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Changing Face: A Key Residue for the Addition of Water by Sclareol Synthase

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/prot.21086openalex-snapshot
ROSETTALIGAND: Protein–small molecule docking with full side‐chain flexibility
inferredcites →https://doi.org/10.1007/10_2014_301openalex-snapshot
Cytochromes P450 for Terpene Functionalisation and Metabolic Engineering
inferredcites →https://doi.org/10.1016/j.phytochem.2011.11.004openalex-snapshot
Mutational analysis of white spruce (Picea glauca) ent-kaurene synthase (PgKS) reveals common and distinct mechanisms of conifer diterpene synthases of general and specialized metabolism
inferredcites →https://doi.org/10.1016/j.phytochem.2014.01.021openalex-snapshot
Characterization of two genes for the biosynthesis of abietane-type diterpenes in rosemary (Rosmarinus officinalis) glandular trichomes
inferredcites →https://doi.org/10.1016/j.str.2013.08.005openalex-snapshot
High-Resolution Comparative Modeling with RosettaCM
inferredcites →https://doi.org/10.1016/j.ymben.2016.04.001openalex-snapshot
Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis
inferredcites →https://doi.org/10.1021/acs.orglett.8b00121openalex-snapshot
Premutilin Synthase: Ring Rearrangement by a Class II Diterpene Cyclase
inferredcites →https://doi.org/10.1021/acschembio.6b01075openalex-snapshot
A Pair of Residues That Interactively Affect Diterpene Synthase Product Outcome
inferredcites →https://doi.org/10.1021/cr050286wopenalex-snapshot
Structural Biology and Chemistry of the Terpenoid Cyclases
inferredcites →https://doi.org/10.1021/ja071158nopenalex-snapshot
A Modular Approach for Facile Biosynthesis of Labdane-Related Diterpenes
inferredcites →https://doi.org/10.1021/ja074977gopenalex-snapshot
A Single Residue Switch Converts Abietadiene Synthase into a Pimaradiene Specific Cyclase
inferredcites →https://doi.org/10.1021/ja307404uopenalex-snapshot
Toward a Biosynthetic Route to Sclareol and Amber Odorants
inferredcites →https://doi.org/10.1021/ja710524wopenalex-snapshot
Increasing Complexity of a Diterpene Synthase Reaction with a Single Residue Switch
inferredcites →https://doi.org/10.1021/ol902051vopenalex-snapshot
A Functional Genomics Approach to Tanshinone Biosynthesis Provides Stereochemical Insights
inferredcites →https://doi.org/10.1038/nprot.2013.074openalex-snapshot
Small-molecule ligand docking into comparative models with Rosetta
inferredcites →https://doi.org/10.1038/srep06214openalex-snapshot
Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum
inferredcites →https://doi.org/10.1039/c0cc02960bopenalex-snapshot
Electrostatic effects on (di)terpene synthase product outcome
inferredcites →https://doi.org/10.1039/c0np00019aopenalex-snapshot
Two rings in them all: The labdane-related diterpenoids
inferredcites →https://doi.org/10.1039/c0ob00884bopenalex-snapshot
Substrate specificity of Rv3378c, an enzyme from Mycobacterium tuberculosis, and the inhibitory activity of the bicyclic diterpenoids against macrophagephagocytosis
inferredcites →https://doi.org/10.1073/pnas.0611454104openalex-snapshot
Following evolution's lead to a single residue switch for diterpene synthase product outcome
inferredcites →https://doi.org/10.1073/pnas.0709466105openalex-snapshot
Functional plasticity of paralogous diterpene synthases involved in conifer defense
inferredcites →https://doi.org/10.1074/jbc.m111.337592openalex-snapshot
Insights into Diterpene Cyclization from Structure of Bifunctional Abietadiene Synthase from Abies grandis
inferredcites →https://doi.org/10.1104/pp.113.228429openalex-snapshot
Manoyl Oxide (13R), the Biosynthetic Precursor of Forskolin, Is Synthesized in Specialized Root Cork Cells in Coleus forskohlii
inferredcites →https://doi.org/10.1105/tpc.106.047779openalex-snapshot
Rational Conversion of Substrate and Product Specificity in a Salvia Monoterpene Synthase: Structural Insights into the Evolution of Terpene Synthase Function
inferredcites →https://doi.org/10.1111/j.1365-313x.2011.04756.xopenalex-snapshot
Domain loss has independently occurred multiple times in plant terpene synthase evolution
inferredcites →https://doi.org/10.1111/j.1742-4658.2010.07938.xopenalex-snapshot
Identification of the single amino acid involved in quenching the ent‐kauranyl cation by a water molecule in ent‐kaurene synthase of Physcomitrella patens
inferredcites →https://doi.org/10.1186/1471-2229-12-119openalex-snapshot
Discovery and functional characterization of two diterpene synthases for sclareol biosynthesis in Salvia sclarea(L.) and their relevance for perfume manufacture
inferredcites →https://doi.org/10.1186/s12870-015-0647-6openalex-snapshot
One amino acid makes the difference: the formation of ent-kaurene and 16α-hydroxy-ent-kaurane by diterpene synthases in poplar
inferredcites →https://doi.org/10.1371/journal.pone.0020161openalex-snapshot
RosettaScripts: A Scripting Language Interface to the Rosetta Macromolecular Modeling Suite
inferredcites →https://doi.org/10.1371/journal.pone.0176507openalex-snapshot
Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases
inferredcites →https://doi.org/10.3389/fpls.2016.01765openalex-snapshot
Extending a Single Residue Switch for Abbreviating Catalysis in Plant ent-Kaurene Synthases

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

inferred← citeshttps://doi.org/10.1016/j.phytochem.2021.112672zenodo-depositor-declared
A pair of threonines mark ent-kaurene synthases for phytohormone biosynthesis
inferred← citeshttps://doi.org/10.1002/cbic.70534openalex-snapshot
Chemoenzymatic Synthesis of (4 R ,7 R )‐Zingiberene Enables Construction of nor ‐Sesquiterpene Semiochemical Analogs
inferred← citeshttps://doi.org/10.1002/hlca.202500222openalex-snapshot
Diterpenoid Diversity across Land Plants
inferred← citeshttps://doi.org/10.1016/j.apsb.2022.02.013openalex-snapshot
Mechanistic analysis for the origin of diverse diterpenes in Tripterygium wilfordii
inferred← citeshttps://doi.org/10.1016/j.jbc.2024.108142openalex-snapshot
Between scents and sterols: Cyclization of labdane-related diterpenes as model systems for enzymatic control of carbocation cascades
inferred← citeshttps://doi.org/10.1016/j.pbi.2022.102189openalex-snapshot
Tanshinones: Leading the way into Lamiaceae labdane-related diterpenoid biosynthesis
inferred← citeshttps://doi.org/10.1021/acs.orglett.5c00858openalex-snapshot
The Pursuit of a Hydroxylation Switch Uncovers a Key Residue for Various Product Outcomes in the ent-Kaurene Synthase from Bradyrhizobium japonicum
inferred← citeshttps://doi.org/10.1021/acsbiomedchemau.2c00023openalex-snapshot
Investigation of Acid–Base Catalysis in Halimadienyl Diphosphate Synthase Involved in Mycobacterium tuberculosis Virulence
inferred← citeshttps://doi.org/10.1021/acscatal.0c04647openalex-snapshot
Redesigning the Molecular Choreography to Prevent Hydroxylation in Germacradien-11-ol Synthase Catalysis
inferred← citeshttps://doi.org/10.1021/acscatal.3c05918openalex-snapshot
From Functional Plasticity of Two Diterpene Synthases (IrTPS2/IrKSL3a) to Enzyme Evolution
inferred← citeshttps://doi.org/10.1021/acscatal.9b02783openalex-snapshot
Switching on a Nontraditional Enzymatic Base—Deprotonation by Serine in the ent-Kaurene Synthase from Bradyrhizobium japonicum
inferred← citeshttps://doi.org/10.1039/d3cy00115fopenalex-snapshot
Harnessing the catalytic plasticity of the ent -kaurene synthase from Bradyrhizobium japonicum to produce the ent -rosane and ent -pimarane scaffolds
inferred← citeshttps://doi.org/10.1039/d6np00035eopenalex-snapshot
Growth, signals, and survival: the evolutionary divergence of terpenoid metabolism in terrestrial plants
inferred← citeshttps://doi.org/10.1074/jbc.ra118.006025openalex-snapshot
A database-driven approach identifies additional diterpene synthase activities in the mint family (Lamiaceae)
inferred← citeshttps://doi.org/10.1093/pcp/pcab089openalex-snapshot
Discovery and Functional Characterization of a Diverse Diterpene Synthase Family in the Medicinal Herb Isodon lophanthoides Var. gerardiana
inferred← citeshttps://doi.org/10.1104/pp.18.00590openalex-snapshot
Functional Diversity of Diterpene Synthases in the Biofuel Crop Switchgrass
inferred← citeshttps://doi.org/10.15421/022176openalex-snapshot
Effect of Salvia officinalis and S. sclarea on rats with a high-fat hypercaloric diet
inferred← citeshttps://doi.org/10.31274/td-20240329-820openalex-snapshot
Transcending eons; evolutionary and mechanistic insight into plant Class I Diterpene synthases
inferred← citeshttps://doi.org/10.3389/fmolb.2022.908285openalex-snapshot
Redesigning Enzymes for Biocatalysis: Exploiting Structural Understanding for Improved Selectivity
inferred← citeshttps://doi.org/10.3389/fpls.2019.01166openalex-snapshot
Terpene Synthases as Metabolic Gatekeepers in the Evolution of Plant Terpenoid Chemical Diversity
inferred← citeshttps://doi.org/10.64898/2026.04.15.718773openalex-snapshot
Discovery of the rosalexin pathway expands the modular network of maize diterpenoid chemical defenses
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