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Unravelling the Mechanisms of Proline Analogues Against Trypanosoma Cruzi

https://doi.org/10.2139/ssrn.4764060
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The phosphoglycerate kinase isoenzymes have distinct roles in the regulation of carbohydrate metabolism in Trypanosoma cruzi
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Glucose uptake in the mammalian stages of Trypanosoma cruzi
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Chemical Proteomics and Super-resolution Imaging Reveal That Chloroquine Interacts with Plasmodium falciparum Multidrug Resistance-Associated Protein and Lipids
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Synthesis and Biological Evaluation of Fluorescent Leishmanicidal Analogues of Hexadecylphosphocholine (Miltefosine) as Probes of Antiparasite Mechanisms
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A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemase
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Artemisinins target the SERCA of Plasmodium falciparum
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Synthesis of a fluorescent analogue of geranylgeranyl pyrophosphate and its use in a high-throughput fluorometric assay for Rab geranylgeranyltransferase
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Shining new light on ancient drugs: preparation and subcellular localisation of novel fluorescent analogues of Cinchona alkaloids in intraerythrocytic Plasmodium falciparum
inferredcites →https://doi.org/10.1039/c7md00008aopenalex-extracted
Antitrypanosomal and antileishmanial activity of prenyl-1,2,3-triazoles
inferredcites →https://doi.org/10.1042/bcj20200232openalex-extracted
Trypanosoma cruzi synthesizes proline via a Δ1-pyrroline-5-carboxylate reductase whose activity is fine-tuned by NADPH cytosolic pools
inferredcites →https://doi.org/10.1074/jbc.m114.574525openalex-extracted
Role of Δ1-Pyrroline-5-Carboxylate Dehydrogenase Supports Mitochondrial Metabolism and Host-Cell Invasion of Trypanosoma cruzi
inferredcites →https://doi.org/10.1074/jbc.m117.778522openalex-extracted
Metabolomic profiling reveals a finely tuned, starvation-induced metabolic switch in Trypanosoma cruzi epimastigotes
inferredcites →https://doi.org/10.1074/jbc.m301875200openalex-extracted
Translocation of Phospholipids Is Facilitated by a Subset of Membrane-spanning Proteins of the Bacterial Cytoplasmic Membrane
inferredcites →https://doi.org/10.1111/j.1462-5822.2004.00397.xopenalex-extracted
l-Proline is essential for the intracellular differentiation of Trypanosoma cruzi
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Some Factors Inducing Formation of Metacyclic Stages of Trypanosoma cruzi
inferredcites →https://doi.org/10.1111/j.1550-7408.2002.tb00225.xopenalex-extracted
Active Transport of L‐Proline in Trypanosoma cruzi
inferredcites →https://doi.org/10.1128/iai.00138-09openalex-extracted
Use of l -Proline and ATP Production by Trypanosoma cruzi Metacyclic Forms as Requirements for Host Cell Invasion
inferredcites →https://doi.org/10.1194/jlr.m100404-jlr200openalex-extracted
Uptake of long-chain fatty acids in HepG2 cells involves caveolae
inferredcites →https://doi.org/10.1371/journal.pntd.0004359openalex-extracted
The Trypanosoma cruzi Protein TcHTE Is Critical for Heme Uptake
inferredcites →https://doi.org/10.1371/journal.pntd.0006612openalex-extracted
Development of Trypanosoma cruzi in vitro assays to identify compounds suitable for progression in Chagas’ disease drug discovery
inferredcites →https://doi.org/10.1371/journal.pntd.0009994openalex-extracted
An aromatic imidazoline derived from chloroquinoline triggers cell cycle arrest and inhibits with high selectivity the Trypanosoma cruzi mammalian host-cells infection
inferredcites →https://doi.org/10.1371/journal.pone.0069419openalex-extracted
Proline Dehydrogenase Regulates Redox State and Respiratory Metabolism in Trypanosoma cruzi
inferredcites →https://doi.org/10.1371/journal.ppat.1006158openalex-extracted
Proline Metabolism is Essential for Trypanosoma brucei brucei Survival in the Tsetse Vector
inferredcites →https://doi.org/10.2174/1566524043360249openalex-extracted
The Determinants of Chagas Disease: Connecting Parasite and Host Genetics
inferredcites →https://doi.org/10.2174/1568005053174636openalex-extracted
Amino Acid Metabolic Routes in Trypanosoma cruzi: Possible Therapeutic Targets Against Chagas; Disease
inferredcites →https://doi.org/10.2307/3274935openalex-extracted
Comparative Physiological Studies on Four Species of Hemoflagellates in Culture. II. Effect of Carbohydrates and Related Substances and Some Amino Compounds on the Respiration
inferredcites →https://doi.org/10.3389/fchem.2020.00696openalex-extracted
Targeting L-Proline Uptake as New Strategy for Anti-chagas Drug Development
inferredcites →https://doi.org/10.3892/mmr.2015.4154openalex-extracted
Characterization of fluorescent NBD-cholesterol efflux in THP-1-derived macrophages
inferredcites →https://doi.org/10.3998/ark.5550190.0006.624openalex-extracted
An efficient and operationally convenient general synthesis of tertiary amines by direct alkylation of secondary amines with alkyl halides in the presence of Huenig’s base
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Relationship between Trypanosoma cruzi and human chagasic megaesophagus: blood and tissue parasitism.
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