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Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19)
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Phosphorylation events during viral infections provide potential therapeutic targets
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Protein Kinase CK2 in Health and Disease
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Structure-based design, synthesis, and study of pyrazolo[1,5-a][1,3,5]triazine derivatives as potent inhibitors of protein kinase CK2
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Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines
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Identification and evaluation of 4-anilinoquin(az)olines as potent inhibitors of both dengue virus (DENV) and Venezuelan equine encephalitis virus (VEEV)
inferredcites →https://doi.org/10.1016/j.cell.2020.05.042openalex-snapshot
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract
inferredcites →https://doi.org/10.1016/j.cell.2020.06.034openalex-snapshot
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
inferredcites →https://doi.org/10.1016/j.cell.2022.02.025openalex-snapshot
Facile discovery of surrogate cytokine agonists
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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice
inferredcites →https://doi.org/10.1016/j.celrep.2021.109364openalex-snapshot
Systematic analysis of SARS-CoV-2 infection of an ACE2-negative human airway cell
inferredcites →https://doi.org/10.1016/j.chembiol.2017.10.010openalex-snapshot
Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement
inferredcites →https://doi.org/10.1016/j.chembiol.2020.12.013openalex-snapshot
Development of a potent and selective chemical probe for the pleiotropic kinase CK2
inferredcites →https://doi.org/10.1016/j.jbc.2021.100306openalex-snapshot
SARS-CoV-2 infects cells after viral entry via clathrin-mediated endocytosis
inferredcites →https://doi.org/10.1016/s0021-9258(18)54934-6openalex-snapshot
Phosphorylation of the beta subunit of casein kinase II in human A431 cells. Identification of the autophosphorylation site and a site phosphorylated by p34cdc2.
inferredcites →https://doi.org/10.1016/s0021-9258(19)49661-0openalex-snapshot
Phosphorylation of casein kinase II by p34cdc2 in vitro and at mitosis.
inferredcites →https://doi.org/10.1016/s0076-6879(07)38006-3openalex-snapshot
Use of Dynasore, the Small Molecule Inhibitor of Dynamin, in the Regulation of Endocytosis
inferredcites →https://doi.org/10.1021/acs.jmedchem.1c00302openalex-snapshot
Kinase Inhibitors as Underexplored Antiviral Agents
inferredcites →https://doi.org/10.1021/acs.jmedchem.8b01213openalex-snapshot
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK)
inferredcites →https://doi.org/10.1021/acs.jmedchem.9b00136openalex-snapshot
Synthesis and Structure–Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3-b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity
inferredcites →https://doi.org/10.1021/acschembio.1c00036openalex-snapshot
The Promise and Peril of Chemical Probe Negative Controls
inferredcites →https://doi.org/10.1021/acsmedchemlett.9b00399openalex-snapshot
SGC-AAK1-1: A Chemical Probe Targeting AAK1 and BMP2K
inferredcites →https://doi.org/10.1021/cb3002478openalex-snapshot
Engineered Luciferase Reporter from a Deep Sea Shrimp Utilizing a Novel Imidazopyrazinone Substrate
inferredcites →https://doi.org/10.1021/jm049854aopenalex-snapshot
Optimization of Protein Kinase CK2 Inhibitors Derived from 4,5,6,7-Tetrabromobenzimidazole
inferredcites →https://doi.org/10.1021/ml200257nopenalex-snapshot
Potent and Selective Inhibitors of CK2 Kinase Identified through Structure-Guided Hybridization
inferredcites →https://doi.org/10.1038/nature12005openalex-snapshot
Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC
inferredcites →https://doi.org/10.1038/nchembio.1867openalex-snapshot
The promise and peril of chemical probes
inferredcites →https://doi.org/10.1038/nm.3985openalex-snapshot
A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence
inferredcites →https://doi.org/10.1038/nrd.2016.244openalex-snapshot
Applications of chemogenomic library screening in drug discovery
inferredcites →https://doi.org/10.1038/s41392-021-00567-7openalex-snapshot
Protein kinase CK2: a potential therapeutic target for diverse human diseases
inferredcites →https://doi.org/10.1038/s41579-020-00468-6openalex-snapshot
Coronavirus biology and replication: implications for SARS-CoV-2
inferredcites →https://doi.org/10.1038/s41580-021-00418-xopenalex-snapshot
Mechanisms of SARS-CoV-2 entry into cells
inferredcites →https://doi.org/10.1038/s41586-020-2180-5openalex-snapshot
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
inferredcites →https://doi.org/10.1038/s41586-020-2286-9openalex-snapshot
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing
inferredcites →https://doi.org/10.1039/d1ob00257kopenalex-snapshot
Chemical probes targeting the kinase CK2: a journey outside the catalytic box
inferredcites →https://doi.org/10.1042/bj20021469openalex-snapshot
Protein kinase CK2: structure, regulation and role in cellular decisions of life and death
inferredcites →https://doi.org/10.1053/j.seminoncol.2018.04.006openalex-snapshot
CIGB-300: A peptide-based drug that impairs the Protein Kinase CK2-mediated phosphorylation
inferredcites →https://doi.org/10.1073/pnas.1517719113openalex-snapshot
SARS-like WIV1-CoV poised for human emergence
inferredcites →https://doi.org/10.1074/jbc.270.43.25872openalex-snapshot
Phosphorylation of Casein Kinase II by p34cdc2
inferredcites →https://doi.org/10.1093/ve/vew014openalex-snapshot
Antiviral drug resistance as an adaptive process
inferredcites →https://doi.org/10.1096/fj.02-0473revopenalex-snapshot
One‐thousand‐and‐one substrates of protein kinase CK2?
inferredcites →https://doi.org/10.1111/tra.12119openalex-snapshot
Building a Better Dynasore: The Dyngo Compounds Potently Inhibit Dynamin and Endocytosis
inferredcites →https://doi.org/10.1126/science.abe8499openalex-snapshot
SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo
inferredcites →https://doi.org/10.1126/science.abe9403openalex-snapshot
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
inferredcites →https://doi.org/10.1126/science.abf4830openalex-snapshot
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody
inferredcites →https://doi.org/10.1126/science.abi4708openalex-snapshot
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2
inferredcites →https://doi.org/10.1126/scitranslmed.aal3653openalex-snapshot
Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses
inferredcites →https://doi.org/10.1126/scitranslmed.abb5883openalex-snapshot
An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice
inferredcites →https://doi.org/10.1128/cmr.00168-19openalex-snapshot
Host-Directed Antiviral Therapy
inferredcites →https://doi.org/10.1128/jvi.79.6.3846-3850.2005openalex-snapshot
Exogenous ACE2 Expression Allows Refractory Cell Lines To Support Severe Acute Respiratory Syndrome Coronavirus Replication
inferredcites →https://doi.org/10.1146/annurev-virology-110615-042301openalex-snapshot
Structure, Function, and Evolution of Coronavirus Spike Proteins
inferredcites →https://doi.org/10.1172/jci89857openalex-snapshot
Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects
inferredcites →https://doi.org/10.1186/s12967-020-02476-9openalex-snapshot
A painful lesson from the COVID-19 pandemic: the need for broad-spectrum, host-directed antivirals
inferredcites →https://doi.org/10.1186/s12967-020-02480-zopenalex-snapshot
The current landscape of coronavirus-host protein–protein interactions
inferredcites →https://doi.org/10.1200/jco.2011.29.15_suppl.3087openalex-snapshot
Findings from the phase I clinical trials of CX-4945, an orally available inhibitor of CK2.
inferredcites →https://doi.org/10.1200/jco.2021.39.3_suppl.312openalex-snapshot
Silmitasertib (CX-4945) in combination with gemcitabine and cisplatin as first-line treatment for patients with locally advanced or metastatic cholangiocarcinoma: A phase Ib/II study.
inferredcites →https://doi.org/10.1371/journal.ppat.1004502openalex-snapshot
Coronavirus Cell Entry Occurs through the Endo-/Lysosomal Pathway in a Proteolysis-Dependent Manner
inferredcites →https://doi.org/10.1371/journal.ppat.1007788openalex-snapshot
Activity of CK2α protein kinase is required for efficient replication of some HPV types
inferredcites →https://doi.org/10.1371/journal.ppat.1008392openalex-snapshot
Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry
inferredcites →https://doi.org/10.1385/1-59259-861-7:183openalex-snapshot
Well-Differentiated Human Airway Epithelial Cell Cultures
inferredcites →https://doi.org/10.15252/embj.2021107821openalex-snapshot
TMPRSS2 expression dictates the entry route used by SARS‐CoV‐2 to infect host cells
inferredcites →https://doi.org/10.3390/ijms22020566openalex-snapshot
The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification
inferredcites →https://doi.org/10.3390/molecules26071977openalex-snapshot
Downfalls of Chemical Probes Acting at the Kinase ATP-Site: CK2 as a Case Study
inferredcites →https://doi.org/10.3390/v12080880openalex-snapshot
Of Mice and Men: The Coronavirus MHV and Mouse Models as a Translational Approach to Understand SARS-CoV-2

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Identification of 4-(6-((2-Methoxyphenyl)Amino)Pyrazin-2-Yl)Benzoic Acids as Csnk2a Inhibitors with Antiviral Activity and Improved Selectivity Over Pim3
inferred← citeshttps://doi.org/10.1002/ardp.70312openalex-snapshot
Targeting Human Protein Kinase CK2 by a Library of Indeno[1,2‐ b ]Indoles: Contribution of Thermal Shift Assay to Pre‐Screening and Co‐Crystallization to Post‐Screening
inferred← citeshttps://doi.org/10.1007/s11696-025-04591-7openalex-snapshot
A review on indazoles for the treatment of viral diseases
inferred← citeshttps://doi.org/10.1016/j.bmc.2025.118196openalex-snapshot
Scaffold hopping and sidechain modification from a flavone scaffold lead to discovery of potent, selective CK2A2 inhibitors with favorable properties for CNS activity
inferred← citeshttps://doi.org/10.1016/j.bmcl.2024.129617openalex-snapshot
Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3
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Phytoestrogens 7-O-acetylformonetin and khrinone A from Pterocarpus soyauxii Taub. inhibit the human papillomavirus replication: An integrative immunological, chemical, and computational approach to cervical cancer prevention
inferred← citeshttps://doi.org/10.1016/j.drudis.2024.103881openalex-snapshot
Illuminating function of the understudied druggable kinome
inferred← citeshttps://doi.org/10.1016/j.ejmech.2024.116672openalex-snapshot
Synthesis and evaluation of chemical linchpins for highly selective CK2α targeting
inferred← citeshttps://doi.org/10.1016/j.redox.2026.104317openalex-snapshot
Integrated multi-PTM omics reveals key host pathways in human coronavirus 229E infection
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c00697openalex-snapshot
Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β-Coronaviruses
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.2c01523openalex-snapshot
Strategies of Targeting CK2 in Drug Discovery: Challenges, Opportunities, and Emerging Prospects
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c00962openalex-snapshot
More than an Amide Bioisostere: Discovery of 1,2,4-Triazole-containing Pyrazolo[1,5- a ]pyrimidine Host CSNK2 Inhibitors for Combatting β-Coronavirus Replication
inferred← citeshttps://doi.org/10.1021/acs.jproteome.3c00182openalex-snapshot
Investigation of the Host Kinome Response to Coronavirus Infection Reveals PI3K/mTOR Inhibitors as Betacoronavirus Antivirals
inferred← citeshttps://doi.org/10.1021/acsmedchemlett.2c00530openalex-snapshot
Discovery of a Potent and Selective Naphthyridine-Based Chemical Probe for Casein Kinase 2
inferred← citeshttps://doi.org/10.1021/acsomega.2c02794openalex-snapshot
Vandetanib Blocks the Cytokine Storm in SARS-CoV-2-Infected Mice
inferred← citeshttps://doi.org/10.1021/acsomega.3c05377openalex-snapshot
Optimization of 3-Cyano-7-cyclopropylamino-pyrazolo[1,5- a ]pyrimidines toward the Development of an In Vivo Chemical Probe for CSNK2A
inferred← citeshttps://doi.org/10.1093/bioinformatics/btaf349openalex-snapshot
Inference of differential kinase interaction networks with KINference
inferred← citeshttps://doi.org/10.1101/2023.12.04.569845openalex-snapshot
Identification of 4-(6-((2-methoxyphenyl)amino)pyrazin-2-yl)benzoic acids as CSNK2A inhibitors with antiviral activity and improved selectivity over PIM3
inferred← citeshttps://doi.org/10.3390/cells12242834openalex-snapshot
Protein Kinase CK2α’, More than a Backup of CK2α
inferred← citeshttps://doi.org/10.3390/kinasesphosphatases1020009openalex-snapshot
Protein Kinase CK2 and SARS-CoV-2: An Expected Interplay Story
inferred← citeshttps://doi.org/10.3390/kinasesphosphatases1040017openalex-snapshot
CK2 Chemical Probes: Past, Present, and Future
inferred← citeshttps://doi.org/10.3390/molecules29174158openalex-snapshot
Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2
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Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity
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Targeting of Protein Kinase CK2 Elicits Antiviral Activity on Bovine Coronavirus Infection
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