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Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

https://doi.org/10.1172/jci89857
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Outgoing claims: the papers this work cites, builds on, or argues with.

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A tyrosine‐based motif and a casein kinase II phosphorylation site regulate the intracellular trafficking of the varicella‐zoster virus glycoprotein I, a protein localized in the trans‐Golgi network.
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Basolateral Sorting of Human Poliovirus Receptor α Involves an Interaction with the μ1B Subunit of the Clathrin Adaptor Complex in Polarized Epithelial Cells
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Interaction of Endocytic Signals from the HIV-1 Envelope Glycoprotein Complex with Members of the Adaptor Medium Chain Family
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Inhibition by erlotinib of primary lung adenocarcinoma at an early stage in male mice
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Single- and multiple-dose disposition kinetics of sunitinib malate, a multitargeted receptor tyrosine kinase inhibitor: comparative plasma kinetics in non-clinical species
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Sunitinib tissue distribution changes after coadministration with ketoconazole in mice
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Development and characterization of a stable luciferase dengue virus for high-throughput screening
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Celgosivir treatment misfolds dengue virus NS1 protein, induces cellular pro-survival genes and protects against lethal challenge mouse model
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Dengue Virus-Induced Autophagy Regulates Lipid Metabolism
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Clathrin Potentiates Vaccinia-Induced Actin Polymerization to Facilitate Viral Spread
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The TIM and TAM Families of Phosphatidylserine Receptors Mediate Dengue Virus Entry
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Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells
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The dengue virus type 2 envelope protein fusion peptide is essential for membrane fusion
inferredcites →https://doi.org/10.1016/j.virol.2011.04.002openalex-snapshot
Tyrosine kinase receptor Axl enhances entry of Zaire ebolavirus without direct interactions with the viral glycoprotein
inferredcites →https://doi.org/10.1016/j.virol.2011.07.018openalex-snapshot
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Phosphorylation of threonine 156 of the μ2 subunit of the AP2 complex is essential for endocytosis in vitro and in vivo
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Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents
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The global distribution and burden of dengue
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Comprehensive analysis of kinase inhibitor selectivity
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Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
inferredcites →https://doi.org/10.1038/nrc2787openalex-snapshot
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Adaptor protein complexes-1 and 3 are involved at distinct stages of flavivirus life-cycle
inferredcites →https://doi.org/10.1042/bsr20140069openalex-snapshot
Adaptor protein complexes and intracellular transport
inferredcites →https://doi.org/10.1073/pnas.1607931113openalex-snapshot
Human antibody responses after dengue virus infection are highly cross-reactive to Zika virus
inferredcites →https://doi.org/10.1074/jbc.m009516200openalex-snapshot
Binding of AP2 to Sorting Signals Is Modulated by AP2 Phosphorylation
inferredcites →https://doi.org/10.1078/s0171-9335(04)70037-0openalex-snapshot
Identification of the universal cofactor (auxilin 2) in clathrin coat dissociation
inferredcites →https://doi.org/10.1083/jcb.200108123openalex-snapshot
Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis
inferredcites →https://doi.org/10.1083/jcb.200111068openalex-snapshot
Phosphorylation of the AP2 μ subunit by AAK1 mediates high affinity binding to membrane protein sorting signals
inferredcites →https://doi.org/10.1083/jcb.200211080openalex-snapshot
AP-1 binding to sorting signals and release from clathrin-coated vesicles is regulated by phosphorylation
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Infectious Hepatitis C Virus Pseudo-particles Containing Functional E1–E2 Envelope Protein Complexes
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A Dengue Fever Viremia Model in Mice Shows Reduction in Viral Replication and Suppression of the Inflammatory Response after Treatment with Antiviral Drugs
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Antitumor activity of erlotinib (OSI-774, Tarceva) alone or in combination in human non-small cell lung cancer tumor xenograft models
inferredcites →https://doi.org/10.1097/jto.0b013e31825cca1copenalex-snapshot
Sunitinib Plus Erlotinib for the Treatment of Advanced/Metastatic Non–Small-Cell Lung Cancer: A Lead-In Study
inferredcites →https://doi.org/10.1099/vir.0.045088-0openalex-snapshot
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inferredcites →https://doi.org/10.1101/gr.2973604openalex-snapshot
Human ORFeome Version 1.1: A Platform for Reverse Proteomics
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Multiple Roles for Cyclin G‐Associated Kinase in Clathrin‐Mediated Sorting Events
inferredcites →https://doi.org/10.1111/j.1600-0854.2008.00790.xopenalex-snapshot
AAK1 Regulates Numb Function at an Early Step in Clathrin‐Mediated Endocytosis
inferredcites →https://doi.org/10.1111/tra.12046openalex-snapshot
The Cytosolic Adaptor AP‐1A Is Essential for the Trafficking and Function of Niemann‐Pick Type C Proteins
inferredcites →https://doi.org/10.1124/jpet.116.235333openalex-snapshot
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain
inferredcites →https://doi.org/10.1126/science.1110656openalex-snapshot
Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection
inferredcites →https://doi.org/10.1126/science.aaa3778openalex-snapshot
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inferredcites →https://doi.org/10.1126/science.aaf8505openalex-snapshot
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inferredcites →https://doi.org/10.1128/jvi.00354-15openalex-snapshot
Biology of Zika Virus Infection in Human Skin Cells
inferredcites →https://doi.org/10.1128/jvi.00611-08openalex-snapshot
A Mouse-Passaged Dengue Virus Strain with Reduced Affinity for Heparan Sulfate Causes Severe Disease in Mice by Establishing Increased Systemic Viral Loads
inferredcites →https://doi.org/10.1128/jvi.00632-13openalex-snapshot
The Small Molecules AZD0530 and Dasatinib Inhibit Dengue Virus RNA Replication via Fyn Kinase
inferredcites →https://doi.org/10.1128/jvi.00873-12openalex-snapshot
Entry of Hepatitis B Virus into Immortalized Human Primary Hepatocytes by Clathrin-Dependent Endocytosis
inferredcites →https://doi.org/10.1128/jvi.02705-14openalex-snapshot
AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets
inferredcites →https://doi.org/10.1128/jvi.03620-14openalex-snapshot
Clathrin Mediates Infectious Hepatitis C Virus Particle Egress
inferredcites →https://doi.org/10.1128/jvi.73.1.783-786.1999openalex-snapshot
New Mouse Model for Dengue Virus Vaccine Testing
inferredcites →https://doi.org/10.1128/jvi.80.4.1734-1741.2006openalex-snapshot
Time- and Temperature-Dependent Activation of Hepatitis C Virus for Low-pH-Triggered Entry
inferredcites →https://doi.org/10.1159/000350110openalex-snapshot
Skepinone-L, a Novel Potent and Highly Selective Inhibitor of p38 MAP Kinase, Effectively Impairs Platelet Activation and Thrombus Formation
inferredcites →https://doi.org/10.1200/jco.2011.39.2993openalex-snapshot
Sunitinib Plus Erlotinib Versus Placebo Plus Erlotinib in Patients With Previously Treated Advanced Non–Small-Cell Lung Cancer: A Phase III Trial
inferredcites →https://doi.org/10.1242/jcs.02548openalex-snapshot
Depletion of GAK/auxilin 2 inhibits receptor-mediated endocytosis and recruitment of both clathrin and clathrin adaptors
inferredcites →https://doi.org/10.1242/jcs.110.13.1453openalex-snapshot
Microtubule-dependent transport of secretory vesicles visualized in real time with a GFP-tagged secretory protein
inferredcites →https://doi.org/10.1371/journal.pntd.0003335openalex-snapshot
Dengue and Chikungunya Fever among Viral Diseases in Outpatient Febrile Children in Kilosa District Hospital, Tanzania
inferredcites →https://doi.org/10.1371/journal.pntd.0003749openalex-snapshot
The Complexity of a Dengue Vaccine: A Review of the Human Antibody Response
inferredcites →https://doi.org/10.1371/journal.ppat.1002466openalex-snapshot
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inferredcites →https://doi.org/10.1371/journal.ppat.1002845openalex-snapshot
Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly
inferredcites →https://doi.org/10.1371/journal.ppat.1003510openalex-snapshot
EphrinA2 Regulates Clathrin Mediated KSHV Endocytosis in Fibroblast Cells by Coordinating Integrin-Associated Signaling and c-Cbl Directed Polyubiquitination
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Co-infection with Zika and Dengue Viruses in 2 Patients, New Caledonia, 2014
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Endocytic Pathways Involved in Filovirus Entry: Advances, Implications and Future Directions
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Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Drug repurposing for new, efficient, broad spectrum antivirals
inferred← citeshttps://doi.org/10.1016/j.virusres.2019.197777openalex-snapshot
The activity of Aurora kinase B is required for dengue virus release
inferred← citeshttps://doi.org/10.1016/j.virusres.2020.198070openalex-snapshot
COVID-19: Review on latest available drugs and therapies against SARS-CoV-2. Coagulation and inflammation cross-talking
inferred← citeshttps://doi.org/10.1016/j.ymthe.2023.01.025openalex-snapshot
Extracellular vesicle-transmitted miR-671-5p alleviates lung inflammation and injury by regulating the AAK1/NF-κB axis
inferred← citeshttps://doi.org/10.1016/s1473-3099(20)30132-8openalex-snapshot
COVID-19: combining antiviral and anti-inflammatory treatments
inferred← citeshttps://doi.org/10.1016/s2666-5247(21)00087-2openalex-snapshot
Targeting hyperinflammation in infection: can we harness the COVID-19 therapeutics momentum to end the dengue drugs drought?
inferred← citeshttps://doi.org/10.1021/acs.jcim.1c00642openalex-snapshot
Knowledge Graph-Based Approaches to Drug Repurposing for COVID-19
inferred← citeshttps://doi.org/10.1021/acs.jcim.3c01239openalex-snapshot
Machine Learning-Boosted Docking Enables the Efficient Structure-Based Virtual Screening of Giga-Scale Enumerated Chemical Libraries
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c00606openalex-snapshot
COVID-19: Drug Targets and Potential Treatments
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.0c01467openalex-snapshot
Recent Developments in the Use of Kinase Inhibitors for Management of Viral Infections
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00302openalex-snapshot
Kinase Inhibitors as Underexplored Antiviral Agents
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.1c00335openalex-snapshot
Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.4c00411openalex-snapshot
Back-Pocket Optimization of 2-Aminopyrimidine-Based Macrocycles Leads to Potent EPHA2/GAK Kinase Inhibitors
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.5c03414openalex-snapshot
Sulfonyl Anthranilic Acid Analogues Display Pan-Serotype Anti-Dengue Activity by Downregulating the Expression of Ribosomal Proteins Encoded by 5′-Terminal Oligopyrimidine Motif-Containing mRNA
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.8b00613openalex-snapshot
Optimization of Isothiazolo[4,3-b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity
inferred← citeshttps://doi.org/10.1021/acs.jmedchem.9b00136openalex-snapshot
Synthesis and Structure–Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3-b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity
inferred← citeshttps://doi.org/10.1021/acsami.9b20492openalex-snapshot
Dengue Virus–Polymersome Hybrid Nanovesicles for Advanced Drug Screening Using Real-Time Single Nanoparticle–Virus Tracking
inferred← citeshttps://doi.org/10.1021/acschembio.2c00378openalex-snapshot
Host Kinase CSNK2 is a Target for Inhibition of Pathogenic SARS-like β-Coronaviruses
inferred← citeshttps://doi.org/10.1021/acsinfecdis.0c00343openalex-snapshot
Old Drugs for a New Virus: Repurposed Approaches for Combating COVID-19
inferred← citeshttps://doi.org/10.1021/acsinfecdis.0c00456openalex-snapshot
Targeting Crucial Host Factors of SARS-CoV-2
inferred← citeshttps://doi.org/10.1021/acsinfecdis.7b00268openalex-snapshot
Combating Intracellular Pathogens with Repurposed Host-Targeted Drugs
inferred← citeshttps://doi.org/10.1038/nrd.2017.75openalex-snapshot
Targeting host kinases
inferred← citeshttps://doi.org/10.1038/s41392-020-0191-1openalex-snapshot
Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2
inferred← citeshttps://doi.org/10.1038/s41398-021-01724-wopenalex-snapshot
Strategies to identify candidate repurposable drugs: COVID-19 treatment as a case example
inferred← citeshttps://doi.org/10.1038/s41421-020-00217-2openalex-snapshot
Sunitinib reduces the infection of SARS-CoV, MERS-CoV and SARS-CoV-2 partially by inhibiting AP2M1 phosphorylation
inferred← citeshttps://doi.org/10.1038/s41467-019-09867-7openalex-snapshot
PIM kinases facilitate lentiviral evasion from SAMHD1 restriction via Vpx phosphorylation
inferred← citeshttps://doi.org/10.1038/s41563-020-0698-4openalex-snapshot
Materials science approaches in the development of broad-spectrum antiviral therapies
inferred← citeshttps://doi.org/10.1038/s41579-019-0233-2openalex-snapshot
Therapeutic strategies to target the Ebola virus life cycle
inferred← citeshttps://doi.org/10.1038/s41598-021-84044-9openalex-snapshot
Identification of candidate repurposable drugs to combat COVID-19 using a signature-based approach
inferred← citeshttps://doi.org/10.1038/s41598-024-57051-9openalex-snapshot
Development of a novel AAK1 inhibitor via Kinobeads-based screening
inferred← citeshttps://doi.org/10.1038/s44298-024-00031-7openalex-snapshot
The endoplasmic reticulum (ER): a crucial cellular hub in flavivirus infection and potential target site for antiviral interventions
inferred← citeshttps://doi.org/10.1039/9781788016858-00001openalex-snapshot
Overview of Antiviral Drug Discovery and Development: Viral Versus Host Targets
inferred← citeshttps://doi.org/10.1039/9781788016858-00061openalex-snapshot
Small-molecule and Synthetically Derived Antivirals for Ebola Virus and Other Filoviruses
inferred← citeshttps://doi.org/10.1039/9781837674015-00057openalex-snapshot
Isothiazoles: Synthetic Strategies and Pharmacological Applications
inferred← citeshttps://doi.org/10.1039/9781837674015-part1openalex-snapshot
Thiazoles
inferred← citeshttps://doi.org/10.1039/d4ob00908hopenalex-snapshot
Synthesis and evaluation of isothiazolo[4,5- b ]pyridines as cyclin G-associated kinase (GAK) inhibitors
inferred← citeshttps://doi.org/10.1080/08977194.2022.2063123openalex-snapshot
The roles of epidermal growth factor receptor in viral infections
inferred← citeshttps://doi.org/10.1080/1061186x.2021.2013852openalex-snapshot
Drug repurposing strategies and key challenges for COVID-19 management
inferred← citeshttps://doi.org/10.1080/13543776.2021.1928637openalex-snapshot
A patent review of adaptor associated kinase 1 (AAK1) inhibitors (2013-present)
inferred← citeshttps://doi.org/10.1080/14756366.2023.2279906openalex-snapshot
Recent progress in discovery of novel AAK1 inhibitors: from pain therapy to potential anti-viral agents
inferred← citeshttps://doi.org/10.1080/15384101.2019.1637201openalex-snapshot
Clathrin heavy chain phosphorylated at T606 plays a role in proper cell division
inferred← citeshttps://doi.org/10.1080/15548627.2021.2016233openalex-snapshot
AP2M1 mediates autophagy-induced CLDN2 (claudin 2) degradation through endocytosis and interaction with LC3 and reduces intestinal epithelial tight junction permeability
inferred← citeshttps://doi.org/10.1080/17460441.2022.2033205openalex-snapshot
Murine models of dengue virus infection for novel drug discovery
inferred← citeshttps://doi.org/10.1080/22221751.2024.2382237openalex-snapshot
Numb-associated kinases regulate sandfly-borne Toscana virus entry
inferred← citeshttps://doi.org/10.1089/dna.2017.4033openalex-snapshot
Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs
inferred← citeshttps://doi.org/10.1093/bib/bbaa251openalex-snapshot
VPTMdb: a viral posttranslational modification database
inferred← citeshttps://doi.org/10.1093/bib/bbaa362openalex-snapshot
The impact of structural bioinformatics tools and resources on SARS-CoV-2 research and therapeutic strategies
inferred← citeshttps://doi.org/10.1093/cid/ciac724openalex-snapshot
Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients With COVID-19 (September 2022)
inferred← citeshttps://doi.org/10.1093/infdis/jiy304openalex-snapshot
Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures
inferred← citeshttps://doi.org/10.1097/hc9.0000000000000836openalex-snapshot
Chemoprevention of hepatocellular carcinoma
inferred← citeshttps://doi.org/10.1101/2020.04.25.061333openalex-snapshot
Repurposing Pyramax® for the Treatment of Ebola Virus Disease: Additivity of the Lysosomotropic Pyronaridine and Non-Lysosomotropic Artesunate
inferred← citeshttps://doi.org/10.1101/2020.05.12.091256openalex-snapshot
The Host Cell ViroCheckpoint: Identification and Pharmacologic Targeting of Novel Mechanistic Determinants of Coronavirus-Mediated Hijacked Cell States
inferred← citeshttps://doi.org/10.1101/2021.05.15.444128openalex-snapshot
Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects
inferred← citeshttps://doi.org/10.1101/2022.01.03.474779openalex-snapshot
Host kinase CSNK2 is a target for inhibition of pathogenic β-coronaviruses including SARS-CoV-2
inferred← citeshttps://doi.org/10.1101/2022.03.18.484178openalex-snapshot
Numb-associated kinases are required for SARS-CoV-2 infection and are cellular targets for therapy
inferred← citeshttps://doi.org/10.1101/2025.08.28.672794openalex-snapshot
Morphological cell profiling for drug repurposing against SARS-CoV-2 infection
inferred← citeshttps://doi.org/10.1111/bph.15072openalex-snapshot
Current pharmacological treatments for COVID‐19: What's next?
inferred← citeshttps://doi.org/10.1111/cbdd.14179openalex-snapshot
Design, synthesis, and biological evaluation of novel ruxolitinib and baricitinib analogues for potential use against COVID‐19
inferred← citeshttps://doi.org/10.1111/dth.14461openalex-snapshot
Sweet syndrome as an adverse reaction to tyrosine kinase inhibitors: A review
inferred← citeshttps://doi.org/10.1126/sciadv.aba7910openalex-snapshot
Viruses harness YxxØ motif to interact with host AP2M1 for replication: A vulnerable broad-spectrum antiviral target
inferred← citeshttps://doi.org/10.1128/cmr.00168-19openalex-snapshot
Host-Directed Antiviral Therapy
inferred← citeshttps://doi.org/10.1128/jvi.00077-26openalex-snapshot
Broad-acting antivirals: the pursuit of pan-viral therapeutics in the era of pandemics
inferred← citeshttps://doi.org/10.1128/jvi.02164-25openalex-snapshot
AP2: an indispensable host factor in virus infection
inferred← citeshttps://doi.org/10.1128/mbio.02233-17openalex-snapshot
Interactions between the Hepatitis C Virus Nonstructural 2 Protein and Host Adaptor Proteins 1 and 4 Orchestrate Virus Release
inferred← citeshttps://doi.org/10.1128/mbio.02839-20openalex-snapshot
A Targeted Computational Screen of the SWEETLEAD Database Reveals FDA-Approved Compounds with Anti-Dengue Viral Activity
inferred← citeshttps://doi.org/10.1128/mbio.03347-21openalex-snapshot
Drug Combinations as a First Line of Defense against Coronaviruses and Other Emerging Viruses
inferred← citeshttps://doi.org/10.1128/spectrum.03331-22openalex-snapshot
Combinations of Host- and Virus-Targeting Antiviral Drugs Confer Synergistic Suppression of SARS-CoV-2
inferred← citeshttps://doi.org/10.1142/s273741652150054xopenalex-snapshot
In-silicoPharmacokinetic and Affinity Studies of Piperazine/Morpholine Substituted Quinolines in Complex with GAK as Promising Anti-HCV Agent
inferred← citeshttps://doi.org/10.1155/bmri/3429646openalex-snapshot
Multifaceted Small Molecules as Enzyme Modulators: Cases of Drug Discovery/Repurposing Illustrating Nature′s Pragmatism
inferred← citeshttps://doi.org/10.1155/tbed/1766395openalex-snapshot
Numb‐Associated Kinases‐Mediated AP2M1 Activation Facilitates Porcine Reproductive and Respiratory Syndrome Virus Entry
inferred← citeshttps://doi.org/10.1172/jci169510openalex-snapshot
Anticancer pan-ErbB inhibitors reduce inflammation and tissue injury and exert broad-spectrum antiviral effects
inferred← citeshttps://doi.org/10.1172/jci170236openalex-snapshot
Preparing for the next viral threat with broad-spectrum antivirals
inferred← citeshttps://doi.org/10.1177/0961203320961848openalex-snapshot
Clinical management of Lupus patients during the COVID-19 pandemic
inferred← citeshttps://doi.org/10.1186/s43162-026-00659-2openalex-snapshot
Ebola world nightmare from Congo 1976 to Congo again 2026
inferred← citeshttps://doi.org/10.13005/bpj/2395openalex-snapshot
Advantages of Allometric Scaling Methods for Predicting Human Pharmacokinetics of Novel JAK Inhibitor -Baricitinib and Dose Extrapolation
inferred← citeshttps://doi.org/10.13021/g88t24openalex-snapshot
Efficacy of Host-Kinase Inhibitors as Antiviral Agents Against Venezuelan Equine Encephalitis Virus
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1006614openalex-snapshot
PathFX provides mechanistic insights into drug efficacy and safety for regulatory review and therapeutic development
inferred← citeshttps://doi.org/10.1371/journal.pcbi.1012876openalex-snapshot
Host centric drug repurposing for viral diseases
inferred← citeshttps://doi.org/10.1371/journal.pntd.0009633openalex-snapshot
Identification of potential biomarkers in dengue via integrated bioinformatic analysis
inferred← citeshttps://doi.org/10.1371/journal.pntd.0010291openalex-snapshot
Finding a chink in the armor: Update, limitations, and challenges toward successful antivirals against flaviviruses
inferred← citeshttps://doi.org/10.1371/journal.ppat.1008624openalex-snapshot
MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer
inferred← citeshttps://doi.org/10.1371/journal.ppat.1012038openalex-snapshot
Recent advances in the treatment of Ebola disease: A brief overview
inferred← citeshttps://doi.org/10.14336/ad.2023.0406openalex-snapshot
The Intersection of COVID-19 and Rheumatoid Arthritis: Shared Mechanisms, Treatment Challenges, and Potential Therapeutic Approaches
inferred← citeshttps://doi.org/10.14412/1996-7012-2020-2-110-116openalex-snapshot
COVID-19: the new challenge for rheumatologists
inferred← citeshttps://doi.org/10.15252/emmm.202012697openalex-snapshot
Mechanism of baricitinib supports artificial intelligence‐predicted testing in COVID‐19 patients
inferred← citeshttps://doi.org/10.15252/emmm.202012817openalex-snapshot
Can artificial intelligence identify effective COVID‐19 therapies?
inferred← citeshttps://doi.org/10.15252/msb.20209628openalex-snapshot
In vitro and in vivo identification of clinically approved drugs that modify ACE2 expression
inferred← citeshttps://doi.org/10.21248/gups.68695openalex-snapshot
Synthesis and optimization of pyrazolo [1,5-α] pyrimidine-based macrocyclic kinase inhibitors
inferred← citeshttps://doi.org/10.2139/ssrn.4871762openalex-snapshot
Design, Synthesis, and Biological Evaluation of Novel Aak1/Hdacs Dual Inhibitors Against Sars-Cov-2 Entry
inferred← citeshttps://doi.org/10.21518/2079-701x-2020-8-135-143openalex-snapshot
COVID-19 and Rheumatology: so far, so close
inferred← citeshttps://doi.org/10.2174/1381612827666210114150951openalex-snapshot
Therapeutic Agents Against COVID-19 with Clinical Evidence
inferred← citeshttps://doi.org/10.2174/1570159x16666180419124508openalex-snapshot
Viral Induced Oxidative and Inflammatory Response in Alzheimer’s Disease Pathogenesis with Identification of Potential Drug Candidates: A Systematic Review using Systems Biology Approach
inferred← citeshttps://doi.org/10.22037/ijpr.2020.113821.14506openalex-snapshot
Approaches for the Treatment of SARS-CoV-2 Infection: A Pharmacologic View and Literature Review.
inferred← citeshttps://doi.org/10.2217/fvl-2020-0124openalex-snapshot
A Comprehensive Review About SARS-CoV-2
inferred← citeshttps://doi.org/10.24321/0019.5138.202233openalex-snapshot
The Role of IL-6 in Inflammatory Reaction during Coronavirus-19 Infection: A Review
inferred← citeshttps://doi.org/10.24966/amr-694x/vol4iss1openalex-snapshot
inferred← citeshttps://doi.org/10.26434/chemrxiv.12277046openalex-snapshot
Screening of Anticancer Drugs as Potential Candidates to Target COVID-19 Disease
inferred← citeshttps://doi.org/10.26434/chemrxiv.12277046.v1openalex-snapshot
Screening of Anticancer Drugs as Potential Candidates to Target COVID-19 Disease
inferred← citeshttps://doi.org/10.33263/briac123.33573371openalex-snapshot
BCR-ABL Tyrosine Kinase Inhibitors as Candidates for the Treatment of COVID-19: Molecular Docking, Pharmacophore Modeling, ADMET Studies
inferred← citeshttps://doi.org/10.3389/fcell.2020.00616openalex-snapshot
nCOVID-19 Pandemic: From Molecular Pathogenesis to Potential Investigational Therapeutics
inferred← citeshttps://doi.org/10.3389/fcell.2022.1075364openalex-snapshot
Mapping of Tilapia Lake Virus entry pathways with inhibitors reveals dependence on dynamin activity and cholesterol but not endosomal acidification
inferred← citeshttps://doi.org/10.3389/fchem.2022.1058229openalex-snapshot
Synthesis and evaluation of 3-alkynyl-5-aryl-7-aza-indoles as broad-spectrum antiviral agents
inferred← citeshttps://doi.org/10.3389/fcimb.2018.00398openalex-snapshot
Cellular Targets for the Treatment of Flavivirus Infections
inferred← citeshttps://doi.org/10.3389/fcimb.2024.1264525openalex-snapshot
Multiple receptor tyrosine kinases regulate dengue infection of hepatocytes
inferred← citeshttps://doi.org/10.3389/fmed.2021.662460openalex-snapshot
Pan-Cancer Analysis of Genomic and Prognostic Characteristics Associated With Coronavirus Disease 2019 Regulators
inferred← citeshttps://doi.org/10.3389/fmed.2021.749657openalex-snapshot
Impact of the Addition of Baricitinib to Standard of Care Including Tocilizumab and Corticosteroids on Mortality and Safety in Severe COVID-19
inferred← citeshttps://doi.org/10.3389/fphar.2021.660710openalex-snapshot
Strategy, Progress, and Challenges of Drug Repurposing for Efficient Antiviral Discovery
inferred← citeshttps://doi.org/10.3389/fphar.2022.806568openalex-snapshot
Kinase Inhibitors as Potential Therapeutic Agents in the Treatment of COVID-19
inferred← citeshttps://doi.org/10.3390/cells9081876openalex-snapshot
Small Molecule Inhibitors in the Treatment of Rheumatoid Arthritis and Beyond: Latest Updates and Potential Strategy for Fighting COVID-19
inferred← citeshttps://doi.org/10.3390/cosmetics10060159openalex-snapshot
Developing Botanical Formulations for Sustainable Cosmetics
inferred← citeshttps://doi.org/10.3390/ijms20071760openalex-snapshot
Serine/Threonine Protein Kinase STK16
inferred← citeshttps://doi.org/10.3390/ijms21114050openalex-snapshot
Antiviral Activity of Compound L3 against Dengue and Zika Viruses In Vitro and In Vivo
inferred← citeshttps://doi.org/10.3390/ijms21218199openalex-snapshot
Chemical Space Exploration of Oxetanes
inferred← citeshttps://doi.org/10.3390/ijms21249524openalex-snapshot
Potential for Protein Kinase Pharmacological Regulation in Flaviviridae Infections
inferred← citeshttps://doi.org/10.3390/ijms22105274openalex-snapshot
Viral Interactions with Adaptor-Protein Complexes: A Ubiquitous Trait among Viral Species
inferred← citeshttps://doi.org/10.3390/ijms242216078openalex-snapshot
SCARF Genes in COVID-19 and Kidney Disease: A Path to Comorbidity-Specific Therapies
inferred← citeshttps://doi.org/10.3390/ijms25137273openalex-snapshot
Baricitinib and Pulse Steroids Combination Treatment in Hyperinflammatory COVID-19: A Rheumatological Approach in the Intensive Care Unit
inferred← citeshttps://doi.org/10.3390/jcm11154464openalex-snapshot
Factors Modulating COVID-19: A Mechanistic Understanding Based on the Adverse Outcome Pathway Framework
inferred← citeshttps://doi.org/10.3390/jcm9092935openalex-snapshot
Repurposing Immunomodulatory Therapies against Coronavirus Disease 2019 (COVID-19) in the Era of Cardiac Vigilance: A Systematic Review
inferred← citeshttps://doi.org/10.3390/microorganisms11061577openalex-snapshot
Clinically Evaluated COVID-19 Drugs with Therapeutic Potential for Biological Warfare Agents
inferred← citeshttps://doi.org/10.3390/microorganisms7090296openalex-snapshot
Contemporary Strategies and Current Trends in Designing Antiviral Drugs against Dengue Fever via Targeting Host-Based Approaches
inferred← citeshttps://doi.org/10.3390/microorganisms9030566openalex-snapshot
Formulation, Stability, Pharmacokinetic, and Modeling Studies for Tests of Synergistic Combinations of Orally Available Approved Drugs against Ebola Virus In Vivo
inferred← citeshttps://doi.org/10.3390/molecules26237338openalex-snapshot
Optimization of 4-Anilinoquinolines as Dengue Virus Inhibitors
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