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Switching on a Nontraditional Enzymatic Base—Deprotonation by Serine in the ent-Kaurene Synthase from Bradyrhizobium japonicum
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1016/j.febslet.2008.12.052openalex-snapshot
Gibberellin biosynthesis in bacteria: Separate ent ‐copalyl diphosphate and ent ‐kaurene synthases in Bradyrhizobium japonicum
inferredcites →https://doi.org/10.1016/j.phytochem.2011.11.004openalex-snapshot
Mutational analysis of white spruce (Picea glauca) ent-kaurene synthase (PgKS) reveals common and distinct mechanisms of conifer diterpene synthases of general and specialized metabolism
inferredcites →https://doi.org/10.1021/acs.biochem.8b00452openalex-snapshot
Slow-Starter Enzymes: Role of Active-Site Architecture in the Catalytic Control of the Biosynthesis of Taxadiene by Taxadiene Synthase
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Structural and Chemical Biology of Terpenoid Cyclases
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The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design
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Changing Face: A Key Residue for the Addition of Water by Sclareol Synthase
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Predicting Productive Binding Modes for Substrates and Carbocation Intermediates in Terpene Synthases—Bornyl Diphosphate Synthase As a Representative Case
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Protonated Benzofuran, Anthracene, Naphthalene, Benzene, Ethene, and Ethyne: Measurements and Estimates of pKaand pKR
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A Single Residue Switch Converts Abietadiene Synthase into a Pimaradiene Specific Cyclase
inferredcites →https://doi.org/10.1021/ja710524wopenalex-snapshot
Increasing Complexity of a Diterpene Synthase Reaction with a Single Residue Switch
inferredcites →https://doi.org/10.1021/ja9084786openalex-snapshot
Formation of Beyerene, Kaurene, Trachylobane, and Atiserene Diterpenes by Rearrangements That Avoid Secondary Carbocations
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The Basicity of Alcohols and Ethers
inferredcites →https://doi.org/10.1038/ja.2016.39openalex-snapshot
General base-general acid catalysis by terpenoid cyclases
inferredcites →https://doi.org/10.1038/nchembio.2232openalex-snapshot
Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution
inferredcites →https://doi.org/10.1038/srep06214openalex-snapshot
Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum
inferredcites →https://doi.org/10.1039/b517914aopenalex-snapshot
Advances in methods and algorithms in a modern quantum chemistry program package
inferredcites →https://doi.org/10.1039/b810189bopenalex-snapshot
Long-range corrected hybrid density functionals with damped atom–atom dispersion corrections
inferredcites →https://doi.org/10.1039/c0cc02960bopenalex-snapshot
Electrostatic effects on (di)terpene synthase product outcome
inferredcites →https://doi.org/10.1039/c6sc00635copenalex-snapshot
Mechanistically informed predictions of binding modes for carbocation intermediates of a sesquiterpene synthase reaction
inferredcites →https://doi.org/10.1073/pnas.0611454104openalex-snapshot
Following evolution's lead to a single residue switch for diterpene synthase product outcome
inferredcites →https://doi.org/10.1073/pnas.0709466105openalex-snapshot
Functional plasticity of paralogous diterpene synthases involved in conifer defense
inferredcites →https://doi.org/10.1074/jbc.m111.337592openalex-snapshot
Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis
inferredcites →https://doi.org/10.1111/j.1365-313x.2011.04520.xopenalex-snapshot
The family of terpene synthases in plants: a mid‐size family of genes for specialized metabolism that is highly diversified throughout the kingdom
inferredcites →https://doi.org/10.1111/j.1742-4658.2010.07938.xopenalex-snapshot
Identification of the single amino acid involved in quenching the ent‐kauranyl cation by a water molecule in ent‐kaurene synthase of Physcomitrella patens
inferredcites →https://doi.org/10.1186/s12870-015-0647-6openalex-snapshot
One amino acid makes the difference: the formation of ent-kaurene and 16α-hydroxy-ent-kaurane by diterpene synthases in poplar
inferredcites →https://doi.org/10.3389/fpls.2016.01765openalex-snapshot
Extending a Single Residue Switch for Abbreviating Catalysis in Plant ent-Kaurene Synthases
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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A pair of threonines mark ent-kaurene synthases for phytohormone biosynthesis
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inferred← citeshttps://doi.org/10.1002/anie.202315674openalex-snapshot
Characterization and Engineering of Two Highly Paralogous Sesquiterpene Synthases Reveal a Regioselective Reprotonation Switch
inferred← citeshttps://doi.org/10.1002/anie.202407895openalex-snapshot
A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation‐Reprotonation Process
inferred← citeshttps://doi.org/10.1002/cbic.202100484openalex-snapshot
Predictive Engineering of Class I Terpene Synthases Using Experimental and Computational Approaches
inferred← citeshttps://doi.org/10.1016/bs.mie.2024.02.006openalex-snapshot
Docking carbocations into terpene synthase active sites using chemically meaningful constraints—The TerDockin approach
inferred← citeshttps://doi.org/10.1016/bs.mie.2024.04.025openalex-snapshot
Ancestral terpene cyclases: From fundamental science to applications in biosynthesis
inferred← citeshttps://doi.org/10.1016/j.copbio.2020.06.002openalex-snapshot
Enzymatic control of product distribution in terpene synthases: insights from multiscale simulations
inferred← citeshttps://doi.org/10.1016/j.ijbiomac.2024.138333openalex-snapshot
A pivotal switch in β-domain determines the substrate selectivity of terpene synthases involved in Gardenia jasminoides floral scent synthesis
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Between scents and sterols: Cyclization of labdane-related diterpenes as model systems for enzymatic control of carbocation cascades
inferred← citeshttps://doi.org/10.1021/acs.biochem.0c00395openalex-snapshot
Probing Enzymatic Structure and Function in the Dihydroxylating Sesquiterpene Synthase ZmEDS
inferred← citeshttps://doi.org/10.1021/acs.biochem.0c00762openalex-snapshot
Crystal Structure and Mechanistic Molecular Modeling Studies of Mycobacterium tuberculosis Diterpene Cyclase Rv3377c
inferred← citeshttps://doi.org/10.1021/acs.jctc.6c01306openalex-snapshot
Modeling the Impact of Active Site Mutations on the Quenching Fate and Cyclization Depth of a Rare Oxidosqualene Cyclase
inferred← citeshttps://doi.org/10.1021/acs.jnatprod.9b00784openalex-snapshot
Novel Sesquiterpene Skeletons by Multiple Wagner–Meerwein Rearrangements of a Longipinane-1,9-diol Derivative
inferred← citeshttps://doi.org/10.1021/acs.jpcb.6c01900openalex-snapshot
Unraveling the Catalytic Promiscuity Mechanism of Triterpene Synthase AaOSC-22030 via Multiscale QM/MM Simulations and Mutagenesis
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c00858openalex-snapshot
The Pursuit of a Hydroxylation Switch Uncovers a Key Residue for Various Product Outcomes in the ent-Kaurene Synthase from Bradyrhizobium japonicum
inferred← citeshttps://doi.org/10.1021/acsbiomedchemau.2c00023openalex-snapshot
Investigation of Acid–Base Catalysis in Halimadienyl Diphosphate Synthase Involved in Mycobacterium tuberculosis Virulence
inferred← citeshttps://doi.org/10.1021/acscatal.3c05918openalex-snapshot
From Functional Plasticity of Two Diterpene Synthases (IrTPS2/IrKSL3a) to Enzyme Evolution
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Unexpected Main-Chain-Mediated and Neutral-Intermediate-Involved Catalytic Reaction in a High-Fidelity ent-Neoabietadiene Synthase
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Customizing Natural Products of Sesquiterpene Synthases by Mechanism-Based Design and DeEnzyme_Score Screening
inferred← citeshttps://doi.org/10.1021/jacs.0c10214openalex-snapshot
Engineering of Ancestors as a Tool to Elucidate Structure, Mechanism, and Specificity of Extant Terpene Cyclase
inferred← citeshttps://doi.org/10.1038/s42004-021-00578-zopenalex-snapshot
Functional characterization and structural bases of two class I diterpene synthases in pimarane-type diterpene biosynthesis
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Chemical control over the conversion between bicyclic and polycyclic terpenes by fungal bifunctional terpene synthases
inferred← citeshttps://doi.org/10.1039/d2np00054gopenalex-snapshot
Plant (di)terpenoid evolution: from pigments to hormones and beyond
inferred← citeshttps://doi.org/10.1039/d3cy00115fopenalex-snapshot
Harnessing the catalytic plasticity of the ent -kaurene synthase from Bradyrhizobium japonicum to produce the ent -rosane and ent -pimarane scaffolds
inferred← citeshttps://doi.org/10.1039/d4cc03922jopenalex-snapshot
Serine 85 functions as a catalytic acid in the reprotonation process during EvAS-catalyzed astellifadiene biosynthesis
inferred← citeshttps://doi.org/10.1039/d5np00066aopenalex-snapshot
Engineering class I terpene synthases for skeletal diversity: strategies and applications
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Peeking behind the carbocation: identification of (alternative) catalytic bases in the class II active site of conifer resin acid diterpene synthases
inferred← citeshttps://doi.org/10.1042/bcj20250294openalex-snapshot
Docking in the Abies grandis abietaenol synthase to investigate the mechanism underlying conifer resin acid diterpene synthase evolution
inferred← citeshttps://doi.org/10.1093/hr/uhae221openalex-snapshot
Discovery of bifunctional diterpene cyclases/synthases in bacteria supports a bacterial origin for the plant terpene synthase gene family
inferred← citeshttps://doi.org/10.1093/plphys/kiac056openalex-snapshot
Diterpene synthases fromLeonurus japonicuselucidate epoxy-bridge formation of spiro-labdane diterpenoids
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Transcending eons; evolutionary and mechanistic insight into plant Class I Diterpene synthases
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