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Sixteen Different Types of Lipid-Conjugated siRNAs Containing Saturated and Unsaturated Fatty Acids and Exhibiting Enhanced RNAi Potency

https://doi.org/10.1021/acschembio.0c00847

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1 of the 58 references listed on this page is in the Retraction Watch database as retracted (export 2026-10-21): 10.1021/jacs.6b08854 (notice 2019-05-30).

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

inferredcites →https://doi.org/10.1002/cbic.201402551openalex-snapshot

Base Modification Strategies to Modulate Immune Stimulation by an siRNA

inferredcites →https://doi.org/10.1002/wnan.1606openalex-snapshot

Insight into the siRNA transmembrane delivery—From cholesterol conjugating to tagging

inferredcites →https://doi.org/10.1016/j.addr.2009.04.018openalex-snapshot

siRNA delivery systems for cancer treatment

inferredcites →https://doi.org/10.1016/j.bbrc.2012.08.128openalex-snapshot

SiRNAs conjugated with aromatic compounds induce RISC-mediated antisense strand selection and strong gene-silencing activity

inferredcites →https://doi.org/10.1016/j.biomaterials.2014.03.017openalex-snapshot

Tumor-targeting dual peptides-modified cationic liposomes for delivery of siRNA and docetaxel to gliomas

inferredcites →https://doi.org/10.1016/j.bmcl.2015.12.074openalex-snapshot

Gene silencing by 2′-O-methyldithiomethyl-modified siRNA, a prodrug-type siRNA responsive to reducing environment

inferredcites →https://doi.org/10.1016/j.bmcl.2018.05.016openalex-snapshot

Effective gene silencing activity of prodrug-type 2′-O-methyldithiomethyl siRNA compared with non-prodrug-type 2′-O-methyl siRNA

inferredcites →https://doi.org/10.1016/j.critrevonc.2015.12.005openalex-snapshot

The Wnt signaling pathway in cancer

inferredcites →https://doi.org/10.1016/j.drudis.2008.05.007openalex-snapshot

Chemically modified siRNA: tools and applications

inferredcites →https://doi.org/10.1016/j.jconrel.2019.03.028openalex-snapshot

The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo

inferredcites →https://doi.org/10.1016/j.jconrel.2019.06.022openalex-snapshot

Chemical modulation of siRNA lipophilicity for efficient delivery

inferredcites →https://doi.org/10.1016/j.nbt.2012.07.002openalex-snapshot

Gene silencing by chemically modified siRNAs

inferredcites →https://doi.org/10.1016/j.omtn.2016.12.011openalex-snapshot

Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene

inferredcites →https://doi.org/10.1016/j.omtn.2020.05.010openalex-snapshot

2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA

inferredcites →https://doi.org/10.1016/j.omtn.2020.07.029openalex-snapshot

Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy

inferredcites →https://doi.org/10.1016/j.tips.2020.08.004openalex-snapshot

Paving the Road for RNA Therapeutics

inferredcites →https://doi.org/10.1016/j.ymthe.2017.12.021openalex-snapshot

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

inferredcites →https://doi.org/10.1016/j.ymthe.2018.03.019openalex-snapshot

Hydrophobicity of Lipid-Conjugated siRNAs Predicts Productive Loading to Small Extracellular Vesicles

inferredcites →https://doi.org/10.1021/acschembio.5b00218openalex-snapshot

Locked 2′-Deoxy-2′,4′-Difluororibo Modified Nucleic Acids: Thermal Stability, Structural Studies, and siRNA Activity

inferredcites →https://doi.org/10.1021/bc200333wopenalex-snapshot

Amino-Modified and Lipid-Conjugated Dicer-Substrate siRNA Enhances RNAi Efficacy

inferredcites →https://doi.org/10.1021/bc400391nopenalex-snapshot

Gene-Silencing Potency of Symmetric and Asymmetric Lipid-Conjugated siRNAs and Its Correlation with Dicer Recognition

inferredcites →https://doi.org/10.1021/cb300078eopenalex-snapshot

Gene Silencing Activity of siRNA Molecules Containing Phosphorodithioate Substitutions

inferredcites →https://doi.org/10.1021/jacs.6b08854openalex-snapshot

Synthesis of Phosphorodiamidate Morpholino Oligonucleotides and Their Chimeras Using Phosphoramidite Chemistry

inferredcites →https://doi.org/10.1021/jm050822copenalex-snapshot

Improving RNA Interference in Mammalian Cells by 4‘-Thio-Modified Small Interfering RNA (siRNA): Effect on siRNA Activity and Nuclease Stability When Used in Combination with 2‘-O-Alkyl Modifications

inferredcites →https://doi.org/10.1021/mp200250fopenalex-snapshot

Palmitic Acid-Conjugated 21-Nucleotide siRNA Enhances Gene-Silencing Activity

inferredcites →https://doi.org/10.1021/mp2006278openalex-snapshot

Lipid-Conjugated 27-Nucleotide Double-Stranded RNAs with Dicer-Substrate Potency Enhance RNAi-Mediated Gene Silencing

inferredcites →https://doi.org/10.1038/35078107openalex-snapshot

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

inferredcites →https://doi.org/10.1038/35888openalex-snapshot

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

inferredcites →https://doi.org/10.1038/mt.2008.14openalex-snapshot

Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol

inferredcites →https://doi.org/10.1038/mt.2013.233openalex-snapshot

Knockdown of β-catenin with Dicer-Substrate siRNAs Reduces Liver Tumor Burden In vivo

inferredcites →https://doi.org/10.1038/mtna.2012.32openalex-snapshot

Development of a 2′,4′-BNA/LNA-based siRNA for Dyslipidemia and Assessment of the Effects of Its Chemical Modifications In Vivo

inferredcites →https://doi.org/10.1038/mtna.2015.48openalex-snapshot

Gene Silencing Using 4′-thioDNA as an Artificial Template to Synthesize Short Hairpin RNA Without Inducing a Detectable Innate Immune Response

inferredcites →https://doi.org/10.1038/nbt.1564openalex-snapshot

In vivo delivery of siRNA to immune cells by conjugation to a TLR9 agonist enhances antitumor immune responses

inferredcites →https://doi.org/10.1038/sj.cgt.7700857openalex-snapshot

RNA interference and potential therapeutic applications of short interfering RNAs

inferredcites →https://doi.org/10.1038/srep16151openalex-snapshot

Wnt/β-catenin coupled with HIF-1α/VEGF signaling pathways involved in galangin neurovascular unit protection from focal cerebral ischemia

inferredcites →https://doi.org/10.1039/c2ob25647aopenalex-snapshot

7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove

inferredcites →https://doi.org/10.1080/10717544.2016.1267821openalex-snapshot

A tumor-targeting cRGD-EGFR siRNA conjugate and its anti-tumor effect on glioblastoma in vitro and in vivo

inferredcites →https://doi.org/10.1080/14656566.2019.1671352openalex-snapshot

An evaluation of patisiran: a viable treatment option for transthyretin-related hereditary amyloidosis

inferredcites →https://doi.org/10.1089/nat.2019.0794openalex-snapshot

Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells

inferredcites →https://doi.org/10.1089/nat.2020.0848openalex-snapshot

Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells

inferredcites →https://doi.org/10.1089/oli.2008.0164openalex-snapshot

Chemical Modification of siRNAs for In Vivo Use

inferredcites →https://doi.org/10.1093/nar/gkaa125openalex-snapshot

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease

inferredcites →https://doi.org/10.1093/nar/gkaa595openalex-snapshot

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy

inferredcites →https://doi.org/10.1093/nar/gkl339openalex-snapshot

High potency silencing by single-stranded boranophosphate siRNA

inferredcites →https://doi.org/10.1093/nar/gks204openalex-snapshot

Intracellular stability of 2′-OMe-4′-thioribonucleoside modified siRNA leads to long-term RNAi effect

inferredcites →https://doi.org/10.1093/nar/gky1239openalex-snapshot

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo

inferredcites →https://doi.org/10.1093/nar/gkz354openalex-snapshot

Fatty acid conjugation enhances potency of antisense oligonucleotides in muscle

inferredcites →https://doi.org/10.1093/nar/gkz360openalex-snapshot

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates

inferredcites →https://doi.org/10.1111/cbdd.12720openalex-snapshot

In Vivo RNAi Efficacy of Palmitic Acid‐Conjugated Dicer‐Substrate siRNA in a Subcutaneous Tumor Mouse Model

inferredcites →https://doi.org/10.1111/cbdd.12993openalex-snapshot

Therapeutic potential of chemically modified si RNA : Recent trends

inferredcites →https://doi.org/10.1111/cbdd.13454openalex-snapshot

Antitumor effect of palmitic acid‐conjugated Dsi RNA for colon cancer in a mouse subcutaneous tumor model

inferredcites →https://doi.org/10.1111/exd.13881openalex-snapshot

Exploring the potential for rosacea therapeutics of si RNA dispersion in topical emulsions

inferredcites →https://doi.org/10.1186/s13023-015-0326-6openalex-snapshot

Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study

inferredcites →https://doi.org/10.1186/s13045-017-0471-6openalex-snapshot

Wnt/beta-catenin pathway: modulating anticancer immune response

inferredcites →https://doi.org/10.2174/138161208786898770openalex-snapshot

Phosphorothioate-Stimulated Cellular Uptake of siRNA: A Cell Culture Model for Mechanistic Studies

inferredcites →https://doi.org/10.3389/fphar.2019.00444openalex-snapshot

Current Development of siRNA Bioconjugates: From Research to the Clinic

inferredcites →https://doi.org/10.3390/molecules170911089openalex-snapshot

Enhancement of Gene Silencing Effect and Membrane Permeability by Peptide-Conjugated 27-Nucleotide Small Interfering RNA

inferredcites →https://doi.org/10.3390/nano9020159openalex-snapshot

Enhancing PD-1 Gene Silence in T Lymphocytes by Comparing the Delivery Performance of Two Inorganic Nanoparticle Platforms

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Delivery of Rna Drugs: Beyond the Liver, More than Vaccine

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Lipid–drug conjugates for enhanced drug delivery and targeting

inferred← citeshttps://doi.org/10.1016/b978-0-443-40443-6.00013-1openalex-snapshot

siRNA–polymer conjugates for the delivery of RNAi therapeutics for the treatment of colon cancer

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inferred← citeshttps://doi.org/10.1016/j.jconrel.2022.07.041openalex-snapshot

Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo

inferred← citeshttps://doi.org/10.1016/j.xcrm.2026.102929openalex-snapshot

Fatty-acid-based antimiR-23b delivery in the DMSXL model: A potential therapeutic strategy for brain dysfunction in myotonic dystrophy type 1

inferred← citeshttps://doi.org/10.1021/acs.molpharmaceut.4c00502openalex-snapshot

Antitumor Effect of Oleoyl-siRNA against Pancreatic Cancer Using a Portal Vein Infusion Liver-Metastatic Mouse Model

inferred← citeshttps://doi.org/10.1021/acsabm.1c01182openalex-snapshot

Complexing the Pre-assembled Brush-like siRNA with Poly(β-amino ester) for Efficient Gene Silencing

inferred← citeshttps://doi.org/10.1080/15476286.2022.2027150openalex-snapshot

Innovative developments and emerging technologies in RNA therapeutics

inferred← citeshttps://doi.org/10.1080/15476286.2022.2147278openalex-snapshot

Evolution of complexity in non-viral oligonucleotide delivery systems: from gymnotic delivery through bioconjugates to biomimetic nanoparticles

inferred← citeshttps://doi.org/10.3390/biom15020293openalex-snapshot

Lipid-siRNA Conjugates Targeting High PD-L1 Expression as Potential Novel Immune Checkpoint Inhibitors

inferred← citeshttps://doi.org/10.3791/63720openalex-snapshot

Identification of RNA Fragments Resulting from Enzymatic Degradation using MALDI-TOF Mass Spectrometry

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