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Chemical Proteomics and Super-resolution Imaging Reveal That Chloroquine Interacts with Plasmodium falciparum Multidrug Resistance-Associated Protein and Lipids

https://doi.org/10.1021/acschembio.8b00583

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What this work says

Outgoing claims: the papers this work cites, builds on, or argues with.

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MRP 1 mediates folate transport and antifolate sensitivity in Plasmodium falciparum

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Cinchona Alkaloids in Synthesis and Catalysis

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Identification of intracellular targets of small molecular weight chemical compounds using affinity chromatography

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In vitro stage-specific sensitivity of Plasmodium falciparum to quinine and artemisinin drugs

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Photoaffinity labeling of mefloquine-binding proteins in human serum, uninfected erythrocytes and Plasmodium falciparum-infected erythrocytes

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A colorimetric high-throughput β-hematin inhibition screening assay for use in the search for antimalarial compounds

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Plasmodium falciparum expresses a multidrug resistance-associated protein

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Transporters as mediators of drug resistance in Plasmodium falciparum

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Effects of solvent composition and ionic strength on the interaction of quinoline antimalarials with ferriprotoporphyrin IX

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Multiple spectroscopic and magnetic techniques show that chloroquine induces formation of the μ-oxo dimer of ferriprotoporphyrin IX

inferredcites →https://doi.org/10.1016/j.jinorgbio.2015.06.010openalex-snapshot

Solution structures of chloroquine–ferriheme complexes modeled using MD simulation and investigated by EXAFS spectroscopy

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Reversal of MRP-mediated doxorubicin resistance with quinoline-based drugs

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Differential effects of 4-aminoquinoline-containing antimalarial drugs on hemoglobin digestion in Plasmodium falciparum-infected erythrocytes

inferredcites →https://doi.org/10.1016/s0006-2952(98)00217-2openalex-snapshot

Direct binding of chloroquine to the multidrug resistance protein (MRP)

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7-nitrobenz-2-oxa-1,3-diazole-4-yl-labeled phospholipids in lipid membranes: differences in fluorescence behavior

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Photoaffinity labeling of chloroquine-binding proteins in Plasmodium falciparum.

inferredcites →https://doi.org/10.1021/bi901034ropenalex-snapshot

Chloroquine Transport in Plasmodium falciparum. 1. Influx and Efflux Kinetics for Live Trophozoite Parasites Using a Novel Fluorescent Chloroquine Probe

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Insights into the Role of Heme in the Mechanism of Action of Antimalarials

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Interplay Between Malaria, Crystalline Hemozoin Formation, and Antimalarial Drug Action and Design

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The Single Crystal X-ray Structure of β-Hematin DMSO Solvate Grown in the Presence of Chloroquine, a β-Hematin Growth-Rate Inhibitor

inferredcites →https://doi.org/10.1021/jm020858uopenalex-snapshot

Structure−Activity Relationships in 4-Aminoquinoline Antiplasmodials. The Role of the Group at the 7-Position

inferredcites →https://doi.org/10.1021/jm980146xopenalex-snapshot

Structure−Activity Relationships for Antiplasmodial Activity among 7-Substituted 4-Aminoquinolines

inferredcites →https://doi.org/10.1021/jm990437lopenalex-snapshot

Structure−Function Relationships in Aminoquinolines: Effect of Amino and Chloro Groups on Quinoline−Hematin Complex Formation, Inhibition of β-Hematin Formation, and Antiplasmodial Activity

inferredcites →https://doi.org/10.1038/355167a0openalex-snapshot

Inhibition by chloroquine of a novel haem polymerase enzyme activity in malaria trophozoites

inferredcites →https://doi.org/10.1038/374269a0openalex-snapshot

Malarial haemozoin/β-haematin supports haem polymerization in the absence of protein

inferredcites →https://doi.org/10.1038/sj.emboj.7600681openalex-snapshot

A critical role for PfCRT K76T in Plasmodium falciparum verapamil‐reversible chloroquine resistance

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P-glycoprotein: from genomics to mechanism

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Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum

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Oriented nucleation of hemozoin at the digestive vacuole membrane in Plasmodium falciparum

inferredcites →https://doi.org/10.1073/pnas.1118134109openalex-snapshot

Aligned hemozoin crystals in curved clusters in malarial red blood cells revealed by nanoprobe X-ray Fe fluorescence and diffraction

inferredcites →https://doi.org/10.1073/pnas.1501023112openalex-snapshot

Mechanisms of hematin crystallization and inhibition by the antimalarial drug chloroquine

inferredcites →https://doi.org/10.1074/jbc.m806944200openalex-snapshot

Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and Glutathione

inferredcites →https://doi.org/10.1074/mcp.m114.040956openalex-snapshot

Sex-partitioning of the Plasmodium falciparum Stage V Gametocyte Proteome Provides Insight into falciparum-specific Cell Biology

inferredcites →https://doi.org/10.1086/606009openalex-snapshot

Plasmodium falciparumMultidrug Resistance Protein 1 and Artemisinin‐Based Combination Therapy in Africa

inferredcites →https://doi.org/10.1093/rheumatology/36.7.799openalex-snapshot

Antimalarial drugs in the treatment of rheumatological diseases.

inferredcites →https://doi.org/10.1111/j.1365-2958.2005.04699.xopenalex-snapshot

Development of the endoplasmic reticulum, mitochondrion and apicoplast during the asexual life cycle of Plasmodium falciparum

inferredcites →https://doi.org/10.1111/j.1550-7408.1983.tb05336.xopenalex-snapshot

Stage‐Dependent Effects of Chloroquine on Plasmodium falciparum In Vitro1

inferredcites →https://doi.org/10.1124/mol.62.6.1364openalex-snapshot

Discovery of Novel Targets of Quinoline Drugs in the Human Purine Binding Proteome

inferredcites →https://doi.org/10.1128/aac.00091-09openalex-snapshot

Polymorphism in PfMRP1 ( Plasmodium falciparum Multidrug Resistance Protein 1) Amino Acid 1466 Associated with Resistance to Sulfadoxine-Pyrimethamine Treatment

inferredcites →https://doi.org/10.1128/aac.00121-11openalex-snapshot

Use of the NP-40 Detergent-Mediated Assay in Discovery of Inhibitors of β-Hematin Crystallization

inferredcites →https://doi.org/10.1128/aac.01478-07openalex-snapshot

Differential Effects of Quinoline Antimalarials on Endocytosis inPlasmodium falciparum

inferredcites →https://doi.org/10.1128/aac.01881-12openalex-snapshot

Defining the Timing of Action of Antimalarial Drugs against Plasmodium falciparum

inferredcites →https://doi.org/10.1128/aac.40.8.1846openalex-snapshot

4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum

inferredcites →https://doi.org/10.1134/s0006297911110101openalex-snapshot

The Molecular Probes handbook. A guide to fluorescent probes and labeling technologies

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Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membrane

inferredcites →https://doi.org/10.3109/01913123.2011.601405openalex-snapshot

Ultrastructural and Real-time Microscopic Changes inP. falciparum-infected Red Blood Cells Following Treatment with Antimalarial Drugs

inferredcites →https://doi.org/10.4155/fmc.13.113openalex-snapshot

Hemozoin and Antimalarial Drug Discovery

inferredcites →https://doi.org/10.4269/ajtmh.1988.39.15openalex-snapshot

Ultrastructural Study of the Effects of Chloroquine and Verapamil on Plasmodium Falciparum

inferredcites →https://doi.org/10.4269/ajtmh.1993.48.739openalex-snapshot

Parasite Lactate Dehydrogenase as an Assay for Plasmodium falciparum Drug Sensitivity

What points at this work

Incoming claims: where this work appears in other papers’ reference lists and arguments.

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Subcellular Localisation of a Quinoline‐Containing Fluorescent Cyclometallated IrIII Complex in Plasmodium falciparum

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inferred← citeshttps://doi.org/10.2174/1568026620666200127141550openalex-snapshot

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Additional file 1 of Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

inferred← citeshttps://doi.org/10.6084/m9.figshare.20064464openalex-snapshot

Additional file 2 of Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

inferred← citeshttps://doi.org/10.6084/m9.figshare.20064470openalex-snapshot

Additional file 3 of Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA

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Additional file 1 of Successful treatment with doxycycline monotherapy for human infection with Babesia venatorum (Babesiidae, Sporozoa) in China: a case report and proposal for a clinical regimen

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Synthèse stéréosélective et étude de nouveaux arylaminoalcools antipaludiques

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