Silanes, Silyl Enol Ethers, and Oxindoles
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Highly Enantioselective Construction of 3‐Hydroxy Oxindoles through a Decarboxylative Aldol Addition of Trifluoromethyl α‐Fluorinated gem ‐Diols to N ‐Benzyl Isatins
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N‐Heterocyclic Carbene Catalyzed Formal [3+2] Annulation Reaction of Enals: An Efficient Enantioselective Access to Spiro‐Heterocycles
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Michael Addition Catalyzed by Chiral Secondary Amine Phosphoramide Using Fluorinated Silyl Enol Ethers: Formation of Quaternary Carbon Stereocenters
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Dual Catalysis for the Redox Annulation of Nitroalkynes with Indoles: Enantioselective Construction of Indolin‐3‐ones Bearing Quaternary Stereocenters
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InCl3‐Mediated Addition of Indole to Isatogens: An Expeditious Synthesis of 13‐deoxy‐Isatisine A
inferredcites →https://doi.org/10.1002/chem.201302407openalex-snapshot
Visible‐Light‐Induced Trifluoromethylation of N‐Aryl Acrylamides: A Convenient and Effective Method To Synthesize CF3‐Containing Oxindoles Bearing a Quaternary Carbon Center
inferredcites →https://doi.org/10.1002/chem.201601573openalex-snapshot
Organocatalytic Enantioselective Aza‐Friedel–Crafts Reaction of Cyclic Ketimines with Pyrroles using Imidazolinephosphoric Acid Catalysts
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3‐Alkenyl‐oxindoles: Natural Products, Pharmaceuticals, and Recent Synthetic Advances in Tandem/Telescoped Approaches
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Asymmetric Proline‐Catalyzed Addition of Aldehydes to 3H‐Indol‐3‐ones: Enantioselective Synthesis of 2,3‐Dihydro‐1H‐indol‐3‐ones with Quaternary Stereogenic Centers
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On the preparation of indoxyl red from indican and some new characteristics
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2-Aryl-3H-indol-3-ones: Synthesis, electrochemical behaviour and antiplasmodial activities
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Fluorine chemistry at the millennium
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One-pot synthesis of polyhydropyrido[1,2- a ]indoles and tetracyclic quinazolinones from 2-arylindoles using copper-mediated oxidative tandem reactions
inferredcites →https://doi.org/10.1016/j.tetlet.2010.06.132openalex-snapshot
Chiral Brønsted acid-catalyzed regio- and enantioselective arylation of α,β-unsaturated trifluoromethyl ketones
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A new finding in selective Baeyer–Villiger oxidation of α-fluorinated ketones; a new and practical route for the synthesis of α-fluorinated esters
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Organocatalyzed Asymmetric Michael Addition of 1-Acetylindolin-3-ones to β,γ-Unsaturated α-Ketoesters: An Access to Chiral Indolin-3-ones with Two Adjacent Tertiary Stereogenic Centers
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Chiral Phosphoric Acid Catalyzed Enantioselective Decarboxylative Alkylation of β-Keto Acids with 3-Hydroxy-3-indolyloxindoles
inferredcites →https://doi.org/10.1021/acs.orglett.6b02798openalex-snapshot
Synthesis of the Azepinobisindole Alkaloid Iheyamine A Enabled by a Cross-Mannich Reaction
inferredcites →https://doi.org/10.1021/acs.orglett.6b03473openalex-snapshot
Organocatalytic Enantioselective Amination of 2-Substituted Indolin-3-ones: A Strategy for the Synthesis of Chiral α-Hydrazino Esters
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Asymmetric Fluorination, Trifluoromethylation, and Perfluoroalkylation Reactions
inferredcites →https://doi.org/10.1021/cr100166aopenalex-snapshot
Asymmetric Construction of Stereogenic Carbon Centers Featuring a Trifluoromethyl Group from Prochiral Trifluoromethylated Substrates
inferredcites →https://doi.org/10.1021/cr5002386openalex-snapshot
Good Partnership between Sulfur and Fluorine: Sulfur-Based Fluorination and Fluoroalkylation Reagents for Organic Synthesis
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Advances in Catalytic Enantioselective Fluorination, Mono-, Di-, and Trifluoromethylation, and Trifluoromethylthiolation Reactions
inferredcites →https://doi.org/10.1021/cs300733sopenalex-snapshot
Palladium-Catalyzed C–C Triple Bond Cleavage: Efficient Synthesis of 4H-Benzo[d][1,3]oxazin-4-ones
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Asymmetric, stereocontrolled total synthesis of (-)-brevianamide B
inferredcites →https://doi.org/10.1021/ja026663topenalex-snapshot
A Short Synthetic Route to (+)-Austamide, (+)-Deoxyisoaustamide, and (+)-Hydratoaustamide from a Common Precursor by a Novel Palladium-Mediated Indole → Dihydroindoloazocine Cyclization
inferredcites →https://doi.org/10.1021/ja0513077openalex-snapshot
Catalytic Enantioselective Fluorination of Oxindoles
inferredcites →https://doi.org/10.1021/ja501117vopenalex-snapshot
Pd-Catalyzed α-Arylation of α,α-Difluoroketones with Aryl Bromides and Chlorides. A Route to Difluoromethylarenes
inferredcites →https://doi.org/10.1021/jm800219fopenalex-snapshot
The Many Roles for Fluorine in Medicinal Chemistry
inferredcites →https://doi.org/10.1021/jo301886jopenalex-snapshot
Organocatalytic Asymmetric Michael Addition of Oxindoles to Nitroolefins for the Synthesis of 2,2-Disubstituted Oxindoles Bearing Adjacent Quaternary and Tertiary Stereocenters
inferredcites →https://doi.org/10.1021/jo971173iopenalex-snapshot
Electrolytic Partial Fluorination of Organic Compounds. 22.1 Highly Regioselective Anodic Monofluorination of Oxindole and 3-Oxo-1,2,3,4-tetrahydroisoquinoline Derivatives: Effects of Supporting Fluoride Salts and Anode Materials
inferredcites →https://doi.org/10.1021/np060395lopenalex-snapshot
Indole Alkaloids from Cephalanceropsis gracilis
inferredcites →https://doi.org/10.1021/np1002498openalex-snapshot
Notoamide O, a Structurally Unprecedented Prenylated Indole Alkaloid, and Notoamides P−R from a Marine-Derived Fungus, Aspergillus sp.
inferredcites →https://doi.org/10.1021/np5003274openalex-snapshot
Indole Alkaloid Glycosides from the Aerial Parts of Strobilanthes cusia
inferredcites →https://doi.org/10.1021/ol200374mopenalex-snapshot
Chiral Phosphoric Acid Catalyzed Enantioselective Synthesis of β-Amino-α,α-difluoro Carbonyl Compounds
inferredcites →https://doi.org/10.1021/ol502163fopenalex-snapshot
Photoredox-Catalyzed Tandem Radical Cyclization of N-Arylacrylamides: General Methods To Construct Fluorinated 3,3-Disubstituted 2-Oxindoles Using Fluoroalkylsulfonyl Chlorides
inferredcites →https://doi.org/10.1021/ol701540yopenalex-snapshot
Isatisine A, a Novel Alkaloid with an Unprecedented Skeleton from Leaves of Isatis indigotica
inferredcites →https://doi.org/10.1039/b610213copenalex-snapshot
Fluorine in medicinal chemistry
inferredcites →https://doi.org/10.1039/b711844aopenalex-snapshot
Understanding organofluorine chemistry. An introduction to the C–F bond
inferredcites →https://doi.org/10.1039/b812433gopenalex-snapshot
New chemical and biological applications of fluorous technologies
inferredcites →https://doi.org/10.1039/b819925fopenalex-snapshot
Biogenetically inspired syntheses of alkaloid natural products
inferredcites →https://doi.org/10.1039/b900474bopenalex-snapshot
A perfect double role of CF3 groups in activating substrates and stabilizing adducts: the chiral Brønsted acid-catalyzed direct arylation of trifluoromethyl ketones
inferredcites →https://doi.org/10.1039/b916463dopenalex-snapshot
Selective difluoromethylation and monofluoromethylation reactions
inferredcites →https://doi.org/10.1039/b924272dopenalex-snapshot
Brønsted acid-catalyzed efficient Strecker reaction of ketones, amines and trimethylsilyl cyanide
inferredcites →https://doi.org/10.1039/c1sc00190fopenalex-snapshot
Chiral phosphoric acid-catalysed Friedel–Crafts alkylation reaction of indoles with racemic spiro indolin-3-ones
inferredcites →https://doi.org/10.1039/c2cc17140fopenalex-snapshot
Organocatalytic asymmetric synthesis of 3-difluoroalkyl 3-hydroxyoxindoles
inferredcites →https://doi.org/10.1039/c2cc34053dopenalex-snapshot
Enantioselective aza-Henry reactions of cyclic α-carbonyl ketimines under bifunctional catalysis
inferredcites →https://doi.org/10.1039/c2cs35100eopenalex-snapshot
Recent advances in organocatalytic methods for the synthesis of disubstituted 2- and 3-indolinones
inferredcites →https://doi.org/10.1039/c3ob41698dopenalex-snapshot
An asymmetric normal-electron-demand aza-Diels–Alder reaction via trienamine catalysis
inferredcites →https://doi.org/10.1039/c4qo00078aopenalex-snapshot
Catalytic fluorination of unactivated C(sp 3 )–H bonds
inferredcites →https://doi.org/10.1039/c5qo00407aopenalex-snapshot
Organocatalytic enantioselective Mukaiyama–Mannich reaction of fluorinated enol silyl ethers and cyclic N-sulfonyl ketimines
inferredcites →https://doi.org/10.1039/c6cc00177gopenalex-snapshot
Visible-light-initiated difluoromethylation of arene diazonium tetrafluoroborates
inferredcites →https://doi.org/10.1039/c6cc02284gopenalex-snapshot
Radical perfluoroalkylation – easy access to 2-perfluoroalkylindol-3-imines via electron catalysis
inferredcites →https://doi.org/10.1039/c6ra24834aopenalex-snapshot
TEMPO-catalyzed oxidative homocoupling route to 3,2′-biindolin-2-ones via an indolin-3-one intermediate
inferredcites →https://doi.org/10.1039/c7qo00129kopenalex-snapshot
Asymmetric amination of 2-substituted indolin-3-ones catalyzed by natural cinchona alkaloids
inferredcites →https://doi.org/10.1055/s-0029-1216975openalex-snapshot
Asymmetric Syntheses of Oxindole and Indole Spirocyclic Alkaloid Natural Products
inferredcites →https://doi.org/10.1055/s-0030-1260773openalex-snapshot
Proline-Catalyzed Enantioselective Synthesis of Aza-Quaternary Carbon Derivatives
inferredcites →https://doi.org/10.1055/s-0034-1379043openalex-snapshot
Palladium-Catalyzed Asymmetric Allylic Alkylation Reaction of 2-Monosubstituted Indolin-3-ones
inferredcites →https://doi.org/10.1055/s-2005-916016openalex-snapshot
Catalytic Enantioselective Fluorination of Oxindoles
inferredcites →https://doi.org/10.1080/00397919508011457openalex-snapshot
Facile Synthesis of 2-Aryl-3H-indol-3-onesviaSinglet Oxygenation of 2-Arylindoles
inferredcites →https://doi.org/10.1126/science.1131943openalex-snapshot
Fluorine in Pharmaceuticals: Looking Beyond Intuition
inferredcites →https://doi.org/10.1126/science.aaf8078openalex-snapshot
Catalytic, asymmetric difluorination of alkenes to generate difluoromethylated stereocenters
inferredcites →https://doi.org/10.1246/cl.2012.728openalex-snapshot
Isolation and Structure of a Novel Biindole Pigment Substituted with an Ethyl Group from a Metagenomic Library Derived from the Marine Sponge Halichondria okadai
inferredcites →https://doi.org/10.3762/bjoc.8.208openalex-snapshot
Asymmetric Brønsted acid-catalyzed aza-Diels–Alder reaction of cyclic C-acylimines with cyclopentadiene
inferredcites →https://doi.org/10.3987/com-07-s(u)42openalex-snapshot
Asymmetric Alkylation of 2-Monosubstituted Indolin-3-ones
inferredcites →https://doi.org/10.6023/a14110758openalex-snapshot
Advances in Transition-Metal-Mediated Di-and Monofluoroalkylations

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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B(C6f5)3-Catalyzed Regio- and Stereoselective Cyanation of Isatogens and Their Derivatives
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The Difluoromethylation Protocols
inferred← citeshttps://doi.org/10.1002/adsc.201800345openalex-snapshot
Organocatalytic Asymmetric Transformations Involving the Cyclic Imine Moiety in Indole and Isoindole Related Heterocycles
inferred← citeshttps://doi.org/10.1002/adsc.201900710openalex-snapshot
Enantioselective Addition of Enamides to Cyclic Ketimines: Access to Chiral 3,3‐Disubstituted Isoindolin‐1‐Ones
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One‐Pot Asymmetric Oxidative Dearomatization of 2‐Substituted Indoles by Merging Transition Metal Catalysis with Organocatalysis to Access C2‐Tetrasubstituted Indolin‐3‐Ones
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HFIP‐Catalyzed Mannich Reaction: Divergent Synthesis of Difluoro‐Substituted 3,4‐Dihydroquinoxalin‐2(1H)‐ones and Monofluoroquinoxalin‐2(1H)‐ones
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Recent Advances in the Enantioselective Construction of gem‐Difluorinated Carbonyl Moieties
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Catalytic Asymmetric Difluoroalkylation Using In Situ Generated Difluoroenol Species as the Privileged Synthon
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Catalytic Enantioselective Aldol‐Type Reaction Using α‐Fluorinated Enolates
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Synthetic Applications of Ambiphilic C‐acylimines in Organic Synthesis
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Organocatalyst‐Controlled Divergent Asymmetric Aza‐Friedel‐Crafts Reactions of Indol‐3‐ones with 1‐ and 2‐Naphthols
inferred← citeshttps://doi.org/10.1002/ajoc.70417openalex-snapshot
Enantioselective Aerobic Construction of C2‐Quaternary Indolin‐3‐ones by Gold/Chiral Amine Relay Catalysis
inferred← citeshttps://doi.org/10.1002/ange.202115036openalex-snapshot
Katalytische asymmetrische Additionen von Enolsilanen an in situ erzeugte zyklische, aliphatischeN‐Acyliminiumionen
inferred← citeshttps://doi.org/10.1002/ange.202208742openalex-snapshot
Catalytic and Stereoselective Transformations with Easily Accessible and Purchasable Allyl and Alkenyl Fluorides
inferred← citeshttps://doi.org/10.1002/ange.202420360openalex-snapshot
Goldkatalysierte Intramolekulare Reaktion von Alkinen mit Sulfoximinen als N‐ und O‐Transferreagenzien
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Reductant‐Free Enantioselective Aza ‐Reformatsky Reaction Enabled by Synergistic Visible Light Photocatalysis and Lewis Acid Catalysis
inferred← citeshttps://doi.org/10.1002/anie.202115036openalex-snapshot
Catalytic Asymmetric Additions of Enol Silanes to In Situ Generated Cyclic, AliphaticN‐Acyliminium Ions
inferred← citeshttps://doi.org/10.1002/anie.202208742openalex-snapshot
Catalytic and Stereoselective Transformations with Easily Accessible and Purchasable Allyl and Alkenyl Fluorides
inferred← citeshttps://doi.org/10.1002/anie.202420360openalex-snapshot
Gold‐Catalysed Intramolecular Reaction of Alkynes with Sulfoximines Acting as N‐ and O‐Transfer Reagents
inferred← citeshttps://doi.org/10.1002/anie.202500756openalex-snapshot
Reductant‐Free Enantioselective Aza ‐Reformatsky Reaction Enabled by Synergistic Visible Light Photocatalysis and Lewis Acid Catalysis
inferred← citeshttps://doi.org/10.1002/asia.201800300openalex-snapshot
Oxidative Asymmetric Aza‐Friedel–Crafts Alkylation of Indoles with 3‐Indolinone‐2‐carboxylates Catalyzed by a BINOL Phosphoric Acid and Promoted by DDQ
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Organocatalytic Asymmetric Cascade Aerobic Oxidation and Semipinacol Rearrangement Reaction: A Visible Light‐Induced Approach to Access Chiral 2,2‐Disubstituted Indolin‐3‐ones
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Synthesis of Multifunctional α,α‐Difluoroketones through Allylic Alkylation of Difluoroenoxysilanes with MBH Carbonates
inferred← citeshttps://doi.org/10.1002/bkcs.12293openalex-snapshot
Mannich Reaction as a Key Strategy for the Synthesis of Trifluoroethyl Derived Tertiary and Secondary Amine
inferred← citeshttps://doi.org/10.1002/cjoc.70131openalex-snapshot
Recent Advances in gem‐Difluoroalkenes and Difluroenoxysilanes for Asymmetric Synthesis
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Microwave‐Assisted Domino Palladium Catalysis in Water: A Diverse Synthesis of 3,3′‐Disubstituted Heterocyclic Compounds
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Synthesis of N‐Fused Seven‐Membered Indoline‐3‐ones via a Palladium‐Catalyzed One‐Pot Insertion Reaction from 2‐Alkynyl Arylazides and Cyclic β‐Diketones
inferred← citeshttps://doi.org/10.1002/slct.201802476openalex-snapshot
Pd‐Catalyzed One‐Pot Two‐Step Synthesis of 2‐(1 H ‐indol‐3‐yl)‐2‐phenylindolin‐3‐ones from 2‐Alkynyl Arylazides and Indoles
inferred← citeshttps://doi.org/10.1002/slct.202504555openalex-snapshot
DBU‐Mediated Difluoroalkylation of Cyclic Sulfonyl Aldimines with Difluoroenoxysilanes
inferred← citeshttps://doi.org/10.1007/s11030-021-10235-1openalex-snapshot
Catalytic stereoselective Mannich-type reactions for construction of fluorinated compounds
inferred← citeshttps://doi.org/10.1007/s11030-022-10464-yopenalex-snapshot
Design of a new method for the synthesis of novel 2-aryl/alkyl-3H-indol-3-ones
inferred← citeshttps://doi.org/10.1016/j.cclet.2021.07.030openalex-snapshot
Iron-catalyzed cyanoalkylation of difluoroenol silyl ethers with cyclobutanone oxime esters
inferred← citeshttps://doi.org/10.1016/j.cclet.2021.12.002openalex-snapshot
HFIP-catalyzed highly diastereoselective formal [4 + 2] cyclization to synthesize difluorinated multisubstituted chromans using difluoroenoxysilanes as C2 synthons
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Copper-Catalyzed Highly Enantioselective Difluoroalkylation of Secondary Propargyl Sulfonates with Difluoroenoxysilanes
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Internally reuse by-product as promoter: A catalyst-free imine formation/Mukaiyama-Mannich sequence of α-amido sulfones with fluorinated silyl enol ethers
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An efficient Fe(III)-catalyzed 1,6-conjugate addition of para-quinone methides with fluorinated silyl enol ethers toward β,β-diaryl α-fluorinated ketones
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Enantioselective synthesis of hetero-triarylmethanes by chiral phosphoric acid-catalyzed 1,4-addition of 3-substituted indoles with azadienes
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Reinventing the wheel for enabling the synthesis of hinckdentine A
inferred← citeshttps://doi.org/10.1016/j.tetlet.2024.154909openalex-snapshot
B(C6F5)3-catalyzed regio- and stereoselective cyanation of isatogens and their derivatives
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Recent Advances on Catalytic Asymmetric Synthesis of Molecules Bearing a Fluorine-Containing Stereogenic Carbon Center (2015–2024)
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Catalytic Asymmetric Access to Noncanonical Chiral α-Amino Acids from Cyclic Iminoglyoxylates and Enamides
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Regiodivergent Synthesis of Penta-Substituted Pyrroles through a Cascade [3 + 2] Cyclization of C-Acylimines with Activated Alkynes and Aromatic Nucleophiles
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Construction of gem-Difluoroenol Esters through Catalytic O-Selective Addition of Difluoroenoxysilanes to Ketenes
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Catalyst-Free and Solvent-Controlled Divergent Synthesis of Difluoromethylene-Containing S-Heterocycles
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Palladium-Catalyzed One-Pot Synthesis of Pyrroloindolines from 2-Alkynyl Arylazides and Thioacetamides
inferred← citeshttps://doi.org/10.1021/acs.joc.1c01485openalex-snapshot
Synthesis of Hydroxysuccinimide Substituted Indolin-3-ones via One-Pot Cascade Reaction of o-Alkynylnitrobenzenes with Maleimides under Au(III)–Cu(II) Relay/Synergetic Catalysis
inferred← citeshttps://doi.org/10.1021/acs.joc.1c02501openalex-snapshot
Dieckmann Condensation of Ugi N-Acylamino Amide Product: Facile Access to Functionalized 2,2-Disubstituted Indolin-3-ones
inferred← citeshttps://doi.org/10.1021/acs.joc.1c03120openalex-snapshot
Indoles Oxidative Ring-Opening/Cyclization Cascade with the 1,2-Diaminoarenes: Direct Synthesis of 2-Aryl-3-(2-aminoaryl)quinoxalines
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PPh3-Mediated Cascade Reaction of 2-Alkynylnitrobenzenes and Thioureas for the Construction of Imidazo[4,5-b]indole-2-thiones
inferred← citeshttps://doi.org/10.1021/acs.joc.2c02765openalex-snapshot
Organocatalyzed Enantioselective Aza-Morita–Baylis–Hillman Reaction of Cyclic Ketimine with α,β-Unsaturated γ-Butyrolactam
inferred← citeshttps://doi.org/10.1021/acs.joc.5c01028openalex-snapshot
High Enantioselective and Unprecedented Diastereoselective Synthesis of C2-Quaternary Indolin-3-ones by CPA-Catalyzed Asymmetric Mannich Reaction of 3,3-Difluoro-2-aryl-3H-indoles with Cycloketones
inferred← citeshttps://doi.org/10.1021/acs.joc.8b00231openalex-snapshot
Solvent-Dependent Copper-Catalyzed Indolyl C3-Oxygenation and N1-Cyclization Reactions: Selective Synthesis of 3H-Indol-3-ones and Indolo[1,2-c]quinazolines
inferred← citeshttps://doi.org/10.1021/acs.joc.8b01488openalex-snapshot
N-Heterocyclic Carbene-Catalyzed Formal Conjugate Hydroacylation: An Atom-Economic Synthesis of 1H-Indol-3-yl Esters
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c00018openalex-snapshot
[3,3]-Sigmatropic Rearrangement/Haller–Bauer Reaction of Aryl Sulfoxides and Selenoxides with Difluoroenoxysilanes: Access to CF2H-Containing Chalcogenides
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c02323openalex-snapshot
Selective Synthesis of 2-Indolyl-3-oxoindolines or 2-(2-Aminophenyl)quinolines through Cu(II)- or Bi(III)-Catalyzed Tunable Dimerizations of 2-Alkynylanilines
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c03123openalex-snapshot
Construction of β-Quaternary α,α-Difluoroketones via Catalytic Nucleophilic Substitution of Tertiary Alcohols with Difluoroenoxysilanes
inferred← citeshttps://doi.org/10.1021/acs.orglett.0c03406openalex-snapshot
Catalytic Enantioselective Synthesis of Difluoromethylated Tetrasubstituted Stereocenters in Isoindolones Enabled by a Multiple-Fluorine System
inferred← citeshttps://doi.org/10.1021/acs.orglett.2c01445openalex-snapshot
Divergent Reaction of Activated Pyridines with α,α-Difluorinated gem-Diols: Regioselective Synthesis of gem-Difluorinated Dihydropyridines and Dihydropyridones
inferred← citeshttps://doi.org/10.1021/acs.orglett.3c01361openalex-snapshot
Photoredox-Catalyzed N-Directed Regioselective Difluoroalkylation of Unactivated C(sp3)–H Bonds
inferred← citeshttps://doi.org/10.1021/acs.orglett.3c01427openalex-snapshot
Iron-Catalyzed Alkoxyl Radical-Induced C–C Bond Cleavage/gem-Difluoroalkylation Cascade
inferred← citeshttps://doi.org/10.1021/acs.orglett.3c04285openalex-snapshot
Gold/Chiral Amine Relay Catalysis Enables Asymmetric Synthesis of C2-Quaternary Indolin-3-ones
inferred← citeshttps://doi.org/10.1021/acs.orglett.4c01958openalex-snapshot
B(C6F5)3/Chiral Phosphoric Acid Promoted Asymmetric C-3 gem-Difluoroalkylation of Quinoxalin-2-ones with Difluoroenoxysilanes
inferred← citeshttps://doi.org/10.1021/acs.orglett.4c04279openalex-snapshot
Difluoroenoxysilanes in Catalytic Asymmetric Allylic Alkylation
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c00712openalex-snapshot
Chiral Phosphoric Acid Catalyzed Asymmetric Mannich Reaction of 2-Aryl-3H-indol-3-ones with α-H Diazoacetates
inferred← citeshttps://doi.org/10.1021/acs.orglett.8b01900openalex-snapshot
Divergent Reactivity of gem-Difluoro-enolates toward Nitrogen Electrophiles: Unorthodox Nitroso Aldol Reaction for Rapid Synthesis of α-Ketoamides
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b01823openalex-snapshot
Asymmetric Synthesis of C2-Quaternary Indolin-3-ones Enabled by N-Heterocyclic Carbene Catalysis
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b01849openalex-snapshot
CuH-Catalyzed Synthesis of 3-Hydroxyindolines and 2-Aryl-3H-indol-3-ones from o-Alkynylnitroarenes, Using Nitro as Both the Nitrogen and Oxygen Source
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b01965openalex-snapshot
Organocatalytic Asymmetric Dearomative Oxyalkylation of Indoles Enables Access to C2-Quaternary Indolin-3-ones
inferred← citeshttps://doi.org/10.1021/acs.orglett.9b03181openalex-snapshot
Chiral β-Keto Propargylamine Synthesis via Enantioselective Mannich Reaction of Enamides with C -Alkynyl N -Boc N , O -Acetals
inferred← citeshttps://doi.org/10.1021/acscatal.2c00100openalex-snapshot
Synthesis of Enantioenriched Fluorinated Enol Silanes Enabled by Asymmetric Reductive Coupling of Fluoroalkylacylsilanes and 1,3-Enynes and Brook Rearrangement
inferred← citeshttps://doi.org/10.1021/acscatal.5c05967openalex-snapshot
Asymmetric Diamination of the In Situ Generated Difluoroenol Species Using Azocarboxamides as an N Source
inferred← citeshttps://doi.org/10.1021/acscatal.6c04996openalex-snapshot
Enantioconvergent Assembly of Chiral Difluoromethyl Stereocenters by Nickel-Catalyzed Reductive Cross-Coupling
inferred← citeshttps://doi.org/10.1021/acsomega.4c07691openalex-snapshot
One-Pot Synthesis of N-Fused Quinolone-4 Tetracyclic Scaffolds from 2,2-Disubstituted Indolin-3-ones
inferred← citeshttps://doi.org/10.1021/jacs.1c12723openalex-snapshot
A Powerful Chiral Super Brønsted C–H Acid for Asymmetric Catalysis
inferred← citeshttps://doi.org/10.1038/s41467-024-50400-2openalex-snapshot
Enantioselective de novo construction of 3‑oxindoles via organocatalyzed formal [3 + 2] annulation from simple arylamines
inferred← citeshttps://doi.org/10.1038/s41467-024-55488-0openalex-snapshot
Nucleophilic addition of bulk chemicals with imines using N-functionalized hydroxylamine reagents as precursors
inferred← citeshttps://doi.org/10.1039/9781788016988-00234openalex-snapshot
Quinquevalent phosphorus acids
inferred← citeshttps://doi.org/10.1039/c8cc05125aopenalex-snapshot
Chiral phosphoric acid-catalyzed direct asymmetric mannich reaction of cyclic C -acylimines with simple ketones: facile access to C2-quaternary indolin-3-ones
inferred← citeshttps://doi.org/10.1039/c8ob00541aopenalex-snapshot
Neighboring phenolic group-activated gem -difluoroallylboration of imines for the catalyst-free synthesis of gem -difluorohomoallylamines
inferred← citeshttps://doi.org/10.1039/c8ob01874jopenalex-snapshot
Cyclic imines – preparation and application in synthesis
inferred← citeshttps://doi.org/10.1039/c8ob03057jopenalex-snapshot
Metal-free synthesis of 2,2-disubstituted indolin-3-ones
inferred← citeshttps://doi.org/10.1039/c9cc07677hopenalex-snapshot
Catalytic selective mono- and difluoroalkylation using fluorinated silyl enol ethers
inferred← citeshttps://doi.org/10.1039/c9ob02129aopenalex-snapshot
HClO 4 catalysed aldol-type reaction of fluorinated silyl enol ethers with acetals or ketals toward fluoroalkyl ethers
inferred← citeshttps://doi.org/10.1039/c9qo00577copenalex-snapshot
A Sc(OTf) 3 catalyzed Mukaiyama–Mannich reaction of difluoroenoxysilanes with unactivated ketimines
inferred← citeshttps://doi.org/10.1039/d0cc03591bopenalex-snapshot
Photoredox-catalyzed sulfonylation of difluoroenoxysilanes with the insertion of sulfur dioxide
inferred← citeshttps://doi.org/10.1039/d0cc05432aopenalex-snapshot
Organocatalytic asymmetric synthesis of arylindolyl indolin-3-ones with both axial and central chirality
inferred← citeshttps://doi.org/10.1039/d0cc06980aopenalex-snapshot
HFIP-catalyzed direct dehydroxydifluoroalkylation of benzylic and allylic alcohols with difluoroenoxysilanes
inferred← citeshttps://doi.org/10.1039/d0nj04588hopenalex-snapshot
One-pot synthesis of 3-hydroxy-2-oxindoles via acyloin rearrangements of 2-hydroxy-indolin-3-ones generated in situ from 2-alkynyl arylazides
inferred← citeshttps://doi.org/10.1039/d0qo00799dopenalex-snapshot
Palladium-catalyzed one-pot cycloaddition reactions of thioureas with 3 H -indol-3-ones generated in situ from 2-alkynyl arylazides: rapid and efficient access to imidazoloindolines
inferred← citeshttps://doi.org/10.1039/d1qo01493eopenalex-snapshot
Access to enantioenriched molecules with diverse fluorinated tetrasubstituted stereocenters using hydroxy as a kinetic resolution auxiliary group
inferred← citeshttps://doi.org/10.1039/d1sc03533aopenalex-snapshot
A general approach to 2,2-disubstituted indoxyls: total synthesis of brevianamide A and trigonoliimine C
inferred← citeshttps://doi.org/10.1039/d2cc02774gopenalex-snapshot
Gold-catalyzed redox cycloisomerization/nucleophilic addition/reduction: direct access to 2-phosphoryl indolin-3-ones
inferred← citeshttps://doi.org/10.1039/d2ob01763fopenalex-snapshot
A Cu-BOX catalysed enantioselective Mukaiyama-aldol reaction with difluorinated silyl enol ethers and acylpyridine N -oxides
inferred← citeshttps://doi.org/10.1039/d2ob02152hopenalex-snapshot
A highly efficient metal-free selective 1,4-addition of difluoroenoxysilanes to chromones
inferred← citeshttps://doi.org/10.1039/d2qo00775dopenalex-snapshot
Asymmetric difluorocarbonylation reactions of non-active imines catalyzed by Bi(OAc) 3 /chiral phosphoric acid
inferred← citeshttps://doi.org/10.1039/d2qo01209jopenalex-snapshot
An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to CO and CN bonds
inferred← citeshttps://doi.org/10.1039/d2ra00456aopenalex-snapshot
A solid-supported organocatalyst for asymmetric Mannich reaction to construct C2-quaternary indolin-3-ones
inferred← citeshttps://doi.org/10.1039/d3nj04336copenalex-snapshot
PPh 3 -Mediated cascade reaction of 2-alkynylnitrobenzenes and 1,2-diaminoarenes for the construction of 2-aryl-3-(2-aminoaryl)quinoxalines
inferred← citeshttps://doi.org/10.1039/d4ob02028fopenalex-snapshot
Recent developments in the catalytic asymmetric synthesis of indolin-3-one derivatives
inferred← citeshttps://doi.org/10.1039/d4qo00987hopenalex-snapshot
Asymmetric difluoroalkylation via Michael addition of an in situ generated difluoroenol intermediate
inferred← citeshttps://doi.org/10.1039/d5cc04004copenalex-snapshot
Rh( iii )-catalyzed C–H activation/β-F elimination/Michael addition: diastereoselective access to dihydroisoquinolinones featuring β-amino α-fluorocarbonyl motif
inferred← citeshttps://doi.org/10.1039/d6nj01151aopenalex-snapshot
PPh 3 -Mediated synthesis of multifunctional indolin-3-one derivatives from 2-(ethynyl)nitrobenzenes and aryl ketones
inferred← citeshttps://doi.org/10.1055/a-1274-2959openalex-snapshot
Enantioselective Synthesis of Difluoroalkylated Isoindolinones via Chiral Spirocyclic Phosphoric Acid Catalyzed Mannich-Type Reaction
inferred← citeshttps://doi.org/10.1055/a-2020-8717openalex-snapshot
2,2-Disubstituted Indoxyls via Oxidative Dearomatization: Generalization to 2-Alkylindoles and Application to Alkaloid Synthesis
inferred← citeshttps://doi.org/10.1055/a-2971-3679openalex-snapshot
Expedient Access to gem-Difluoromethyl Cyclic Sulfamidates via Mannich Reaction and Reductive C–C Bond Fission
inferred← citeshttps://doi.org/10.1055/s-0040-1720150openalex-snapshot
Synthetic Organic Chemistry of α-Imino Ketones: A Graphical Review
inferred← citeshttps://doi.org/10.1080/00397911.2026.2666763openalex-snapshot
Cu(OAc) 2 /Cs 2 CO 3 -promoted one-pot synthesis of 2,3-disubstituted quinolin-4(1H)-ones from spiro[indole-3,5′-isoxazoles]
inferred← citeshttps://doi.org/10.21203/rs.3.rs-2995436/v1openalex-snapshot
De novo construction of chiral 3‑oxindoles via organocatalyzed enantioselective ortho-Friedel-Crafts addition/novel [1,2]-ester migration
inferred← citeshttps://doi.org/10.6023/cjoc202104057openalex-snapshot
Cobalt-Catalyzed Aerobic Oxidative Dearomatization of 2-Aryl Indoles and in situ [3+2] Annulation with Enamides
inferred← citeshttps://doi.org/10.6023/cjoc202311013openalex-snapshot
Syntheses and Structural Characterizations of Benzoxazolyl N-Heterocyclic Carbene-Palladium Complexes and Their Applications
inferred← citeshttps://doi.org/10.6023/cjoc202407039openalex-snapshot
Research Progress in Asymmetric Synthesis of C2 Chiral Indolin-3-ones Involving 2-Substituted-3H-indol-3-ones
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