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The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo
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What this work says
Outgoing claims: the papers this work cites, builds on, or argues with.
inferredcites →https://doi.org/10.1002/cbic.201500023openalex-snapshot
Hepatocyte‐Specific Delivery of siRNAs Conjugated to Novel Non‐nucleosidic Trivalent N ‐Acetylgalactosamine Elicits Robust Gene Silencing in Vivo
inferredcites →https://doi.org/10.1002/cbic.201600130openalex-snapshot
5′‐( E )‐Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA–GalNAc Conjugates
inferredcites →https://doi.org/10.1002/hep.20702openalex-snapshot
Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication†
inferredcites →https://doi.org/10.1016/j.addr.2015.01.008openalex-snapshot
Pharmacokinetics, biodistribution and cell uptake of antisense oligonucleotides
inferredcites →https://doi.org/10.1016/j.cell.2012.08.014openalex-snapshot
Single-Stranded siRNAs Activate RNAi in Animals
inferredcites →https://doi.org/10.1016/j.drudis.2007.10.014openalex-snapshot
Snapshot PK: a rapid rodent in vivo preclinical screening approach
inferredcites →https://doi.org/10.1016/j.jconrel.2016.05.059openalex-snapshot
Influence of particle size on the in vivo potency of lipid nanoparticle formulations of siRNA
inferredcites →https://doi.org/10.1016/j.jconrel.2017.04.042openalex-snapshot
RETRACTED: Lipid-oligonucleotide conjugates improve cellular uptake and efficiency of TCTP-antisense in castration-resistant prostate cancer
inferredcites →https://doi.org/10.1016/j.omtn.2016.12.003openalex-snapshot
Preclinical and Clinical Advances of GalNAc-Decorated Nucleic Acid Therapeutics
inferredcites →https://doi.org/10.1016/j.physbeh.2007.03.026openalex-snapshot
Forty mouse strain survey of body composition
inferredcites →https://doi.org/10.1016/j.ymthe.2016.10.019openalex-snapshot
Clinical Proof of Concept for a Novel Hepatocyte-Targeting GalNAc-siRNA Conjugate
inferredcites →https://doi.org/10.1016/s0022-2275(20)37381-8openalex-snapshot
Reversed-phase high performance liquid chromatography of phosphatidylcholine: a simple method for determining relative hydrophobic interaction of various molecular species.
inferredcites →https://doi.org/10.1021/acs.bioconjchem.7b00226openalex-snapshot
Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl- l -serine siRNA Conjugate in Mouse Brain
inferredcites →https://doi.org/10.1021/cb501028copenalex-snapshot
siRNA Conjugates Carrying Sequentially Assembled Trivalent N-Acetylgalactosamine Linked Through Nucleosides Elicit Robust Gene Silencing In Vivo in Hepatocytes
inferredcites →https://doi.org/10.1021/ja505986aopenalex-snapshot
Multivalent N -Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing
inferredcites →https://doi.org/10.1021/jm049167jopenalex-snapshot
Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA
inferredcites →https://doi.org/10.1038/gt.2017.6openalex-snapshot
Genetic pharmacology: progresses in siRNA delivery and therapeutic applications
inferredcites →https://doi.org/10.1038/ki.1995.406openalex-snapshot
Renal uptake of an 18-mer phosphorothioate oligonucleotide
inferredcites →https://doi.org/10.1038/mt.2008.14openalex-snapshot
Efficient In Vivo Delivery of siRNA to the Liver by Conjugation of α-Tocopherol
inferredcites →https://doi.org/10.1038/mtna.2015.38openalex-snapshot
Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain
inferredcites →https://doi.org/10.1038/mtna.2016.50openalex-snapshot
Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain
inferredcites →https://doi.org/10.1038/mtna.2016.55openalex-snapshot
Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth
inferredcites →https://doi.org/10.1038/nature03121openalex-snapshot
Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
inferredcites →https://doi.org/10.1038/nature03514openalex-snapshot
Structural basis for 5′-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
inferredcites →https://doi.org/10.1038/nature09039openalex-snapshot
Structural basis for 5′-nucleotide base-specific recognition of guide RNA by human AGO2
inferredcites →https://doi.org/10.1038/nbt1339openalex-snapshot
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs
inferredcites →https://doi.org/10.1038/nbt1402openalex-snapshot
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
inferredcites →https://doi.org/10.1038/ncomms5277openalex-snapshot
Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity
inferredcites →https://doi.org/10.1038/nnano.2014.84openalex-snapshot
In vivo endothelial siRNA delivery using polymeric nanoparticles with low molecular weight
inferredcites →https://doi.org/10.1038/srep15699openalex-snapshot
Plasmodium berghei ANKA causes intestinal malaria associated with dysbiosis
inferredcites →https://doi.org/10.1039/c3tb20357copenalex-snapshot
Lipid oligonucleotide conjugates as responsive nanomaterials for drug delivery
inferredcites →https://doi.org/10.1046/j.1523-1747.1999.00807.xopenalex-snapshot
Overgrowth of Skin in Growth Hormone Transgenic Mice Depends on the Presence of Male Gonads
inferredcites →https://doi.org/10.1056/nejmp1614154openalex-snapshot
Oligonucleotide Therapeutics — A New Class of Cholesterol-Lowering Drugs
inferredcites →https://doi.org/10.1073/pnas.1621240114openalex-snapshot
Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing
inferredcites →https://doi.org/10.1089/108729003321629638openalex-snapshot
Sequence, Chemical, and Structural Variation of Small Interfering RNAs and Short Hairpin RNAs and the Effect on Mammalian Gene Silencing
inferredcites →https://doi.org/10.1089/nat.2012.0371openalex-snapshot
Toxicological and Pharmacokinetic Properties of Chemically Modified siRNAs Targeting p53 RNA Following Intravenous Administration
inferredcites →https://doi.org/10.1089/nat.2014.0489openalex-snapshot
Toxicological and Pharmacokinetic Properties of QPI-1007, a Chemically Modified Synthetic siRNA Targeting Caspase 2 mRNA, Following Intravitreal Injection
inferredcites →https://doi.org/10.1089/nat.2015.0578openalex-snapshot
A High-Throughput Method for Direct Detection of Therapeutic Oligonucleotide-Induced Gene Silencing In Vivo
inferredcites →https://doi.org/10.1089/nat.2017.0690openalex-snapshot
Pharmacokinetic Profiling of Conjugated Therapeutic Oligonucleotides: A High-Throughput Method Based Upon Serial Blood Microsampling Coupled to Peptide Nucleic Acid Hybridization Assay
inferredcites →https://doi.org/10.1089/nat.2018.0725openalex-snapshot
Improving siRNA Delivery In Vivo Through Lipid Conjugation
inferredcites →https://doi.org/10.1093/nar/gku531openalex-snapshot
Targeted delivery of antisense oligonucleotides to hepatocytes using triantennaryN-acetyl galactosamine improves potency 10-fold in mice
inferredcites →https://doi.org/10.1093/nar/gkw1005openalex-snapshot
Visualization of self-delivering hydrophobically modified siRNA cellular internalization
inferredcites →https://doi.org/10.1093/nar/gkx507openalex-snapshot
5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo
inferredcites →https://doi.org/10.1093/nar/gkx960openalex-snapshot
Asialoglycoprotein receptor 1 mediates productive uptake of N-acetylgalactosamine-conjugated and unconjugated phosphorothioate antisense oligonucleotides into liver hepatocytes
inferredcites →https://doi.org/10.1093/nar/gky037openalex-snapshot
Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
inferredcites →https://doi.org/10.1093/nar/gky1232openalex-snapshot
Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
inferredcites →https://doi.org/10.1093/nar/gky1239openalex-snapshot
Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo
inferredcites →https://doi.org/10.1186/s13023-015-0326-6openalex-snapshot
Efficacy and safety of patisiran for familial amyloidotic polyneuropathy: a phase II multi-dose study
inferredcites →https://doi.org/10.1261/rna.1007408openalex-snapshot
Nucleoside modifications modulate activation of the protein kinase PKR in an RNA structure-specific manner
inferredcites →https://doi.org/10.1261/rna.30706openalex-snapshot
Position-specific chemical modification of siRNAs reduces “off-target” transcript silencing
inferredcites →https://doi.org/10.1517/17425250902877680openalex-snapshot
Antisense oligonucleotide pharmacokinetics and metabolism
inferredcites →https://doi.org/10.3390/ph6010085openalex-snapshot
Nanoparticle-Based Delivery of RNAi Therapeutics: Progress and Challenges
What points at this work
Incoming claims: where this work appears in other papers’ reference lists and arguments.
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inferred← citeshttps://doi.org/10.1002/mabi.202300362openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/b978-0-443-33382-8.00004-2openalex-snapshot
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Synthesis of multivalent fatty acid-conjugated antisense oligonucleotides: Cell internalization, physical properties, and in vitro and in vivo activities
inferred← citeshttps://doi.org/10.1016/j.cbpa.2024.102501openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.chemphyslip.2021.105053openalex-snapshot
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inferred← citeshttps://doi.org/10.1016/j.ejpb.2024.114203openalex-snapshot
Recent trends in the delivery of RNA drugs: Beyond the liver, more than vaccine
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Small Interfering RNA Therapy Targeting the Long Noncoding RNA SMILR for Therapeutic Intervention in Coronary Artery Bypass Graft Failure
inferred← citeshttps://doi.org/10.1016/j.jconrel.2020.04.020openalex-snapshot
Detailed cellular assessment of albumin-bound oligonucleotides: Increased stability and lower non-specific cell uptake
inferred← citeshttps://doi.org/10.1016/j.jconrel.2022.07.041openalex-snapshot
Engineered ionizable lipid siRNA conjugates enhance endosomal escape but induce toxicity in vivo
inferred← citeshttps://doi.org/10.1016/j.jconrel.2025.02.025openalex-snapshot
Pharmacokinetics and protein binding of cholesterol-conjugated heteroduplex oligonucleotide
inferred← citeshttps://doi.org/10.1016/j.mattod.2026.103204openalex-snapshot
Advances in oligonucleotide therapeutics: recent bench-side progress in ASO, siRNA, and aptamer
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Hydrophobically Modified let-7b miRNA Enhances Biodistribution to NSCLC and Downregulates HMGA2 In Vivo
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Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy
inferred← citeshttps://doi.org/10.1016/j.omtn.2023.102088openalex-snapshot
Single intravitreal administration of a tetravalent siRNA exhibits robust and efficient gene silencing in mouse and pig photoreceptors
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Docosanoic acid conjugation to siRNA enables functional and safe delivery to skeletal and cardiac muscles
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Sixteen Different Types of Lipid-Conjugated siRNAs Containing Saturated and Unsaturated Fatty Acids and Exhibiting Enhanced RNAi Potency
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Lipidation as a Driver of Spatial Organization and Function in Proteins and Nucleic Acids
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SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity
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